Cytotoxic CD8+ T cell-neuron interactions: Perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death

Journal of Neuroscience

Volumn 29, Issue 49, 2009, Pages 15397-15409

  Meuth, Sven G ^a   Herrmann, Alexander M ^a   Simon, Ole J ^a   Siffrin, Volker ^b   Melzer, Nico ^a   Bittner, Stefan ^a   Meuth, Patrick ^c   Langer, Harald F ^d   Hallermann, Stefan ^e   Boldakowa, Nadia ^b   Herz, Josephine ^b   Munsch, Thomas ^f   Landgraf, Peter ^f   Aktas, Orhan ^b,g   Heckmann, Manfred ^a   Lessmann, Volkmar ^f   Budde, Thomas ^c   Kieseier, Bernd C ^g   Zipp, Frauke ^b   Wiendl, Heinz ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e UNIVERSITY OF LEIPZIG   (Germany)

^f OTTO VON GUERICKE UNIVERSITY   (Germany)

^g HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN ANTIGEN; CALCIUM ION; CD8 ANTIGEN; GRANZYME B; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; BRAIN SLICE; CALCIUM CELL LEVEL; CD8+ T LYMPHOCYTE; CELL CONTACT; CELL INTERACTION; CELL MIGRATION; CHANNEL GATING; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MEMBRANE CONDUCTANCE; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE CELL NETWORK; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD8; CALCIUM; CELL COMMUNICATION; CELL DEATH; CELL MOVEMENT; CELLS, CULTURED; ELECTRIC CAPACITANCE; GENES, MHC CLASS I; GRANZYMES; HIPPOCAMPUS; INTRACELLULAR SPACE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL PATHWAYS; NEURONS; PERFORIN; T-LYMPHOCYTES; TIME FACTORS;

EID: 71849115156     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4339-09.2009     Document Type: Article

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