Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Zhang, Jin ^a   Wu, Dan ^a   Xie, Cheng ^a   Wang, Huan ^a   Wang, Wei ^a   Zhang, Hui ^a   Liu, Rui ^a   Xu, Li Xian ^a   Mei, Xiao Peng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; PROPENTOFYLLINE; TRAMADOL;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DNA SEQUENCE; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; MALE; MOTOR PERFORMANCE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; ROTAROD TEST; SEQUENCE ANALYSIS; SPINAL NERVE;

ANALGESICS, OPIOID; ANIMALS; DRUG COMBINATIONS; DRUG SYNERGISM; HYPERALGESIA; INJECTIONS, SPINAL; INTERLEUKIN-1BETA; LIGATION; MALE; MOTOR ACTIVITY; NEURALGIA; POSTERIOR HORN CELLS; RATS; SPINAL NERVES; TRAMADOL; XANTHINES;

EID: 84883236421     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072943     Document Type: Article

References (45)

1. Gao YJ, Ji RR, (2010) Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther 126: 56-68.
2. Wrzosek A, Obara I, Wordliczek J, Przewlocka B, (2009) Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. J Physiol Pharmacol 60: 71-78.
3. Brattwall M, Turan I, Jakobsson J, (2010) Pain management after elective hallux valgus surgery: a prospective randomized double-blind study comparing etoricoxib and tramadol. Anesth Analg 111: 544-549.
4. Alvarez P, Saavedra G, Hernandez A, Paeile C, Pelissier T, (2003) Synergistic antinociceptive effects of ketamine and morphine in the orofacial capsaicin test in the rat. Anesthesiology 99: 969-975.
5. Cavazzini F, (2008) The combination acetominophen/tramadol in hematological daily practice. Minerva Med 99: 631-641.
6. Tsuda M, Inoue K, Salter MW, (2005) Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci 28: 101-107.
7. Scholz J, Woolf CJ, (2007) The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 10: 1361-1368.
8. Ikeda H, Tsuda M, Inoue K, Murase K, (2007) Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn. Eur J Neurosci 25: 1297-1306.
9. Sweitzer S, De Leo J, (2011) Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. Handb Exp Pharmacol pp. 235-250.
10. Raghavendra V, Tanga F, Rutkowski MD, DeLeo JA, (2003) Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines. Pain 104: 655-664.
11. Tawfik VL, Regan MR, Haenggeli C, Lacroix-Fralish ML, Nutile-McMenemy N, et al. (2008) Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. Neuroscience 152: 1086-1092.
12. Austin PJ, Moalem-Taylor G, (2010) The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. J Neuroimmunol 229: 26-50.
13. Zimmermann M, (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110.
14. Kim SH, Chung JM, (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50: 355-363.
15. Mei XP, Zhang H, Wang W, Wei YY, Zhai MZ, et al. (2011) Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. J Neuroinflammation 8: 6.
16. Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, et al. (2003) Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci 23: 1026-1040.
17. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL, (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53: 55-63.
18. Arguelles CF, Torres-Lopez JE, Granados-Soto V, (2002) Peripheral antinociceptive action of morphine and the synergistic interaction with lamotrigine. Anesthesiology 96: 921-925.
19. Wang W, Mei XP, Wei YY, Zhang MM, Zhang T, et al. (2011) Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain. Brain Behav Immun 25: 1355-1366.
20. Onal A, Parlar A, Ulker S, (2007) Milnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic pain. Pharmacol Biochem Behav 88: 171-178.
21. Tallarida RJ, Porreca F, Cowan A, (1989) Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci 45: 947-961.
22. Mei XP, Zhou Y, Wang W, Tang J, Zhang H, et al. (2011) Ketamine Depresses Toll-Like Receptor 3 Signaling in Spinal Microglia in a Rat Model of Neuropathic Pain. Neurosignals 19: 44-53.
23. Norrbrink C, Lundeberg T, (2009) Tramadol in neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled trial. Clin J Pain 25: 177-184.
24. Gwak YS, Crown ED, Unabia GC, Hulsebosch CE, (2008) Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. Pain 138: 410-422.
25. Kraychete DC, Sakata RK, Issy AM, Bacellar O, Jesus RS, et al. (2009) Proinflammatory cytokines in patients with neuropathic pain treated with Tramadol. Rev Bras Anestesiol 59: 297-303.
26. Wilder-Smith CH, Schimke J, Osterwalder B, Senn HJ, (1994) Oral tramadol, a mu-opioid agonist and monoamine reuptake-blocker, and morphine for strong cancer-related pain. Ann Oncol 5: 141-146.
27. Erichsen HK, Hao JX, Xu XJ, Blackburn-Munro G, (2005) Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain. Pain 116: 347-358.
28. Berrocoso E, De Benito MD, Mico JA, (2007) Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. Psychopharmacology (Berl) 193: 97-105.
29. Kino Y, Tanabe M, Honda M, Ono H, (2005) Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes. J Pharmacol Sci 99: 52-60.
30. Iyengar S, Webster AA, Hemrick-Luecke SK, Xu JY, Simmons RM, (2004) Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. J Pharmacol Exp Ther 311: 576-584.
31. Zhuang ZY, Gerner P, Woolf CJ, Ji RR, (2005) ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114: 149-159.
32. Tawfik VL, Nutile-McMenemy N, Lacroix-Fralish ML, Deleo JA, (2007) Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. Brain Behav Immun 21: 238-246.
33. Sweitzer SM, Schubert P, DeLeo JA, (2001) Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 297: 1210-1217.
34. Milligan ED, Watkins LR, (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10: 23-36.
35. Miller RJ, Jung H, Bhangoo SK, White FA (2009) Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol: 417-449.
36. Mika J, (2008) Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness. Pharmacol Rep 60: 297-307.
37. Inoue K, (2006) The function of microglia through purinergic receptors: neuropathic pain and cytokine release. Pharmacol Ther 109: 210-226.
38. Li Y, Liu L, Kang J, Sheng JG, Barger SW, et al. (2000) Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J Neurosci 20: 149-155.
39. Guo W, Wang H, Watanabe M, Shimizu K, Zou S, et al. (2007) Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci 27: 6006-6018.
40. Nadeau S, Filali M, Zhang J, Kerr BJ, Rivest S, et al. (2011) Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1beta and TNF: implications for neuropathic pain. J Neurosci 31: 12533-12542.
41. Inoue K, Koizumi S, Tsuda M, (2007) The role of nucleotides in the neuron-glia communication responsible for the brain functions. J Neurochem 102: 1447-1458.
42. Sun S, Cao H, Han M, Li TT, Pan HL, et al. (2007) New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial activation in rat model of monoarthritis. Pain 129: 64-75.
43. Milligan ED, Sloane EM, Watkins LR, (2008) Glia in pathological pain: a role for fractalkine. J Neuroimmunol 198: 113-120.
44. Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, et al. (2004) Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci 20: 1150-1160.
45. Inoue K, Koizumi S, Tsuda M, Shigemoto-Mogami Y, (2003) Signaling of ATP receptors in glia-neuron interaction and pain. Life Sci 74: 189-197.