Mechanistic Inferences from the Crystal Structure of Fumarylacetoacetate Hydrolase with a Bound Phosphorus-based Inhibitor

Journal of Biological Chemistry

Volumn 276, Issue 18, 2001, Pages 15284-15291

  Bateman, Raynard L ^a,b   Bhanumoorthy, P ^c   Witte, John F ^b   McClard, Ronald W ^b   Grompe, Markus ^a   Timm, David E ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b REED COLLEGE   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DEGRADATION; DISEASE CONTROL; HYDROLYSIS; METABOLISM;

MOLECULAR BASIS;

BIOCHEMISTRY;

4 (HYDROXYMETHYLPHOSPHINOYL) 3 OXOBUTANOIC ACID; ENZYME INHIBITOR; FUMARYLACETOACETASE; FUMARYLACETOACETASE INHIBITOR; UNCLASSIFIED DRUG; 4-(HYDROXYMETHYLPHOSPHINOYL)-3-OXOBUTANOIC ACID; ACETOACETIC ACID DERIVATIVE; CALCIUM; HYDROLASE; MAGNESIUM; ORGANOPHOSPHORUS COMPOUND;

ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; HUMAN; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TYROSINEMIA; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ACETOACETATES; ANIMALS; BINDING SITES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROLASES; MAGNESIUM; MICE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN CONFORMATION;

EID: 0035805603     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007621200     Document Type: Article

References (36)

1. Lindblad, B., Lindstedt, S., and Steen, G. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 4641-4645
2. Kvittingen, E. (1986) Scan. J. Clin. Lab. Invest. 46, 27-34
3. Mitchell, G., Larochelle, J., Lambert, M., Michaud, J., Grenier, A., Ogier, H., Gauthier, M., Lacroix, J., Vanasse, M., Larbrisseau, A., Paradis, K., Weber, A., Lefevre, Y., Melançon, S., and Dallaire, L. (1990) N. Engl. J. Med. 322, 432-437
4. Jorquera, R., and Tanguay, R. M. (1997) Biochem. Biophys. Res. Commun. 232, 42-48
5. Grompe, M., Lindstedt, S., al-Dhalimy, M., Kennaway, N. G., Papaconstantinou, J., Torres-Ramos, C. A., Ou, C. N., and Finegold, M. (1995) Nat. Genet. 10, 453-460
6. Ruppert, S., Kelsey, G., Schedl, A., Schmid, E., Thies, E., and Schütz, G. (1992) Genes Dev. 6, 1430-1443
7. Gilbert-Barness, E., Barness, L. A., and Meisner, L. F. (1990) Pediatr. Pathol. 10, 243-252
8. Jorquera, R., and Tanquay, R. M. (1999) FASEB J. 13, 2284-2298
9. Stoner, E., Starkman, H., Wellner, D., Wellner, V. P., Sassa, S., Rifkind, A. B., Grenier, A., Steinherz, P. G., Meister, A., New, M. I., and Levine, L. S. (1984) Pediatr. Res. 18, 1332-1336
10. Endo, F., Kubo, S., Awata, H., Kiwaki, K., Katoh, H., Kanegae, Y., Saito, I., Miyazaki, J., Yamamoto, T., Jakobs, C., Hattori, S., and Matsuda, I. (1997) J. Biol. Chem. 272, 24426-24432
11. Paradis, K., Weber, A., Seidman, E. G., Larochelle, J., Garel, L., Lenaerts, C., and Roy, C. C. (1990) Am. J. Hum. Genet. 47, 338-342
12. Lindstedt, S., Holme, E., Lock, E. A., Hjalmarson, O., and Strandvik, B. (1992) Lancet 340, 813-817
13. Harding, M. M. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 1432-1443
14. Grompe, M., Al-Dhalimy, M., Finegold, M., Ou, C. N., Burlingame, T., Kennaway, N. G., and Soriano, P. (1993) Genes Dev. 7, 2298-2307
15. Overturf, K., al-Dhalimy, M., Tanguay, R., Brantly, M., Ou, C. N., Finegold, M., and Grompe, M. (1996) Nat. Genet. 12, 266-273
16. Overturf, K., al-Dhalimy, M., Ou, C. N., Finegold, M., Tanguay, R., Lieber, A., Kay, M., and Grompe, M. (1997) Hum. Gene Ther. 8, 513-521
17. Hsiang, H. H., Sim, S. S., Mahuran, D. J., and Schmidt, D. E. (1972) Biochemistry 11, 2098-2102
18. Mahuran, D. J., Angus, R. H., Braun, C. V., Sim, S. S., and Schmidt, D. E. (1977) Can. J. Biochem. 55, 1-8
19. Nandhagopal, N., Senda, T., Hatta, T., Yamada, A., Masai, E., Fukuda, M., and Mitsui, Y. (1997) Proc. Jpn. Acad. 73, 154-157
20. Diaz, E., Timmis, K. N. (1995) J. Biol. Chem. 270, 6403-6411
21. Timmis, K. N., Steffan, R. J., and Unterman, R. (1994) Ann. Rev. Microbiol. 48, 525-557
22. Timm, D. E., Mueller, H. A., Bhanumoorthy, P., Harp, J. M., and Bunick, G. J. (1999) Structure 7, 1023-1033
23. St-Louis, M., and Tanguay, R. M. (1997) Hum. Mutat. 9, 291-299
24. Phillips, M., Kaplan, A., Rutter, W., and Bartlett, P. A. (1992) Biochemistry 31, 959-963
25. Fraser, M. E., Strynadka, N. C. J., Bartlett, P. A., Hanson, J. E., and James, M. N. G. (1992) Biochemistry 31, 5201-5214
26. Manne, V., Yan, N., Carboni, J., Tuomari, A., Ricca, C., Brown, J. G., Andahazy, M. L., Schmidt, R., Patel, D., Zahler, R., Weinmann, R., Der, C., Cox, A., Hunt, J., Gordon, E. M., Barbacid, M., and Seizinger, B. R. (1995) Oncogene 10, 1763-1779
27. Bartlett, P. A., and Marlowe, C. K. (1983) Biochemistry 22, 4618-4624
28. Hanson, J. E., Kaplan, A. P., and Bartlett, P. A. (1989) Biochemistry 28, 6294-6305
29. Ames, B. N. (1966) Met. Enzymol. 3, 115-118
30. Knox, W. E., and Edwards, S. W. (1955) J. Biol. Chem. 216, 479-487
31. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
32. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
33. CCP4. (1979) The SERC (UK) Collaborative Computing Project No. 4, A suite of programs for protein crystallography, distributed from Daresbury Laboratory, Warrington WA4 4AD, UK
34. Brunger, A. T. (1992) X-PLOR version 3.1. A system for X-ray crystallography and NMR. Yale University Press, New Haven, CT
35. Kraulis, P. J. (1991) J Appl Crystallogr. 24, 946-950
36. Weiler, L. (1970) J. Am. Chem. Soc. 92, 6702-6704