Environmental impact on direct neuronal reprogramming in vivo in the adult brain

Nature Communications

Volumn 4, Issue , 2013, Pages

  Grande, Andrew ^a,b,c   Sumiyoshi, Kyoko ^a   López Juárez, Alejandro ^a   Howard, Jennifer ^a   Sakthivel, Bhuvaneswari ^a   Aronow, Bruce ^a   Campbell, Kenneth ^a,b   Nakafuku, Masato ^a,b  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; NEUROGENIN 2;

ADULT; BRAIN; CYTOLOGY; ENVIRONMENTAL EFFECT; FUNCTIONAL ROLE; GENE EXPRESSION; NEUROLOGY; PHENOTYPE; PHYSIOLOGY; RODENT;

ARTICLE; BRAIN NERVE CELL; CELL DIFFERENTIATION; CELL SURVIVAL; CORPUS STRIATUM; ENVIRONMENTAL IMPACT; GENE EXPRESSION; IN VIVO STUDY; NEOCORTEX; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; RETROVIRUS; RODENT;

AGING; ANIMALS; BRAIN; GENE EXPRESSION PROFILING; GREEN FLUORESCENT PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISCHEMIA; MALE; NEOCORTEX; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONS; NUCLEAR REPROGRAMMING; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; RETROVIRIDAE; SPHEROIDS, CELLULAR;

EID: 84883303815     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3373     Document Type: Article

References (60)

1. Yamanaka, S. Induced pluripotent stem cells: past, present, and future. Cell Stem Cell 10, 678-684 (2012).
2. Sancho-Martinez, I. & Izpisua Belmonte, J. C. Stem cells: surf the waves of reprogramming. Nature 493, 310-311 (2013).
3. Yang, N., Ng, Y. H., Pang, Z. P., Su?dhof, T. C. & Wernig, M. Induced neuronal cells: how to make and define a neuron. Cell Stem Cell 9, 517-525 (2011).
4. Leung, C. T., Coulombe, P. A. & Reed, R. R. Contribution of olfactory neural stem cells to tissue maintenance and regeneration. Nat. Neurosci. 10, 720-726 (2007). (Pubitemid 46828492)
5. Barroca, V. et al. Mouse differentiating spermatogonia can generate germinal stem cells in vivo. Nat. Cell Biol. 11, 190-196 (2009).
6. Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632 (2008).
7. Yechoor, V. et al. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev. Cell 16, 358-373 (2009).
8. Buffo, A. et al. Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc. Natl Acad. Sci. USA 102, 18183-18188 (2005). (Pubitemid 41798522)
9. Ohori, Y. et al. Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. J. Neurosci. 26, 11948-11960 (2006). (Pubitemid 44772106)
10. Torper, O. et al. Generation of induced neurons via direct conversion in vivo. Proc. Natl Acad. Sci. USA 110, 7038-7043 (2013).
11. Ming, G.-L. & Song, H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci. 28, 223-250 (2005). (Pubitemid 41098905)
12. Dayer, A. G., Cleaver, K. M., Abouantoun, T. & Cameron, H. A. New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors. J. Cell Biol. 168, 415-427 (2005). (Pubitemid 40205064)
13. Gould, E. How widespread is adult neurogenesis in mammals? Nat. Rev. Neurosci. 8, 481-488 (2007). (Pubitemid 46789229)
14. Nakatomi, H. et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110, 429-441 (2002). (Pubitemid 35232287)
15. Kernie, S. G. & Parent, J. M. Forebrain neurogenesis after focal ischemic and traumatic brain injury. Neurobiol. Dis. 37, 267-274 (2010).
16. Nakafuku, M. & Grande, A. in Patterning and Cell Type Specification in the Developing CNS and PNS - Comprehensive Developmental Neuroscience. (eds Rubenstein, J. L. R. & Rakic, P.) (Elsevier Inc., Maryland, 2013; in press).
17. Yamamoto, S. et al. Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord. J. Neurosci. 21, 9814-9823 (2001). (Pubitemid 34184066)
18. Vierbuchen, T. et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041 (2010).
19. Pang, Z. P. et al. Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223 (2011).
20. Caiazzo, M. et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224-227 (2011).
21. Qiang, L. et al. Directed conversion of Alzheimer?s disease patient skin fibroblasts into functional neurons. Cell 146, 359-371 (2011).
22. Son, E. Y., Ichida, J. K., Wainger, B. J., Toma, J. S. & Rafuse, V. F. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 9, 205-218 (2011).
23. Ambasudhan, R., Talantova, M., Coleman, R. & Yuan, X. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 9, 113-118 (2011).
24. Kim, J. et al. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell 9, 413-419 (2011).
25. Pfisterer, U. et al. Direct conversion of human fibroblasts to dopaminergic neurons. Proc. Natl Acad. Sci. USA 108, 10343-10348 (2011).
26. Marro, S. et al. Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell 9, 374-382 (2011).
27. Ackman, J. B., Siddiqi, F., Walikonis, R. S. & Loturco, J. J. Fusion of microglia with pyramidal neurons after retroviral infection. J. Neurosci. 26, 11413-11422 (2006). (Pubitemid 44772171)
28. Buffo, A. et al. Origin and progeny of reactive gliosis: a source of multipotent cells in the injured brain. Proc. Natl Acad. Sci. USA 105, 3581-3586 (2008). (Pubitemid 351723595)
29. Sirko, S. et al. Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog glia. Cell Stem Cell 12, 426-439 (2013).
30. Jessberger, S., Toni, N., Clemenson, G. D., Ray, J. & Gage, F. H. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat. Neurosci. 11, 888-893 (2008).
31. Sugimori, M. et al. Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development 134, 1617-1629 (2007). (Pubitemid 46746313)
32. Mattar, P. et al. Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity. Mol. Cell Biol. 28, 1456-1469 (2008).
33. Parras, C. M. et al. Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes. Dev. 16, 324-338 (2002). (Pubitemid 34111412)
34. Shigeno, T., McCulloch, J., Graham, D. I., Mendelow, A. D. & Teasdale, G. M. Pure cortical ischemia versus striatal ischemia. Circulatory, metabolic, and neuropathologic consequences. Surg. Neurol. 24, 47-51 (1985).
35. Kim, J. et al. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc. Natl Acad. Sci. USA 108, 7838-7843 (2011).
36. Lujan, E., Chanda, S., Ahlenius, H., Su?dhof, T. C. & Wernig, M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc. Natl Acad. Sci. USA 109, 2527-2532 (2012).
37. Ring, K. L. et al. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 11, 1-10 (2012).
38. Thier, M. et al. Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 10, 473-479 (2012).
39. Nunes, M. C. et al. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat. Med. 9, 439-447 (2003). (Pubitemid 36460078)
40. Shimada, I. S., LeComte, M. D., Granger, J. C., Quinlan, N. J. & Spees, J. L. Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J. Neurosci. 32, 7926-7940 (2012).
41. Ninkovic, J. & Go?tz, M. Signaling in adult neurogenesis: from stem cell niche to neuronal networks. Curr. Opin. Neurobio. 17, 338-344 (2007). (Pubitemid 46887663)
42. Puelles, L. & Rubenstein, J. L. R. Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci. 26, 469-476 (2003). (Pubitemid 37025784)
43. Corti, S. et al. Direct reprogramming of human astrocytes into neural stem cells and neurons. Exp. Cell Res. 318, 1528-1541 (2012).
44. Heinrich, C. et al. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol. 8, e1000373 (2010).
45. Addis, R. C. et al. Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PLoS One 6, e28719 (2011).
46. Karow, M. et al. Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell 11, 471-476 (2012).
47. Rivers, L. E. et al. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat. Neurosci. 11, 1392-1401 (2008).
48. Guo, F. et al. Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J. Neurosci. 30, 12036-12049 (2010).
49. Ohira, K. et al. Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nat. Neurosci. 13, 173-179 (2010).
50. Arsenijevic, Y. Isolation of multipotent neural precursors residing in the cortex of the adult human brain. Exp. Neurol. 170, 48-62 (2001). (Pubitemid 32641773)
51. Russo, I., Barlati, S. & Bosetti, F. Effects of neuroinflammation on the regenerative capacity of brain stem cells. J. Neurochem. 116, 947-956 (2011).
52. Englund, U., Bjorklund, A., Wictorin, K., Lindvall, O. & Kokaia, M. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc. Natl Acad. Sci. USA 99, 17089-17094 (2002). (Pubitemid 36034103)
53. Yamasaki, T. R. et al. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J. Neurosci. 27, 11925-11933 (2007). (Pubitemid 350072121)
54. Ideguchi, M., Palmer, T. D., Recht, L. D. & Weimann, J. M. Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J. Neurosci. 30, 894-904 (2010).
55. Southwell, D. G., Froemke, R. C., Alvarez-Buylla, A., Stryker, M. P. & Gandhi, S. P. Cortical plasticity induced by inhibitory neuron transplantation. Science 327, 1145-1148 (2010).
56. Paxinos, G. & Watson, C. in The Rat Brain In Stereotaxic Coordinates 4th edn (Academic Press, Inc., 1998).
57. Olsson, M., Bentlage, C., Wictorin, K., Campbell, K. & Bjo?rklund, A. Extensive migration and target innervation by striatal precursors after grafting into the neonatal striatum. Neuroscience 79, 57-78 (1997). (Pubitemid 27245000)
58. Franklin, K. B. J. & Paxinos, G. in The Mouse Brain In Stereotaxic Coordinate (Academic Press, Inc., 1997).
59. Parmar, M., Skogh, C., Bjo?rklund, A. & Campbell, K. Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon. Mol. Cell Neurosci. 21, 645-656 (2002). (Pubitemid 36062721)
60. Yamamoto, S., Yamamoto, N., Kitamura, T., Nakamura, K. & Nakafuku, M. Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp. Neurol. 172, 115-127 (2001). (Pubitemid 33141159)