메뉴 건너뛰기




Volumn 6, Issue 9, 2011, Pages

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; 2 CHLORO 5 NITROBENZANILIDE; 3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; 5,8,11,14 ICOSATETRAYNOIC ACID; 7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; A 3; AMOXAPINE; ANTIFUNGAL AGENT; BUDDED TO HYPHAL TRANSITION INHIBITOR; CALCINEURIN; CHLORPROMAZINE; CLOTIAPINE; CLOZAPINE; CLOZAPINE N OXIDE; FLUPERLAPINE; G PROTEIN COUPLED RECEPTOR; KETOTIFEN; LIFICIGUAT; LOXAPINE; MIRTAZAPINE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; NIGERICIN; NORCLOZAPINE; PROTEIN CPH1 TRANSCRIPTION FACTOR; PROTEIN EFG1 TRANSCRIPTION FACTOR; PROTEIN KINASE INHIBITOR; REGULATOR PROTEIN; TACROLIMUS; UNCLASSIFIED DRUG; DRUG DERIVATIVE; METHIONINE;

EID: 80053162338     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025395     Document Type: Article
Times cited : (41)

References (66)
  • 1
    • 0032801225 scopus 로고    scopus 로고
    • Nosocomial bloodstream infections in United States hospitals: a three-year analysis
    • Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN, et al. (1999) Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 29: 239-244.
    • (1999) Clin Infect Dis , vol.29 , pp. 239-244
    • Edmond, M.B.1    Wallace, S.E.2    McClish, D.K.3    Pfaller, M.A.4    Jones, R.N.5
  • 2
    • 33847114442 scopus 로고    scopus 로고
    • Trends in the epidemiology of invasive fungal infections
    • Warnock DW, (2007) Trends in the epidemiology of invasive fungal infections. Jpn J Med Mycol 48: 1-12.
    • (2007) Jpn J Med Mycol , vol.48 , pp. 1-12
    • Warnock, D.W.1
  • 3
    • 0001802677 scopus 로고    scopus 로고
    • Expression of growth form-specific factors during morphogenesis in Candida albicans
    • Candida and Candidiasis, ed Calderone RA (ASM Press, Washington, D.C.)
    • Brown AJP, (2002) Expression of growth form-specific factors during morphogenesis in Candida albicans. pp. 87-93 Candida and Candidiasis, ed Calderone RA (ASM Press, Washington, D.C.).
    • (2002) , pp. 87-93
    • Brown, A.J.P.1
  • 4
    • 79959572449 scopus 로고    scopus 로고
    • The metabolic basis of Candida albicans morphogenesis and quorum sensing
    • doi:10.1016/j.fgb.2011.04.002
    • Han T-L, Cannon RD, Villas-Bôas SG, (2011) The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genet Biol doi:10.1016/j.fgb.2011.04.002.
    • (2011) Fungal Genet Biol
    • Han, T.-L.1    Cannon, R.D.2    Villas-Bôas, S.G.3
  • 5
    • 65449119161 scopus 로고    scopus 로고
    • Sensing the environment: response of Candida albicans to the X factor
    • Cottier F, Muhlschlegel FA, (2009) Sensing the environment: response of Candida albicans to the X factor. FEMS Microbiol Lett 295: 1-9.
    • (2009) FEMS Microbiol Lett , vol.295 , pp. 1-9
    • Cottier, F.1    Muhlschlegel, F.A.2
  • 6
    • 84907128740 scopus 로고
    • An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans
    • Lee KL, Buckley HR, Campbell CC, (1975) An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 13: 148-153.
    • (1975) Sabouraudia , vol.13 , pp. 148-153
    • Lee, K.L.1    Buckley, H.R.2    Campbell, C.C.3
  • 7
    • 0028569082 scopus 로고
    • Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog
    • Liu H, Köhler J, Fink GR, (1994) Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726.
    • (1994) Science , vol.266 , pp. 1723-1726
    • Liu, H.1    Köhler, J.2    Fink, G.R.3
  • 8
    • 0002012286 scopus 로고    scopus 로고
    • Morphogenetic signaling pathways in Candida albicans
    • Candida and Candidiasis, ed Calderone RA (ASM Press, Washington, D.C.)
    • Brown AJP, (2002) Morphogenetic signaling pathways in Candida albicans. pp. 95-106 Candida and Candidiasis, ed Calderone RA (ASM Press, Washington, D.C.).
    • (2002) , pp. 95-106
    • Brown, A.J.P.1
  • 10
    • 34250759780 scopus 로고    scopus 로고
    • Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans
    • Biswas S, Dijck PV, Datta A, (2007) Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev 71: 348-376.
    • (2007) Microbiol Mol Biol Rev , vol.71 , pp. 348-376
    • Biswas, S.1    Dijck, P.V.2    Datta, A.3
  • 11
    • 0032692954 scopus 로고    scopus 로고
    • Ras signaling is required for serum-induced hyphal differentiation in Candida albicans
    • Feng QH, Summers E, Guo B, Fink G, (1999) Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J Bacteriol 181 (20): 6339-6346.
    • (1999) J Bacteriol , vol.181 , Issue.20 , pp. 6339-6346
    • Feng, Q.H.1    Summers, E.2    Guo, B.3    Fink, G.4
  • 12
    • 65049086509 scopus 로고    scopus 로고
    • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
    • Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, et al. (2009) Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Curr Biol 19: 621-629.
    • (2009) Curr Biol , vol.19 , pp. 621-629
    • Shapiro, R.S.1    Uppuluri, P.2    Zaas, A.K.3    Collins, C.4    Senn, H.5
  • 13
    • 0031596819 scopus 로고    scopus 로고
    • Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis
    • Csank C, Schröppel K, Leberer E, Harcus D, Mohamed O, et al. (1998) Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis. Infect Immun 66 (6): 2713-2721.
    • (1998) Infect Immun , vol.66 , Issue.6 , pp. 2713-2721
    • Csank, C.1    Schröppel, K.2    Leberer, E.3    Harcus, D.4    Mohamed, O.5
  • 14
    • 0029832793 scopus 로고    scopus 로고
    • Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development
    • Köhler JR, Fink GR, (1996) Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Proc Natl Acad Sci USA 93 (23): 13223-13228.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.23 , pp. 13223-13228
    • Köhler, J.R.1    Fink, G.R.2
  • 15
    • 10544224146 scopus 로고    scopus 로고
    • Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans
    • Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, et al. (1996) Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 93 (23): 13217-13222.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.23 , pp. 13217-13222
    • Leberer, E.1    Harcus, D.2    Broadbent, I.D.3    Clark, K.L.4    Dignard, D.5
  • 16
  • 17
    • 0030945488 scopus 로고    scopus 로고
    • Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi
    • Stoldt VR, Sonneborn A, Leuker CE, Ernst JF, (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16: 1982-1991.
    • (1997) EMBO J , vol.16 , pp. 1982-1991
    • Stoldt, V.R.1    Sonneborn, A.2    Leuker, C.E.3    Ernst, J.F.4
  • 18
    • 0034013217 scopus 로고    scopus 로고
    • TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans
    • Braun BR, Johnson AD, (2000) TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 155 (1): 57-67.
    • (2000) Genetics , vol.155 , Issue.1 , pp. 57-67
    • Braun, B.R.1    Johnson, A.D.2
  • 19
    • 4143137516 scopus 로고    scopus 로고
    • Gpr1, a putative G-Protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans
    • Miwa T, Takagi Y, Shinozaki M, Yun C-W, Schell WA, et al. (2004) Gpr1, a putative G-Protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryot Cell 3: 919-931.
    • (2004) Eukaryot Cell , vol.3 , pp. 919-931
    • Miwa, T.1    Takagi, Y.2    Shinozaki, M.3    Yun, C.-W.4    Schell, W.A.5
  • 20
    • 14644415945 scopus 로고    scopus 로고
    • Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1
    • Maidan MM, Thevelein JM, Dijck PV, (2005) Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1. Biochem Soc Trans 33: 291-293.
    • (2005) Biochem Soc Trans , vol.33 , pp. 291-293
    • Maidan, M.M.1    Thevelein, J.M.2    Dijck, P.V.3
  • 21
    • 0037995222 scopus 로고    scopus 로고
    • Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans
    • Sanchez-Martinez C, Perez-Martin J, (2002) Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans. Eukaryot Cell 1: 865-874.
    • (2002) Eukaryot Cell , vol.1 , pp. 865-874
    • Sanchez-Martinez, C.1    Perez-Martin, J.2
  • 22
    • 16344394213 scopus 로고    scopus 로고
    • The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans
    • Maidan MM, De Rop L, Serneels J, Exler S, Rupp S, et al. (2005) The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans. Mol Biol Cell 16: 1971-1986.
    • (2005) Mol Biol Cell , vol.16 , pp. 1971-1986
    • Maidan, M.M.1    de Rop, L.2    Serneels, J.3    Exler, S.4    Rupp, S.5
  • 23
    • 33947122180 scopus 로고    scopus 로고
    • Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans
    • Alvarez FJ, Konopka JB, (2007) Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans. Mol Biol Cell 18: 965-975.
    • (2007) Mol Biol Cell , vol.18 , pp. 965-975
    • Alvarez, F.J.1    Konopka, J.B.2
  • 24
    • 0141703404 scopus 로고    scopus 로고
    • N-acetylglucosamine-inducible CaGAP1 encodes a general amino acid permease which co-ordinates external nitrogen source response and morphogenesis in Candida albicans
    • Biswas S, Roy M, Datta A, (2003) N-acetylglucosamine-inducible CaGAP1 encodes a general amino acid permease which co-ordinates external nitrogen source response and morphogenesis in Candida albicans. Microbiology 149: 2597-2608.
    • (2003) Microbiology , vol.149 , pp. 2597-2608
    • Biswas, S.1    Roy, M.2    Datta, A.3
  • 25
    • 0035184418 scopus 로고    scopus 로고
    • Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway
    • Singh P, Ghosh S, Datta A, (2001) Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway. Infec Immun 69 (12): 7898-7903.
    • (2001) Infec Immun , vol.69 , Issue.12 , pp. 7898-7903
    • Singh, P.1    Ghosh, S.2    Datta, A.3
  • 26
    • 0033710445 scopus 로고    scopus 로고
    • The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans
    • Schweizer A, Rupp S, Taylor BN, Rollinghoff M, Schroppel K, (2000) The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Mol Microbiol 38 (3): 435-445.
    • (2000) Mol Microbiol , vol.38 , Issue.3 , pp. 435-445
    • Schweizer, A.1    Rupp, S.2    Taylor, B.N.3    Rollinghoff, M.4    Schroppel, K.5
  • 27
    • 0034811675 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via Tec1
    • Lane S, Zhou S, Pan T, Dai Q, Liu HP, (2001) The basic helix-loop-helix transcription factor Cph2 regulates hyphal development in Candida albicans partly via Tec1. Mol Cell Biol 21 (19): 6418-6428.
    • (2001) Mol Cell Biol , vol.21 , Issue.19 , pp. 6418-6428
    • Lane, S.1    Zhou, S.2    Pan, T.3    Dai, Q.4    Liu, H.P.5
  • 28
    • 0035966045 scopus 로고    scopus 로고
    • DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans
    • Lane S, Birse C, Zhou S, Matson R, Liu H, (2001) DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans. J Biol Chem 276: 48988-48996.
    • (2001) J Biol Chem , vol.276 , pp. 48988-48996
    • Lane, S.1    Birse, C.2    Zhou, S.3    Matson, R.4    Liu, H.5
  • 29
    • 48749105018 scopus 로고    scopus 로고
    • Niche-specific gene expression during C. albicans infection
    • Kumamoto CA, (2008) Niche-specific gene expression during C. albicans infection. Curr Opin Microbiol 11: 325-330.
    • (2008) Curr Opin Microbiol , vol.11 , pp. 325-330
    • Kumamoto, C.A.1
  • 30
    • 0033796715 scopus 로고    scopus 로고
    • Candida albicans RIM101 pH response pathway is required for host-pathogen interactions
    • Davis D, Edwards JE Jr, Mitchell AP, Ibrahim AS, (2000) Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect Immun 68: 5953-5959.
    • (2000) Infect Immun , vol.68 , pp. 5953-5959
    • Davis, D.1    Edwards Jr., J.E.2    Mitchell, A.P.3    Ibrahim, A.S.4
  • 31
    • 0033985662 scopus 로고    scopus 로고
    • RIM101-dependent and -independent pathways govern pH responses in Candida albicans
    • Davis D, Wilson RB, Mitchell AP, (2000) RIM101-dependent and-independent pathways govern pH responses in Candida albicans. Mol Cell Biol 20: 971-978.
    • (2000) Mol Cell Biol , vol.20 , pp. 971-978
    • Davis, D.1    Wilson, R.B.2    Mitchell, A.P.3
  • 32
    • 0035801610 scopus 로고    scopus 로고
    • NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction
    • Braun BR, Kadosh D, Johnson AD, (2001) NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction. EMBO J 20 (17): 4753-4761.
    • (2001) EMBO J , vol.20 , Issue.17 , pp. 4753-4761
    • Braun, B.R.1    Kadosh, D.2    Johnson, A.D.3
  • 33
    • 0035103777 scopus 로고    scopus 로고
    • Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans
    • Kadosh D, Johnson AD, (2001) Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans. Mol Cell Biol 21 (7): 2496-2505.
    • (2001) Mol Cell Biol , vol.21 , Issue.7 , pp. 2496-2505
    • Kadosh, D.1    Johnson, A.D.2
  • 34
    • 17944370004 scopus 로고    scopus 로고
    • NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans
    • Murad AMA, Leng P, Straffon M, Wishart J, Macaskill S, et al. (2001) NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J 20 (17): 4742-4752.
    • (2001) EMBO J , vol.20 , Issue.17 , pp. 4742-4752
    • Murad, A.M.A.1    Leng, P.2    Straffon, M.3    Wishart, J.4    Macaskill, S.5
  • 35
    • 14744280227 scopus 로고    scopus 로고
    • Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans
    • Toenjes KA, Munsee SM, Ibrahim AS, Jeffrey RJEE Jr, et al. (2005) Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans. Antimicrob Agents Chemother 49: 963-972.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 963-972
    • Toenjes, K.A.1    Munsee, S.M.2    Ibrahim, A.S.3    Jeffrey Jr., R.J.E.E.4
  • 36
    • 66449119098 scopus 로고    scopus 로고
    • Inhibitors of cellular signaling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans
    • Toenjes KA, Stark BC, Brooks KM, Johnson DI, (2009) Inhibitors of cellular signaling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans. J Med Microbiol 58: 779-790.
    • (2009) J Med Microbiol , vol.58 , pp. 779-790
    • Toenjes, K.A.1    Stark, B.C.2    Brooks, K.M.3    Johnson, D.I.4
  • 37
    • 0142106370 scopus 로고    scopus 로고
    • Integrative, multifunctional plasmids for hypha-specific or constitutive expression of green fluorescent protein in Candida albicans
    • Staab JF, Bahn Y-S, Sundstrom P, (2003) Integrative, multifunctional plasmids for hypha-specific or constitutive expression of green fluorescent protein in Candida albicans. Microbiology 149: 2977-2986.
    • (2003) Microbiology , vol.149 , pp. 2977-2986
    • Staab, J.F.1    Bahn, Y.-S.2    Sundstrom, P.3
  • 38
    • 0032880015 scopus 로고    scopus 로고
    • HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1
    • Sharkey LL, McNemar MD, Saporito-Irwin SM, Sypherd PS, Fonzi WA, (1999) HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1. J Bacteriol 181: 5273-5279.
    • (1999) J Bacteriol , vol.181 , pp. 5273-5279
    • Sharkey, L.L.1    McNemar, M.D.2    Saporito-Irwin, S.M.3    Sypherd, P.S.4    Fonzi, W.A.5
  • 39
    • 10744223983 scopus 로고    scopus 로고
    • N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity
    • Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, et al. (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci USA 100: 13674-13679.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13674-13679
    • Sur, C.1    Mallorga, P.J.2    Wittmann, M.3    Jacobson, M.A.4    Pascarella, D.5
  • 40
    • 0034464742 scopus 로고    scopus 로고
    • Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
    • Gether U, (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocrine Rev 21: 90-113.
    • (2000) Endocrine Rev , vol.21 , pp. 90-113
    • Gether, U.1
  • 41
    • 0035053398 scopus 로고    scopus 로고
    • A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans
    • Bockmuhl DP, Ernst JF, (2001) A potential phosphorylation site for an A-type kinase in the Efg1 regulator protein contributes to hyphal morphogenesis of Candida albicans. Genetics 157 (4): 1523-1530.
    • (2001) Genetics , vol.157 , Issue.4 , pp. 1523-1530
    • Bockmuhl, D.P.1    Ernst, J.F.2
  • 42
    • 0035724309 scopus 로고    scopus 로고
    • Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans
    • Bockmuhl DP, Krishnamurthy S, Gerads M, Sonneborn A, Ernst JF, (2001) Distinct and redundant roles of the two protein kinase A isoforms Tpk1p and Tpk2p in morphogenesis and growth of Candida albicans. Mol Microbiol 42: 1243-1257.
    • (2001) Mol Microbiol , vol.42 , pp. 1243-1257
    • Bockmuhl, D.P.1    Krishnamurthy, S.2    Gerads, M.3    Sonneborn, A.4    Ernst, J.F.5
  • 43
    • 0027403343 scopus 로고
    • Selectivity of inhibition on Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157
    • Cox DA, Conforti L, Sperelakis N, Matlib MA, (1993) Selectivity of inhibition on Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J Cardiovasc Pharmacol 21: 595-599.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 595-599
    • Cox, D.A.1    Conforti, L.2    Sperelakis, N.3    Matlib, M.A.4
  • 44
    • 0021718634 scopus 로고
    • 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets
    • Kawamoto S, Hidaka H, (1984) 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets. Biochem Biophys Res Commun 125: 258-264.
    • (1984) Biochem Biophys Res Commun , vol.125 , pp. 258-264
    • Kawamoto, S.1    Hidaka, H.2
  • 45
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • Schreiber SL, Crabtree GR, (1992) The mechanism of action of cyclosporin A and FK506. Immunol Today 13: 136-142.
    • (1992) Immunol Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 46
    • 0016654038 scopus 로고
    • Studies on the mechanism of action of a new Ca2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles
    • Chiou CY, Malagodi MH, (1975) Studies on the mechanism of action of a new Ca2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles. Br J Pharmacol 53: 279-285.
    • (1975) Br J Pharmacol , vol.53 , pp. 279-285
    • Chiou, C.Y.1    Malagodi, M.H.2
  • 47
    • 0027339649 scopus 로고
    • Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria
    • Vercesi AE, Moreno SNJ, Bernardes CF, Meinicke AR, Fernandes EC, et al. (1993) Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria. J Biol Chem 268: 8564-8568.
    • (1993) J Biol Chem , vol.268 , pp. 8564-8568
    • Vercesi, A.E.1    Moreno, S.N.J.2    Bernardes, C.F.3    Meinicke, A.R.4    Fernandes, E.C.5
  • 48
    • 0025784197 scopus 로고
    • Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase
    • Cho H, Ueda M, Tamaoka M, Hamaguchi M, Aisaka K, et al. (1991) Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase. J Med Chem 34: 1503-1505.
    • (1991) J Med Chem , vol.34 , pp. 1503-1505
    • Cho, H.1    Ueda, M.2    Tamaoka, M.3    Hamaguchi, M.4    Aisaka, K.5
  • 49
    • 0018422346 scopus 로고
    • Slow reacting substance (SRS) from ionophore A23187-stimulated peritoneal mast cells of the normal rat. II. Evidence for a precursor role of arachidonic acid and further purification
    • Yecies LD, Johnson SM, Wedner HJ, Parker CW, (1979) Slow reacting substance (SRS) from ionophore A23187-stimulated peritoneal mast cells of the normal rat. II. Evidence for a precursor role of arachidonic acid and further purification. J Immun 122: 2090-2095.
    • (1979) J Immun , vol.122 , pp. 2090-2095
    • Yecies, L.D.1    Johnson, S.M.2    Wedner, H.J.3    Parker, C.W.4
  • 50
    • 0027278522 scopus 로고
    • Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)
    • Dreyer C, Keller H, Mahfoudi A, Laudet V, Krey G, et al. (1993) Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol Cell 77: 67-76.
    • (1993) Biol Cell , vol.77 , pp. 67-76
    • Dreyer, C.1    Keller, H.2    Mahfoudi, A.3    Laudet, V.4    Krey, G.5
  • 51
    • 0027447461 scopus 로고
    • Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers
    • Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, et al. (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA 90: 2160-2164.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2160-2164
    • Keller, H.1    Dreyer, C.2    Medin, J.3    Mahfoudi, A.4    Ozato, K.5
  • 52
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J, Moller DE, (2002) The mechanisms of action of PPARs. Annu Rev Med 53: 409-435.
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 53
    • 0033883547 scopus 로고    scopus 로고
    • Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmed cell death
    • Maccarrone M, Zadelhoff GV, Veldink GA, Vliegenthart JFG, Finazzi-Agro A, (2000) Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmed cell death. Eur J Biochem 267: 5078-5084.
    • (2000) Eur J Biochem , vol.267 , pp. 5078-5084
    • Maccarrone, M.1    Zadelhoff, G.V.2    Veldink, G.A.3    Vliegenthart, J.F.G.4    Finazzi-Agro, A.5
  • 54
    • 0034040620 scopus 로고    scopus 로고
    • Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via antioxidant action
    • Takami M, Preston SL, Behrman HR, (2000) Eicosatetraynoic and eicosatriynoic acids, lipoxygenase inhibitors, block meiosis via antioxidant action. Am J Physiol Cell Physiol 278: C646-C650.
    • (2000) Am J Physiol Cell Physiol , vol.278
    • Takami, M.1    Preston, S.L.2    Behrman, H.R.3
  • 55
  • 56
    • 36849075751 scopus 로고    scopus 로고
    • Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis
    • Davis-Hanna A, Piispanen AE, Stateva LI, Hogan DA, (2008) Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Mol Microbiol 67: 47-62.
    • (2008) Mol Microbiol , vol.67 , pp. 47-62
    • Davis-Hanna, A.1    Piispanen, A.E.2    Stateva, L.I.3    Hogan, D.A.4
  • 57
    • 0038107709 scopus 로고    scopus 로고
    • Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes
    • Noverr MC, Erb-Downward JR, Huffnagle GB, (2003) Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin Microbiol Rev 16: 517-533.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 517-533
    • Noverr, M.C.1    Erb-Downward, J.R.2    Huffnagle, G.B.3
  • 58
    • 27644599133 scopus 로고    scopus 로고
    • Prostaglandin production during growth of Candida albicans biofilms
    • Alem MAS, Douglas LJ, (2005) Prostaglandin production during growth of Candida albicans biofilms. J Med Microbiol 54: 1001-1005.
    • (2005) J Med Microbiol , vol.54 , pp. 1001-1005
    • Alem, M.A.S.1    Douglas, L.J.2
  • 59
    • 79952833264 scopus 로고    scopus 로고
    • Oxylipins in fungi
    • Brodhun F, Feussner I, (2011) Oxylipins in fungi. FEBS Journal 278: 1047-1063.
    • (2011) FEBS Journal , vol.278 , pp. 1047-1063
    • Brodhun, F.1    Feussner, I.2
  • 60
    • 78651441292 scopus 로고    scopus 로고
    • Lipid signaling in pathogenic fungi
    • Singh A, Poeta MD, (2011) Lipid signaling in pathogenic fungi. Cell Microbiol 13: 177-185.
    • (2011) Cell Microbiol , vol.13 , pp. 177-185
    • Singh, A.1    Poeta, M.D.2
  • 61
    • 0022532881 scopus 로고
    • Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors
    • Inagaki M, Kawamoto S, Itoh H, Saitoh M, Hagiwara M, et al. (1986) Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol 29: 577-581.
    • (1986) Mol Pharmacol , vol.29 , pp. 577-581
    • Inagaki, M.1    Kawamoto, S.2    Itoh, H.3    Saitoh, M.4    Hagiwara, M.5
  • 62
    • 0031983131 scopus 로고    scopus 로고
    • A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
    • Barrington RE, Subler MA, Rands E, Omer CA, Miller PJ, et al. (1998) A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol 18: 85-92.
    • (1998) Mol Cell Biol , vol.18 , pp. 85-92
    • Barrington, R.E.1    Subler, M.A.2    Rands, E.3    Omer, C.A.4    Miller, P.J.5
  • 64
    • 0027166121 scopus 로고
    • Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans
    • Birse CE, Irwin MY, Fonzi WA, Sypherd PS, (1993) Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans. Infec Immun 61: 3648-3655.
    • (1993) Infec Immun , vol.61 , pp. 3648-3655
    • Birse, C.E.1    Irwin, M.Y.2    Fonzi, W.A.3    Sypherd, P.S.4
  • 65
    • 0003529274 scopus 로고
    • Methods in yeast genetics: Laboratory manual
    • (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.)
    • Sherman F, Fink GR, Hicks JB, (1986) Methods in yeast genetics: Laboratory manual. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.).
    • (1986)
    • Sherman, F.1    Fink, G.R.2    Hicks, J.B.3
  • 66
    • 0021742042 scopus 로고
    • Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
    • Gillum AM, Tsay EY, Kirsch DR, (1984) Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198: 179-182.
    • (1984) Mol Gen Genet , vol.198 , pp. 179-182
    • Gillum, A.M.1    Tsay, E.Y.2    Kirsch, D.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.