메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages 1117-1126

Candidiasis drug discovery and development: New approaches targeting virulence for discovering and identifying new drugs

Author keywords

Antifungals; Biofilms; Candida albicans; Candidiasis; Filamentation; Targeting virulence; Virulence factors

Indexed keywords

ANTIFUNGAL AGENT; NEW DRUG; VIRULENCE FACTOR;

EID: 84883004752     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2013.807245     Document Type: Review
Times cited : (134)

References (103)
  • 1
    • 84871502341 scopus 로고    scopus 로고
    • Hidden killers: Human fungal infections
    • Brown GD, Denning DW, Gow NA, et al. Hidden killers: Human fungal infections. Sci Transl Med 2012;4(165):165rv13
    • (2012) Sci Transl Med , vol.165 , Issue.4
    • Brown, G.D.1    Denning, D.W.2    Gow, N.A.3
  • 2
    • 33846466508 scopus 로고    scopus 로고
    • Epidemiology of invasive candidiasis: A persistent public health problem
    • DOI 10.1128/CMR.00029-06
    • Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: A persistent public health problem. Clin Microbiol Rev 2007;20(1):133-63 (Pubitemid 46167771)
    • (2007) Clinical Microbiology Reviews , vol.20 , Issue.1 , pp. 133-163
    • Pfaller, M.A.1    Diekema, D.J.2
  • 4
    • 77950215343 scopus 로고    scopus 로고
    • Candidosis a new challenge
    • Lopez-Martinez R. Candidosis, a new challenge. Clin Dermatol 2010;28(2):178-84
    • (2010) Clin Dermatol , vol.28 , Issue.2 , pp. 178-184
    • Lopez-Martinez, R.1
  • 5
    • 0032723144 scopus 로고    scopus 로고
    • Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancer
    • Redding SW, Zellars RC, Kirkpatrick WR, et al. Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancer. J Clin Microbiol 1999;37(12):3896-900
    • (1999) J Clin Microbiol , vol.37 , Issue.12 , pp. 3896-3900
    • Redding, S.W.1    Zellars, R.C.2    Kirkpatrick, W.R.3
  • 7
    • 0344333468 scopus 로고    scopus 로고
    • Vaginal candidiasis: Review and role of local mucosal immunity
    • Fidel PL Jr. Vaginal candidiasis: Review and role of local mucosal immunity. AIDS Patient Care STDS 1998;12(5):359-66
    • (1998) AIDS Patient Care STDS , vol.12 , Issue.5 , pp. 359-366
    • Fidel Jr., P.L.1
  • 10
    • 60549098868 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of candidiasis 2009 update by the Infectious Diseases Society of America
    • Pappas PG, Kauffman CA, Andes D, et al Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;48(5):503-35
    • (2009) Clin Infect Dis , vol.48 , Issue.5 , pp. 503-535
    • Pappas, P.G.1    Kauffman, C.A.2    Andes, D.3
  • 11
    • 0030977378 scopus 로고    scopus 로고
    • Microbiological factors influencing the outcome of nosocomial bloodstream infections: A 6-year validated, population-based model
    • Pittet D, Li N, Woolson RF, et al. Microbiological factors influencing the outcome of nosocomial bloodstream infections: A 6-year validated, population-based model. Clin Infect Dis 1997;24(6):1068-78 (Pubitemid 27249003)
    • (1997) Clinical Infectious Diseases , vol.24 , Issue.6 , pp. 1068-1078
    • Pittet, D.1    Li, N.2    Woolson, R.F.3    Wenzel, R.P.4
  • 12
    • 27444432361 scopus 로고    scopus 로고
    • The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: A propensity analysis
    • DOI 10.1086/496922
    • Zaoutis TE, Argon J, Chu J, et al. The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: A propensity analysis. Clin Infect Dis 2005;41(9):1232-9 (Pubitemid 41532664)
    • (2005) Clinical Infectious Diseases , vol.41 , Issue.9 , pp. 1232-1239
    • Zaoutis, T.E.1    Argon, J.2    Chu, J.3    Berlin, J.A.4    Walsh, T.J.5    Feudtner, C.6
  • 14
    • 77956343542 scopus 로고    scopus 로고
    • An insight into the antifungal pipeline: Selected new molecules and beyond
    • Ostrosky-Zeichner L, Casadevall A, Galgiani JN, et al. An insight into the antifungal pipeline: Selected new molecules and beyond. Nat Rev Drug Discov 2010;9(9):719-27
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.9 , pp. 719-727
    • Ostrosky-Zeichner, L.1    Casadevall, A.2    Galgiani, J.N.3
  • 15
    • 0038341642 scopus 로고    scopus 로고
    • Antifungal agents: Mechanisms of action
    • DOI 10.1016/S0966-842X(03)00117-3
    • Odds FC, Brown AJ, Gow NA. Antifungal agents: Mechanisms of action. Trends Microbiol 2003;11(6):272-9 (Pubitemid 36725017)
    • (2003) Trends in Microbiology , vol.11 , Issue.6 , pp. 272-279
    • Odds, F.C.1    Brown, A.J.P.2    Gow, N.A.R.3
  • 16
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
    • DOI 10.1128/AAC.45.10.2676-2684.2001
    • Perea S, Lopez-Ribot JL, Kirkpatrick WR, et al. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 2001;45(10):2676-84 (Pubitemid 32906656)
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , Issue.10 , pp. 2676-2684
    • Perea, S.1    Lopez-Ribot, J.L.2    Kirkpatrick, W.R.3    McAtee, R.K.4    Santillan, R.A.5    Martinez, M.6    Calabrese, D.7    Sanglard, D.8    Patterson, T.F.9
  • 17
    • 3042761501 scopus 로고    scopus 로고
    • Candida biofilms: Antifungal resistance and emerging therapeutic options
    • Kuhn DM, Ghannoum MA. Candida biofilms: Antifungal resistance and emerging therapeutic options. Curr Opin Investig Drugs 2004;5(2):186-97
    • (2004) Curr Opin Investig Drugs , vol.5 , Issue.2 , pp. 186-197
    • Kuhn, D.M.1    Ghannoum, M.A.2
  • 18
    • 0034863427 scopus 로고    scopus 로고
    • Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms
    • DOI 10.1128/AAC.45.9.2475-2479.2001
    • Ramage G, Vande Walle K, Wickes BL, et al. Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob Agents Chemother 2001;45(9):2475-9 (Pubitemid 32801898)
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , Issue.9 , pp. 2475-2479
    • Ramage, G.1    Vande Walle, K.2    Wickes, B.L.3    Lopez-Ribot, J.L.4
  • 19
    • 1642420267 scopus 로고    scopus 로고
    • Caspofungin Resistance in Candida albicans: Correlating Clinical Outcome with Laboratory Susceptibility Testing of Three Isogenic Isolates Serially Obtained from a Patient with Progressive Candida Esophagitis
    • DOI 10.1128/AAC.48.4.1382-1383.2004
    • Hernandez S, Lopez-Ribot JL, Najvar LK, et al. Caspofungin resistance in Candida albicans: Correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis. Antimicrob Agents Chemother 2004;48(4):1382-3 (Pubitemid 38405501)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.4 , pp. 1382-1383
    • Hernandez, S.1    Lopez-Ribot, J.L.2    Najvar, L.K.3    McCarthy, D.I.4    Bocanegra, R.5    Graybill, J.R.6
  • 20
    • 55849095115 scopus 로고    scopus 로고
    • Pyrosequencing to detect mutations in FKS1 that confer reduced echinocandin susceptibility in Candida albicans
    • Wiederhold NP, Grabinski JL, Garcia-Effron G, et al. Pyrosequencing to detect mutations in FKS1 that confer reduced echinocandin susceptibility in Candida albicans. Antimicrob Agents Chemother 2008;52(11):4145-8
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.11 , pp. 4145-4148
    • Wiederhold, N.P.1    Grabinski, J.L.2    Garcia-Effron, G.3
  • 21
    • 34548108138 scopus 로고    scopus 로고
    • Targeting virulence: A new paradigm for antimicrobial therapy
    • DOI 10.1038/nchembio.2007.24, PII NCHEMBIO200724
    • Clatworthy AE, Pierson E, Hung DT. Targeting virulence: A new paradigm for antimicrobial therapy. Nat Chem Biol 2007;3(9):541-8 (Pubitemid 47294400)
    • (2007) Nature Chemical Biology , vol.3 , Issue.9 , pp. 541-548
    • Clatworthy, A.E.1    Pierson, E.2    Hung, D.T.3
  • 22
    • 58849109341 scopus 로고    scopus 로고
    • Targeting virulence: A new paradigm for antifungals
    • Gauwerky K, Borelli C, Korting HC. Targeting virulence: A new paradigm for antifungals. Drug Discov Today 2009;14(3-4):214-22
    • (2009) Drug Discov Today , vol.14 , Issue.3-4 , pp. 214-222
    • Gauwerky, K.1    Borelli, C.2    Korting, H.C.3
  • 23
    • 1842671656 scopus 로고    scopus 로고
    • The damage-response framework of microbial pathogenesis
    • Casadevall A, Pirofski LA. The damage-response framework of microbial pathogenesis. Nat Rev Microbiol 2003;1(1):17-24
    • (2003) Nat Rev Microbiol , vol.1 , Issue.1 , pp. 17-24
    • Casadevall, A.1    Pirofski, L.A.2
  • 24
    • 0037386575 scopus 로고    scopus 로고
    • Microbial virulence results from the interaction between host and microorganism
    • author reply 58-59
    • Casadevall A, Pirofski LA. Microbial virulence results from the interaction between host and microorganism. Trends Microbiol 2003;11(4):157-8; author reply 58-9
    • (2003) Trends Microbiol , vol.11 , Issue.4 , pp. 157-158
    • Casadevall, A.1    Pirofski, L.A.2
  • 25
    • 0035425835 scopus 로고    scopus 로고
    • Host-pathogen interactions: The attributes of virulence
    • DOI 10.1086/322044
    • Casadevall A, Pirofski L. Host-pathogen interactions: The attributes of virulence. J Infect Dis 2001;184(3):337-44; Epub 2001 Jun 27 (Pubitemid 32662181)
    • (2001) Journal of Infectious Diseases , vol.184 , Issue.3 , pp. 337-344
    • Casadevall, A.1    Pirofski, L.-A.2
  • 26
    • 0034444550 scopus 로고    scopus 로고
    • Host-pathogen interactions: Basic concepts of microbial commensalism, colonization, infection, and disease
    • DOI 10.1128/IAI.68.12.6511-6518.2000
    • Casadevall A, Pirofski LA. Host-pathogen interactions: Basic concepts of microbial commensalism, colonization, infection, and disease. Infect Immun 2000;68(12):6511-18 (Pubitemid 32463348)
    • (2000) Infection and Immunity , vol.68 , Issue.12 , pp. 6511-6518
    • Casadevall, A.1    Pirofski, L.-A.2
  • 27
  • 29
    • 0035399946 scopus 로고    scopus 로고
    • Virulence factors of Candida albicans
    • DOI 10.1016/S0966-842X(01)02094-7, PII S0966842X01020947
    • Calderone RA, Fonzi WA. Virulence factors of Candida albicans. Trends Microbiol 2001;9(7):327-35 (Pubitemid 32575277)
    • (2001) Trends in Microbiology , vol.9 , Issue.7 , pp. 327-335
    • Calderone, R.A.1    Fonzi, W.A.2
  • 30
    • 0142092728 scopus 로고    scopus 로고
    • Adaptation to environmental pH in Candida albicans and its relation to pathogenesis
    • Epub 2003 Jun 18
    • Davis D. Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Curr Genet 2003;44(1):1-7; Epub 2003 Jun 18
    • (2003) Curr Genet , vol.44 , Issue.1 , pp. 1-7
    • Davis, D.1
  • 31
    • 0036155879 scopus 로고    scopus 로고
    • Candida commensalism and virulence: The evolution of phenotypic plasticity
    • DOI 10.1016/S0001-706X(01)00200-5, PII S0001706X01002005
    • Soll DR. Candida commensalism and virulence: The evolution of phenotypic plasticity. Acta Trop 2002;81(2):101-10 (Pubitemid 34093800)
    • (2002) Acta Tropica , vol.81 , Issue.2 , pp. 101-110
    • Soll, D.R.1
  • 33
    • 0025989934 scopus 로고
    • Putative virulence factors of Candida albicans
    • Cutler JE. Putative virulence factors of Candida albicans. Annu Rev Microbiol 1991;45:187-218 (Pubitemid 21903789)
    • (1991) Annual Review of Microbiology , vol.45 , Issue.1 , pp. 187-218
    • Cutler, J.E.1
  • 34
    • 0035087418 scopus 로고    scopus 로고
    • Fungal virulence studies come of age
    • Odds FC, Gow NA, Brown AJ. Fungal virulence studies come of age. Genome Biol 2001;2:1009.1-4
    • (2001) Genome Biol , vol.2 , Issue.1009 , pp. 1-4
    • Odds, F.C.1    Gow, N.A.2    Brown, A.J.3
  • 35
    • 80052965456 scopus 로고    scopus 로고
    • Growth of Candida Albicans Hyphae
    • Sudbery PE. Growth of Candida albicans hyphae. Nat Rev Microbiol 2011;9(10):737-48
    • (2011) Nat Rev Microbiol , vol.9 , Issue.10 , pp. 737-748
    • Sudbery, P.E.1
  • 37
    • 0030824249 scopus 로고    scopus 로고
    • Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    • DOI 10.1126/science.277.5322.105
    • Braun BR, Johnson AD. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 1997;277(5322):105-9 (Pubitemid 27450657)
    • (1997) Science , vol.277 , Issue.5322 , pp. 105-109
    • Braun, B.R.1    Johnson, A.D.2
  • 38
    • 0034013217 scopus 로고    scopus 로고
    • TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans
    • Braun BR, Johnson AD. TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 2000;155(1):57-67 (Pubitemid 30257110)
    • (2000) Genetics , vol.155 , Issue.1 , pp. 57-67
    • Braun, B.R.1    Johnson, A.D.2
  • 39
    • 0035801610 scopus 로고    scopus 로고
    • NRG1, a repressor of filamentous growth in C albicans, is down-regulated during filament induction
    • DOI 10.1093/emboj/20.17.4753
    • Braun BR, Kadosh D, Johnson AD. NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction. Embo J 2001;20(17):4753-61 (Pubitemid 32848628)
    • (2001) EMBO Journal , vol.20 , Issue.17 , pp. 4753-4761
    • Braun, B.R.1    Kadosh, D.2    Johnson, A.D.3
  • 40
    • 58849131459 scopus 로고    scopus 로고
    • Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence
    • Carlisle PL, Banerjee M, Lazzell A, et al. Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence. Proc Natl Acad Sci USA 2009;106(2):599-604
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.2 , pp. 599-604
    • Carlisle, P.L.1    Banerjee, M.2    Lazzell, A.3
  • 41
    • 0033870274 scopus 로고    scopus 로고
    • Transcription factors in Candida albicans - environmental control of morphogenesis
    • Pt8
    • Ernst JF. Transcription factors in Candida albicans - environmental control of morphogenesis. Microbiology 2000;146(Pt 8):1763-74
    • (2000) Microbiology , vol.146 , pp. 1763-1774
    • Ernst, J.F.1
  • 43
    • 0142216110 scopus 로고    scopus 로고
    • Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    • DOI 10.1128/EC.2.5.1053-1060.2003
    • Saville SP, Lazzell AL, Monteagudo C, et al. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell 2003;2(5):1053-60 (Pubitemid 37298719)
    • (2003) Eukaryotic Cell , vol.2 , Issue.5 , pp. 1053-1060
    • Saville, S.P.1    Lazzell, A.L.2    Monteagudo, C.3    Lopez-Ribot, J.L.4
  • 44
    • 2442548488 scopus 로고    scopus 로고
    • Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis
    • DOI 10.1038/sj.emboj.7600195
    • Zheng X, Wang Y. Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis. Embo J 2004;23(8):1845-56 (Pubitemid 38649647)
    • (2004) EMBO Journal , vol.23 , Issue.8 , pp. 1845-1856
    • Zheng, X.1    Wang, Y.2    Wang, Y.3
  • 45
    • 17844406907 scopus 로고    scopus 로고
    • Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice
    • DOI 10.1111/j.1439-0507.2005.01121.x
    • MacCallum DM, Odds FC. Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice. Mycoses 2005;48(3):151-61 (Pubitemid 40592846)
    • (2005) Mycoses , vol.48 , Issue.3 , pp. 151-161
    • MacCallum, D.M.1    Odds, F.C.2
  • 46
    • 0034115442 scopus 로고    scopus 로고
    • Role of hyphal formation in interactions of Candida albicans with endothelial cells
    • DOI 10.1128/IAI.68.6.3485-3490.2000
    • Phan QT, Belanger PH, Filler SG. Role of hyphal formation in interactions of Candida albicans with endothelial cells. Infect Immun 2000;68(6):3485-90 (Pubitemid 30340448)
    • (2000) Infection and Immunity , vol.68 , Issue.6 , pp. 3485-3490
    • Phan, Q.T.1    Belanger, P.H.2    Filler, S.G.3
  • 48
    • 79957500651 scopus 로고    scopus 로고
    • Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease
    • Chaturvedi AK, Lazzell AL, Saville SP, et al. Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease. PLoS One 2011;6(5):e20449
    • (2011) PLoS One , vol.6 , Issue.5
    • Chaturvedi, A.K.1    Lazzell, A.L.2    Saville, S.P.3
  • 49
    • 0034351185 scopus 로고    scopus 로고
    • Tetracyline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans
    • DOI 10.1128/IAI.68.12.6712-6719.2000
    • Nakayama H, Mio T, Nagahashi S, et al. Tetracycline-regulatable system to tightly control gene expression in the pathogenic fungus Candida albicans. Infect Immun 2000;68(12):6712-19 (Pubitemid 32463375)
    • (2000) Infection and Immunity , vol.68 , Issue.12 , pp. 6712-6719
    • Nakayama, H.1    Mio, T.2    Nagahashi, S.3    Kokado, M.4    Arisawa, M.5    Aoki, Y.6
  • 51
    • 84864257452 scopus 로고    scopus 로고
    • Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production
    • Chang W, Li Y, Zhang L, et al. Retigeric acid B attenuates the virulence of Candida albicans via inhibiting adenylyl cyclase activity targeted by enhanced farnesol production. PLoS ONE 2012;7(7):e41624
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Chang, W.1    Li, Y.2    Zhang, L.3
  • 52
    • 58149389286 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa-Candida albicans interactions: Localization and fungal toxicity of a phenazine derivative
    • Gibson J, Sood A, Hogan DA. Pseudomonas aeruginosa-Candida albicans interactions: Localization and fungal toxicity of a phenazine derivative. Appl Environ Microbiol 2009;75(2):504-13
    • (2009) Appl Environ Microbiol , vol.75 , Issue.2 , pp. 504-513
    • Gibson, J.1    Sood, A.2    Hogan, D.A.3
  • 53
    • 9644264336 scopus 로고    scopus 로고
    • A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology
    • DOI 10.1111/j.1365-2958.2004.04349.x
    • Hogan DA, Vik A, Kolter R. A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. Mol Microbiol 2004;54(5):1212-23 (Pubitemid 39578266)
    • (2004) Molecular Microbiology , vol.54 , Issue.5 , pp. 1212-1223
    • Hogan, D.A.1    Vik, A.2    Kolter, R.3
  • 55
    • 78649495633 scopus 로고    scopus 로고
    • Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition
    • Joyner PM, Liu J, Zhang Z, et al. Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. Org Biomol Chem 2010;8(24):5486-9
    • (2010) Org Biomol Chem , vol.8 , Issue.24 , pp. 5486-5489
    • Joyner, P.M.1    Liu, J.2    Zhang, Z.3
  • 56
    • 37549004437 scopus 로고    scopus 로고
    • Morphogenesis control in Candida albicans and Candida dubliniensis through signaling molecules produced by planktonic and biofilm cells
    • Martins M, Henriques M, Azeredo J, et al. Morphogenesis control in Candida albicans and Candida dubliniensis through signaling molecules produced by planktonic and biofilm cells. Eukaryot Cell 2007;6(12):2429-36
    • (2007) Eukaryot Cell , vol.6 , Issue.12 , pp. 2429-2436
    • Martins, M.1    Henriques, M.2    Azeredo, J.3
  • 57
    • 77957775514 scopus 로고    scopus 로고
    • Capric acid secreted by S boulardii inhibits C albicans filamentous growth adhesion and biofilm formation
    • Murzyn A, Krasowska A, Stefanowicz P, et al. Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation. PLoS One 2010;5(8):e12050
    • (2010) PLoS One , vol.5 , Issue.8
    • Murzyn, A.1    Krasowska, A.2    Stefanowicz, P.3
  • 58
    • 83155176335 scopus 로고    scopus 로고
    • Bisbibenzyls a new type of antifungal agent inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans
    • Zhang L, Chang W, Sun B, et al. Bisbibenzyls, a new type of antifungal agent, inhibit morphogenesis switch and biofilm formation through upregulation of DPP3 in Candida albicans. PLoS ONE 2011;6(12):e28953
    • (2011) PLoS ONE , vol.6 , Issue.12
    • Zhang, L.1    Chang, W.2    Sun, B.3
  • 59
    • 80053162338 scopus 로고    scopus 로고
    • Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways
    • Midkiff J, Borochoff-Porte N, White D, et al. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 2011;6(9):e25395
    • (2011) PLoS One , vol.6 , Issue.9
    • Midkiff, J.1    Borochoff-Porte, N.2    White, D.3
  • 61
    • 79961089526 scopus 로고    scopus 로고
    • Modulation of morphogenesis in Candida albicans by various small molecules
    • Shareck J, Belhumeur P. Modulation of morphogenesis in Candida albicans by various small molecules. Eukaryot Cell 2011;3:3
    • (2011) Eukaryot Cell , Issue.3 , pp. 3
    • Shareck, J.1    Belhumeur, P.2
  • 62
  • 63
    • 84864793854 scopus 로고    scopus 로고
    • Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis
    • Martins M, Lazzell AL, Lopez-Ribot JL, et al. Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis. J Basic Microbiol 2012;52(4):487-91
    • (2012) J Basic Microbiol , vol.52 , Issue.4 , pp. 487-491
    • Martins, M.1    Lazzell, A.L.2    Lopez-Ribot, J.L.3
  • 64
    • 84860244125 scopus 로고    scopus 로고
    • Interplay between Candida albicans and the mammalian innate host defense
    • Cheng SC, Joosten LA, Kullberg BJ, et al. Interplay between Candida albicans and the mammalian innate host defense. Infect Immun 2012;80(4):1304-13
    • (2012) Infect Immun , vol.80 , Issue.4 , pp. 1304-1313
    • Cheng, S.C.1    Joosten, L.A.2    Kullberg, B.J.3
  • 65
    • 37349015349 scopus 로고    scopus 로고
    • An integrated model of the recognition of Candida albicans by the innate immune system
    • DOI 10.1038/nrmicro1815, PII NRMICRO1815
    • Netea MG, Brown GD, Kullberg BJ, et al. An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 2008;6(1):67-78 (Pubitemid 350286221)
    • (2008) Nature Reviews Microbiology , vol.6 , Issue.1 , pp. 67-78
    • Netea, M.G.1    Brown, G.D.2    Kullberg, B.J.3    Gow, N.A.R.4
  • 67
    • 77956583415 scopus 로고    scopus 로고
    • A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells
    • Moyes DL, Runglall M, Murciano C, et al. A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. Cell Host Microbe 2010;8(3):225-35
    • (2010) Cell Host Microbe , vol.8 , Issue.3 , pp. 225-235
    • Moyes, D.L.1    Runglall, M.2    Murciano, C.3
  • 68
    • 0035811478 scopus 로고    scopus 로고
    • The glyoxylate cycle is required for fungal virulence
    • DOI 10.1038/35083594
    • Lorenz MC, Fink GR. The glyoxylate cycle is required for fungal virulence. Nature 2001;412(6842):83-6 (Pubitemid 32851514)
    • (2001) Nature , vol.412 , Issue.6842 , pp. 83-86
    • Lorenz, M.C.1    Fink, G.R.2
  • 69
    • 68149155888 scopus 로고    scopus 로고
    • Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections
    • MacCallum DM, Castillo L, Brown AJ, et al. Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS One 2009;4(7):e6420
    • (2009) PLoS One , vol.4 , Issue.7
    • MacCallum, D.M.1    Castillo, L.2    Brown, A.J.3
  • 71
    • 0036711963 scopus 로고    scopus 로고
    • Biofilms: Microbial life on surfaces
    • Donlan RM. Biofilms: Microbial life on surfaces. Emerg Infect Dis 2002;8(9):881-90 (Pubitemid 35000803)
    • (2002) Emerging Infectious Diseases , vol.8 , Issue.9 , pp. 881-890
    • Donlan, R.M.1
  • 72
    • 0033591467 scopus 로고    scopus 로고
    • Bacterial biofilms: A common cause of persistent infections
    • DOI 10.1126/science.284.5418.1318
    • Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: A common cause of persistent infections. Science 1999;284(5418):1318-22 (Pubitemid 29289651)
    • (1999) Science , vol.284 , Issue.5418 , pp. 1318-1322
    • Costerton, J.W.1    Stewart, P.S.2    Greenberg, E.P.3
  • 73
    • 1842483412 scopus 로고    scopus 로고
    • Treatment of Infections Associated with Surgical Implants
    • DOI 10.1056/NEJMra035415
    • Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med 2004;350(14):1422-9 (Pubitemid 38419996)
    • (2004) New England Journal of Medicine , vol.350 , Issue.14 , pp. 1422-1429
    • Darouiche, R.O.1
  • 74
    • 0036228505 scopus 로고    scopus 로고
    • Biofilms: Survival mechanisms of clinically relevant microorganisms
    • DOI 10.1128/CMR.15.2.167-193.2002
    • Donlan RM, Costerton JW. Biofilms: Survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 2002;15(2):167-93 (Pubitemid 34303762)
    • (2002) Clinical Microbiology Reviews , vol.15 , Issue.2 , pp. 167-193
    • Donlan, R.M.1    Costerton, J.W.2
  • 75
    • 2042519310 scopus 로고    scopus 로고
    • Candida Infections of Medical Devices
    • DOI 10.1128/CMR.17.2.255-267.2004
    • Kojic EM, Darouiche RO. Candida infections of medical devices. Clin Microbiol Rev 2004;17(2):255-67 (Pubitemid 38534029)
    • (2004) Clinical Microbiology Reviews , vol.17 , Issue.2 , pp. 255-267
    • Kojic, E.M.1    Darouiche, R.O.2
  • 76
    • 33746300488 scopus 로고    scopus 로고
    • Candida albicans biofilm development, modeling a host-pathogen interaction
    • DOI 10.1016/j.mib.2006.06.007, PII S1369527406000907
    • Nett J, Andes D. Candida albicans biofilm development, modeling a host-pathogen interaction. Curr Opin Microbiol 2006;9(4):340-5 (Pubitemid 44108718)
    • (2006) Current Opinion in Microbiology , vol.9 , Issue.4 , pp. 340-345
    • Nett, J.1    Andes, D.2
  • 77
    • 33749986341 scopus 로고    scopus 로고
    • Candida biofilms on implanted biomaterials: A clinically significant problem
    • DOI 10.1111/j.1567-1364.2006.00117.x
    • Ramage G, Martinez JP, Lopez-Ribot JL. Candida biofilms on implanted biomaterials: A clinically significant problem. FEMS Yeast Res 2006;6(7):979-86 (Pubitemid 44568854)
    • (2006) FEMS Yeast Research , vol.6 , Issue.7 , pp. 979-986
    • Ramage, G.1    Martinez, J.P.2    Lopez-Ribot, J.L.3
  • 78
    • 70350557500 scopus 로고    scopus 로고
    • Our current understanding of fungal biofilms
    • Ramage G, Mowat E, Jones B, et al. Our current understanding of fungal biofilms. Crit Rev Microbiol 2009;35(4):340-55
    • (2009) Crit Rev Microbiol , vol.35 , Issue.4 , pp. 340-355
    • Ramage, G.1    Mowat, E.2    Jones, B.3
  • 81
    • 0032554513 scopus 로고    scopus 로고
    • Intravascular-catheter-related infections
    • DOI 10.1016/S0140-6736(97)10006-X
    • Raad I. Intravascular-catheter-related infections. Lancet 1998;351(9106):893-8 (Pubitemid 28121188)
    • (1998) Lancet , vol.351 , Issue.9106 , pp. 893-898
    • Raad, I.1
  • 83
    • 0034870709 scopus 로고    scopus 로고
    • Biofilm formation by the fungal pathogen Candida albicans: Development, architecture, and drug resistance
    • DOI 10.1128/JB.183.18.5385-5394.2001
    • Chandra J, Kuhn DM, Mukherjee PK, et al. Biofilm formation by the fungal pathogen Candida albicans: Development, architecture, and drug resistance. J Bacteriol 2001;183(18):5385-94 (Pubitemid 32802612)
    • (2001) Journal of Bacteriology , vol.183 , Issue.18 , pp. 5385-5394
    • Chandra, J.1    Kuhn, D.M.2    Mukherjee, P.K.3    Hoyer, L.L.4    McCormick, T.5    Ghannoum, M.A.6
  • 84
    • 33746889838 scopus 로고    scopus 로고
    • Genetics and genomics of Candida albicans biofilm formation
    • DOI 10.1111/j.1462-5822.2006.00761.x
    • Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol 2006;8(9):1382-91 (Pubitemid 44194572)
    • (2006) Cellular Microbiology , vol.8 , Issue.9 , pp. 1382-1391
    • Nobile, C.J.1    Mitchell, A.P.2
  • 85
    • 77950392425 scopus 로고    scopus 로고
    • Dispersion as an important step in the Candida albicans biofilm developmental cycle
    • Uppuluri P, Chaturvedi AK, Srinivasan A, et al. Dispersion as an important step in the Candida albicans biofilm developmental cycle. PLoS Pathog 2010;6(3):e1000828
    • (2010) PLoS Pathog , vol.6 , Issue.3
    • Uppuluri, P.1    Chaturvedi, A.K.2    Srinivasan, A.3
  • 87
    • 0037183376 scopus 로고    scopus 로고
    • The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans
    • DOI 10.1016/S0378-1097(02)00853-4, PII S0378109702008534
    • Ramage G, VandeWalle K, Lopez-Ribot JL, et al. The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development in Candida albicans. FEMS Microbiol Lett 2002;214(1):95-100 (Pubitemid 35245528)
    • (2002) FEMS Microbiology Letters , vol.214 , Issue.1 , pp. 95-100
    • Ramage, G.1    VandeWalle, K.2    Lopez-Ribot, J.L.3    Wickes, B.L.4
  • 88
    • 20544445249 scopus 로고    scopus 로고
    • Candida albicans biofilms: More than filamentation
    • Lopez-Ribot JL. Candida albicans biofilms: More than filamentation. Curr Biol 2005;15(12):R453-5
    • (2005) Curr Biol , vol.15 , Issue.12
    • Lopez-Ribot, J.L.1
  • 89
    • 84856117019 scopus 로고    scopus 로고
    • A recently evolved transcriptional network controls biofilm development in Candida albicans
    • Nobile CJ, Fox EP, Nett JE, et al. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 2012;148(1-2):126-38
    • (2012) Cell , vol.148 , Issue.1-2 , pp. 126-138
    • Nobile, C.J.1    Fox, E.P.2    Nett, J.E.3
  • 90
    • 45749112170 scopus 로고    scopus 로고
    • In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth
    • DOI 10.1093/jac/dkn160
    • Cateau E, Rodier MH, Imbert C. In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth. J Antimicrob Chemother 2008;62(1):153-5 (Pubitemid 351865889)
    • (2008) Journal of Antimicrobial Chemotherapy , vol.62 , Issue.1 , pp. 153-155
    • Cateau, E.1    Rodier, M.-H.2    Imbert, C.3
  • 92
    • 51649130981 scopus 로고    scopus 로고
    • A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing
    • Pierce CG, Uppuluri P, Tristan AR, et al. A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. Nat Protoc 2008;3(9):1494-500
    • (2008) Nat Protoc , vol.3 , Issue.9 , pp. 1494-1500
    • Pierce, C.G.1    Uppuluri, P.2    Tristan, A.R.3
  • 93
    • 80053455899 scopus 로고    scopus 로고
    • Hsp90 governs dispersion and drug resistance of fungal biofilms
    • Robbins N, Uppuluri P, Nett J, et al. Hsp90 governs dispersion and drug resistance of fungal biofilms. PLoS Pathog 2011;7(9):e1002257
    • (2011) PLoS Pathog , vol.7 , Issue.9
    • Robbins, N.1    Uppuluri, P.2    Nett, J.3
  • 94
    • 40549140735 scopus 로고    scopus 로고
    • Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms
    • DOI 10.1128/AAC.01397-07
    • Uppuluri P, Nett J, Heitman J, et al. Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother 2008;52(3):1127-32 (Pubitemid 351358397)
    • (2008) Antimicrobial Agents and Chemotherapy , vol.52 , Issue.3 , pp. 1127-1132
    • Uppuluri, P.1    Nett, J.2    Heitman, J.3    Andes, D.4
  • 95
    • 84871118785 scopus 로고    scopus 로고
    • Candida species: Current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
    • Pt1
    • Sardi JC, Scorzoni L, Bernardi T, et al. Candida species: Current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol 2013;62(Pt 1):10-24
    • (2013) J Med Microbiol , Issue.62 , pp. 10-24
    • Sardi, J.C.1    Scorzoni, L.2    Bernardi, T.3
  • 96
    • 79952792302 scopus 로고    scopus 로고
    • Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms
    • LaFleur MD, Lucumi E, Napper AD, et al. Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. J Antimicrob Chemother 2011;66(4):820-6
    • (2011) J Antimicrob Chemother , vol.66 , Issue.4 , pp. 820-826
    • LaFleur, M.D.1    Lucumi, E.2    Napper, A.D.3
  • 97
    • 84880275318 scopus 로고    scopus 로고
    • High-throughput screening of a collection of known pharmacologically active small compounds for the identification of Candida albicans biofilm inhibitors
    • Epub ahead of print]
    • Siles S, Srinivasan A, Pierce CP, et al. High-throughput screening of a collection of known pharmacologically active small compounds for the identification of Candida albicans biofilm inhibitors. Antimicrob Agents Chemother 2013; [Epub ahead of print]
    • (2013) Antimicrob Agents Chemother
    • Siles, S.1    Srinivasan, A.2    Pierce, C.P.3
  • 98
    • 83655192068 scopus 로고    scopus 로고
    • Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms
    • Martins M, Henriques M, Lopez-Ribot JL, et al. Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms. Mycoses 2012;55(1):80-5
    • (2012) Mycoses , vol.55 , Issue.1 , pp. 80-85
    • Martins, M.1    Henriques, M.2    Lopez-Ribot, J.L.3
  • 99
    • 77952674175 scopus 로고    scopus 로고
    • Presence of extracellular DNA in the Candida albicans biofilm matrix and its contribution to biofilms
    • Martins M, Uppuluri P, Thomas DP, et al. Presence of extracellular DNA in the Candida albicans biofilm matrix and its contribution to biofilms. Mycopathologia 2010;169(5):323-31
    • (2010) Mycopathologia , vol.169 , Issue.5 , pp. 323-331
    • Martins, M.1    Uppuluri, P.2    Thomas, D.P.3
  • 100
    • 79955526276 scopus 로고    scopus 로고
    • Development of a High-Throughput Candida albicans Biofilm Chip
    • Srinivasan A, Uppuluri P, Lopez-Ribot J, et al. Development of a High-Throughput Candida albicans Biofilm Chip. PLoS ONE 2011;6(4):e19036
    • (2011) PLoS ONE , vol.6 , Issue.4
    • Srinivasan, A.1    Uppuluri, P.2    Lopez-Ribot, J.3
  • 101
    • 77955617560 scopus 로고    scopus 로고
    • A human-curated annotation of the Candida albicans genome
    • Braun BR, van Het Hoog M, d'Enfert C, et al. A human-curated annotation of the Candida albicans genome. PLoS Genet 2005;1(1):36-57
    • (2005) PLoS Genet , vol.1 , Issue.1 , pp. 36-57
    • Braun, B.R.1    Van Het Hoog, M.2    D'Enfert, C.3
  • 102
    • 32644434444 scopus 로고    scopus 로고
    • Use of genome information for the study of the pathogenesis of fungal infections and the development of diagnostic tools
    • Saville SP, Thomas DP, Lopez-Ribot JL. Use of genome information for the study of the pathogenesis of fungal infections and the development of diagnostic tools. Rev Iberoam Micol 2005;22(4):238-41 (Pubitemid 43241085)
    • (2005) Revista Iberoamericana de Micologia , vol.22 , Issue.4 , pp. 238-241
    • Saville, S.P.1    Thomas, D.P.2    Lopez-Ribot, J.L.3
  • 103
    • 0037339171 scopus 로고    scopus 로고
    • Caspofungin: The first representative of a new antifungal class
    • DOI 10.1093/jac/dkg117
    • Letscher-Bru V, Herbrecht R. Caspofungin: The first representative of a new antifungal class. J Antimicrob Chemother 2003;51(3):513-21 (Pubitemid 36336143)
    • (2003) Journal of Antimicrobial Chemotherapy , vol.51 , Issue.3 , pp. 513-521
    • Letscher-Bru, V.1    Herbrecht, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.