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Volumn 87, Issue 18, 2013, Pages 9983-9996

The effect of the PB2 mutation 627k on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; PROTEIN PB2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 84883303054     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01399-13     Document Type: Article
Times cited : (49)

References (73)
  • 1
    • 68149159094 scopus 로고    scopus 로고
    • History of highly pathogenic avian influenza
    • Alexander D, Brown I. 2009. History of highly pathogenic avian influenza. Rev. Sci. Tech. 28:19-38.
    • (2009) Rev. Sci. Tech. , vol.28 , pp. 19-38
    • Alexander, D.1    Brown, I.2
  • 2
    • 0018406665 scopus 로고
    • The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses
    • Bosch FX, Orlich M, Klenk HD, Rott R. 1979. The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses. Virology 95:197-207.
    • (1979) Virology , vol.95 , pp. 197-207
    • Bosch, F.X.1    Orlich, M.2    Klenk, H.D.3    Rott, R.4
  • 3
    • 0028331821 scopus 로고
    • Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus
    • Horimoto T, Kawaoka Y. 1994. Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus. J. Virol. 68:3120-3128.
    • (1994) J. Virol. , vol.68 , pp. 3120-3128
    • Horimoto, T.1    Kawaoka, Y.2
  • 4
    • 0033602713 scopus 로고    scopus 로고
    • Role of hemagglutinin cleavage for the pathogenicity of influenza virus
    • Steinhauer DA. 1999. Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology 258:1-20.
    • (1999) Virology , vol.258 , pp. 1-20
    • Steinhauer, D.A.1
  • 5
    • 34447104395 scopus 로고    scopus 로고
    • An overview of the epidemiology of avian influenza
    • Alexander DJ. 2007. An overview of the epidemiology of avian influenza. Vaccine 25:5637-5644.
    • (2007) Vaccine , vol.25 , pp. 5637-5644
    • Alexander, D.J.1
  • 7
    • 14444284599 scopus 로고    scopus 로고
    • Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
    • Subbarao K. 1998. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279:393-396.
    • (1998) Science , vol.279 , pp. 393-396
    • Subbarao, K.1
  • 11
    • 33745610024 scopus 로고    scopus 로고
    • Characterization of a highly pathogenic H5N1 influenza virus derived from bar-headed geese in China
    • Zhou J-Y, Shen H-G, Chen H-X, Tong G-Z, Liao M, Yang H-C, Liu J-X. 2006. Characterization of a highly pathogenic H5N1 influenza virus derived from bar-headed geese in China. J. Gen. Virol. 87:1823-1833.
    • (2006) J. Gen. Virol. , vol.87 , pp. 1823-1833
    • Zhou, J.-Y.1    Shen, H.-G.2    Chen, H.-X.3    Tong, G.-Z.4    Liao, M.5    Yang, H.-C.6    Liu, J.-X.7
  • 12
    • 77955298876 scopus 로고    scopus 로고
    • Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variants
    • Neumann G, Green MA, Macken CA. 2010. Evolution of highly pathogenic avian H5N1 influenza viruses and the emergence of dominant variants. J. Gen. Virol. 91:1984-1995.
    • (2010) J. Gen. Virol. , vol.91 , pp. 1984-1995
    • Neumann, G.1    Green, M.A.2    Macken, C.A.3
  • 16
    • 33744938909 scopus 로고    scopus 로고
    • Properties and dissemination of H5N1viruses isolated during an influenza outbreak in migratory waterfowl in western China
    • Chen H, Li Y, Li Z, Shi J, Shinya K, Deng G, Qi Q, Tian G, Fan S, Zhao H, Sun Y, Kawaoka Y. 2006. Properties and dissemination of H5N1viruses isolated during an influenza outbreak in migratory waterfowl in western China. J. Virol. 80:5976-5983.
    • (2006) J. Virol. , vol.80 , pp. 5976-5983
    • Chen, H.1    Li, Y.2    Li, Z.3    Shi, J.4    Shinya, K.5    Deng, G.6    Qi, Q.7    Tian, G.8    Fan, S.9    Zhao, H.10    Sun, Y.11    Kawaoka, Y.12
  • 17
  • 19
    • 75849136881 scopus 로고    scopus 로고
    • Adaptive strategies of the influenza virus polymerase for replication in humans
    • Mehle A, Doudna JA. 2009. Adaptive strategies of the influenza virus polymerase for replication in humans. Proc. Natl. Acad. Sci. U. S. A. 106: 21312-21316.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 21312-21316
    • Mehle, A.1    Doudna, J.A.2
  • 20
    • 77950835010 scopus 로고    scopus 로고
    • PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells
    • Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T. 2010. PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J. Virol. 84:4395-4406.
    • (2010) J. Virol. , vol.84 , pp. 4395-4406
    • Bussey, K.A.1    Bousse, T.L.2    Desmet, E.A.3    Kim, B.4    Takimoto, T.5
  • 21
    • 84863128008 scopus 로고    scopus 로고
    • Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo
    • Liu Q, Qiao C, Marjuki H, Bawa B, Ma J, Guillossou S, Webby RJ, Richt JA, Ma W. 2012. Combination of PB2 271A and SR polymorphism at positions 590/591 is critical for viral replication and virulence of swine influenza virus in cultured cells and in vivo. J. Virol. 86:1233-1237.
    • (2012) J. Virol. , vol.86 , pp. 1233-1237
    • Liu, Q.1    Qiao, C.2    Marjuki, H.3    Bawa, B.4    Ma, J.5    Guillossou, S.6    Webby, R.J.7    Richt, J.A.8    Ma, W.9
  • 22
    • 0027468737 scopus 로고
    • A single amino acid in the PB2 gene of influenza A virus is a determinant of host range
    • Subbarao EK, London W, Murphy BR. 1993. A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J. Virol. 67:1761-1764.
    • (1993) J. Virol. , vol.67 , pp. 1761-1764
    • Subbarao, E.K.1    London, W.2    Murphy, B.R.3
  • 23
    • 0035030379 scopus 로고    scopus 로고
    • Sequences in influenza A virus PB2 protein that determine productive infection for an avian influenza virus in mouse and human cell lines
    • Yao Y, Mingay LJ, McCauley JW, Barclay WS. 2001. Sequences in influenza A virus PB2 protein that determine productive infection for an avian influenza virus in mouse and human cell lines. J. Virol. 75:5410-5415.
    • (2001) J. Virol. , vol.75 , pp. 5410-5415
    • Yao, Y.1    Mingay, L.J.2    McCauley, J.W.3    Barclay, W.S.4
  • 24
    • 0035026051 scopus 로고    scopus 로고
    • Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses
    • Massin P, Van der Werf S, Naffakh N. 2001. Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. J. Virol. 75:5398-5404.
    • (2001) J. Virol. , vol.75 , pp. 5398-5404
    • Massin, P.1    Van der Werf, S.2    Naffakh, N.3
  • 25
    • 77956839458 scopus 로고    scopus 로고
    • Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase
    • Moncorgé O, Mura M, Barclay WS. 2010. Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase. J. Virol. 84:9978-9986.
    • (2010) J. Virol. , vol.84 , pp. 9978-9986
    • Moncorgé, O.1    Mura, M.2    Barclay, W.S.3
  • 27
    • 84871007119 scopus 로고    scopus 로고
    • Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
    • Mänz B, Brunotte L, Reuther P, Schwemmle M. 2012. Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. Nat. Commun. 3:802.
    • (2012) Nat. Commun. , vol.3 , pp. 802
    • Mänz, B.1    Brunotte, L.2    Reuther, P.3    Schwemmle, M.4
  • 28
    • 0035823083 scopus 로고    scopus 로고
    • Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
    • Hatta M, Gao P, Halfmann P. 2001. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293:1840-1842.
    • (2001) Science , vol.293 , pp. 1840-1842
    • Hatta, M.1    Gao, P.2    Halfmann, P.3
  • 29
    • 1542315573 scopus 로고    scopus 로고
    • PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice
    • Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y. 2004. PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 320:258-266.
    • (2004) Virology , vol.320 , pp. 258-266
    • Shinya, K.1    Hamm, S.2    Hatta, M.3    Ito, H.4    Ito, T.5    Kawaoka, Y.6
  • 32
    • 0033014710 scopus 로고    scopus 로고
    • Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong
    • Gao P, Watanabe S, Ito T, Goto H, Wells K, McGregor M, Cooley AJ, Kawaoka Y. 1999. Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J. Virol. 73:3184-3189.
    • (1999) J. Virol. , vol.73 , pp. 3184-3189
    • Gao, P.1    Watanabe, S.2    Ito, T.3    Goto, H.4    Wells, K.5    McGregor, M.6    Cooley, A.J.7    Kawaoka, Y.8
  • 36
    • 59249096926 scopus 로고    scopus 로고
    • Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
    • doi:10.1371/journal.ppat.1000252
    • Steel J, Lowen AC, Mubareka S, Palese P. 2009. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 5:e1000252. doi:10.1371/journal.ppat.1000252.
    • (2009) PLoS Pathog. , vol.5
    • Steel, J.1    Lowen, A.C.2    Mubareka, S.3    Palese, P.4
  • 38
    • 77950952992 scopus 로고    scopus 로고
    • Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity
    • Leung BW, Chen H, Brownlee GG. 2010. Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Virology 401:96-106.
    • (2010) Virology , vol.401 , pp. 96-106
    • Leung, B.W.1    Chen, H.2    Brownlee, G.G.3
  • 41
    • 80054995402 scopus 로고    scopus 로고
    • Reversion of PB2-627E to-627K during replication of an H5N1 clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein
    • Bogs J, Kalthoff D, Veits J, Pavlova S, Schwemmle M, Mänz B, Mettenleiter TC, Stech J. 2011. Reversion of PB2-627E to-627K during replication of an H5N1 clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J. Virol. 85:10691-10698.
    • (2011) J. Virol. , vol.85 , pp. 10691-10698
    • Bogs, J.1    Kalthoff, D.2    Veits, J.3    Pavlova, S.4    Schwemmle, M.5    Mänz, B.6    Mettenleiter, TC.7    Stech, J.8
  • 42
    • 84857387170 scopus 로고    scopus 로고
    • Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks
    • doi:10.1371/journal.pone.0030960
    • Schat KA, Bingham J, Butler JM, Chen L-M, Lowther S, Crowley TM, Moore RJ, Donis RO, Lowenthal JW. 2012. Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks. PLoS One 7:e30960. doi:10.1371/journal.pone.0030960.
    • (2012) PLoS One , vol.7
    • Schat, K.A.1    Bingham, J.2    Butler, J.M.3    Chen, L.-M.4    Lowther, S.5    Crowley, T.M.6    Moore, R.J.7    Donis, R.O.8    Lowenthal, J.W.9
  • 43
    • 0028891037 scopus 로고
    • Replication of influenza A viruses of high and low pathogenicity for chickens at different sites in chickens and ducks following intranasal inoculation
    • Wood GW, Parsons G, Alexander DJ. 1995. Replication of influenza A viruses of high and low pathogenicity for chickens at different sites in chickens and ducks following intranasal inoculation. Avian Pathol. 24: 545-551.
    • (1995) Avian Pathol. , vol.24 , pp. 545-551
    • Wood, G.W.1    Parsons, G.2    Alexander, D.J.3
  • 44
    • 0027922273 scopus 로고
    • An outbreak of highly pathogenic avian influenza in turkeys in Great Britain in 1991
    • Alexander DJ, Lister SA, Johnson MJ, Randall CJ, Thomas PJ. 1993. An outbreak of highly pathogenic avian influenza in turkeys in Great Britain in 1991. Vet Rec. 132:535-536.
    • (1993) Vet Rec. , vol.132 , pp. 535-536
    • Alexander, D.J.1    Lister, S.A.2    Johnson, M.J.3    Randall, C.J.4    Thomas, P.J.5
  • 45
    • 56749133264 scopus 로고    scopus 로고
    • Pathogenesis of highly pathogenic avian influenza A/Turkey/Turkey/1/ 2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally
    • Löndt BZ, Nunez A, Banks J, Nili H, Johnson LK, Alexander DJ. 2008. Pathogenesis of highly pathogenic avian influenza A/Turkey/Turkey/1/ 2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally. Avian Pathol. 37:619-627.
    • (2008) Avian Pathol. , vol.37 , pp. 619-627
    • Löndt, B.Z.1    Nunez, A.2    Banks, J.3    Nili, H.4    Johnson, L.K.5    Alexander, D.J.6
  • 46
    • 34247646634 scopus 로고    scopus 로고
    • Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/ England/50-92/91 (H5N1)
    • Howard W, Hayman A, Lackenby A, Whiteley A, Londt B, Banks J, McCauley J, Barclay W. 2007. Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/ England/50-92/91 (H5N1). Avian Dis. 51:393-395.
    • (2007) Avian Dis. , vol.51 , pp. 393-395
    • Howard, W.1    Hayman, A.2    Lackenby, A.3    Whiteley, A.4    Londt, B.5    Banks, J.6    McCauley, J.7    Barclay, W.8
  • 47
    • 84883308693 scopus 로고    scopus 로고
    • Avian influenza
    • World Organisation for Animal Health, World Organisation for Animal Health, Paris, France
    • World Organisation for Animal Health. 2012. Avian influenza. In OIE manual of diagnostic tests and vaccines for terrestrial animals. World Organisation for Animal Health, Paris, France.
    • (2012) In OIE manual of diagnostic tests and vaccines for terrestrial animals
  • 48
    • 71849114707 scopus 로고    scopus 로고
    • The effect of age on the pathogenesis of a highly pathogenic avian influenza (HPAI) H5N1 virus in Pekin ducks (Anas platyrhynchos) infected experimentally
    • Löndt BZ, Núñez A, Banks J, Alexander DJ, Russell C, Richard-Löndt AC, Brown IH. 2010. The effect of age on the pathogenesis of a highly pathogenic avian influenza (HPAI) H5N1 virus in Pekin ducks (Anas platyrhynchos) infected experimentally. Influenza Other Respir. Viruses 4:17-25.
    • (2010) Influenza Other Respir. Viruses , vol.4 , pp. 17-25
    • Löndt, B.Z.1    Núñez, A.2    Banks, J.3    Alexander, D.J.4    Russell, C.5    Richard-Löndt, A.C.6    Brown, I.H.7
  • 53
    • 48749093648 scopus 로고    scopus 로고
    • Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity
    • Stevens J, Blixt O, Chen L-M, Donis RO, Paulson JC, Wilson IA. 2008. Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. J. Mol. Biol. 381:1382-1394.
    • (2008) J. Mol. Biol. , vol.381 , pp. 1382-1394
    • Stevens, J.1    Blixt, O.2    Chen, L.-M.3    Donis, R.O.4    Paulson, J.C.5    Wilson, I.A.6
  • 54
    • 4043177653 scopus 로고    scopus 로고
    • Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193
    • Medeiros R, Naffakh N, Manuguerra J-C, Van der Werf S. 2004. Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193. Arch Virol. 149: 1663-1671.
    • (2004) Arch Virol. , vol.149 , pp. 1663-1671
    • Medeiros, R.1    Naffakh, N.2    Manuguerra, J.-C.3    Van der Werf, S.4
  • 55
    • 77049105618 scopus 로고    scopus 로고
    • Differences in influenza virus receptors in chickens and ducks: implications for interspecies transmission
    • Kuchipudi SV, Nelli R, White GA, Bain M, Chang KC, Dunham S. 2009. Differences in influenza virus receptors in chickens and ducks: implications for interspecies transmission. J. Mol. Genet. Med. 3:143-151.
    • (2009) J. Mol. Genet. Med. , vol.3 , pp. 143-151
    • Kuchipudi, S.V.1    Nelli, R.2    White, G.A.3    Bain, M.4    Chang, K.C.5    Dunham, S.6
  • 56
    • 78649782957 scopus 로고    scopus 로고
    • Characterization of influenza virus sialic acid receptors in minor poultry species
    • Kimble B, Nieto GR, Perez DR. 2010. Characterization of influenza virus sialic acid receptors in minor poultry species. Virol. J. 7:365.
    • (2010) Virol. J. , vol.7 , pp. 365
    • Kimble, B.1    Nieto, G.R.2    Perez, D.R.3
  • 57
    • 72849148491 scopus 로고    scopus 로고
    • Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein
    • Shinya K, Makino A, Ozawa M, Kim JH, Sakai-Tagawa Y, Ito M, Le QM, Kawaoka Y. 2009. Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein. J. Virol. 83:13015-13018.
    • (2009) J. Virol. , vol.83 , pp. 13015-13018
    • Shinya, K.1    Makino, A.2    Ozawa, M.3    Kim, J.H.4    Sakai-Tagawa, Y.5    Ito, M.6    Le, Q.M.7    Kawaoka, Y.8
  • 60
    • 84863106204 scopus 로고    scopus 로고
    • Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice
    • doi:10.1371/journal.pone.0040118
    • Li X, Qi W, He J, Ning Z, Hu Y, Tian J, Jiao P, Xu C, Chen J, Richt J, Ma W, Liao M. 2012. Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice. PLoS One 7:e40118. doi:10.1371/journal.pone.0040118.
    • (2012) PLoS One , vol.7
    • Li, X.1    Qi, W.2    He, J.3    Ning, Z.4    Hu, Y.5    Tian, J.6    Jiao, P.7    Xu, C.8    Chen, J.9    Richt, J.10    Ma, W.11    Liao, M.12
  • 61
    • 84862226996 scopus 로고    scopus 로고
    • A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level
    • doi:10.1371/journal.pone.0038233
    • Tian J, Qi W, Li X, He J, Jiao P, Zhang C, Liu G-Q, Liao M. 2012. A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level. PLoS One 7:e38233. doi:10.1371/journal.pone.0038233.
    • (2012) PLoS One , vol.7
    • Tian, J.1    Qi, W.2    Li, X.3    He, J.4    Jiao, P.5    Zhang, C.6    Liu, G.-Q.7    Liao, M.8
  • 65
    • 84876494442 scopus 로고    scopus 로고
    • Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013
    • Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, Uchida Y, Neumann G, Saito T, Kawaoka Y, Tashiro M. 2013. Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill. 18(15):pii=20453. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20453.
    • (2013) Euro Surveill. , vol.18 , Issue.15 , pp. 20453
    • Kageyama, T.1    Fujisaki, S.2    Takashita, E.3    Xu, H.4    Yamada, S.5    Uchida, Y.6    Neumann, G.7    Saito, T.8    Kawaoka, Y.9    Tashiro, M.10
  • 66
    • 84876477307 scopus 로고    scopus 로고
    • Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis
    • Jonges M, Meijer A, Fouchier R, Koch G, Li J, Pan J, Chen H, Shu Y, Koopmans M. 2013. Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis. Euro Surveill. 18(16:pii=20460. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20460.
    • (2013) Euro Surveill. , vol.18 , Issue.16 , pp. 20460
    • Jonges, M.1    Meijer, A.2    Fouchier, R.3    Koch, G.4    Li, J.5    Pan, J.6    Chen, H.7    Shu, Y.8    Koopmans, M.9
  • 68
    • 84864148469 scopus 로고    scopus 로고
    • The influenza A virus PB2, PA, NP, andMsegments play a pivotal role during genome packaging
    • Gao Q, Chou Y-Y, Doǧanay S, Vafabakhsh R, Ha T, Palese P. 2012. The influenza A virus PB2, PA, NP, andMsegments play a pivotal role during genome packaging. J. Virol. 86:7043-7051.
    • (2012) J. Virol. , vol.86 , pp. 7043-7051
    • Gao, Q.1    Chou, Y.-Y.2    Doǧanay, S.3    Vafabakhsh, R.4    Ha, T.5    Palese, P.6
  • 70
    • 84875475885 scopus 로고    scopus 로고
    • An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus
    • Gavazzi C, Isel C, Fournier E, Moules V, Cavalier A, Thomas D, Lina B, Marquet R. 2013. An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus. Nucleic Acids Res. 41:1241-1254.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 1241-1254
    • Gavazzi, C.1    Isel, C.2    Fournier, E.3    Moules, V.4    Cavalier, A.5    Thomas, D.6    Lina, B.7    Marquet, R.8
  • 72
    • 25144479801 scopus 로고    scopus 로고
    • The generation of recombinant influenza A viruses expressing a PB2 fusion protein requires the conservation of a packaging signal overlapping the coding and noncoding regions at the 5= end of the PB2 segment
    • Dos Santos Afonso E, Escriou N, Leclercq I, Van der Werf S, Naffakh N. 2005. The generation of recombinant influenza A viruses expressing a PB2 fusion protein requires the conservation of a packaging signal overlapping the coding and noncoding regions at the 5= end of the PB2 segment. Virology 341:34-46.
    • (2005) Virology , vol.341 , pp. 34-46
    • Dos Santos Afonso, E.1    Escriou, N.2    Leclercq, I.3    Van der Werf, S.4    Naffakh, N.5


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