Molecular function prediction for a family exhibiting evolutionary tendencies toward substrate specificity swapping: Recurrence of tyrosine aminotransferase activity in the Iα subfamily

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 9, 2013, Pages 1593-1609

  Muratore, Kathryn E ^a   Engelhardt, Barbara E ^b,e   Srouji, John R ^a   Jordan, Michael I ^a,b   Brenner, Steven E ^a,c   Kirsch, Jack F ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aspartate aminotransferase; Enzyme; Kinetics; Phylogenetics; Pyridoxal 5' phosphate; Transaminase

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; AROMATIC AMINO ACID; ASPARTATE AMINOTRANSFERASE; HYDROXYPHENYLPYRUVIC ACID; I ALPHA AMINOTRANSFERASE; MITOCHONDRIAL ENZYME; OXALOACETIC ACID; PHENYLPYRUVIC ACID; PYRUVIC ACID DERIVATIVE; TYROSINE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARABIDOPSIS THALIANA; ARTICLE; CAENORHABDITIS ELEGANS; CHLAMYDIA TRACHOMATIS; ELECTROPORATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; GIARDIA LAMBLIA; INFORMATION PROCESSING; MAXIMUM LIKELIHOOD METHOD; MOLECULAR EVOLUTION; NONHUMAN; PARACOCCUS DENITRIFICANS; PHYLOGENETIC TREE; PLASMODIUM FALCIPARUM; PREDICTION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SCORING SYSTEM; SEQUENCE ALIGNMENT; TRYPANOSOMA BRUCEI; VIBRIO CHOLERAE;

ASPARTATE AMINOTRANSFERASE; ENZYME; KINETICS; PHYLOGENETICS; PYRIDOXAL 5'-PHOSPHATE; TRANSAMINASE;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; FUNGAL PROTEINS; KINETICS; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; TRANSAMINASES;

EID: 84882822968     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24318     Document Type: Article

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