The Genetics of Personality

Emery and Rimoin's Principles and Practice of Medical Genetics

Volumn , Issue , 2013, Pages 1-12

  McGue, Matt ^a,b   Matteson, Lindsay K ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882800463     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-383834-6.00111-7     Document Type: Chapter

References (106)

1. D.C. Funder and D.J. Ozer (1997) Pieces of the Personality Puzzle. New York: Norton
2. O.P. John, A. Angleitner and F. Ostendorf (1988) The Lexical Approach to Personality: A Historical Review of Trait Taxonomic Research. Eur. J. Personality 2 171-203.
3. O.P. John and S. Srivastava (1999) The Big Five Trait Taxonomy: History, Measurement, and Theoretical Perspectives. L.A. Pervin, O.P. John (Eds) Handbook of Personality: Theory and Research, 2nd ed New York: Guilford 102-138..
4. R.R. McCrae and A. Terracciano (2005) Personal Profiles Cultures, P., Universal Features of Personality Traits from the Observer’s Perspective: Data from 50 Cultures. J. Pers. Soc. Psychol. 88(3), 547-561.
5. B.B. Lahey (2009) Public Health Significance of Neuroticism. Am. Psychol. 64(4), 241-256..
6. B.W. Roberts, K.E. Walton and T. Bogg (2005) Conscientiousness and Health Across the Life Course. Rev. Gen. Psychol 9(2), 156-168.
7. P.L. Hill, N.A. Turiano, M.D. Hurd, D.K. Mroczek and B.W. Roberts (2011) Conscientiousness and Longevity: An Examination of Possible Mediators. Health Psychol. 30(5), 536-541..
8. M.E. Sadler, C.J. Miller, K. Christensen and M. McGue (2011) Subjective Wellbeing and Longevity: A Co-Twin Control Study. Twin Res. Hum. Genet. 14(3), 249-256.
9. A.E. Poropat (2009) A Meta-Analysis of the Five-Factor Model of Personality and Academic Performance. Psychol. Bull. 135(2), 322-338.
10. M.R. Barrick and M.K. Mount (1991) The Big 5 Personality Dimensions and Job Performance: A Meta-Analysis. Pers. Psychol. 44(1), 1-26.
11. D.J. Ozer and V. Benet-Martinez (2006) Personality and the Prediction of Consequential Outcomes. Annual Review of Psychology Vol. 57 Palo Alto: Annual Reviews 401-421.
12. W. Johnson, M. McGue, R.F. Krueger and T.J. Bouchard (2004) Marriage and Personality: A Genetic Analysis. J. Pers. Soc. Psychol. 86(2), 285-294.
13. V. Jockin, M. McGue and D.T. Lykken (1996) Personality and Divorce: A Genetic Analysis. J. Pers. Soc. Psychol. 71(2), 288-299.
14. B.W. Roberts, N.R. Kuncel, R. Shiner, A. Caspi and L.R. Goldberg (2007) The Power of Personality: The Comparative Validity of Personality Traits, Socioeconomic Status, and Cognitive Ability for Predicting Important Life Outcomes. Perspect. Psychol. Sci. 2(4), 313-345.
15. J.M. Malouff, E.B. Thorsteinsson and N.S. Schutte (2005) The Relationship between the Five-Factor Model of Personality and Symptoms of Clinical Disorders: A Meta-Analysis. J. Psychopathol. Behav. Assess. 27(2), 101-114.
16. J.D. Ranseen, D.A. Campbell and R.A. Baer (1998) NEO PI-R Profiles of Adults with Attention Deficit Disorder. Assessment 5(1), 19-24.
17. M. McGue, W. Slutske and W.G. Iacono (1999) Personality and Substance Use Disorders: II. Alcoholism versus Drug Use Disorders. J. Consult. Clin. Psychol. 67(3), 394-404.
18. A. Caspi, T.E. Moffitt, D.L. Newman and P.A. Silva (1996) Behavioral Observations at Age 3 Years Predict Adult Psychiatric Disorders—Longitudinal Evidence from a Birth Cohort. Arch. Gen. Psychiatry 53(11), 1033-1039.
19. D. Watson, L.A. Clark and A.R. Harkness (1994) Structure of Personality and Their Relevance to Psychopathology. J. Abnorm. Psychol. 103 18-31.
20. J.L. Tackett (2006) Evaluating Models of the Personality-Psychopathology Relationship in Children and Adolescents. Clin. Psychol. Rev. 26(5), 584-599.
21. D.S. Falconer and T. Mackay (1996) Introduction to Quantitative Genetics. 4th ed Harlow, UK: Longman Science and Technology
22. T.J. Bouchard (1997) The Genetics of Personality. K. Blum, E.P. Noble (Eds) Handbook of Psychiatric Genetics Boca Raton, FL: CRC Press 273-296.
23. K.L. Jang, W.J. Livesly and P.A. Vernon (1996) Heritability of the Big Five Personality Dimensions and Their Facets: A Twin Study. J. Pers. 64 577-591..
24. R. Riemann, A. Angleitner and J. Strelau (1997) Genetic and Environmental Influences on Personality: A Study of Twins Reared Together Using the Self- and Peer Report NEO-FFI Scales. J. Pers. 65 449-475..
25. N.G. Waller (1999) Evaluating the Structure of Personality. C.R. Cloninger (Eds) Personality and Psychopathology Washington D.C: American Psychiatric Association 155-197.
26. H. Wolf, A. Angleitner, F.M. Spinath, R. Riemann and J. Strelau (2004) Genetic and Environmental Influences on the EPQ-RS Scales: A Twin Study Using Self- and Peer Reports. Pers. Individ. Differ. 37 579-590.
27. W. Johnson, M. McGue and R.F. Krueger (2005) Personality Stability in Late Adulthood: A Behavioral Genetic Analysis. J. Pers. 73 523-551..
28. J.C. Loehlin and N.G. Martin (2001) Age Changes in Personality Traits and Their Heritabilities During the Adult Years: Evidence from Australian Twin Registry Samples. Pers. Individ. Differ. 30 1147-1160.
29. W. Johnson, R.F. Krueger, T. Bouchard and M. McGue (2002) The Personalities of Twins: Just Ordinary Folks. Twin Res. 5 125-131.
30. T.J. Bouchard and M. McGue (2003) Genetic and Environmental Influences on Human Psychological Differences. J. Neurobiol. 54 4-45..
31. R. Plomin, J.C. DeFries, G.E. McClearn and P. McGuffin (2000) Behavioral Genetics. 4th ed New York: Worth Publishers
32. H. Langinvainio, J. Kaprio, M. Koskenvuo and J. Lonnqvist (1984) Finnish Twins Reared Apart. III: Personality Factors. Acta Genet. Med. Gemellol. 33 259-264..
33. N.L. Pedersen, R. Plomin, G.E. McClearn and L. Friberg (1988) Neuroticism, Extraversion, and Related Traits in Adult Twins Reared Apart and Reared Together. J. Soc. Pers. Psychol. 55 950-957..
34. J. Shields (1962) Monozygotic Twins: Brought Up Apart and Brought Up Together. London: Oxford University Press
35. A. Tellegen, D.T. Lykken, T.J. Bouchard, K.J. Wilcox, N.L. Segal and S. Rich (1988) Personality Similarity in Twins Reared Apart and Together. J. Pers. Soc. Psychol. 54 1031-1039.
36. T. Bouchard, D.T. Lykken, M. McGue, N. Segal and A. Tellegen (1990) Sources of Human Psychological Differences: The Minnesota Study of Twins Reared Apart. Science 250 223-228.
37. J.C. Loehlin (1992) Genes and Environment in Personality Development. Newbury Park, CA: Sage Publications
38. R. Plomin, R. Corley, A. Caspi, D.W. Fulker and J. DeFries (1998) Adoption Results for Self-Reported Personality: Evidence for Nonadditive Genetic Effects? J. Pers. Soc. Psychol. 75 211-218.
39. D. Finkel and M. McGue (1997) Sex Differences and Nonadditivity in Heritability of the Multidimensional Personality Questionnaire Scales. J. Pers. Soc. Psychol. 72 929-938.
40. R. Lake, L.J. Eaves, H. Maes, A.C. Heath and N.G. Martin (2000) Further Evidence Against the Environmental Transmission of Individual Differences in Neuroticism from a Collaborative Study of 45,850 Twins and Relatives on Two Continents. Behav. Genet. 30(3), 223-233.
41. J.C. Loehlin, J.M. Neiderhiser and D. Reiss (2003) The Behavior Genetics of Personaity and the NEAD Study. J. Res. Pers. 37 373-387.
42. S. Bezdjian, L.A. Baker and C. Tuvblad (2011) Genetic and Environmental Influences on Impulsivity: A Meta-Analysis of Twin, Family and Adoption Studies. Clin. Psychol. Rev. 31(7), 1209-1223.
43. J.R. Harris (1998) The Nurture Assumption: Why Children Turn Out the Way They Do. London: Bloomsbury
44. D. Reiss, J.M. Neiderhiser, M. Hetherington and R. Plomin (2000) The Relationship Code: Deciphering Genetic and Social Patterns in Adolescent Development. Cambridge, MA: Harvard University Press
45. P. Molenaar, D.I. Boomsma and C.V. Dolan (1993) A Third Source of Developmental Differences. Behav. Genet. 23 519-524.
46. A. Wong, I.I. Gottesman and A. Petronis (2005) Phenotypic Differences in Genetically Identical Organisms: The Epigenetic Perspective. Hum. Mol. Genet. 14 R11-R18.
47. E. Turkheimer (2000) Three Laws of Behavior Genetics and What They Mean. Curr. Dir. Psychol. Sci. 9 160-164.
48. C.R. Cloninger (1987) Neurogenetic Adaptive Mechanisms in Alcoholism. Science 236 410-416..
49. R.A. Wise and P.P. Rompre (1989) Brain Dopamine and Reward. Annu. Rev. Psychol. 40 191-225.
50. I. Lucki (1998) The Spectrum of Behaviors Influenced by Serotonin. Biol. Psychiatry 44 151-162.
51. F.I. Tarazi and R.J. Baldessarini (1999) Dopamine D-4 Receptors: Significance for Molecular Psychiatry at the Millennium. Mol. Psychiatry 4(6), 529-538.
52. A. Heils, A. Teufel, S. Petri, G. Stober, P. Riederer, D. Bengel and K.P. Lesch (1996) Allelic Variation of Human Serotonin Transporter Gene Expression. J. Neurochem. 66(6), 2621-2624.
53. R.P. Benjamin, O. Novick, R. Umansky, B. Priel, Y. Osher, D. Blaine, E.R. Bennett, L. Nemanov, M. Katz and R.H. Belmaker (1996) Dopamine D4 Recptor (D4DR) Exon III Polymorphism Associated with Human Personality Trait of Novelty Seeking. Nat. Genet. 12 78-80..
54. R.P. Ebstein, O. Novick, R. Umansky, B. Priel, Y. Osher, D. Blaine, E.R. Bennett, L. Nemanov, M. Katz and R.H. Belmaker (1996) Dopamine D4 Receptor (D4DR) Exon III Polymorphism Associated with the Human Personality Trait of Novelty Seeking. Nat. Genet. 12 78-80.
55. C.R. Cloninger, D.M. Svrakic and T.R. Przybeck (1993) A Psychobiological Model of Temperament and Character. Arch. Gen. Psychiatry 50(12), 975-990.
56. K.P. Lesch, D. Bengel, A. Heils, S.Z. Sabol, B.D. Greenberg, S. Petri, J. Benjamin, C.R. Muller, D.H. Hamer and D.L. Murphy (1996) Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region. Science 274(5292), 1527-1531.
57. C.R. Cloninger, R. Adolfsson and N.M. Svrakic (1996) Mapping Genes for Human Personality. Nat. Genet. 12(1), 3-4.
58. J. Ioannidis, E.E. Ntzani, T.A. Trikalinos and D.G. Contopoulos-Ioannidis (2001) Replication Validity of Genetic Association Studies. Nat. Genet. 29(3), 306-309.
59. J. Ioannidis (2008) Why Most Discovered True Associations are Inflated. Epidemiology 19(5), 640-648.
60. M.R. Munafo and J. Flint (2004) Meta-Analysis of Genetic Association Studies. Trends Genet. 20(9), 439-444.
61. Amin, N.; Schuur, M.; Gusareva, E. S.; Isaacs, A.; Aulchenko, Y. S.; Kirichenko, A. V.; Zorkoltseva, I. V.; Axenovich, T. I.; Oostra, B. A.; Janssens, A. C. J. W., et al. A Genome-Wide Linkage Study of Individuals with High Scores on NEO Personality Traits. Mol. Psychiatry In Press, Advanced Publication.
62. N. Risch and K. Merikangas (1996) The Future of Genetic Studies of Complex Human Diseases. Science 273(5281), 1516-1517.
63. F. Calboli, F. Tozzi, N.W. Galwey, A. Antoniades, V. Mooser, M. Preisig, P. Vollenweider, D. Waterworth, G. Waeber, M.R. Johnson, et al. (2010) A Genome-Wide Association Study of Neuroticism in a Population-Based Sample. PLoS One 5(7)
64. S. Shifman, A. Bhomra, S. Smiley, N.R. Wray, M.R. James, N.G. Martin, J.M. Hettema, S.S. An, M.C. Neale, E. Van den Oord, et al. (2008) A Whole Genome Association Study of Neuroticism Using DNA Pooling. Mol. Psychiatry 13(3), 302-312..
65. E. van den Oord, P.H. Kuo, A.M. Hartmann, B.T. Webb, H.J. Moller, J.M. Hettema, I. Giegling, J. Bukszar and D. Rujescu (2008) Genomewide Association Analysis Followed by a Replication Study Implicates a Novel Candidate Gene for Neuroticism. Arch. Gen. Psychiatry 65(9), 1062-1071.
66. A. Terracciano, S. Sanna, M. Uda, B. Deiana, G. Usala, F. Busonero, A. Maschio, M. Scally, N. Patriciu, W.M. Chen, et al. (2010) Genome-Wide Association Scan for Five Major Dimensions of Personality. Mol. Psychiatry 15(6), 647-656.
67. K. Verweij, B.P. Zietsch, S.E. Medland, S.D. Gordon, B. Benyamin, D.R. Nyholt, B.P. McEvoy, P.F. Sullivan, A.C. Heath, P. Madden, et al. (2010) A Genome-Wide Association Study of Cloninger’s Temperament Scales: Implications for the Evolutionary Genetics of Personality. Biol. Psychol. 85(2), 306-317.
68. M. de Moor, P.T. Costa, A. Terracciano, R.F. Krueger, E. de Geus, T. Toshiko, B. Penninx, T. Esko, P. Madden, J. Derringer, et al. (2012) Meta-Analysis of Genome-Wide Association Studies for Personality. Mol. Psychiatry 17 337-349.
69. R.R. McCrae, M. Scally, A. Terracciano, G.R. Abecasis and P.T. Costa (2010) An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model. J. Pers. Soc. Psychol. 99(6), 1014-1024.
70. C.H. Chen, C.S. Chen, R. Moyzis, H. Stern, Q.H. He, H. Li, J. Li, B. Zhu and Q. Dong (2011) Contributions of Dopamine-Related Genes and Environmental Factors to Highly Sensitive Personality: A Multi-Step Neuronal System-Level Approach. PLoS One 6(7)
71. Gottesman II and T.D. Gould (2003) The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions. Am. J. Psychiatry 160(4), 636-645.
72. F. Ducci and D. Goldman (2008) Genetic Approaches to Addiction: Genes and Alcohol. Addiction 103(9), 1414-1428.
73. C.G. DeYoung, J.B. Hirsh, M.S. Shane, X. Papademetris, N. Rajeevan and J.R. Gray (2010) Testing Predictions from Personality Neuroscience: Brain Structure and the Big Five. Psychol. Sci. 21(6), 820-828..
74. A.R. Hariri (2009) The Neurobiology of Individual Differences in Complex Behavioral Traits. Annual Review of Neuroscience Vol. 32 Palo Alto: Annual Reviews 225-247.
75. M.R. Munafo, S.M. Brown and A.R. Hariri (2008) Serotonin Transporter (5-HTTLPR) Genotype and Amygdala Activation: A Meta-Analysis. Biol. Psychiatry 63(9), 852-857.
76. D. Mier, P. Kirsch and A. Meyer-Lindenberg (2010) Neural Substrates of Pleiotropic Action of Genetic Variation in COMT: A Meta-Analysis. Mol. Psychiatry 15(9), 918-927.
77. K.L. Bigos and D.R. Weinberger (2010) Imaging Genetics—Days of Future Past. Neuroimage 53(3), 804-809.
78. S.D. Gosling and O.P. John (1999) Personality Dimensions in NonHuman Animals: A Cross-Species Review. Curr. Dir. Psychol. Sci. 8(3), 69-75.
79. K. van Oers, G. de Jong, A.J. van Noordwijk, B. Kempenaers and P.J. Drent (2005) Contribution of Genetics to the Study of Animal Personalities: A Review of Case Studies. Behaviour 142 1185-1206..
80. A. Weiss, J.E. King and A.J. Figueredo (2000) The Heritability of Personality Factors in Chimpanzees (Pan Troglodytes). Behavior Genetics 30(3), 213-221.
81. P. Korsten, J.C. Mueller, C. Hermannstadter, K.M. Bouwman, N.J. Dingemanse, P.J. Drent, M. Liedvogel, E. Matthysen, K. van Oers, T. van Overveld, et al. (2010) Association between DRD4 Gene Polymorphism and Personality Variation in Great Tits: A Test across Four Wild Populations. Mol. Ecol. 19(4), 832-843.
82. G.D. Gale, R.D. Yazdi, A.H. Khan, A.J. Lusis, R.C. Davis and D.J. Smith (2009) A Genome-Wide Panel of Congenic Mice Reveals Widespread Epistasis of Behavior Quantitative Trait Loci. Mol. Psychiatry 14(6), 631-645.
83. J. Flint, R. Corley, J.C. DeFries, D.W. Fulker, J.A. Gray, S. Miller and A.C. Collins (1995) A Simple Genetic Basis for a Complex Psychological Trait in Laboratory Mice. Science 269(522), 1432-1435.
84. H.K. Gershenfeld, P.E. Neumann, C. Mathis, J.N. Crawley, X. Li and S.M. Paul (1997) Mapping Quantitative Trait Loci for Open-Field Behavior in Mice. Behav. Genet. 27 201-210.
85. B. Caldarone, C. Saavedra, K. Tartaglia, J.M. Wehner, B.C. Dudek and L. Flaherty (1997) Quantitative Trait Loci Analysis Affecting Contextual Conditioning in Mice. Nat. Genet. 17 335-337.
86. J.M. Wehner, R.A. Radcliffe, S.T. Rossmann, S.C. Christensen, D.L. Rasmussen, D.W. Fulker and M. Wiles (1997) Quantitative Trait Locus Analysis of Contextual Fear Conditioning in Mice. Nat. Genet. 17 331-334.
87. A.F. Eisener-Dorman, L. Grabowski-Boase, B.M. Steffy, T. Wiltshire and L.M. Tarantino (2010) Quantitative Trait Locus and Haplotype Mapping in Closely Related Inbred Strains Identifies a Locus for Open Field Behavior. Mamm. Genome 21(5–6), 231-246.
88. C.J. Talbot, R.A. Radcliffe, J. Fullerton, R. Hitzemann, J.N. Wehner and J. Flint (2003) Fine Scale Mapping of a Genetic Locus for Conditioned Fear. Mamm. Genome 14 223-230.
89. J. Flint (2004) The Genetic Basis for Neuroticism. Neurosci. Biobehav. Rev. 28 307-316.
90. K.S. Kendler, C.O. Gardner and C.A. Prescott (2003) Personality and the Experience of Environmental Adversity. Psychol. Med. 33 1193-1202.
91. S. Clarke and I.T. Robertson (2005) A Meta-Analytic Review of the Big Five Personality Factors and Accident Involvement in Occupational and Non-occupational Settings. J. Occup. Organ. Psychol. 78 355-376.
92. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I. Craig, H.L. Harrington, J. McClay, J. Mill, J. Martin, A. Braithwaite, et al. (2003) Influence of Life Stress on Depression: Moderation by Polymorphism in the 5-HTT Gene. Science 301 386-389.
93. A. Caspi, J. McClay, T.E. Moffitt, J. Mill, J. Martin, I.W. Craig, A. Taylor and R. Poulton (2002) Role of Genotype in the Cycle of Violence in Maltreated Children. Science 297 851-854.
94. M. McGue (2010) The End of Behavioral Genetics? Behav. Genet. 40(3), 284-296.
95. N. Risch, R. Herrell, T. Lehner, K.Y. Liang, L. Eaves, J. Hoh, A. Griem, M. Kovacs, J. Ott and K.R. Merikangas (2009) Interaction between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression a Meta-Analysis. JAMA 301(23), 2462-2471.
96. L.E. Duncan and M.C. Keller (2011) A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry. Am. J. Psychiatry 168(10), 1041-1049.
97. D.M. Dick (2011) Gene-Environment Interaction in Psychological Traits and Disorders. S. NolenHoeksema, T.D. Cannon, T. Widiger (Eds) Annu. Rev. Clin. Psychol Vol. 7 Palo Alto: Annual Reviews 383-409.
98. M.R. Munafo, B. Yalcin, S.A. Willis-Owen and J. Flint (2008) Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data. Biol. Psychiatry 63(2), 197-206.
99. M.R. Munafo, N.B. Freimer, W. Ng, R. Ophoff, J. Veijola, J. Miettunen, M.R. Jarvelin, A. Taanila and J. Flint (2009) 5-HTTLPR Genotype and Anxiety-Related Personality Traits: A Meta-Analysis and New Data. Am. J Med. Genet. B-Neuropsychiatr. Genet. 150B(2), 271-281.
100. A. Frustaci, G. Pozzi, F. Gianfagna, L. Manzoli and S. Boccia (2008) Meta-Analysis of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism in Anxiety Disorders and Anxiety-Related Personality Traits. Neuropsychobiology 58(3–4), 163-170.
101. T. Bouchard, D.T. Lykken, M. McGue, N. Segal and A. Tellegen (1990) Sources of Human Psychological Differences: The Minnesota Study of Twins Reared Apart. Science 250 223-228.
102. M. de Moor, P.T. Costa, A. Terracciano, R.F. Krueger, E. de Geus, T. Toshiko and G. Willemsen (2012) Meta-Analysis of Genome-Wide Association Studies for Personality. Mol. Psychiatry 17 337-349.
103. L.E. Duncan and M.C. Keller (2011) A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry. Am. J. Psychiatry 168(10), 1041-1049.
104. R.R. McCrae, M. Scally, A. Terracciano, G.R. Abecasis and P.T. Costa (2010) An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model. J. Pers. Soc. Psychol. 99(6), 1014-1024. [Article]
105. M.R. Munafo, S.M. Brown and A.R. Hariri (2008) Serotonin Transporter (5-HTTLPR) Genotype and Amygdala Activation: A Meta-Analysis. Biol. Psychiatry 63(9), 852-857. [Article]
106. N. Risch, R. Herrell, T. Lehner, K.Y. Liang, L. Eaves, J. Hoh and K.R. Merikangas (2009) Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression a Meta-Analysis. JAMA 301(23), 2462-2471.