Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation

Journal of Pharmacological Sciences

Volumn 108, Issue 1, 2008, Pages 18-31

  Samee, Mayurach ^a   Kasugai, Shohei ^a   Kondo, Hisatomo ^a   Ohya, Keiichi ^a   Shimokawa, Hitoyata ^a   Kuroda, Shinji ^a  

^a Tokyo Medical and Dental University ^*  (Japan)

Author keywords

Bone morphogenetic protein 2 (BMP 2); Gene transfer; Periosteal cell; Tissue engineering; Vascular endothelial growth factor (VEGF)

Indexed keywords

ALIZARIN RED S; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CD31 ANTIGEN; COLLAGEN TYPE 1; DRUG VEHICLE; MESSENGER RNA; OSTEOCALCIN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REGENERATION; CELL DIFFERENTIATION; CELL REGENERATION; CONTROLLED STUDY; ECTOPIC BONE; ECTOPIC TISSUE; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OSSIFICATION; OSTEOBLAST; PERIOSTEUM; REAL TIME POLYMERASE CHAIN REACTION; STAINING; TISSUE ENGINEERING;

EID: 52949105668     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08036FP     Document Type: Article

References (43)

1. Franceschi RT. Biological approaches to bone regeneration by gene therapy. J Dent Res. 2005;84:1093-1103.
2. Nakahara H, Bruder SP, Haynesworth SE, Holecek JJ, Baber MA, Goldberg VM, et al. Bone and cartilage formation in diffusion chambers by subcultured cells derived from the periosteum. Bone. 1990;11:181-188.
3. Nakahara H, Goldberg VM, Caplan AI. Culture-expanded human periosteal-derived cells exhibit osteochondral potential in vivo. J Orthop Res. 1991;9:465-476.
4. Akiyama M, Nonomura H, Kamil SH, Ignotz RA. Periosteal cell pellet culture system: a new technique for bone engineering. Cell Transplant. 2006;15:521-532.
5. Hutmacher DW, Sittinger M. Periosteal cells in bone tissue engineering. Tissue Eng. 2003;9 Suppl 1:S45-S64.
6. Sakata Y, Ueno T, Kagawa T, Kanou M, Fujii T, Yamachika E, et al. Osteogenic potential of cultured human periosteum-derived cells - a pilot study of human cell transplantation into a rat calvarial defect model. J Craniomaxillofac Surg. 2006;34:461-465.
7. Fang J, Hall BK. Chondrogenic cell differentiation from membrane bone periostea. Anat Embryol (Berl). 1997;196:349-362.
8. Ito Y, Fitzsimmons JS, Sanyal A, Mello MA, Mukherjee N, O'Driscoll SW. Localization of chondrocyte precursors in periosteum. Osteoarthritis Cartilage. 2001;9:215-223.
9. De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, et al. Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. Arthritis Rheum. 2006;54:1209-1221.
10. Fell HB. The osteogenic capacity in vitro of periosteum and endosteum isolated from the limb skeleton of fowl embryos and young chicks. J Anat. 1932;66:157-180.11.
11. Tang XM, Chai BF. Ultrastructural investigation of osteogenic cells. Chin Med J (Engl). 1986;99:950-956.
12. Tenenbaum HC, Palangio KG, Holmyard DP, Pritzker KP. An ultrastructural study of osteogenesis in chick periosteum in vitro. Bone. 1986;7:295-302.
13. Breitbart AS, Grande DA, Kessler R, Ryaby JT, Fitzsimmons RJ, Grant RT. Tissue engineered bone repair of calvarial defects using cultured periosteal cells. Plast Reconstr Surg. 1998;101: 567-574; discussion 575-576.
14. Redlich A, Perka C, Schultz O, Spitzer R, Haupl T, Burmester GR, et al. Bone engineering on the basis of periosteal cells cultured in polymer fleeces. J Mater Sci Mater Med. 1999;10: 767-772.
15. Isogai N, Landis WJ, Mori R, Gotoh Y, Gerstenfeld LC, Upton J, et al. Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells. Plast Reconstr Surg. 2000;105:953-963.
16. Jaquiery C, Schaeren S, Farhadi J, Mainil-Varlet P, Kunz C, Zeilhofer HF, et al. In vitro osteogenic differentiation and in vivo bone-forming capacity of human isogenic jaw periosteal cells and bone marrow stromal cells. Ann Surg. 2005;242:859-867, discussion 867-868.
17. Ono T, Yoshida T, Hoh C, Davies JE, Sakae T, Nagai N. A morphological study on the response between primary periosteum cultures and synthetic hydroxyapatite particles. Shika Kiso Igakkai Zasshi. 1990;32:83-86.
18. Perka C, Schultz O, Spitzer RS, Lindenhayn K, Burmester GR, Sittinger M. Segmental bone repair by tissue-engineered periosteal cell transplants with bioresorbable fleece and fibrin scaffolds in rabbits. Biomaterials. 2000;21:1145-1153.
19. Schantz JT, Hutmacher DW, Chim H, Ng KW, Lim TC, Teoh SH. Induction of ectopic bone formation by using human periosteal cells in combination with a novel scaffold technology. Cell Transplant. 2002;11:125-138.
20. Spitzer RS, Perka C, Lindenhayn K, Zippel H. Matrix engineering for osteogenic differentiation of rabbit periosteal cells using alpha-tricalcium phosphate particles in a three-dimensional fibrin culture. J Biomed Mater Res. 2002;59:690-696.
21. Groger A, Klaring S, Merten HA, Holste J, Kaps C, Sittinger M. Tissue engineering of bone for mandibular augmentation in immunocompetent minipigs: preliminary study. Scand J Plast Reconstr Surg Hand Surg. 2003;37:129-133.
22. Puelacher WC, Vacanti JP, Ferraro NF, Schloo B, Vacanti CA. Femoral shaft reconstruction using tissue-engineered growth of bone. Int J Oral Maxillofac Surg. 1996;25:223-228.
23. Vacanti CA, Bonassar LJ, Vacanti MP, Shufflebarger J. Replacement of an avulsed phalanx with tissue-engineered bone. N Engl J Med. 2001;344:1511-1514.
24. Schmelzeisen R, Schimming R, Sittinger M. Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report. J Craniomaxillofac Surg. 2003;31:34-39.
25. Yang ZM, Huang FG, Qin TW. [Bio-derived bone transplantation with tissue engineering technique: preliminary clinical trial]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002;16:311-314.
26. Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, et al. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology. 2002;143: 1545-1553.
27. Furumatsu T, Shen ZN, Kawai A, Nishida K, Manabe H, Oohashi T, et al. Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. J Biochem (Tokyo). 2003;133:633-639.
28. Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, et al. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. Embo J. 2004;23:541-551.
29. Endo M, Kuroda S, Kondo H, Maruoka Y, Ohya K, Kasugai S. Bone regeneration by modified gene-activated matrix: effectiveness in segmental tibial defects in rats. Tissue Eng. 2006;12: 489-497.
30. Maruoka Y, Oida S, Iimura T, Takeda K, Asahina I, Enomoto S, et al. Production of functional human bone morphogenetic protein-2 using a baculovirus/Sf-9 insect cell system. Biochem Mol Biol Int. 1995;35:957-963.
31. Hawley-Nelson P. Lipofectamine reagent: a new, higher efficiency polycationic liposome transfection reagent. Focus. 1993;15:73-79.
32. Kim SW, Ogawa T, Tabata Y, Nishimura I. Efficacy and cytotoxicity of cationic-agent-mediated nonviral gene transfer into osteoblasts. J Biomed Mater Res A. 2004;71:308-315.
33. Nakahara H, Bruder SP, Goldberg VM, Caplan AI. In vivo osteochondrogenic potential of cultured cells derived from the periosteum. Clin Orthop Relat Res. 1990;223-232.
34. Zhang C. A study on a tissue-engineered bone using rhBMP-2 induced periosteal cells with a porous nano-hydroxyapatite / collagen/poly(L-lactic acid) scaffold. J Biomed Mater Res. 2006;1:52-62.
35. Raida M, Heymann AC, Gunther C, Niederwieser D. Role of bone morphogenetic protein 2 in the crosstalk between endothelial progenitor cells and mesenchymal stem cells. Int J Mol Med. 2006;18:735-739.
36. Peng H, Usas A, Olshanski A, Ho AM, Gearhart B, Cooper GM, et al. VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res. 2005;20:2017-2027.
37. Peng H, Wright V, Usas A, Gearhart B, Shen HC, Cummins J, et al. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest. 2002;110:751-759.
38. Matsushita N, Terai H, Okada T, Nozaki K, Inoue H, Miyamoto S, et al. A new bone-inducing biodegradable porous beta-tricalcium phosphate. J Biomed Mater Res A. 2004;70:450-458.
39. Ito Y, Tanaka N, Fujimoto Y, Yasunaga Y, Ishida O, Agung M, et al. Bone formation using novel interconnected porous calcium hydroxyapatite ceramic hybridized with cultured marrow stromal stem cells derived from Green rat. J Biomed Mater Res A. 2004;69:454-461.
40. Koshihara Y, Kawamura M, Endo S, Tsutsumi C, Kodama H, Oda H, et al. Establishment of human osteoblastic cells derived from periosteum in culture. In Vitro Cell Dev Biol. 1989;25:37-43.
41. Muschler GF, Midura RJ. Connective tissue progenitors: practical concepts for clinical applications. Clin Orthop Relat Res. 2002;66-80.
42. Muschler GF, Nitto H, Boehm CA, Easley KA. Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors. J Orthop Res. 2001;19:117-125.
43. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002;84-A:2123-2134.