Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Addis, Russell C ^a   Hsu, Fu Chun ^b   Wright, Rebecca L ^a   Dichter, Marc A ^a   Coulter, Douglas A ^a,b   Gearhart, John D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPAMINE; LENTIVIRUS VECTOR; NUCLEAR RECEPTOR RELATED FACTOR 1; POLYCISTRONIC LENTIVIRUS VECTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LMX1B; TRANSCRIPTION FACTOR MASH1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; COMPLEMENTARY DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM SIGNALING; CELLULAR REPROGRAMMING; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; EMBRYO; FIBROBLAST; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MESENCEPHALON; MOUSE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE POTENTIAL; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PARKINSON DISEASE; PHENOTYPE; POTASSIUM CURRENT; PROCEDURES CONCERNING CELLS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SODIUM CURRENT; UPREGULATION; VOLTAGE CLAMP; ANIMAL; CYTOLOGY; ELECTROPHYSIOLOGY; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM;

ANIMALS; ASTROCYTES; DNA, COMPLEMENTARY; DOPAMINERGIC NEURONS; ELECTROPHYSIOLOGICAL PHENOMENA; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MICE; OPEN READING FRAMES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 83055173820     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028719     Document Type: Article

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