메뉴 건너뛰기




Volumn 133, Issue 6, 2010, Pages 1622-1636

T cell recognition of self-antigen presenting cells by protein transfer assay reveals a high frequency of anti-myelin T cells in multiple sclerosis

Author keywords

Monocytes; Multiple sclerosis; Myelin; TRAP; Trogocytosis

Indexed keywords

ANTIBODY; AUTOANTIGEN; CD40 LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MYELIN; MYELIN BASIC PROTEIN; PADGEM PROTEIN;

EID: 77952980176     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq074     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 0036042848 scopus 로고    scopus 로고
    • Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis
    • Andersson M, Yu M, Sö derströ m M, Weerth S, Baig S, Solders G, et al. Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis. Eur J Neurol 2002; 9: 243-251
    • (2002) Eur J Neurol , vol.9 , pp. 243-251
    • Andersson, M.1    Yu, M.2    Söderström, M.W.3
  • 2
    • 70350721913 scopus 로고    scopus 로고
    • + T-lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line
    • + T-lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. J Leuk Biol 2009; 86: 1049-1063
    • (2009) J Leuk Biol , vol.86 , pp. 1049-1063
    • Bahbouhi, B.1    Berthelot, L.2    Pettré, S.3    Michel, L.4    Wiertlewski, S.5    Weksler, B.6
  • 3
    • 33749512392 scopus 로고    scopus 로고
    • Quantifying viable virus-specific T-cells without a priori knowledge of fine epitope specificity
    • Beadling C, Slifka MK. Quantifying viable virus-specific T-cells without a priori knowledge of fine epitope specificity. Nat Med 2006; 12: 1208-1212
    • (2006) Nat Med , vol.12 , pp. 1208-1212
    • Beadling, C.1    Slifka, M.K.2
  • 4
    • 50549088349 scopus 로고    scopus 로고
    • Class-I restricted myelin epitopes eliciting blood CD8+ T-cell response in multiple sclerosis patients
    • Berthelot L, Laplaud DA, Pettré S, Michel L, Hillion S, Braudeau C, et al. Class-I restricted myelin epitopes eliciting blood CD8+ T-cell response in multiple sclerosis patients. Eur J Immunol 2008; 38: 1889-1899
    • (2008) Eur J Immunol , vol.38 , pp. 1889-1899
    • Berthelot, L.1    Laplaud, D.A.2    Pettré, S.3    Michel, L.4    Hillion, S.5    Braudeau, C.6
  • 5
    • 0030973104 scopus 로고    scopus 로고
    • Direct ex vivo analysis of activated, Fas-sensitive auto-reactive T-cells in human autoimmune disease
    • Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated, Fas-sensitive auto-reactive T-cells in human autoimmune disease. J Exp Med 1997; 185: 1585-1594
    • (1997) J Exp Med , vol.185 , pp. 1585-1594
    • Bieganowska, K.D.1    Ausubel, L.J.2    Modabber, Y.3    Slovik, E.4    Messersmith, W.5    Hafler, D.A.6
  • 6
    • 1542723658 scopus 로고    scopus 로고
    • Expansion and functional relevance of high-avidity myelin-specific CD4+ T-cells in multiple sclerosis
    • Bielekova B, Sung MH, Kadom N, Simon R, McFarland H, Martin R. Expansion and functional relevance of high-avidity myelin-specific CD4+ T-cells in multiple sclerosis. J Immunol 2004; 172: 3893-3904
    • (2004) J Immunol , vol.172 , pp. 3893-3904
    • Bielekova, B.1    Sung, M.H.2    Kadom, N.3    Simon, R.4    McFarland, H.5    Martin, R.6
  • 8
    • 0034047716 scopus 로고    scopus 로고
    • Efficient detection and immunomagnetic sorting of specific T-cells using multimers of MHC class i and peptide with reduced CD8 binding
    • Bodinier M, Peyrat MA, Tournay C, Davodeau F, Romagne F, Bonneville M, et al. Efficient detection and immunomagnetic sorting of specific T-cells using multimers of MHC class I and peptide with reduced CD8 binding. Nat Med 2000; 6: 707-710
    • (2000) Nat Med , vol.6 , pp. 707-710
    • Bodinier, M.1    Peyrat, M.A.2    Tournay, C.3    Davodeau, F.4    Romagne, F.5    Bonneville, M.6
  • 9
    • 31544466262 scopus 로고    scopus 로고
    • Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis
    • Boven LA, Van Meurs M, Van Zwam M, Wierenga-Wolf A, Hintzen RQ, Boot RG, et al. Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis. Brain 2006; 129: 517-526
    • (2006) Brain , vol.129 , pp. 517-526
    • Boven, L.A.1    Van Meurs, M.2    Van Zwam, M.3    Wierenga-Wolf, A.4    Hintzen, R.Q.5    Boot, R.G.6
  • 10
    • 0026556063 scopus 로고
    • Frequency of T-cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis
    • Chou YK, Bourdette DN, Offner H, Whitham R, Wang RY, Hashim GA, et al. Frequency of T-cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 1992; 38: 105-113
    • (1992) J Neuroimmunol , vol.38 , pp. 105-113
    • Chou, Y.K.1    Bourdette, D.N.2    Offner, H.3    Whitham, R.4    Wang, R.Y.5    Hashim, G.A.6
  • 12
    • 34548569316 scopus 로고    scopus 로고
    • A simple trogocytosis-based method to detect, quantify, characterize and purify antigen-specific live lymphocytes by flow cytometry, via their capture of membrane fragments from antigen-presenting cells
    • Daubeuf S, Puaux AL, Joly E, Hudrisier D. A simple trogocytosis-based method to detect, quantify, characterize and purify antigen-specific live lymphocytes by flow cytometry, via their capture of membrane fragments from antigen-presenting cells. Nat Protoc 2006; 1: 2536-2542
    • (2006) Nat Protoc , vol.1 , pp. 2536-2542
    • Daubeuf, S.1    Puaux, A.L.2    Joly, E.3    Hudrisier, D.4
  • 13
    • 0032879769 scopus 로고    scopus 로고
    • Autoreactivity to myelin antigens: Myelin/oligodendrocyte glycoprotein is a prevalent autoantigen
    • Diaz-Villoslada P, Shih A, Shao L, Genain CP, Hauser SL. Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. J Neuroimmunol 1999; 99: 36-43.
    • (1999) J Neuroimmunol , vol.99 , pp. 36-43
    • Diaz-Villoslada, P.1    Shih, A.2    Shao, L.3    Genain, C.P.4    Hauser, S.L.5
  • 14
    • 27144540183 scopus 로고    scopus 로고
    • Direct access to CD4+ T cells specific for defined antigens according to CD154 expression
    • Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, Rothe M, et al. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 2005; 11: 1118-1124
    • (2005) Nat Med , vol.11 , pp. 1118-1124
    • Frentsch, M.1    Arbach, O.2    Kirchhoff, D.3    Moewes, B.4    Worm, M.5    Rothe, M.6
  • 16
    • 0035254476 scopus 로고    scopus 로고
    • T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls
    • Hellings N, Barée M, Verhoeven C, D'hooghe MB, Medaer R, Bernard CC, et al. T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J Neurosci Res 2001; 63: 290-302.
    • (2001) J Neurosci Res , vol.63 , pp. 290-302
    • Hellings, N.1    Barée, M.2    Verhoeven, C.3    D'Hooghe, M.B.4    Medaer, R.5    Bernard, C.C.6
  • 17
    • 0036096668 scopus 로고    scopus 로고
    • Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: Association with clinical and MRI activity
    • Hellings N, Gelin G, Medaer R, Bruckers L, Palmers Y, Raus J, et al. Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: association with clinical and MRI activity. J Neuroimmunol 2002; 126: 143-160
    • (2002) J Neuroimmunol , vol.126 , pp. 143-160
    • Hellings, N.1    Gelin, G.2    Medaer, R.3    Bruckers, L.4    Palmers, Y.5    Raus, J.6
  • 18
    • 11944255564 scopus 로고    scopus 로고
    • Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease
    • Howard LM, Miller SD. Immunotherapy targeting the CD40/CD154 costimulatory pathway for treatment of autoimmune disease. Autoimmunity 2004; 37: 411-418
    • (2004) Autoimmunity , vol.37 , pp. 411-418
    • Howard, L.M.1    Miller, S.D.2
  • 19
    • 33947233247 scopus 로고    scopus 로고
    • Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells
    • Hudrisier D, Aucher A, Puaux AL, Bordier C, Joly E. Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells. J Immunol 2007; 178: 3637-3647 (Pubitemid 46417631)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3637-3647
    • Hudrisier, D.1    Aucher, A.2    Puaux, A.-L.3    Bordier, C.4    Joly, E.5
  • 20
    • 0030040363 scopus 로고    scopus 로고
    • Regulation of CD40 ligand expression on naive CD4 T cells: A role for TCR but not co-stimulatory signals
    • Jaiswal AI, Dubey C, Swain SL, Croft M. Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. Int Immunol 1996; 8: 275-285
    • (1996) Int Immunol , vol.8 , pp. 275-285
    • Jaiswal, A.I.1    Dubey, C.2    Swain, S.L.3    Croft, M.4
  • 21
    • 0030697438 scopus 로고    scopus 로고
    • Predominance of the autoimmune response to myelin oligo-dendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions
    • Kerlero de Rosbo N, Hoffman M, Mendel I, Yust I, Kaye J, Bakimer R, et al. Predominance of the autoimmune response to myelin oligo-dendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur J Immunol 1997; 27: 3059-3069
    • (1997) Eur J Immunol , vol.27 , pp. 3059-3069
    • Kerlero De Rosbo, N.1    Hoffman, M.2    Mendel, I.3    Yust, I.4    Kaye, J.5    Bakimer, R.6
  • 24
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: An overview
    • Lassmann H, Brü ck W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol 2007; 17: 210-218
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Brück, W.2    Lucchinetti, C.F.3
  • 25
    • 33947653766 scopus 로고    scopus 로고
    • Exchanges of membrane patches (trogocytosis) split theoretical and actual functions of immune cells
    • LeMaoult J, Caumartin J, Carosella ED. Exchanges of membrane patches (trogocytosis) split theoretical and actual functions of immune cells. Hum Immunol 2007; 68: 240-243
    • (2007) Hum Immunol , vol.68 , pp. 240-243
    • Lemaoult, J.1    Caumartin, J.2    Carosella, E.D.3
  • 26
    • 40949158562 scopus 로고    scopus 로고
    • Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs
    • Machlenkin A, Uzana R, Frankenburg S, Eisenberg G, Eisenbach L, Pitcovski J, et al. Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs. Cancer Res 2008; 68: 2006-2013
    • (2008) Cancer Res , vol.68 , pp. 2006-2013
    • MacHlenkin, A.1    Uzana, R.2    Frankenburg, S.3    Eisenberg, G.4    Eisenbach, L.5    Pitcovski, J.6
  • 27
    • 34250159112 scopus 로고    scopus 로고
    • Interferon-beta: Mechanism of action and dosing issues
    • Markowitz CE. Interferon-beta: mechanism of action and dosing issues. Neurology 2007; 68: 8-11.
    • (2007) Neurology , vol.68 , pp. 8-11
    • Markowitz, C.E.1
  • 28
    • 0032005129 scopus 로고    scopus 로고
    • T-cell response to myelin basic protein and lipid-bound myelin basic protein in patients with multiple sclerosis and healthy donors
    • Mazzanti B, Vergelli M, Riccio P, Martin R, McFarland HF, Liuzzi GM, et al. T-cell response to myelin basic protein and lipid-bound myelin basic protein in patients with multiple sclerosis and healthy donors. J Neuroimmunol 1998; 82: 96-100.
    • (1998) J Neuroimmunol , vol.82 , pp. 96-100
    • Mazzanti, B.1    Vergelli, M.2    Riccio, P.3    Martin, R.4    McFarland, H.F.5    Liuzzi, G.M.6
  • 29
    • 0036721711 scopus 로고    scopus 로고
    • IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: Disruption of both IL-12-dependent and-independent pathways of IFN-gamma production
    • McDyer JF, Li Z, John S, Yu X, Wu CY, Ragheb JA. IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: disruption of both IL-12-dependent and-independent pathways of IFN-gamma production. J Immunol 2002; 169: 2736-2746
    • (2002) J Immunol , vol.169 , pp. 2736-2746
    • McDyer, J.F.1    Li, Z.2    John, S.3    Yu, X.4    Wu, C.Y.5    Ragheb, J.A.6
  • 30
    • 55849126729 scopus 로고    scopus 로고
    • Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis
    • Michel L, Berthelot L, Pettré S, Wiertlewski S, Lefrère F, Braudeau C, et al. Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor alpha-chain are excluded from the analysis. J Clin Invest 2008; 118: 3411-3419
    • (2008) J Clin Invest , vol.118 , pp. 3411-3419
    • Michel, L.1    Berthelot, L.2    Pettré, S.3    Wiertlewski, S.4    Lefrère, F.5    Braudeau, C.6
  • 31
    • 0025013169 scopus 로고
    • Hö jeberg B, Kostulas V, Jiang YP, Anderson G, et al. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma
    • Olsson T, Zhi WW, Hö jeberg B, Kostulas V, Jiang YP, Anderson G, et al. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. J Clin Invest 1990; 86: 981-985
    • (1990) J Clin Invest , vol.86 , pp. 981-985
    • Olsson, T.1    Zhi, W.W.2
  • 32
    • 0034254825 scopus 로고    scopus 로고
    • Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production
    • Pelfrey CM, Rudick RA, Cotleur AC, Lee JC, Tary-Lehmann M, Lehmann PV. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J Immunol 2000; 165: 1641-1651
    • (2000) J Immunol , vol.165 , pp. 1641-1651
    • Pelfrey, C.M.1    Rudick, R.A.2    Cotleur, A.C.3    Lee, J.C.4    Tary-Lehmann, M.5    Lehmann, P.V.6
  • 33
    • 28544436950 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2005 revisions to the "mcDonald Criteria"
    • Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 2005; 58: 840-846
    • (2005) Ann Neurol , vol.58 , pp. 840-846
    • Polman, C.H.1    Reingold, S.C.2    Edan, G.3    Filippi, M.4    Hartung, H.P.5    Kappos, L.6
  • 34
    • 33644966324 scopus 로고    scopus 로고
    • A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry
    • Puaux AL, Campanaud J, Salles A, Préville X, Timmerman B, Joly E, et al. A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry. Eur J Immunol 2006; 36: 779-788
    • (2006) Eur J Immunol , vol.36 , pp. 779-788
    • Puaux, A.L.1    Campanaud, J.2    Salles, A.3    Préville, X.4    Timmerman, B.5    Joly, E.6
  • 35
    • 34447331260 scopus 로고    scopus 로고
    • The molecular makeup and function of regulatory and effector synapses
    • Reichardt P, Dornbach B, Gunzer M. The molecular makeup and function of regulatory and effector synapses. Immunol Rev 2007; 218: 165-177
    • (2007) Immunol Rev , vol.218 , pp. 165-177
    • Reichardt, P.1    Dornbach, B.2    Gunzer, M.3
  • 36
    • 0034769286 scopus 로고    scopus 로고
    • Functional antigen-independent synapses formed between T cells and dendritic cells
    • Revy P, Sospedra M, Barbour B, Trautmann A. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat Immunol 2001; 2: 925-931
    • (2001) Nat Immunol , vol.2 , pp. 925-931
    • Revy, P.1    Sospedra, M.2    Barbour, B.3    Trautmann, A.4
  • 40
    • 47049100425 scopus 로고    scopus 로고
    • Activation of myelin reactive T cells in multiple sclerosis: A possible role for T cell degeneracy?
    • Stinissen P, Hellings N. Activation of myelin reactive T cells in multiple sclerosis: a possible role for T cell degeneracy? Eur J Immunol 2008; 38: 1190-1193
    • (2008) Eur J Immunol , vol.38 , pp. 1190-1193
    • Stinissen, P.1    Hellings, N.2
  • 41
    • 0025979945 scopus 로고
    • T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis
    • Sun J, Link H, Olsson T, Xiao BG, Andersson G, Ekre HP, et al. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 1991; 146: 1490-1495
    • (1991) J Immunol , vol.146 , pp. 1490-1495
    • Sun, J.1    Link, H.2    Olsson, T.3    Xiao, B.G.4    Andersson, G.5    Ekre, H.P.6
  • 43
    • 0035086802 scopus 로고    scopus 로고
    • Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals
    • Tejada-Simon MV, Hong J, Rivera VM, Zhang JZ. Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals. Eur J Immunol 2001; 31: 907-917
    • (2001) Eur J Immunol , vol.31 , pp. 907-917
    • Tejada-Simon, M.V.1    Hong, J.2    Rivera, V.M.3    Zhang, J.Z.4
  • 44
    • 0037395115 scopus 로고    scopus 로고
    • + T-cell epitopes by acquisition ofpeptide-HLA-GFP complexes: Analysis of T-cell pheno-type and function in chronic viral infections
    • + T-cell epitopes by acquisition ofpeptide-HLA-GFP complexes: analysis of T-cell pheno-type and function in chronic viral infections. Nat Med 2003; 9: 469-476
    • (2003) Nat Med , vol.9 , pp. 469-476
    • Tomaru, U.1    Yamano, Y.2    Nagai, M.3    Maric, D.4    Kaumaya, P.T.5    Biddison, W.6
  • 45
    • 0037376324 scopus 로고    scopus 로고
    • Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls
    • Van der Aa A, Hellings N, Bernard CC, Raus J, Stinissen P. Functional properties of myelin oligodendrocyte glycoprotein-reactive T cells in multiple sclerosis patients and controls. J Neuroimmunol 2003; 137: 164-176
    • (2003) J Neuroimmunol , vol.137 , pp. 164-176
    • Van Der Aa, A.1    Hellings, N.2    Bernard, C.C.3    Raus, J.4    Stinissen, P.5
  • 48
    • 0027957780 scopus 로고
    • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 1994; 179: 973-984
    • (1994) J Exp Med , vol.179 , pp. 973-984
    • Zhang, J.1    Markovic-Plese, S.2    Lacet, B.3    Raus, J.4    Weiner, H.L.5    Hafler, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.