Multiple lethal effects induced by a benzimidazole anthelmintic in the anterior intestine of the nematode Haemonchus contortus

Molecular and Biochemical Parasitology

Volumn 105, Issue 1, 2000, Pages 81-90

  Jasmer, Douglas P ^a   Yao, Chaoqun ^a   Rehman, Abdur ^a   Johnson, Sandra ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

Apoptosis; Benzimidazole; Haemonchus contortus; Intestine; Nematoda; Secretory vesicle

Indexed keywords

ANTHELMINTIC AGENT; BENZIMIDAZOLE; DNA FRAGMENT; FENBENDAZOLE;

ANTHELMINTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ERYTHROCYTE MEMBRANE; HAEMONCHUS CONTORTUS; MEMBRANE TRANSPORT; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEMATODAL AGENTS; APOPTOSIS; CELL NUCLEUS; CYTOPLASMIC GRANULES; DNA FRAGMENTATION; ERYTHROCYTES; FENBENDAZOLE; HAEMONCHIASIS; HAEMONCHUS; INTESTINES; MICROSCOPY, ELECTRON; MICROSCOPY, IMMUNOELECTRON; SHEEP; SHEEP DISEASES; TUBULIN;

HAEMONCHUS CONTORTUS; NEMATODA; OVIS ARIES;

EID: 0033991107     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00169-3     Document Type: Article

References (32)

1. Borgers M., De Nollin S. Ultrastructural changes in Ascaris suum intestine after mebendazole treatment. J. Parasitol. 61:1975;110-122.
2. Borgers M., De Nollin S., De Brabander M., Thienpont D. Influence of the anthelmintic mebendazole on microtubules and intracellular organelle movement in nematode intestinal cells. Am. J. Vet. Res. 36:1975;1153-1166.
3. Borgers M., De Nollin S., Verheysen A., De Brabander M., Thienpont D. Effects of new anthelmintics on the microtubular system of parasites. Borgers M., de Brabander M. Microtubules and Microtubule Inhibitors. 1975;497-508 North Holland Publishing Co.
4. Hedgecock E.M., White J.G. Polyploid tissues in the nematode Caenorhabditis elegans. Dev. Biol. 107:1985;128-133.
5. Atkinson C., Newsam R.J., Gull K. Influence of the antimicrotubule agent, mebendazole, on the secretory activity of intestinal cells of Ascaridia galli. Protoplasm. 105:1980;69-76.
6. Comley J.C.W. Ultrastructure of the intestinal cells of Aspiculuris tetraptera after in vivo treatment of mice with mebendazole and thiabendazole. Int. J. Parasitol. 10:1980;143-150.
7. Zintz K., Frank W. Ultrastructural modification in Heterakis spumosa after treatment with febantel and mebendazole. Vet. Parasitol. 10:1982;47-56.
8. Nare B., Lubega G., Prichard R.K., Georges E. P-Azidosalicyl-5-amino-6-phenoxybenzimidazole photolabels the N-terminal 63-103 amino acids of Haemonchus contortus β-tubulin 1. J. Biol. Chem. 271:1996;8575-8581.
9. Lacey E. The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles. Int. J. Parasitol. 18:1988;885-936.
10. Lacey E., Prichard R.K. Interactions of benzimidazoles (BZ) with tubulin from BZ-sensitive and BZ-resistant isolates of Haemonchus contortus. Mol. Biochem. Parasitol. 19:1986;171-181.
11. Lubega G.W., Prichard R.K. Specific interaction of benzimidazole anthelmintics with tubulin: high-affinity binding and benzimidazole resistance in Haemonchus contortus. Mol. Biochem. Parasitol. 38:1990;221-232.
12. Franz M., Zahner H., Benten P. Fine Structure alterations in female Brugia malayi and Litomosoides carinii after in vivo treatment with flubendazole. Parasitol. Res. 76:1990;401-405.
13. Spence A.M., Malone K.M.B., Novak M.M.A., Woods R.A. The effects of mebendazole on the growth and development of Caenorhabditis elegans. Can. J. Zool. 60:1982;2616-2623.
14. Driscoll M., Dean E., Reilly E., Bergholz E., Chalfie M. Genetic and molecular analysis of Caenorhabditis elegans β-tubulin that conveys benzimidazole sensitivity. J. Cell Biol. 109:1989;2993-3003.
15. Prichard R. Anthelmintic resistance. Vet. Parasitol. 54:1994;259-268.
16. Kwa M.S., Kooyman F.N., Boersema J.H., Roos M.H. Effect of selection for benzimidazole resistance in Haemonchus contortus on β-tubulin isotype 1 and isotype 2 genes. Biochem. Biophys. Res. Commun. 191:1993;413-419.
17. Kwa M.S., Veenstra J.G., Roos M.H. Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in β-tubulin isotype 1. Mol. Biochem. Parasitol. 63:1994;299-303.
18. Lubega G.W., Klein R.D., Geary T.G., Prichard R.K. Haemonchus contortus: the role of two beta-tubulin gene subfamilies in the resistance to benzimidazole anthelmintics. Biochem. Pharmacol. 47:1994;1705-1715.
19. Kwa M.S., Veenstra J.G., Van Dijk M., Roos M.H. β-tubulin genes from the parasitic nematode Haemonchus contortus modulate drug resistance in Caenorhabditis elegans. J. Mol. Biol. 246:1995;500-510.
20. Jasmer D.P., Perryman L.E., Conder G.A., Crow S., McGuire T.C. Protective immunity to Haemonchus contortus induced by immunoaffinity isolated antigens that share a phylogenetically conserved gut surface epitope. J. Immunol. 151:1993;5450-5460.
21. Geary T.G., Nulf S.C., Favreau M.A., Tang L., Prichard R.K., Hatzenbuhler N.T., Shea M.H., Alexander S.J., Klein R.D. Three β-tubulin cDNAs from the parasitic nematode Haemonchus contortus. Mol. Biochem. Parasitol. 50:1992;295-306.
22. Smith L.M., Sanders J.Z., Kaiser R.J., Hughes P., Dodd C., Connell C.R., Heiner C., Kent S.B.H., Hood L.E. Fluorescence detection in automated DNA sequence analysis. Nature. 321:1986;674-679.
23. Dowling S.C., Perryman L.E., Jasmer D.P. A Babesia bovis 225 kilodalton spherical body protein: localization to the cytoplasmic face of infected erythrocytes after merozoite invasion. Infect. Immun. 64:1996;2618-2626.
24. Tilly J.L., Hsueh A.J.W. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J. Cell. Physiol. 154:1993;519-526.
25. Beech R.N., Prichard R.K., Scott M.E. Genetic variability of the β-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus. Genetics. 138:1994;103-110.
26. Magambo J.K. Ascaris suum: Ultrstructual effect of in vitro albendazole therapy. E. Afr. Med. J. 73:1996;140-142.
27. Rehman A., Jasmer D.P. A tissue specific approach for analysis of membrane and secreted protein antigens from Haemonchus contortus gut and its application to diverse nematode species. Mol. Biochem. Parasitol. 97:1998;55-68.
28. Sulston J.E. Post-embryonic development in the ventral cord of Caenorhabditis elegans. Philos. Trans. R. Soc. Lond. B Biol. Sci. 275:1976;287-297.
29. Ellis H.M., Horvitz H.R. Genetic control of programmed cell death in the nematode C. elegans. Cell. 44:1986;817-829.
30. Yuan J., Shaham S., Ledoux S., Ellis H.M., Horvitz H.R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell. 75:1993;641-652.
31. Bughio N.I., Faubert G.M., Prichard R.K. Identification of tubulin isoforms in different tissues of Ascaris suum, using anti-tubulin monoclonal antibodies. Int. J. Parasitol. 21:1991;913-918.
32. Bughio N.I., Faubert G.M., Prichard R.K. Interaction of mebendazole with tubulin from body wall muscle, intestine, and reproductive system of Ascaris suum. J. Parasitol. 80:1994;126-132.