NF-kappaB Mediated Transcriptional Repression of Acid Modifying Hormone Gastrin

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Datta De, Dipanjana ^a   Datta, Arindam ^a   Bhattacharjya, Sumana ^a   Roychoudhury, Susanta ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN; HISTONE DEACETYLASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; HISTONE MODIFICATION; HORMONE INHIBITION; HORMONE RELEASE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION TERMINATION; UPREGULATION;

CELL LINE; CO-REPRESSOR PROTEINS; E1A-ASSOCIATED P300 PROTEIN; ENZYME ACTIVATION; GASTRINS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE 1; HUMANS; INTERLEUKIN-1BETA; MAP KINASE KINASE KINASES; NF-KAPPA B; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC;

EID: 84883020248     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073409     Document Type: Article

References (43)

1. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, et al. (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325: 1127-1131. doi:10.1056/NEJM199110173251603. PubMed: 1891020.
2. Nedrud JG, Czinn SJ, Lee A, (1997) Role of the host in Helicobacter disease. Gastroenterology 112: 670. doi:10.1053/gast.1997.v112.agast970670b. PubMed: 9024326.
3. Baron JH, (1998) Clinical Tests of Gastric Secretion. London: Macmillan Press.
4. Harris AW, Gummett PA, Misiewicz JJ, Baron JH, (1996) Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin. Gut 38: 663-667. doi:10.1136/gut.38.5.663. PubMed: 8707109.
5. Beales IL, (2000) Effect of pro-inflammatory cytokines on acid secretion. Dig Dis Sci 45: 289-290. doi:10.1023/A:1005452307860. PubMed: 10711440.
6. Chakravorty M, Datta De D, Choudhury A, Roychoudhury S, (2009) IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int J Biochem Cell Biol 41: 1502-1510.
7. Datta De D, Bhattacharjya S, Maitra M, Datta A, Choudhury A, et al. (2011) IL1B Induced Smad 7 Negatively Regulates Gastrin Expression. PLOS ONE 6: e14775. doi:10.1371/journal.pone.0014775. PubMed: 21445336.
8. Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, et al. (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappa B activation and prevention of apoptosis. J Exp Med 189: 1839-1845. doi:10.1084/jem.189.11.1839. PubMed: 10359587.
9. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S, (1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev 9: 2723-2735. doi:10.1101/gad.9.22.2723. PubMed: 7590248.
10. Carlotti F, Dower SK, Qwarnstrom EE, (2000) Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation. J Biol Chem 275: 41028-41034. doi:10.1074/jbc.M006179200. PubMed: 11024020.
11. Ashburner BP, Westerheide SD, Baldwin AS Jr., (2001) The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 21: 7065-7077. doi:10.1128/MCB.21.20.7065-7077.2001. PubMed: 11564889.
12. Shaw J, Zhang T, Rzeszutek M, Yurkova N, Baetz D, et al. (2006) Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes. Circ Res 99: 1347-1354. doi:10.1161/01.RES.0000251744.06138.50. PubMed: 17082476.
13. Baetz D, Regula KM, Ens K, Shaw J, Kothari S, et al. (2005) Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation 112: 3777-3785. doi:10.1161/CIRCULATIONAHA.105.573899. PubMed: 16344406.
14. Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, et al. (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci U S A 94: 10057-10062. doi:10.1073/pnas.94.19.10057. PubMed: 9294162.
15. Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr., (1998) NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683. doi:10.1126/science.281.5383.1680. PubMed: 9733516.
16. Chen LF, Greene WC, (2004) Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 5: 392-401. doi:10.1038/nrm1368. PubMed: 15122352.
17. Israël A, (1995) A role for phosphorylation and degradation in the control of NF-kappa B activity. Trends Genet 11: 203-205. doi:10.1016/S0168-9525(00)89045-9. PubMed: 7638895.
18. Schmitz ML, Mattioli I, Buss H, Kracht M, (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem 5: 1348-1358. doi:10.1002/cbic.200400144. PubMed: 15457532.
19. Wan F, Lenardo MJ, (2009) Specification of DNA binding activity of NF-kappaB proteins. Cold Spring Harb Perspect Biol 1: a000067. doi:10.1101/cshperspect.a000067. PubMed: 20066093.
20. Seto E, (2003) Histone modifications. Methods 31: 1-2. doi:10.1016/S1046-2023(03)00081-1. PubMed: 12893167.
21. Muzio M, Ni J, Feng P, Dixit VM, (1997) IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278: 1612-1615. doi:10.1126/science.278.5343.1612. PubMed: 9374458.
22. Morlon A, Munnich A, Smahi A, (2005) TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd. Hum Mol Genet 14: 3751-3757. doi:10.1093/hmg/ddi405. PubMed: 16251197.
23. O'Neill LA, (2003) The role of MyD88-like adapters in Toll-like receptor signal transduction. Biochem Soc Trans 31: 643-647. PubMed: 12773173.
24. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, et al. (1996) TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272: 1179-1182. doi:10.1126/science.272.5265.1179. PubMed: 8638164.
25. Oeckinghaus A, Ghosh S, (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1: a000034. doi:10.1101/cshperspect.a000034. PubMed: 20066092.
26. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB, (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370: 737-749. doi:10.1042/BJ20021321. PubMed: 12429021.
27. Heinzel T, Lavinsky RM, Mullen TM, Söderstrom M, Laherty CD, et al. (1997) A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387: 43-48. doi:10.1038/387043a0. PubMed: 9139820.
28. Tominaga K, Higuchi K, Tsuno M, Watanabe T, Fujiwara Y, et al. (2000) Induction of signal transduction pathways in rat gastric epithelial cells stimulated with interleukin-1beta. Aliment Pharmacol Ther 14 (Suppl 1):: 101-108. doi:10.1046/j.1365-2036.2000.014s1101.x. PubMed: 10807411.
29. Beg AA, Baltimore D, (1996) An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274: 782-784. doi:10.1126/science.274.5288.782. PubMed: 8864118.
30. Zhong H, May MJ, Jimi E, Ghosh S, (2002) The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 9: 625-636. doi:10.1016/S1097-2765(02)00477-X. PubMed: 11931769.
31. Buss H, Dorrie A, Schmitz ML, Hoffmann E, Resch K, et al. (2004) Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem 279: 55633-55643.
32. Jiang X, Takahashi N, Matsui N, Tetsuka T, Okamoto T, (2003) The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. J Biol Chem 278: 919-926. doi:10.1074/jbc.M208696200. PubMed: 12419817.
33. O'Mahony AM, Montano M, Van Beneden K, Chen LF, Greene WC, (2004) Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65. J Biol Chem 279: 18137-18145. doi:10.1074/jbc.M401397200. PubMed: 14963024.
34. Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W, (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274: 30353-30356. doi:10.1074/jbc.274.43.30353. PubMed: 10521409.
35. Sengupta N, Seto E, (2004) Regulation of histone deacetylase activities. J Cell Biochem 93: 57-67. doi:10.1002/jcb.20179. PubMed: 15352162.
36. Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, et al. (2003) Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J Cell Biol 160: 1017-1027. doi:10.1083/jcb.200209065. PubMed: 12668657.
37. McKinsey TA, Zhang CL, Olson EN, (2001) Control of muscle development by dueling HATs and HDACs. Curr Opin Genet Dev 11: 497-504. doi:10.1016/S0959-437X(00)00224-0. PubMed: 11532390.
38. McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ, (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259. doi:10.1128/MCB.21.4.1249-1259.2001. PubMed: 11158311.
39. Nozaki S, Sledge GW Jr, Nakshatri H, (2001) Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death. Oncogene 20: 2178-2185. doi:10.1038/sj.onc.1204292. PubMed: 11360202.
40. Bannister AJ, Kouzarides T, (1996) The CBP co-activator is a histone acetyltransferase. Nature 384: 641-643. doi:10.1038/384641a0. PubMed: 8967953.
41. Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y, (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959. doi:10.1016/S0092-8674(00)82001-2. PubMed: 8945521.
42. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, et al. (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389: 194-198. doi:10.1038/38304. PubMed: 9296499.
43. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y, (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319-324. doi:10.1038/382319a0. PubMed: 8684459.