Transcription factor expression and notch-dependent regulation of neural progenitors in the adult rat spinal cord

Journal of Neuroscience

Volumn 21, Issue 24, 2001, Pages 9814-9823

  Yamamoto, Shin Ichi ^a   Nagao, Motoshi ^a   Sugimori, Michiya ^a   Kosako, Hidetaka ^a   Nakatomi, Hirofumi ^a   Yamamoto, Naoya ^a   Takebayashi, Hirohide ^b   Nabeshima, Yo Ichi ^b,e   Kitamura, Toshio ^c   Weinmaster, Gerry ^d   Nakamura, Kozo ^a   Nakafuku, Masato ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Adult neurogenesis; Injury; Neural progenitor; Notch signaling; Regeneration; Spinal cord; Stem cell; Transcription factor

Indexed keywords

CELL MARKER; HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; NOTCH RECEPTOR; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PROTEIN HB9; PROTEIN ISLET1; PROTEIN LIM1; PROTEIN LIM3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR NGN2; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PAX7; TRANSCRIPTION FACTOR PROX1; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INTERNEURON; MALE; NERVE FIBER REGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD MOTONEURON; SPINAL CORD NERVE CELL; SPINAL CORD TRANSSECTION; STEM CELL;

EID: 0035894866     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-24-09814.2001     Document Type: Article

References (56)

1. Endogenous repair after spinal cord contusion injuries in the rat
2. Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors
3. Characterization and intraspinal grafting of EGF/bFGF-dependent neurospheres derived from embryonic rat spinal cord
4. NG2-expressing cells in the central nervous system: Are they oligodendroglial progenitors?
5. Conservation of the Notch signalling pathway in mammalian neurogenesis
6. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
7. Sonic hedgehog promotes neuronal differentiation of murine spinal cord precursors and collaborates with neurotrophin 3 to induce Islet-1
8. Rapid, widespread, and long lasting induction of nestin contributes to the generation of glial scar tissue after CNS injury
9. Mammalian neural stem cells
10. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor
11. Regenerating the damaged central nervous system
12. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
13. Identification of a neural stem cell in the adult mammalian central nervous system
14. Neuroepithelial stem cells from the embryonic spinal cord: Isolation, characterization, and clonal analysis
15. Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture
16. Visualization of mitotic radial glial lineage cells in the developing rat brain by Cdc2 kinase-phosphorylated vimentin
17. Neurogenesis in postnatal rat spinal cord: A study in primary culture
18. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
19. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
20. CNS stem cells express a new class of intermediate filament protein
21. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
22. Identification of neurogenin, a vertebrate neuronal determination gene
23. Isolation and developmental characterization of cerebral cortical multipotent progenitors
24. Stem cells in the central nervous system
25. Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord
26. Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1
27. Plat-E: An efficient and stable system for transient packaging of retroviruses
28. A new "spin" on neural stem cells?
29. Establishment and characterization of a multipotential neural cell line that can conditionally generate neurons, astrocytes, and oligodendrocytes in vitro
30. Role of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells
31. Cell proliferation and nestin expression in the ependyma of the adult rat spinal cord after injury
32. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors
33. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
34. FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain
35. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS
36. Multipotent and restricted precursors in the central nervous system
37. Nuclear notch1 signaling and the regulation of dendritic development
38. Lineage specification of neuronal precursors in the mouse spinal cord
39. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling
40. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
41. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord
42. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus
43. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
44. New prospects for human stem-cell therapy in the nervous system
45. Dynamic expression of basic helix-loop-helix Olig family members: Implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3
46. Diversity and pattern in the developing spinal cord
47. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate
48. Stem cells in the adult mammalian central nervous system
49. Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system
50. Up a notch: Instructing gliogenesis
51. Notch receptor activation inhibits oligodendrocyte differentiation
52. The ins and outs of notch signaling
53. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis
54. Selective expression of Nkx-2.2 transcription factor in chicken oligodendrocyte progenitors and implications for the embryonic origin of oligodendrocytes
55. Sox2 regulatory sequences direct expression of aβ-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells
56. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors