Comparison of human ET A and ET B receptor signalling via G-protein and β-arrestin pathways

Life Sciences

Volumn 91, Issue 13-14, 2012, Pages 544-549

  Maguire, Janet J ^a   Kuc, Rhoda E ^a   Pell, Victoria R ^a   Green, Andrew ^b   Brown, Mike ^b   Kumar, Sanj ^b   Wehrman, Tom ^b   Quinn, Elizabeth ^b   Davenport, Anthony P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b DiscoveRx Corporation   (United States)

Author keywords

arrestin recruitment; Ambrisentan; Biased agonist; Biased antagonist; BQ123; BQ788; Endothelin; ET A; ET B; Human left ventricle; Human pharmacology; Sitaxentan; Vasoconstriction

Indexed keywords

AMBRISENTAN; BETA ARRESTIN; BOSENTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SARAFOTOXIN S6B; SARAFOTOXIN S6C; SITAXSENTAN; RETINA S ANTIGEN; SARAFOTOXINS S6; SULFONAMIDE; VASOCONSTRICTOR AGENT; VIPER VENOM;

ANIMAL CELL; BINDING AFFINITY; CHO CELL; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG COMPETITION; DRUG POTENCY; DRUG SELECTIVITY; HEART LEFT VENTRICLE; HUMAN; HUMAN TISSUE; INTRACELLULAR SIGNALING; NONHUMAN; ANIMAL; ARTICLE; CRICETULUS; DRUG POTENTIATION; HAMSTER; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ARRESTINS; CHO CELLS; CRICETINAE; CRICETULUS; ENDOTHELIN-1; ENDOTHELIN-2; ENDOTHELIN-3; GTP-BINDING PROTEINS; HUMANS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SIGNAL TRANSDUCTION; SULFONAMIDES; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 84867581538     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.03.021     Document Type: Conference Paper

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