AMP-Activated Protein Kinase

Handbook of Cell Signaling, Second Edition

Volumn 2, Issue , 2009, Pages 551-557

  Grahame Hardie, D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882824218     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374145-5.00073-5     Document Type: Chapter

References (85)

1. DG Hardie (2007) AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 47 185-210.
2. DG Hardie (2007) AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8 774-785.
3. DG Hardie (2008) Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease. FEBS Letts 582 81-89.
4. DG Hardie and SA Hawley (2001) AMP-activated protein kinase: the energy charge hypothesis revisited. BioEssays 23 1112-1119.
5. BB Kahn, T Alquier, D Carling and DG Hardie (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1 15-25.
6. DG Hardie, D Carling and M Carlson (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67 821-855.
7. C Polge and M Thomas (2007) SNF1/AMPK/SnRK1 kinases, global regulators at the heart of energy control? Trends Plant Sci 12 20-28.
8. M Thelander, T Olsson and H Ronne (2004) Snf1-related protein kinase 1 is needed for growth in a normal day–night light cycle. EMBO J 23 1900-1910.
9. PCF Cheung, IP Salt, SP Davies, DG Hardie and D Carling (2000) Characterization of AMP-activated protein kinase g subunit isoforms and their role in AMP binding. Biochem J 346 659-669.
10. R Jiang and M Carlson (1997) The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol Cell Biol 17 2099-2106.
11. R Jiang and M Carlson (1996) Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev 10 3105-3115.
12. T Pang, B Xiong, JY Li, et al. (2007) Conserved α-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J Biol Chem 282 495-506.
13. TJ Iseli, M Walter, BJ van Denderen, et al. (2005) AMP-activated protein kinase β subunit tethers α and γsubunits via its C-terminal sequence (186–270). J Biol Chem 280 13,395-13,400.
14. B Xiao, R Heath, P Saiu, et al. (2007) Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449 496-500.
15. GA Amodeo, MJ Rudolph and L Tong (2007) Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature 449 192-495.
16. JW Scott, SA Hawley, KA Green, et al. (2004) CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest 113 274-284.
17. A Bateman (1997) The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem Sci 22 12-13.
18. R Townley and L Shapiro (2007) Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315 1726-1729.
19. ER Hudson, DA Pan, J James, et al. (2003) A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr Biol 13 861-866.
20. G Polekhina, A Gupta, BJ Michell, et al. (2003) AMPK β-subunit targets metabolic stress-sensing to glycogen. Curr Biol 13 867-871.
21. G Polekhina, A Gupta, BJ van Denderen, et al. (2005) Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (Camb) 13 1453-1462.
22. SB Jorgensen, JN Nielsen, JB Birk, et al. (2004) The α2-5′AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. Diabetes 53 3074-3081.
23. F Estruch, MA Treitel, X Yang and M Carlson (1992) N-terminal mutations modulate yeast SNF1 protein kinase function. Genetics 132 639-650.
24. SA Hawley, M Davison, A Woods, et al. (1996) Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein kinase. J Biol Chem 271 27,879-27,887.
25. CM Sutherland, SA Hawley, RR McCartney, et al. (2003) Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol 13 1299-1305.
26. SP Hong, FC Leiper, A Woods, D Carling and M Carlson (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci USA 100 8839-8843.
27. SA Hawley, J Boudeau, JL Reid, et al. (2003) Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J Biology 2 28.
28. A Woods, SR Johnstone, K Dickerson, et al. (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13 2004-2008.
29. SA Hawley, MA Selbert, EG Goldstein, AM Edelman, D Carling and DG Hardie (1995) 5′- AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem 270 27,186-27,191.
30. SA Hawley, DA Pan, KJ Mustard, et al. (2005) Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2 9-19.
31. A Woods, K Dickerson, R Heath, et al. (2005) Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2 21-33.
32. RL Hurley, KA Anderson, JM Franzone, BE Kemp, AR Means and LA Witters (2005) The Ca2+/calmoldulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 280 29,060-29,066.
33. M Suter, U Riek, R Tuerk, U Schlattner, T Wallimann and D Neumann (2006) Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 281 32,207-32,216.
34. SP Davies, NR Helps, PTW Cohen and DG Hardie (1995) 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Cα and native bovine protein phosphatase-2AC. FEBS Letts 377 421-425.
35. MJ Sanders, PO Grondin, BD Hegarty, MA Snowden and D Carling (2007) Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403 139-148.
36. JM Corton, JG Gillespie and DG Hardie (1994) Role of the AMP-activated protein kinase in the cellular stress response. Curr Biol 4 315-324.
37. N Kudo, AJ Barr, RL Barr, S Desai and GD Lopaschuk (1995) High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5′-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270 17,513-17,520.
38. AS Marsin, L Bertrand, MH Rider, et al. (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol 10 1247-1255.
39. LG Fryer, A Parbu-Patel and D Carling (2002) The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways. J Biol Chem 277 25,226-25,232.
40. SL Choi, SJ Kim, KT Lee, et al. (2001) The regulation of AMP-activated protein kinase by H2O2. Biochem Biophys Res Commun 287 92-97.
41. IP Salt, G Johnson, SJH Ashcroft and DG Hardie (1998) AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic b cells, and may regulate insulin release. Biochem J 335 533-539.
42. WA Wilson, SA Hawley and DG Hardie (1996) The mechanism of glucose repression/derepression in yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio. Curr Biol 6 1426-1434.
43. WW Winder and DG Hardie (1996) Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 270 E299-E304.
44. J Mu, JT Brozinick, O Valladares, M Bucan and MJ Birnbaum (2001) A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose ransport in skeletal muscle. Molecular Cell 7 1085-1094.
45. K Sakamoto, A McCarthy, D Smith, et al. (2005) Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 24 1810-1820.
46. SB Jorgensen, B Viollet, F Andreelli, et al. (2004) Knockout of the α2 but not α1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 279 1070-1079.
47. P Tamas, SA Hawley, RG Clarke, et al. (2006) Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med 203 1665-1670.
48. N Stahmann, A Woods, D Carling and R Heller (2006) Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. Mol Cell Biol 26 5933-5945.
49. Thornton C, Sardini A, Carling D. Muscarinic receptor activation of AMP-activated protein kinase inhibits orexigenic neuropeptide mRNA expression. J Biol Chem 2008. in press.
50. Y Minokoshi, YB Kim, OD Peroni, et al. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 339-343.
51. Y Minokoshi, T Alquier, N Furukawa, et al. (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428 569-574.
52. T Yamauchi, J Kamon, Y Minokoshi, et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 6 1288-1295.
53. N Kubota, W Yano, T Kubota, et al. (2007) Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 6 55-68.
54. U Andersson, K Filipsson, CR Abbott, et al. (2004) AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 279 12,005-12,008.
55. B Kola, E Hubina, SA Tucci, et al. (2005) Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 280 25,196-25,201.
56. JW Scott, DG Norman, SA Hawley, L Kontogiannis and DG Hardie (2002) Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate. J Mol Biol 317 309-323.
57. DM Gwinn, DB Shackelford, DF Egan, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30 214-226.
58. WW Winder and DG Hardie (1999) The AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. Am J Physiol 277 E1-E10.
59. PR Clarke and DG Hardie (1990) Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J 9 2439-2446.
60. JM Corton, JG Gillespie, SA Hawley and DG Hardie (1995) 5-Aminoimidazole-4-carboxamide ribonucleoside: a specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem 229 558-565.
61. WW Winder, HA Wilson, DG Hardie, et al. (1997) Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and cAMP-dependent protein kinase. J Appl Physiol 82 219-225.
62. GM Merrill, E Kurth, DG Hardie and WW Winder (1997) AICAR decreases malonyl-CoA and increases fatty acid oxidation in skeletal muscle of the rat. Am J Physiol 273 E1107-E1112.
63. G Zhou, R Myers, Y Li, et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108 1167-1174.
64. RJ Shaw, KA Lamia, D Vasquez, et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642-1646.
65. AK Saha, PR Avilucea, JM Ye, MM Assifi, EW Kraegen and NB Ruderman (2004) Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun 314 580-585.
66. JM Lehmann, LB Moore, TA Smith-Oliver, WO Wilkison, TM Willson and SA Kliewer (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270 12,953-12,956.
67. N Kubota, Y Terauchi, T Kubota, et al. (2006) Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 281 8748-8755.
68. JA Baur, KJ Pearson, NL Price, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 337-342.
69. QF Collins, HY Liu, J Pi, Z Liu, MJ Quon and W Cao (2007) Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase. J Biol Chem 282 30,143-30,149.
70. YS Lee, WS Kim, KH Kim, et al. (2006) Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55 2256-2264.
71. SA Hawley, AE Gadalla, GS Olsen and DG Hardie (2002) The anti-diabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 51 2420-2425.
72. B Cool, B Zinker, W Chiou, et al. (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 3 403-416.
73. O Goransson, A McBride, SA Hawley, et al. (2007) Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282 32,549-32,560.
74. MJ Sanders, ZS Ali, BD Hegarty, R Heath, MA Snowden and D Carling (2007) Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem 282 32,539-32,548.
75. JM Lizcano, O Göransson, R Toth, et al. (2004) LKB1 is a master kinase that activates 13 protein kinases of the AMPK subfamily, including the MARK/PAR-1 kinases. EMBO J 23 833-843.
76. K Imamura, T Ogura, A Kishimoto, M Kaminishi and H Esumi (2001) Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-β-d-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 287 562-567.
77. RG Jones, DR Plas, S Kubek, et al. (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18 283-293.
78. K Inoki, T Zhu and KL Guan (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 577-590.
79. JM Evans, LA Donnelly, AM Emslie-Smith, DR Alessi and AD Morris (2005) Metformin and reduced risk of cancer in diabetic patients. Br Med J 330 1304-1305.
80. SL Bowker, SR Majumdar, P Veugelers and JA Johnson (2006) Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29 254-258.
81. X Huang, S Wullschleger, N Shpiro, et al. (2008) Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 412 211-221.
82. M Arad, CE Seidman and JG Seidman (2007) AMP-activated protein kinase in the heart: role during health and disease. Circ Res 100 474-488.
83. B Burwinkel, JW Scott, C Buhrer, et al. (2005) Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the g2 subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Am J Hum Genet 76 1034-1049.
84. HO Akman, JN Sampayo, FA Ross, et al. (2007) Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma-2 subunit of AMP-activated protein kinase. Pediatr Res 62 499-504.
85. I Luptak, M Shen, H He, et al. (2007) Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest 117 1432-1439.