-
1
-
-
50149108858
-
Conserved functions of the pRB and E2F families
-
van den Heuvel S, Dyson NJ. Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol 2008; 9: 713-724.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 713-724
-
-
Van Den Heuvel, S.1
Dyson, N.J.2
-
2
-
-
36749050812
-
Life and death decisions by the E2F transcription factors
-
Iaquinta PJ, Lees JA. Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol 2007; 19: 649-657.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 649-657
-
-
Iaquinta, P.J.1
Lees, J.A.2
-
3
-
-
33750920705
-
Distinct and overlapping roles for e2f family members in transcription, proliferation and apoptosis
-
DeGregori J, Johnson DG. Distinct and overlapping roles for e2f family members in transcription, proliferation and apoptosis. Curr Mol Med 2006; 6: 739-748.
-
(2006)
Curr Mol Med
, vol.6
, pp. 739-748
-
-
Degregori, J.1
Johnson, D.G.2
-
4
-
-
33751239778
-
Re-evaluating cell-cycle regulation by E2Fs
-
Rowland BD, Bernards R. Re-evaluating cell-cycle regulation by E2Fs. Cell 2006; 127: 871-874.
-
(2006)
Cell
, vol.127
, pp. 871-874
-
-
Rowland, B.D.1
Bernards, R.2
-
5
-
-
0035936113
-
The E2F1-3 transcription factors are essential for cellular proliferation
-
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001; 414: 457-462.
-
(2001)
Nature
, vol.414
, pp. 457-462
-
-
Wu, L.1
Timmers, C.2
Maiti, B.3
Saavedra, H.I.4
Sang, L.5
Chong, G.T.6
-
6
-
-
72449177341
-
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells
-
Chong J-L, Wenzel PL, Saenz-Robles MT, Nair V, Ferrey A, Hagan JP et al. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 2009; 462: 930-934.
-
(2009)
Nature
, vol.462
, pp. 930-934
-
-
Chong, J.-L.1
Wenzel, P.L.2
Saenz-Robles, M.T.3
Nair, V.4
Ferrey, A.5
Hagan, J.P.6
-
7
-
-
72449178334
-
Division and apoptosis of E2f-deficient retinal progenitors
-
Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R. Division and apoptosis of E2f-deficient retinal progenitors. Nature 2009; 462: 925-929.
-
(2009)
Nature
, vol.462
, pp. 925-929
-
-
Chen, D.1
Pacal, M.2
Wenzel, P.3
Knoepfler, P.S.4
Leone, G.5
Bremner, R.6
-
8
-
-
0033666776
-
Role of the p53-homologue p73 in E2F1-induced apoptosis
-
Stiewe T, Putzer BM. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat Genet 2000; 26: 464-469.
-
(2000)
Nat Genet
, vol.26
, pp. 464-469
-
-
Stiewe, T.1
Putzer, B.M.2
-
9
-
-
0034609864
-
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
-
Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature 2000; 407: 642-645.
-
(2000)
Nature
, vol.407
, pp. 642-645
-
-
Lissy, N.A.1
Davis, P.K.2
Irwin, M.3
Kaelin, W.G.4
Dowdy, S.F.5
-
10
-
-
0034609798
-
Role for the p53 homologue p73 in E2F-1-induced apoptosis
-
Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 2000; 407: 645-648.
-
(2000)
Nature
, vol.407
, pp. 645-648
-
-
Irwin, M.1
Marin, M.C.2
Phillips, A.C.3
Seelan, R.S.4
Smith, D.I.5
Liu, W.6
-
11
-
-
1542305653
-
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis
-
Hershko T, Ginsberg D. Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis. J Biol Chem 2004; 279: 8627-8634.
-
(2004)
J Biol Chem
, vol.279
, pp. 8627-8634
-
-
Hershko, T.1
Ginsberg, D.2
-
12
-
-
24944474714
-
Bim is a direct target of a neuronal E2F-dependent apoptotic pathway
-
Biswas SC, Liu DX, Greene LA. Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J Neurosci 2005; 25: 8349-8358.
-
(2005)
J Neurosci
, vol.25
, pp. 8349-8358
-
-
Biswas, S.C.1
Liu, D.X.2
Greene, L.A.3
-
13
-
-
0034977277
-
Apaf-1 is a transcriptional target for E2F and p53
-
Moroni MC, Hickman ES, Denchi EL, Caprara G, Colli E, Cecconi F et al. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol 2001; 3: 552-558.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 552-558
-
-
Moroni, M.C.1
Hickman, E.S.2
Denchi, E.L.3
Caprara, G.4
Colli, E.5
Cecconi, F.6
-
14
-
-
85006277004
-
Direct coupling of the cell cycle and cell death machinery by E2F
-
Nahle Z, Polakoff J, Davuluri RV, McCurrach ME, Jacobson MD, Narita M et al. Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol 2002; 4: 859-864.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 859-864
-
-
Nahle, Z.1
Polakoff, J.2
Davuluri, R.V.3
McCurrach, M.E.4
Jacobson, M.D.5
Narita, M.6
-
15
-
-
33644776551
-
Jab1 is a specificity factor for E2F1-induced apoptosis
-
Hallstrom TC, Nevins JR. Jab1 is a specificity factor for E2F1-induced apoptosis. Genes Dev 2006; 20: 613-623.
-
(2006)
Genes Dev
, vol.20
, pp. 613-623
-
-
Hallstrom, T.C.1
Nevins, J.R.2
-
16
-
-
0141814666
-
Specificity in the activation and control of transcription factor E2F-dependent apoptosis
-
Hallstrom TC, Nevins JR. Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Nat Acad Sci USA 2003; 100: 10848-10853.
-
(2003)
Proc Nat Acad Sci USA
, vol.100
, pp. 10848-10853
-
-
Hallstrom, T.C.1
Nevins, J.R.2
-
17
-
-
23744507860
-
E2F1 is crucial for E2F-dependent apoptosis
-
Lazzerini Denchi E, Helin K. E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep 2005; 6: 661-668.
-
(2005)
EMBO Rep
, vol.6
, pp. 661-668
-
-
Lazzerini Denchi, E.1
Helin, K.2
-
18
-
-
73549095168
-
E2F3 is a mediator of dna damage-induced apoptosis
-
Martinez LA, Goluszko E, Chen H-Z, Leone G, Post S, Lozano G et al. E2F3 is a mediator of dna damage-induced apoptosis. Mol Cell Biol 2010; 30: 524-536.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 524-536
-
-
Martinez, L.A.1
Goluszko, E.2
Chen, H.-Z.3
Leone, G.4
Post, S.5
Lozano, G.6
-
19
-
-
0035878122
-
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
-
Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 2001; 15: 1833-1844.
-
(2001)
Genes Dev
, vol.15
, pp. 1833-1844
-
-
Lin, W.C.1
Lin, F.T.2
Nevins, J.R.3
-
21
-
-
10644270921
-
P73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2
-
Urist M, Tanaka T, Poyurovsky MV, Prives C. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev 2004; 18: 3041-3054.
-
(2004)
Genes Dev
, vol.18
, pp. 3041-3054
-
-
Urist, M.1
Tanaka, T.2
Poyurovsky, M.V.3
Prives, C.4
-
22
-
-
0038142184
-
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
-
Pediconi N, Ianari A, Costanzo A, Belloni L, Gallo R, Cimino L et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol 2003; 5: 552-558.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 552-558
-
-
Pediconi, N.1
Ianari, A.2
Costanzo, A.3
Belloni, L.4
Gallo, R.5
Cimino, L.6
-
23
-
-
51049100399
-
MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint DNA repair and apoptosis
-
Yang SZ, Lin FT, Lin WC. MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep 2008; 9: 907-915.
-
(2008)
EMBO Rep
, vol.9
, pp. 907-915
-
-
Yang, S.Z.1
Lin, F.T.2
Lin, W.C.3
-
24
-
-
53249154203
-
Function and regulation of protein neddylation. 'Protein modifications: Beyond the usual suspects' review series
-
Rabut G, Peter M. Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 2008; 9: 969-976.
-
(2008)
EMBO Rep
, vol.9
, pp. 969-976
-
-
Rabut, G.1
Peter, M.2
-
25
-
-
74449093655
-
Chemotherapy induces NEDP1-mediated destabilization of MDM2
-
Watson IR, Li BK, Roche O, Blanch A, Ohh M, Irwin MS. Chemotherapy induces NEDP1-mediated destabilization of MDM2. Oncogene 2009; 29: 297-304.
-
(2009)
Oncogene
, vol.29
, pp. 297-304
-
-
Watson, I.R.1
Li, B.K.2
Roche, O.3
Blanch, A.4
Ohh, M.5
Irwin, M.S.6
-
26
-
-
0029820095
-
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
-
Hofmann F, Martelli F, Livingston DM, Wang Z. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev 1996; 10: 2949-2959.
-
(1996)
Genes Dev
, vol.10
, pp. 2949-2959
-
-
Hofmann, F.1
Martelli, F.2
Livingston, D.M.3
Wang, Z.4
-
27
-
-
0029797841
-
Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
-
Hateboer G, Kerkhoven RM, Shvarts A, Bernards R, Beijersbergen RL. Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev 1996; 10: 2960-2970.
-
(1996)
Genes Dev
, vol.10
, pp. 2960-2970
-
-
Hateboer, G.1
Kerkhoven, R.M.2
Shvarts, A.3
Bernards, R.4
Beijersbergen, R.L.5
-
28
-
-
25444505677
-
P14 ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners
-
Rizos H, Woodruff S, Kefford RF. p14 ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners. Cell Cycle 2005; 4: 597-603.
-
(2005)
Cell Cycle
, vol.4
, pp. 597-603
-
-
Rizos, H.1
Woodruff, S.2
Kefford, R.F.3
-
29
-
-
64749098830
-
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
-
Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009; 458: 732-736.
-
(2009)
Nature
, vol.458
, pp. 732-736
-
-
Soucy, T.A.1
Smith, P.G.2
Milhollen, M.A.3
Berger, A.J.4
Gavin, J.M.5
Adhikari, S.6
-
30
-
-
1842557655
-
PVHL modification by nedd8 is required for fibronectin matrix assembly and suppression of tumor development
-
Stickle NH, Chung J, Klco JM, Hill RP, Kaelin Jr WG,Ohh M. pVHL modification by nedd8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol 2004; 24: 3251-3261.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3251-3261
-
-
Stickle, N.H.1
Chung, J.2
Klco, J.M.3
Hill, R.P.4
Kaelin Jr., W.G.5
Ohh, M.6
-
31
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas DP, Saville MK, Bourdon J-C, Hay RT, Lane DP. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004; 118: 83.
-
(2004)
Cell
, vol.118
, pp. 83
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.-C.3
Hay, R.T.4
Lane, D.P.5
-
32
-
-
33845920314
-
Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function
-
Watson IR, Blanch A, Lin DCC, Ohh M, Irwin MS. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem 2006; 281: 34096-34103.
-
(2006)
J Biol Chem
, vol.281
, pp. 34096-34103
-
-
Watson, I.R.1
Blanch, A.2
Lin, D.C.C.3
Ohh, M.4
Irwin, M.S.5
-
33
-
-
33749173298
-
Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NF[kappa]B-dependent transcription
-
Gao F, Cheng J, Shi T, Yeh ETH. Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NF[kappa]B-dependent transcription. Nat Cell Biol 2006; 8: 1171-1177.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1171-1177
-
-
Gao, F.1
Cheng, J.2
Shi, T.3
Yeh, E.T.H.4
-
34
-
-
40249111681
-
Ribosomal proteins are targets for the NEDD8 pathway
-
Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT. Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep 2008; 9: 280-286.
-
(2008)
EMBO Rep
, vol.9
, pp. 280-286
-
-
Xirodimas, D.P.1
Sundqvist, A.2
Nakamura, A.3
Shen, L.4
Botting, C.5
Hay, R.T.6
-
35
-
-
17644404053
-
E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation
-
Hughes TA, Brady HJM. E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem Biophys Res Commun 2005; 329: 1267-1274.
-
(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 1267-1274
-
-
Hughes, T.A.1
Brady, H.J.M.2
-
36
-
-
52949093102
-
E2F1 represses [bgr]-catenin transcription and is antagonized by both pRB and CDK8
-
Morris EJ, Ji J-Y, Yang F, Di Stefano L, Herr A, Moon N-S et al. E2F1 represses [bgr]-catenin transcription and is antagonized by both pRB and CDK8. Nature 2008; 455: 552-556.
-
(2008)
Nature
, vol.455
, pp. 552-556
-
-
Morris, E.J.1
Ji, J.-Y.2
Yang, F.3
Di Stefano, L.4
Herr, A.5
Moon, N.-S.6
-
37
-
-
36048942316
-
Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1
-
Wu S, Murai S, Kataoka K, Miyagishi M. Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1. Biochem Biophys Res Commun 2008; 365: 75-81.
-
(2008)
Biochem Biophys Res Commun
, vol.365
, pp. 75-81
-
-
Wu, S.1
Murai, S.2
Kataoka, K.3
Miyagishi, M.4
-
38
-
-
3142711538
-
Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage
-
Ianari A, Gallo R, Palma M, Alesse E, Gulino A. Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage. J Biol Chem 2004; 279: 30830-30835.
-
(2004)
J Biol Chem
, vol.279
, pp. 30830-30835
-
-
Ianari, A.1
Gallo, R.2
Palma, M.3
Alesse, E.4
Gulino, A.5
-
39
-
-
0034646630
-
E2F family members are differentially regulated by reversible acetylation
-
Marzio G, Wagener C, Gutierrez MI, Cartwright P, Helin K, Giacca M. E2F family members are differentially regulated by reversible acetylation. J Biol Chem 2000; 275: 10887-10892.
-
(2000)
J Biol Chem
, vol.275
, pp. 10887-10892
-
-
Marzio, G.1
Wagener, C.2
Gutierrez, M.I.3
Cartwright, P.4
Helin, K.5
Giacca, M.6
-
40
-
-
0343484254
-
Regulation of E2F1 activity by acetylation
-
Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. Embo J 2000; 19: 662-671.
-
(2000)
Embo J
, vol.19
, pp. 662-671
-
-
Martinez-Balbas, M.A.1
Bauer, U.M.2
Nielsen, S.J.3
Brehm, A.4
Kouzarides, T.5
-
41
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002; 2: 594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
42
-
-
11144241301
-
A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis
-
Wang B, Liu K, Lin FT, Lin WC. A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem 2004; 279: 54140-54152.
-
(2004)
J Biol Chem
, vol.279
, pp. 54140-54152
-
-
Wang, B.1
Liu, K.2
Lin, F.T.3
Lin, W.C.4
-
43
-
-
1642270611
-
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2
-
Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S et al. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol 2004; 24: 2968-2977.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2968-2977
-
-
Rogoff, H.A.1
Pickering, M.T.2
Frame, F.M.3
Debatis, M.E.4
Sanchez, Y.5
Jones, S.6
-
44
-
-
0029949784
-
E2F-1 functions in mice to promote apoptosis and suppress proliferation
-
Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin Jr WG, Livingston DM et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996; 85: 549-561.
-
(1996)
Cell
, vol.85
, pp. 549-561
-
-
Field, S.J.1
Tsai, F.Y.2
Kuo, F.3
Zubiaga, A.M.4
Kaelin Jr., W.G.5
Livingston, D.M.6
-
45
-
-
0029888359
-
Tumor induction and tissue atrophy in mice lacking E2F-1
-
Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 1996; 85: 537-548.
-
(1996)
Cell
, vol.85
, pp. 537-548
-
-
Yamasaki, L.1
Jacks, T.2
Bronson, R.3
Goillot, E.4
Harlow, E.5
Dyson, N.J.6
-
46
-
-
54049120956
-
E2F-at the crossroads of life and death
-
Polager S, Ginsberg D. E2F-at the crossroads of life and death. Tr Cell Biol 2008; 18: 528-535.
-
(2008)
Tr Cell Biol
, vol.18
, pp. 528-535
-
-
Polager, S.1
Ginsberg, D.2
-
47
-
-
67349191464
-
A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity
-
Engels IH, Daguia C, Huynh T, Urbina H, Buddenkotte J, Schumacher A et al. A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. Anal Biochem 2009; 390: 85-87.
-
(2009)
Anal Biochem
, vol.390
, pp. 85-87
-
-
Engels, I.H.1
Daguia, C.2
Huynh, T.3
Urbina, H.4
Buddenkotte, J.5
Schumacher, A.6
-
48
-
-
0034046944
-
Plat-E: An efficient and stable system for transient packaging of retroviruses
-
Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 2000; 7: 1063-1066.
-
(2000)
Gene Ther
, vol.7
, pp. 1063-1066
-
-
Morita, S.1
Kojima, T.2
Kitamura, T.3
-
49
-
-
0028027308
-
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
-
Treier M, Staszewski LM, Bohmann D. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 1994; 78: 787-798.
-
(1994)
Cell
, vol.78
, pp. 787-798
-
-
Treier, M.1
Staszewski, L.M.2
Bohmann, D.3
|