Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14634-14639

  Xu, Kai ^a   Tzvetkova Robev, Dorothea ^a   Xu, Yan ^a   Goldgur, Yehuda ^a   Chan, Yee Peng ^b   Himanen, Juha P ^a   Nikolov, Dimitar B ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Crystallography; Phosphorylation; Protein; Transmembrane

Indexed keywords

EPHRIN A5; EPHRIN RECEPTOR; EPHRIN RECEPTOR A4; PROTEIN BINDING;

ARTICLE; CELL CONTACT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; LIGAND BINDING; MOLECULAR INTERACTION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BLOTTING, WESTERN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; EPHRIN-A5; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPHA4; SIGNAL TRANSDUCTION;

EID: 84883325814     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1311000110     Document Type: Article

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