메뉴 건너뛰기




Volumn 5, Issue 2, 2013, Pages 85-94

Network nonlinearities in drug treatment

Author keywords

bistability; mathematical modeling; systems pharmacology

Indexed keywords

PROTEIN KINASE B;

EID: 84883302426     PISSN: 19132751     EISSN: 18671462     Source Type: Journal    
DOI: 10.1007/s12539-013-0165-x     Document Type: Article
Times cited : (5)

References (77)
  • 2
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon, U. 2007. Network motifs: Theory and experimental approaches. Nat Rev Genet 8, 450-461.
    • (2007) Nat Rev Genet , vol.8 , pp. 450-461
    • Alon, U.1
  • 3
    • 0037436450 scopus 로고    scopus 로고
    • Taming Winfree turbulence of scroll waves in excitable media
    • Alonso, S., Sagues, F., Mikhailov, A. S. 2003. Taming Winfree turbulence of scroll waves in excitable media. Science 299, 1722-1725.
    • (2003) Science , vol.299 , pp. 1722-1725
    • Alonso, S.1    Sagues, F.2    Mikhailov, A.S.3
  • 6
    • 42949171936 scopus 로고    scopus 로고
    • Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage
    • Batchelor, E., Mock, C. S., Bhan, I., Loewer, A., Lahav, G. 2008. Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage. Mol Cell 30, 277-289.
    • (2008) Mol Cell , vol.30 , pp. 277-289
    • Batchelor, E.1    Mock, C.S.2    Bhan, I.3    Loewer, A.4    Lahav, G.5
  • 7
    • 67349091738 scopus 로고    scopus 로고
    • The ups and downs of p53: Understanding protein dynamics in single cells
    • Batchelor, E., Loewer, A., Lahav, G. 2009. The ups and downs of p53: Understanding protein dynamics in single cells. Nat Rev Cancer 9, 371-377.
    • (2009) Nat Rev Cancer , vol.9 , pp. 371-377
    • Batchelor, E.1    Loewer, A.2    Lahav, G.3
  • 8
    • 0034212551 scopus 로고    scopus 로고
    • Engineering stability in gene networks by autoregulation
    • Becskei, A., Serrano, L. 2000. Engineering stability in gene networks by autoregulation. Nature 405, 590-593.
    • (2000) Nature , vol.405 , pp. 590-593
    • Becskei, A.1    Serrano, L.2
  • 9
    • 17144456808 scopus 로고    scopus 로고
    • Positive feedback in eukaryotic gene networks: Cell differentiation by graded to binary response conversion
    • Becskei, A., Seraphin, B., Serrano, L. 2001. Positive feedback in eukaryotic gene networks: Cell differentiation by graded to binary response conversion. EMBO J 20, 2528-2535.
    • (2001) EMBO J , vol.20 , pp. 2528-2535
    • Becskei, A.1    Seraphin, B.2    Serrano, L.3
  • 10
    • 23944526062 scopus 로고    scopus 로고
    • Activation of AKT kinases in cancer: Implications for therapeutic targeting
    • Bellacosa, A., Kumar, C. C., Di Cristofano, A., Testa, J. R. 2005. Activation of AKT kinases in cancer: Implications for therapeutic targeting. Adv Cancer Res 94, 29-86.
    • (2005) Adv Cancer Res , vol.94 , pp. 29-86
    • Bellacosa, A.1    Kumar, C.C.2    Di Cristofano, A.3    Testa, J.R.4
  • 12
    • 2442465034 scopus 로고    scopus 로고
    • Prospects for productivity
    • Booth, B., Zemmel, R. 2004. Prospects for productivity. Nat Rev Drug Discov 3, 451-456.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 451-456
    • Booth, B.1    Zemmel, R.2
  • 13
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: Of feedbacks and cross-talks
    • Carracedo, A., Pandolfi, P. P. 2008. The PTEN-PI3K pathway: Of feedbacks and cross-talks. Oncogene 27, 5527-5541.
    • (2008) Oncogene , vol.27 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 15
    • 43249116959 scopus 로고    scopus 로고
    • Understanding. NF-kappaB signaling via mathematical modeling
    • Cheong, R., Hoffmann, A., Levchenko, A. 2008. Understanding. NF-kappaB signaling via mathematical modeling. Mol Syst Biol 4, 192.
    • (2008) Mol Syst Biol , vol.4 , pp. 192
    • Cheong, R.1    Hoffmann, A.2    Levchenko, A.3
  • 16
    • 34247580832 scopus 로고    scopus 로고
    • JNK pathway: Diseases and therapeutic potential
    • Cui, J., Zhang, M., Zhang, Y. Q., Xu, Z. H. 2007. JNK pathway: Diseases and therapeutic potential. Acta Pharmacol Sin 28, 601-608.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 601-608
    • Cui, J.1    Zhang, M.2    Zhang, Y.Q.3    Xu, Z.H.4
  • 17
    • 0034625822 scopus 로고    scopus 로고
    • Circadian rhythms in a nutshell
    • Edery, I. 2000. Circadian rhythms in a nutshell. Physiol Genomics 3, 59-74.
    • (2000) Physiol Genomics , vol.3 , pp. 59-74
    • Edery, I.1
  • 18
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman, J. A., Luo, J., Cantley, L. C. 2006. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7, 606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 19
    • 0038756088 scopus 로고    scopus 로고
    • Cooperation between RNA polymerase molecules in transcription elongation
    • Epshtein, V., Nudler, E. 2003. Cooperation between RNA polymerase molecules in transcription elongation. Science 300, 801-805.
    • (2003) Science , vol.300 , pp. 801-805
    • Epshtein, V.1    Nudler, E.2
  • 20
    • 0346690261 scopus 로고    scopus 로고
    • Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach
    • Fan, Q. W., Specht, K. M., Zhang, C., Goldenberg, D. D., Shokat, K. M., Weiss, W. A. 2003. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res 63, 8930-8938.
    • (2003) Cancer Res , vol.63 , pp. 8930-8938
    • Fan, Q.W.1    Specht, K.M.2    Zhang, C.3    Goldenberg, D.D.4    Shokat, K.M.5    Weiss, W.A.6
  • 21
    • 34548596728 scopus 로고    scopus 로고
    • A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    • Fan, Q. W., Cheng, C. K., Nicolaides, T. P., Hackett, C. S., Knight, Z. A., Shokat, K. M., Weiss, W. A. 2007. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 67, 7960-7965.
    • (2007) Cancer Res , vol.67 , pp. 7960-7965
    • Fan, Q.W.1    Cheng, C.K.2    Nicolaides, T.P.3    Hackett, C.S.4    Knight, Z.A.5    Shokat, K.M.6    Weiss, W.A.7
  • 22
    • 51849098272 scopus 로고    scopus 로고
    • Drug discovery approaches targeting the PI3K/Akt pathway in cancer
    • Garcia-Echeverria, C., Sellers, W. R. 2008. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 27, 5511-5526.
    • (2008) Oncogene , vol.27 , pp. 5511-5526
    • Garcia-Echeverria, C.1    Sellers, W.R.2
  • 23
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner, T. S., Cantor, C. R., Collins, J. J. 2000. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342.
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 24
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • Gual, P., Le Marchand-Brustel, Y., Tanti, J. F. 2005. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87, 99-109.
    • (2005) Biochimie , vol.87 , pp. 99-109
    • Gual, P.1    Le Marchand-Brustel, Y.2    Tanti, J.F.3
  • 25
    • 0032588186 scopus 로고    scopus 로고
    • NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge, D. C., Albanese, C., Reuther, J. Y., Pestell, R. G., Baldwin, A. S. 1999. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19, 5785-5799.
    • (1999) Mol Cell Biol , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin, A.S.5
  • 26
    • 33747873543 scopus 로고    scopus 로고
    • Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging
    • Hamstra, D. A., Bhojani, M. S., Griffin, L. B., Laxman, B., Ross, B. D., Rehemtulla, A. 2006. Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Res 66 7482-7489.
    • (2006) Cancer Res , vol.66 , pp. 7482-7489
    • Hamstra, D.A.1    Bhojani, M.S.2    Griffin, L.B.3    Laxman, B.4    Ross, B.D.5    Rehemtulla, A.6
  • 27
    • 11844304072 scopus 로고    scopus 로고
    • Restraining PI3K: mTOR signalling goes back to the membrane
    • Harrington, L. S., Findlay, G. M., Lamb, R. F. 2005. Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci 30, 35-42.
    • (2005) Trends Biochem Sci , vol.30 , pp. 35-42
    • Harrington, L.S.1    Findlay, G.M.2    Lamb, R.F.3
  • 30
    • 0037044575 scopus 로고    scopus 로고
    • The IκB-NF-κB signaling module: Temporal control and selective gene activation
    • Hoffmann, A., Levchenko, A., Scott, M. L., Baltimore, D. 2002. The IκB-NF-κB signaling module: Temporal control and selective gene activation. Science 298, 1241-1245.
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 31
    • 38949194331 scopus 로고    scopus 로고
    • Noise propagation and signaling sensitivity in biological networks
    • Hornung, G., Barkai, N. 2008. Noise propagation and signaling sensitivity in biological networks. PLoS Comput Biol 4, e8.
    • (2008) PLoS Comput Biol , vol.4
    • Hornung, G.1    Barkai, N.2
  • 32
    • 66249147534 scopus 로고    scopus 로고
    • An experimental design method leading to chemical turing patterns
    • Horváth, J., Szalai, I., De Kepper, P. 2009. An experimental design method leading to chemical turing patterns. Science 324, 772-775.
    • (2009) Science , vol.324 , pp. 772-775
    • Horváth, J.1    Szalai, I.2    De Kepper, P.3
  • 33
    • 0038271880 scopus 로고    scopus 로고
    • Prediction and measurement of an autoregulatory genetic module
    • Isaacs, F. J., Hasty, J., Cantor, C. R., Collins, J. J. 2003. Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci USA 100, 7714-7719.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7714-7719
    • Isaacs, F.J.1    Hasty, J.2    Cantor, C.R.3    Collins, J.J.4
  • 34
    • 3042513693 scopus 로고    scopus 로고
    • Control of chemical pattern formation by a clock-and-wavefront type mechanism
    • Kaern, M., M'guez, D. G., Munuzuri, A. P., Menzinger, M. 2004. Control of chemical pattern formation by a clock-and-wavefront type mechanism. Biophys Chem 110, 231-238.
    • (2004) Biophys Chem , vol.110 , pp. 231-238
    • Kaern, M.1    M'guez, D.G.2    Munuzuri, A.P.3    Menzinger, M.4
  • 36
    • 22144452865 scopus 로고    scopus 로고
    • Hysteresis in a synthetic mammalian gene network
    • Kramer, B. P., Fussenegger, M. 2005. Hysteresis in a synthetic mammalian gene network. Proc Natl Acad Sci USA 102, 9517-9522.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9517-9522
    • Kramer, B.P.1    Fussenegger, M.2
  • 37
    • 0026575824 scopus 로고
    • Modeling of turing structures in the chlorite-iodide-malonic Acid-starch reaction system
    • Lengyel, I., Epstein, I. R. 1992. Modeling of turing structures in the chlorite-iodide-malonic Acid-starch reaction system. Proc Natl Acad Sci USA 89, 3977-3979.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3977-3979
    • Lengyel, I.1    Epstein, I.R.2
  • 38
    • 33745873655 scopus 로고    scopus 로고
    • Subjective similarity of patterns of diffuse interstitial lung disease on thin-section CT: An observer performance study
    • Li, F., Li, Q., Engelmann, R., Aoyama, M., Sone, S., MacMahon, H., Doi, K. 2006. Subjective similarity of patterns of diffuse interstitial lung disease on thin-section CT: An observer performance study. Acad Radiol 13, 943-950.
    • (2006) Acad Radiol , vol.13 , pp. 943-950
    • Li, F.1    Li, Q.2    Engelmann, R.3    Aoyama, M.4    Sone, S.5    MacMahon, H.6    Doi, K.7
  • 39
    • 0033517148 scopus 로고    scopus 로고
    • Robustness of a gene regulatory circuit
    • Little, J. W., Shepley, D. P., Wert, D. W. 1999. Robustness of a gene regulatory circuit. EMBO J 18, 4299-4307.
    • (1999) EMBO J , vol.18 , pp. 4299-4307
    • Little, J.W.1    Shepley, D.P.2    Wert, D.W.3
  • 40
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, B. D., Cantley, L. C. 2007. AKT/PKB signaling: Navigating downstream. Cell 129, 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 42
    • 0032519787 scopus 로고    scopus 로고
    • puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    • Martín-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A. M., Martinez-Arias, A. 1998. puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev 12, 557-570.
    • (1998) Genes Dev , vol.12 , pp. 557-570
    • Martín-Blanco, E.1    Gampel, A.2    Ring, J.3    Virdee, K.4    Kirov, N.5    Tolkovsky, A.M.6    Martinez-Arias, A.7
  • 43
    • 37849034945 scopus 로고    scopus 로고
    • Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory
    • Mazzocchi, F. 2008. Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory. EMBO Rep 9, 10-14.
    • (2008) EMBO Rep , vol.9 , pp. 10-14
    • Mazzocchi, F.1
  • 46
    • 34249843900 scopus 로고    scopus 로고
    • Fronts and pulses in an enzymatic reaction catalyzed by glucose oxidase
    • Míguez, D. G., Vanag, V. K., Epstein, I. R. 2007. Fronts and pulses in an enzymatic reaction catalyzed by glucose oxidase. Proc Natl Acad Sci USA 104, 6992-6997.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6992-6997
    • Míguez, D.G.1    Vanag, V.K.2    Epstein, I.R.3
  • 47
    • 69949180066 scopus 로고    scopus 로고
    • Selection of flow-distributed oscillation and Turing patterns by boundary forcing in a linearly growing, oscillating medium
    • Míguez, D. G., McGraw, P., Munuzuri, A. P., Menzinger, M. 2009. Selection of flow-distributed oscillation and Turing patterns by boundary forcing in a linearly growing, oscillating medium. Phys Rev E Stat Nonlin Soft Matter Phys 80, 026208.
    • (2009) Phys Rev E Stat Nonlin Soft Matter Phys , vol.80 , pp. 026208
    • Míguez, D.G.1    McGraw, P.2    Munuzuri, A.P.3    Menzinger, M.4
  • 49
    • 77951977456 scopus 로고    scopus 로고
    • The role of asymmetric binding in ligand-receptor systems with 1: 2 interaction ratio
    • Míguez, D. G. 2010b. The role of asymmetric binding in ligand-receptor systems with 1: 2 interaction ratio. Biophys Chem 148, 74-81.
    • (2010) Biophys Chem , vol.148 , pp. 74-81
    • Míguez, D.G.1
  • 50
    • 20144385541 scopus 로고    scopus 로고
    • Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2
    • Misra, S., Ghatak, S., Toole, B. P. 2005. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2. J Biol Chem 280, 20310-20315.
    • (2005) J Biol Chem , vol.280 , pp. 20310-20315
    • Misra, S.1    Ghatak, S.2    Toole, B.P.3
  • 53
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • Paulsson, J. 2004. Summing up the noise in gene networks. Nature 427, 415-418.
    • (2004) Nature , vol.427 , pp. 415-418
    • Paulsson, J.1
  • 56
    • 0036428761 scopus 로고    scopus 로고
    • Negative autoregulation speeds the response times of transcription networks
    • Rosenfeld, N., Elowitz, M. B., Alon, U. 2002. Negative autoregulation speeds the response times of transcription networks. J Mol Biol 323, 785-793.
    • (2002) J Mol Biol , vol.323 , pp. 785-793
    • Rosenfeld, N.1    Elowitz, M.B.2    Alon, U.3
  • 57
    • 0037077109 scopus 로고    scopus 로고
    • Feedback stabilization of unstable propagating waves
    • Sakurai, T., Mihaliuk, E., Chirila, F., Showalter, K. 2002. Feedback stabilization of unstable propagating waves. Science 296, 2009-2012.
    • (2002) Science , vol.296 , pp. 2009-2012
    • Sakurai, T.1    Mihaliuk, E.2    Chirila, F.3    Showalter, K.4
  • 59
    • 0016145568 scopus 로고
    • Comparison of classical and autogenous systems of regulation in inducible operons
    • Savageau, M. A. 1974. Comparison of classical and autogenous systems of regulation in inducible operons. Nature 252, 546-549.
    • (1974) Nature , vol.252 , pp. 546-549
    • Savageau, M.A.1
  • 60
    • 0036829675 scopus 로고    scopus 로고
    • Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT)1
    • Schauvliege, R., Vanrobaeys, J., Schotte, P., Beyaert, R. 2002. Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT)1. J Biol Chem 277, 41624-41630.
    • (2002) J Biol Chem , vol.277 , pp. 41624-41630
    • Schauvliege, R.1    Vanrobaeys, J.2    Schotte, P.3    Beyaert, R.4
  • 61
    • 0034810894 scopus 로고    scopus 로고
    • Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    • Sesti, G., Federici, M., Hribal, M. L., Lauro, D., Sbraccia, P., Lauro, R. 2001. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 15, 2099-2111.
    • (2001) FASEB J , vol.15 , pp. 2099-2111
    • Sesti, G.1    Federici, M.2    Hribal, M.L.3    Lauro, D.4    Sbraccia, P.5    Lauro, R.6
  • 62
    • 0025223225 scopus 로고
    • Structural analysis of the rabbit TNF locus, containing the genes encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor)
    • Shakhov, A. N., Kuprash, D. V., Azizov, M. M., Jongeneel, C. V., Nedospasov, S. A. 1990. Structural analysis of the rabbit TNF locus, containing the genes encoding TNF-beta (lymphotoxin) and TNF-alpha (tumor necrosis factor). Gene 95, 215-221.
    • (1990) Gene , vol.95 , pp. 215-221
    • Shakhov, A.N.1    Kuprash, D.V.2    Azizov, M.M.3    Jongeneel, C.V.4    Nedospasov, S.A.5
  • 65
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in trail-induced apoptosis
    • Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., Sorger, P. K. 2009. Non-genetic origins of cell-to-cell variability in trail-induced apoptosis. Nature 459, 428-432.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 67
    • 0036790975 scopus 로고    scopus 로고
    • Intrinsic and extrinsic contributions to stochasticity in gene expression
    • Swain, P. S., Elowitz, M. B., Siggia, E. D. 2002. Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc Natl Acad Sci USA 99, 12795-12800.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12795-12800
    • Swain, P.S.1    Elowitz, M.B.2    Siggia, E.D.3
  • 68
    • 51149102891 scopus 로고    scopus 로고
    • Intron length increases oscillatory periods of gene expression in animal cells
    • Swinburne, I. A., Míguez, D. G., Landgraf, D., Silver, P. A. 2008. Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev 22, 2342-2346.
    • (2008) Genes Dev , vol.22 , pp. 2342-2346
    • Swinburne, I.A.1    Míguez, D.G.2    Landgraf, D.3    Silver, P.A.4
  • 70
    • 0032077377 scopus 로고    scopus 로고
    • From specific gene regulation to genomic networks: A global analysis of transcriptional regulation in Escherichia coli
    • Thieffry, D., Huerta, A. M., Pérez-Rueda, E., Collado-Vides, J. 1998. From specific gene regulation to genomic networks: A global analysis of transcriptional regulation in Escherichia coli. Bioessays 20, 433-440.
    • (1998) Bioessays , vol.20 , pp. 433-440
    • Thieffry, D.1    Huerta, A.M.2    Pérez-Rueda, E.3    Collado-Vides, J.4
  • 71
    • 0034721176 scopus 로고    scopus 로고
    • Oscillatory cluster patterns in a homogeneous chemical system with global feedback
    • Vanag, V., Yang, L., Dolnik, M., Zhabotinsky, A., Epstein, I. 2000. Oscillatory cluster patterns in a homogeneous chemical system with global feedback. Nature 406, 389-391.
    • (2000) Nature , vol.406 , pp. 389-391
    • Vanag, V.1    Yang, L.2    Dolnik, M.3    Zhabotinsky, A.4    Epstein, I.5
  • 72
    • 33845286921 scopus 로고    scopus 로고
    • Designing an enzymatic oscillator: Bistability and feedback controlled oscillations with glucose oxidase in a continuous flow stirred tank reactor
    • Vanag, V. K., Míguez, D. G., Epstein, I. R. 2006. Designing an enzymatic oscillator: Bistability and feedback controlled oscillations with glucose oxidase in a continuous flow stirred tank reactor. J Chem Phys 125, 194515.
    • (2006) J Chem Phys , vol.125 , pp. 194515
    • Vanag, V.K.1    Míguez, D.G.2    Epstein, I.R.3
  • 73
    • 0033957661 scopus 로고    scopus 로고
    • The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
    • Vazquez, F., Sellers, W. R. 2000. The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 1470, M21-M35.
    • (2000) Biochim Biophys Acta , vol.1470
    • Vazquez, F.1    Sellers, W.R.2
  • 74
    • 19944374798 scopus 로고    scopus 로고
    • Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    • Wang, H. Q., Altomare, D. A., Skele, K. L., Poulikakos, P. I., Kuhajda, F. P., Di Cristofano, A., Testa, J. R. 2005. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 24, 3574-3582.
    • (2005) Oncogene , vol.24 , pp. 3574-3582
    • Wang, H.Q.1    Altomare, D.A.2    Skele, K.L.3    Poulikakos, P.I.4    Kuhajda, F.P.5    Di Cristofano, A.6    Testa, J.R.7
  • 76
    • 4444222881 scopus 로고    scopus 로고
    • Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex
    • Weissman, T. A., Riquelme, P. A., Ivic, L., Flint, A. C., Kriegstein, A. R. 2004. Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex. Neuron 43, 647-661.
    • (2004) Neuron , vol.43 , pp. 647-661
    • Weissman, T.A.1    Riquelme, P.A.2    Ivic, L.3    Flint, A.C.4    Kriegstein, A.R.5
  • 77
    • 9344260562 scopus 로고
    • Periodical process of oxidation of malonic acid solution
    • Zhabotinsky, A. M. 1964. Periodical process of oxidation of malonic acid solution. Biofizika 9, 306-311.
    • (1964) Biofizika , vol.9 , pp. 306-311
    • Zhabotinsky, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.