Excitatory Eph receptors and adhesive ephrin ligands

Current Opinion in Cell Biology

Volumn 13, Issue 2, 2001, Pages 196-203

  Klein, R ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN; EPHRIN A; EPHRIN B; EPHRIN LIGAND; EPHRIN RECEPTOR; GLUTAMATE RECEPTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL ADHESION; CELL PROLIFERATION; CELL SURFACE; LIGAND BINDING; MOUSE; NERVE CELL EXCITABILITY; NERVE GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RETINA GANGLION CELL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0035313727     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00197-6     Document Type: Review

References (52)

1. Eph receptors and ephrins: Effectors of morphogenesis
2. The ephrins and Eph receptors in neural development
3. Eph receptors and ephrins: Regulators of guidance and assembly
4. Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6
5. Control of cell behaviour by signalling through Eph receptors and ephrins
6. Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatases β
7. Signalling by Eph receptors and their ephrin ligands
8. Topographic mapping: Organising by repulsion and competition?
9. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
10. New paradigms of signaling in the vasculature: Ephrins and metalloproteases
11. Eph receptors and ephrins in neural development
12. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping
13. Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
14. Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system
15. Topographic guidance labels in a sensory projection to the forebrain
16. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina
17. Axon guidance: Starting and stopping with slit
18. Axon guidance at the central nervous system midline
19. The middle and the end: Slit brings guidance and branching together in axon pathway selection
20. Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: A possible role in constraining the orientation of longitudinally projecting axons
21. EphrinB regulates the ipsilateral routing of retinal axons at the optic chiasm
22. EphB2 guides axons at the midline and is necessary for normal vestibular function
23. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
24. Eph signalling is required for segmentation and differentiation of the somites
25. Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons
26. Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles
27. Expression of EphA4, ephrinA2 and ephrinA5 during axon outgrowth to the hindlimb indicates potential roles in pathfinding
28. Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers
29. Eph receptors and ephrin expression in cranial motor neurons and the branchial arches of the chick embryo
30. Synaptic activity and the construction of cortical circuits
31. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation
32. Disruption of Eph/ephrin signalling affects migration and proliferation in the adult subventricular zone
33. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases
34. Regulated cleavage of a contact-mediated axon repellent
35. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
36. Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors
37. Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses
38. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
39. An Eph receptor regulates integrin activity through R-Ras
40. Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through αvβ3 and α5β1 integrins
41. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
42. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
43. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
44. An ephrinA-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120 kDa protein
45. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
46. Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase
47. Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk
48. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation
49. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration
50. Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo
51. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline
52. Defining brain wiring patterns and mechanisms through gene trapping in mice