Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: An isobolographic analysis

Journal of Physiology and Pharmacology

Volumn 60, Issue 4, 2009, Pages 71-78

  Wrzosek, A ^b,c   Obara, I ^a   Wordliczek, J ^b   Przewlocka, Barbara ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c UNIVERSITY HOSPITAL IN KRAKOW   (Poland)

Author keywords

Doxepin; Drug interaction; Isobolographic analysis; Neuropathic pain; Tramadol; Venlafaxine

Indexed keywords

DOXEPIN; TRAMADOL; VENLAFAXINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; HYPERALGESIA; MALE; MONOTHERAPY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; RAT;

ANALGESICS, OPIOID; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CYCLOHEXANOLS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXEPIN; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; HYPERALGESIA; MALE; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, WISTAR; STATISTICS AS TOPIC; TRAMADOL;

EID: 75749118549     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 1999; 353: 1959-1964.
2. Mika J, Przewlocki R, Przewlocka B. The role of deltaopioid receptor subtypes in neuropathic pain. Eur J Pharmacol 2001; 415: 31-37.
3. Obara I, Mika J, Schafer MK, Przewlocka B. Antagonists of the kappa-opioid receptor enhance allodynia in rats and mice after sciatic nerve ligation. Br J Pharmacol 2003; 140: 538-546.
4. Osikowicz M, Mika J, Makuch W, Przewlocka B. Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain. Pain 2008; 139: 117-127.
5. Rodriguez Parkitna J, Korostynski M, Kaminska-Chowaniec D, et al. Comparison of gene expression profiles in neuropathic and inflammatory pain. J Physiol Pharmacol 2006; 57(3): 401-414.
6. Przewlocki R, Przewlocka B. Opioids in chronic pain. Eur J Pharmacol. 2001; 429(1-3): 79-91.
7. Mayer DJ, Mao J, Holt J, Price DD. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci USA 1999; 96: 7731-7736.
8. Mika J, Schafer MK, Obara I, Weihe E, Przewlocka B. Morphine and endomorphin-1 differently influence pronociceptin/orphanin FQ system in neuropathic rats. Pharmacol Biochem Behav 2004; 78: 71-78.
9. Przewlocki R, Przewlocka B. Opioids in neuropathic pain. Curr Pharm Des 2005; 11: 3013-3025.
10. Mika J, Osikowicz M, Makuch W, Przewlocka B. Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol 2007; 560: 142-149.
11. Miranda HF, Pinardi G. Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal antiinflammatory drugs (NSAIDS). J Physiol Pharmacol 2009; 60(2): 71-76.
12. Lopez-Munoz FJ. Surface of synergistic interaction between dipyrone and morfphine in the PIFIR model. Drug Dev Res 1994; 33: 26-32.
13. Lopez-Munoz FJ, Diaz-Reval MI, Terron JA, Deciga-Campos M. Analysis of the analgesic interactions between ketorolac and tramadol during arthritic nociception in rat. Eur J Pharmacol 2004; 484: 157-165.
14. Pinardi G, Pelissier T, Miranda HF. Interactions in the antinociceptive effect of tramadol in mice: an isobolographic analysis. Eur J Pain 1998; 2: 343-350.
15. Wordliczek J, Banach M, Labuz D, Przewlocka B. Intrathecal administration of doxepin attenuated development of formalin-induced pain in rats. J Neural Transm 2005; 112: 1321-1329.
16. Ventafridda V, Bianchi M, Ripamonti C, et al. Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain 1990; 43: 155-162.
17. Acton J, McKenna JE, Melzack R. Amitriptyline produces analgesia in the formalin pain test. Exp Neurol 1992; 117:94-96.
18. Eisenach JC, Gebhart GF. Intrathecal amitriptyline. Antinociceptive interactions with intravenous morphine and intrathecal clonidine, neostigmine, and carbamylcholine in rats. Anesthesiology 1995; 83: 1036-1045.
19. Goldstein FJ, Mojaverian P, Ossipov MH, Swanson BN. Elevation in analgetic effect and plasma levels of morphine by desipramine in rats. Pain 1982; 14: 279-282.
20. Sawynok J, Reid A. Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine. Pain 1992; 50: 113-118.
21. Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL. Opioid and nanopioid componenets independently contribute to the mechanism od action of tramadol, an "atypical" opioid analgesic. J Pharmacol Exp Ther 1992; 260: 275-285.
22. Bamigbade TA, Langford RM. The clinical use of tramadol hydrochloride. Pain Rev 1998; 5: 155-182.
23. Lang E, Hord AH, Denson D. Venlafaxine hydrochloride (Effexor) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. Pain 1996; 68: 151-155.
24. Gutierrez MA, Stimmel GL, Aiso JY. Venlafaxine: A 2003 update. Clin Ther 2003; 25: 2118-2154.
25. Cai Z, McCaslin PP. Amitriptyline, desipramine, cyproheptadine and carbamazepine, in concentrations used therapeutically, reduce kainate- and N-methyl-D-aspartateinduced intracellular Ca2tcombining comma below levels in neuronal culture. Eur J Pharmacol 1992; 219: 53-57.
26. Watanabe Y, Saito H, Abe K. Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices. Neuropharmacology 1993; 32: 479-486.
27. Esser MJ, Sawynok J. Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in rat model of neuropathic pain. Eur J Pharmacol 2000; 399: 131-139.
28. Hall H, Ogren SO. Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol 1981; 70: 393-407.
29. Fryer JD, Lukas RJ. Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function. J Neurochem 1999; 72: 1117-1124.
30. Markowitz JS, Patrick KS. Venlafaxine-tramadol similarities. Med Hypotheses 1998; 51: 167-168.
31. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-110.
32. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces abnormal pain sensation like those seen in man. Pain 1988; 33: 87-107.
33. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.
34. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63.
35. Starowicz K, Przewlocki R, Gispen WH, Przewlocka B. Modulation of melanocortin-induced changes in spinal nociception by mu-opioid receptor agonist and antagonist in neuropathic rats. Neuroreport 2002; 13: 2447-2452.
36. Obara I, Makuch W, Spetea M, et al. Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat. Eur J Pharmacol 2007; 558: 60-67.
37. Tallarida RJ, Porreca F, Cowan A. Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci 1989; 45: 947-961.
38. Tallarida RJ. Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001; 298: 865-872.
39. Tallarida RJ. The interaction index: a measure of drug synergism. Pain 2002; 98: 163-168.
40. Pedersen LH, Nielsen AN, Blackburn-Munro G. Antinociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. Psychopharmacology (Berl) 2005; 182: 551-561.
41. Bomholt SF, Mikkelsen JD. Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuroparmacology 2005; 48: 252-263.
42. Abdi S, Lee DH, Chung JM. The anti-allodynic effects of amitriptyline, gabapentin and lidocaine in a rat model of neuropathic pain. Anesth Analg 1998; 87: 1360-1366.
43. Rojas-Corrales MO, Casas J, Moreno-Brea MR, Gibert-Rahola J, Mico JA. Antinociceptive effects of tricyclic antidepressantos and their noradrenergic metabolites. Eur Neuropsychopharmacol 2003; 13: 355-363.
44. Schreiber S, Backer MM, Pick CG. Antinociceptive effect of venlafaxine in mice is mediated through opioid and adrenergic mechanism. Neurosci Lett 1999; 273: 85-88.
45. Dickenson AH, Chapman V, Green GM. The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. Gen Pharmacol 1997; 28: 633-638.
46. Labuz D, Dobrogowski J, Golec A, Przewlocka B. NMDA receptor antagonists potentiated antinociceptive effect of paracetamol in writhing test in mice. Analgesia 2001; 5: 217-222.
47. Chapman V, Haley JE, Dickenson AH. Electrophysiologic analysis of preemptive effects of spinal opioids on N-methyl-D-aspartate receptor-mediated events. Anesthesiology 1994; 81: 1429-1435.
48. Rogoz Z, Skuza G, Maj J, Danysz W. Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats. Neuropharmacology 2002; 42(8): 1024-1030.
49. Rogoz Z, Skuza G, Legutko B. Repeated co-treatment with imipramine and amantadine induces hippocampal brainderived neurotrophic factor gene expression in rats. J Physiol Pharmacol 2007; 58(2): 219-234.
50. Nichols ML, Lopez Y, Ossipov MH, Bian D, Porreca F. Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1-13) or MK-801 in a nerve-ligation model of peripheral neuropathy. Pain 1997; 69: 317-322.
51. Martinez V, Christensen D, Kayser V. The glycine/NMDA receptor antagonist (+)-HA966 enhances the peripheral effect of morphine in neuropathic rats. Pain 2002; 99: 537-545.
52. Yamamoto T, Yaksh TL. Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy. Neurosci Lett 1992; 135: 67-70.
53. Ossipov MH, Lopez Y, Nichols ML, Bian D, Porreca F. The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive. Neurosci Lett 1995; 199: 87-90.
54. Christensen D, Idanpaan-Heikkila JJ, Guilbaud G, Kayser V. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. Br J Pharmacol 1998; 125: 1641-1650.