Heterodimerization with its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: A study with a purified heterodimer assembled into lipid discs

Journal of Biological Chemistry

Volumn 288, Issue 34, 2013, Pages 24656-24665

  Mary, Sophie ^a   Fehrentz, Jean Alain ^a   Damian, Marjorie ^a   Gaibelet, Gérald ^a,b   Orcel, Hélène ^b   Verdié, Pascal ^a   Mouillac, Bernard ^b   Martinez, Jean ^a   Marie, Jacky ^a   Banères, Jean Louis ^a,c  

^a UNIV MONTPELLIER   (France)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^c UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOMINANT NEGATIVE; FULL-LENGTH PROTEINS; G PROTEIN COUPLED RECEPTORS; GHRELIN RECEPTOR; HETERODIMERIZATION; MOLECULAR MECHANISM; NATURALLY OCCURRING; STRUCTURAL BEHAVIORS;

CHEMICAL ACTIVATION; CONFORMATIONS; DIMERIZATION; DIMERS; PROTEINS; PURIFICATION;

SIGNALING;

G PROTEIN COUPLED RECEPTOR; GHRELIN RECEPTOR; GHRELIN RECEPTOR 1A; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PURIFICATION; RECEPTOR BLOCKING; STOICHIOMETRY;

7-HELIX RECEPTOR; ARRESTIN; DIMERIZATION; FLUORESCENCE; G PROTEIN-COUPLED RECEPTORS (GPCR); G PROTEINS; GHRELIN; MEMBRANE PROTEINS;

ALTERNATIVE SPLICING; ANIMALS; ARRESTIN; HUMANS; LIPID BILAYERS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, GHRELIN; SF9 CELLS; SPODOPTERA;

EID: 84883140705     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.453423     Document Type: Article

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