Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis

EMBO Journal

Volumn 23, Issue 8, 2004, Pages 1845-1856

  Zheng, Xinde ^a   Wang, Yanming ^a   Wang, Yue ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

C. albicans; Cdc28; Hyphal morphogenesis; Polarized growth; Virulence

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE; CYCLINE; PROTEIN HGC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANDIDA ALBICANS; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; FUNGAL VIRULENCE; FUNGUS HYPHAE; FUNGUS MUTANT; GENE DELETION; GENE EXPRESSION; GENE IDENTIFICATION; HWP1 GENE; MORPHOGENESIS; NERVE FIBER GROWTH; NONHUMAN; PHAGOCYTOSIS; PRECIPITATION; PRIORITY JOURNAL;

ACTINS; AMINO ACID SEQUENCE; ANIMALS; CANDIDA ALBICANS; CDC2-CDC28 KINASES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HYPHAE; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; PHENOTYPE; PHYLOGENY; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SURVIVAL RATE; VIRULENCE;

ANIMALIA; CANDIDA; CANDIDA ALBICANS; FUNGI;

EID: 2442548488     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600195     Document Type: Article

References (50)

1. Andrews B, Measday V (1998) The cyclin family of budding yeast: abundant use of a good idea. Trends Genet 14: 66-72
2. Bachewich C, Thomas DY, Whiteway M (2003) Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth. Mol Biol Cell 14: 2163-2180
3. Bai C, Ramanan N, Wang YM, Wang Y (2002) Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice. Mol Microbiol 45: 31-44
4. Bailey DA, Feldmann PJ, Bovey M, Gow NA, Brown AJ (1996) The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins. J Bacteriol 178: 5353-5360
5. Bensen ES, Filler SG, Berman J (2002) A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans. Eukaryot Cell 1: 787-798
6. Berman J, Sudbery PE (2002) Candida albicans: a molecular revolution built on lessons from budding yeast. Nat Rev Genet 3: 918-930
7. Birse CE, Irwin MY, Fonzi WA, Sypherd PS (1993) Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans. Infect Immun 61: 3648-3655
8. Braun BR, Johnson AD (1997) Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277: 105-109
9. Braun BR, Johnson AD (2000) TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans. Genetics 155: 57-67
10. Braun BR, Kadosh D, Johnson AD (2001) NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction. EMBO J 20: 4753-4761
11. Drubin D (2000) Frontiers in Molecular Biology: Cell Polarity. Oxford: Oxford Press
12. Enjalbert B, Nantel A, Whiteway M (2003) Stress-induced gene expression in Candida albicans: absence of a general stress response. Mol Biol Cell 14: 1460-1467
13. Enloe B, Diamond A, Mitchell AP (2000) A single-transformation gene function test in diploid Candida albicans. J Bacteriol 182: 5730-5736
14. Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420: 629-635
15. Fonzi WA, Irwin MY (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728
16. Gow NA, Brown AJ, Odds FC (2002) Fungal morphogenesis and host invasion. Curr Opin Microbiol 5: 366-371
17. Hazan I, Liu H (2002) Hyphal tip-associated localization of Cdc42 is F-actin dependent in Candida albicans. Eukaryot Cell 1: 856-864
18. Hazan I, Sepulveda-Becerra M, Liu H (2002) Hyphal elongation is regulated independently of cell cycle in Candida albicans. Mol Biol Cell 13: 134-145
19. Hu CJ, Bai C, Wang YM, Wang Y (2002) Characterization and functional analysis of the siderophore-iron transporter CaArn1p in Candida albicans. J Biol Chem 277: 30598-30603
20. Kadosh D, Johnson AD (2001) Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans. Mol Cell Biol 21: 2496-2505
21. Kapteyn JC, Hoyer LL, Hecht JE, Muller WH, Andel A, Verkleij AJ, Makarow M, Van Den Ende H, Klis FM (2000) The cell wall architecture of Candida albicans wild-type cells and cell wall-defective mutants. Mol Microbiol 35: 601-611
22. Kron SJ, Styles CA, Fink GR (1994) Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae. Mol Biol Cell 5: 1003-1022
23. Lee KL, Buckley HR, Campbell CC (1975) An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 13: 148-153
24. Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J (2000) Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 64: 746-785
25. Lew DJ, Reed S (1993) Morphogenesis in the yeast cell cycle, regulation by Cdc28 and cyclins. J Cell Biol 120: 1305-1320
26. Li X, Cai M (1999) Recovery of the yeast cell cycle from heat shock-induced G(1) arrest involves a positive regulation of G(1) cyclin expression by the S phase cyclin Clb5. J Biol Chem 274: 24220-24227
27. Liu H (2001) Transcriptional control of dimorphism in Candida albicans. Curr Opin Microbiol 4: 728-735
28. Liu H, Kohler J, Fink GR (1994) Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266: 1723-1726
29. Liu H, Styles CA, Fink GR (1993) Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262: 1741-1744
30. Lo HJ, Kohler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR (1997) Nonfilamentous C. albicans mutants are avirulent. Cell 90: 939-949
31. Loeb JD, Sepulveda-Becerra M, Hazan I, Liu HA (1999) G1 cyclin is necessary for maintenance of filamentous growth in Candida albicans. Mol Cell Biol 19: 4019-4027
32. Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR (2003) Alpha(v)beta3 integrin expression upregulates Cdc2, which modulates cell migration. J Cell Biol 161: 817-826
33. Murad AM, d'Enfert C, Gaillardin C, Tournu H, Tekaia F, Talibi D, Marechal D, Marchais V, Cottin J, Brown AJ (2001c) Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTap1, CaMig1 and CaNrg1. Mol Microbiol 42: 981-993
34. Murad AM, Lee PR, Broadbent ID, Barelle CJ, Brown AJ (2001a) CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16: 325-327
35. Murad AM, Leng P, Straffon M, Wishart J, Macaskill S, MacCallum D, Schnell N, Talibi D, Marechal D, Tekaia F, d'Enfert C, Gaillardin C, Odds FC, Brown AJ (2001b) NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J 20: 4742-4752
36. Naglik JR, Challacombe SJ, Hube B (2003) Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol Mol Biol Rev 67: 400-428
37. Nelson C, Goto S, Lund K, Hung W, Sadowski I (2003) Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12. Nature 421: 187-190
38. Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH (1996) The Cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev 10: 816-825
39. Nurse P (2000) A long twentieth century of the cell cycle and beyond. Cell 100: 71-78
40. Odds FC (1988) Candida and Candidosis, 2nd edn London: Baillière Tindall
41. Ramanan N, Wang Y (2000) A high-affinity iron permease essential for Candida albicans virulence. Science 288: 1062-1064
42. Rocha CR, Schroppel K, Harcus D, Marcil A, Dignard D, Taylor BN, Thomas DY, Whiteway M, Leberer E (2001) Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol Biol Cell 12: 3631-3643
43. Rottmann M, Dieter S, Brunner H, Rupp S (2003) A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis. Mol Microbiol 47: 943-959
44. Rua D, Tobe BT, Kron SJ (2001) Cell cycle control of yeast filamentous growth. Curr Opin Microbiol 4: 720-727
45. Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL (2003) Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell 2: 1053-1060
46. Staab JF, Bradway SD, Fidel PL, Sundstrom P (1999) Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1. Science 283: 1535-1538
47. Stoldt VR, Sonneborn A, Leuker CE, Ernst JF (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16: 1982-1991
48. Surana U, Amon A, Dowzer C, McGrew J, Byers B, Nasmyth K (1993) Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J 12: 1969-1978
49. Wedlich-Soldner R, Altschuler S, Wu L, Li R (2003) Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science 299: 1231-1235
50. Zheng XD, Wang YM, Wang Y (2003) CaSPA2 is important for polarity establishment and maintenance in Candida albicans. Mol Microbiol 49: 1391-1405