The genetic basis of neuroticism

Neuroscience and Biobehavioral Reviews

Volumn 28, Issue 3, 2004, Pages 307-316

  Flint, Jonathan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Neuroticism; Open field activity; Quantitative trait loci

Indexed keywords

DNA;

ANXIETY; AVERSIVE BEHAVIOR; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 14; CHROMOSOME 15; CHROMOSOME 18; CHROMOSOME 19; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 7; EMOTIONALITY; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENETIC VARIABILITY; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; HYPOTHESIS; LINKAGE ANALYSIS; MULTIVARIATE ANALYSIS; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEUROSIS; NONHUMAN; PERSONALITY; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; SIMULATION; UNITED KINGDOM; X CHROMOSOME;

ANIMALS; BEHAVIOR, ANIMAL; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; EMOTIONS; HUMANS; MICE; MICE, INBRED STRAINS; NEUROTIC DISORDERS; SPECIES SPECIFICITY;

EID: 3042689323     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2004.01.004     Document Type: Review

References (63)

1. Bignami G. Selection for high rates and low rates of avoidance conditioning in the rat. Animal Behaviour. 13:1965;221-227
2. Bihl F., Brahic M., Bureau J.F. Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice. Genetics. 152:1999;385-392
3. Broadhurst P.L. Application of biometrical genetics to the inheritance of behaviour. Eysenck H.J. Experiments in personality. 1960;3-102 Routledge and Kegan Paul, London
4. Broadhurst P.L. A note on further progress in a psychogenetic selection experiment. Psychological Reports. 10:1962;65-66
5. Broadhurst P.L., Bignami G. Correlative effect of psychogenetic selection: a study of the Roman high and low avoidance strains of rats. Behaviour Research and Therapy. 2:1965;273-280
6. Caldarone B., Saavedra C., Tartaglia K., Wehner J.M., Dudek B.C., Flaherty L. Quantitative trait loci analysis affecting contextual conditioning in mice. Nature Genetics. 17:1997;335-337
7. Costa P.T., McCrae R.R. Revised NEO personality inventory (NEO-PI-R) and NEO five-factor inventory (NEO-FFI) professional manual. 1992;Psychological Assessment Resources, Inc, Odessa, FL
8. Costall B., Jones B.J., Kelly M.E., Naylor R.J., Tomkins D.M. Exploration of mice in a black and white test box: validation as a model of anxiety. Pharmacology, Biochemistry, and Behavior. 32:1989;777-785
9. Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nature Genetics. 18:1998;19-24
10. Darvasi A., Soller M. A simple method to calculate resolving power and confidence interval of QTL map location. Behavior Genetics. 27:1997;125-132
11. DeFries J.C., Gervais M.C., Thomas E.A. Response to 30 generations of selection for open field activity in laboratory mice. Behavior Genetics. 8:1978;3-13
12. DeFries J.C., Hegman J.P. Genetic analysis of open-field behavior. Lindzey G., Thiessen D.D. Contributions to behavior genetic analysis: the mouse as a prototype. 1970;23-56 Appleton-Century-Crofts, New York
13. DeFries J.C., Wilson J.R., McClearn G.E. Open-field behavior in mice: selection response and situational generality. Behavior Genetics. 1:1970;195-211
14. Dixon L.K., DeFries J.C. Development of open-field behavior in mice: effects of age and experience. Developmental Psychobiology. 1:1968;100-107
15. Doerge R.W. Mapping and analysis of quantitative trait loci in experimental populations. Nature Review. Genetics. 3:2002;43-52
16. Driscoll P., Battig K. Behavioral, emotional and neurochemical profiles of rats selected for extreme differences in active two way avoidance. Lieblich I. Genetics of the brain. 1982;95-123 Elsevier, Amsterdam
17. Driscoll P., Escorihuela R.M., FernandezTeruel A., Giorgi O., Schwegler H., Steimer T., Wiersma A., Corda M.G., Flint J., Koolhaas J.M., Langhans W., Schulz P.E., Siegel J., Tobena A. Genetic selection and differential stress responses - The Roman lines/strains of rats. Annals of the New York Academy of Sciences. 851:1998;501-510
18. Duggan F., Lee A.S., Murray R.M. Does personality predict long-term outcome in depression? British Journal of Psychiatry. 157:1990;19-24
19. Eaves L., Meyer J. Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behavior Genetics. 24:1994;443-455
20. Eaves L.J., Eysenck H.J., Martin N.G. Genes, culture and personality: an empirical approach. 1989;Academic Press, London
21. Eysenck H., Eysenck M.W. Personality and individual differences. A natural science approach. 1985;Plenum Press, New York
22. Falconer D.S., Mackay T.F.C. Quantitative genetics. 1996;Longman, Harlow, UK
23. Fernandez-Teruel A., Escorihuela R.M., Gray J.A., Aguilar R., Gil L., Gimenez-Llort L., Tobena A., Bhomra A., Nicod A., Mott R., Driscoll P., Dawson G.R., Flint J. A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res. 12:2002;618-626
24. Ferre P., Fernandezteruel A., Escorihuela R.M., Driscoll P., Corda M.G., Giorgi O., Tobena A. Behavior of the Roman Verh high-avoidance and low-avoidance rat lines in anxiety tests - relationship with defecation and self-grooming. Physiology and Behavior. 58:1995;1209-1213
25. Flint J. Analysis of quantitative trait loci that influence animal behavior. Journal of Neurobiology. 54:2003;46-77
26. Gershenfeld H.K., Paul S.M. Mapping quantitative trait loci for fear-like behaviors in mice. Genomics. 46:1997;1-8
27. Gray J.A. The neuropsychology of anxiety: an enquiry into the function of the septo-hippocampal system. 1982;Oxford University Press, Oxford
28. Gray J.A. The psychology of fear and stress. 1987;Cambridge University Press, Cambridge
29. Gray J.A., McNaughton N. The neuropsychology of anxiety. 2000;OUP, Oxford
30. Hall C.S. Emotional behaviour in the rat. I. Defecation and urination as measures of individual differences in emotionality. Journal of Comparative Psychology. 22:1934;345-352
31. Hall C.S. Emotional behaviour in the rat: III. The relationship between emotionality and ambulatory activity. Journal of Comparative Psychology. 22:1936;345-352
32. Hall C.S. The inheritance of emotionality in the rat. Psychological Bulletin. 37:1940;432-450
33. Haseman J.K., Elston R.C. The investigation of linkage between a quantitative trait and a marker locus. Behavior Genetics. 2:1972;3-19
34. Hegmann J.P., Defries J.C. Open-field behavior in mice: genetic analysis of repeated measures. Psychonomic Science. 13:1968;27-28
35. Jacob H., Lindpaintner K., Lincoln S., Kusumi K., Bunker R., Mao Y., Ganten D., Dzau V., Lander E. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 67:1991;213-224
36. Kendler K.S., Neale M.C., Kessler R.C., Heath A.C., Eaves L.J. A longitudinal twin study of personality and major depression in women. Archives of General Psychiatry. 50:1993;853-862
37. Kirk K.M., Birley A.J., Statham D.J., Haddon B., Lake R.I., Andrews J.G., Martin N.G. Anxiety and depression in twin and sib pairs extremely discordant and concordant for neuroticism: prodromus to a linkage study. Twin Research. 3:2000;299-309
38. Knott S.A., Haley C.S. Multitrait least squares for quantitative trait loci detection. Genetics. 156:2000;899-911
39. Korol A.B., Ronin Y.I., Itskovich A.M., Peng J., Nevo E. Enhanced efficiency of quantitative trait loci mapping analysis based on multivariate complexes of quantitative traits. Genetics. 157:2001;1789-1803
40. Lake R.I., Eaves L.J., Maes H.H., Heath A.C., Martin N.G. Further evidence against the environmental transmission of individual differences in neuroticism from a collaborative study of 45, 850 twins and relatives on two continents. Behavior Genetics. 30:2000;223-233
41. Legare M.E., Bartlett F.S., Frankel W.N. A major effect QTL determined by multiple genes in epileptic EL mice. Genome Research. 10:2000;42-48
42. Lesch K.-P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1530
43. Loehlin J.C. Genes and environment in personality development. 1992;Sage Publications, London
44. Mott R., Talbot C.J., Turri M.G., Collins A.C., Flint J. A method for fine mapping quantitative trait loci in outbred animal stocks. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;12649-12654
45. Munafo M.R., Clark T.G., Moore L.R., Payne E., Walton R., Flint J. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Molecular Psychiatry. 8:2003;471-484
46. Nagy Z., Glaser D.N. Open-field behavior of C57/BL/6.J mice: effect of illumination, age, and number of test day. Psychonomic Science. 19:1970;273-275
47. Owen E.H., Christensen S.C., Paylor R., Wehner J.M. Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains. Behavioral Neuroscience. 111:1997;292-300
48. Pellow S., Chopin P., File S., Briley M. Validation of open:closed arms entries in an elevated plus maze as a measure of anxiety in the rat. Journal of Neuroscience Methods. 14:1985;149-167
49. Pellow S., File S.E. Anxiolytic and anxiogenic drug effects in exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacology, Biochemistry and Behavior. 24:1986;525-529
50. Puel A., Mevel J.C., Bouthillier Y., Decreusefond C., Fridman W.H., Feingold N., Mouton D. Identification of two quantitative trait loci involved in antibody production on mouse chromosome 8. Immunogenetics. 47:1998;326-331
51. Risch N., Zhang H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science. 268:1995;1584-1589
52. Rose R.J., Koskenvuo M., Kaprio J., Sarna S., Langinvainio H. Shared genes, shared experiences and similarity of personality: data from 14, 288 adult Finnish co-twins. Journal of Personality and Social Psychology. 54:1988;161-171
53. Shepherd J.K., Grewal S.S., Fletcher A., Bill D.J., Dourish C.T. Behavioural and pharmacological characterisation of the elevated zero-maze as an animal model of anxiety. Psychopharmacology (Berl). 116:1994;56-64
54. Talbot C.J., Nicod A., Cherny S.S., Fulker D.W., Collins A.C., Flint J. High-resolution mapping of quantitative trait loci in outbred mice. Nature Genetics. 21:1999;305-308
55. Talbot C.J., Radcliffe R.A., Fullerton J., Hitzemann R., Wehner J.M., Flint J. Fine scale mapping of a genetic locus for conditioned fear. Mammalian Genome. 14:2003;223-230
56. Todd J.A., Aitman T.J., Cornall R.J., Ghosh S., Hall J.R., Hearne C.M., Knight A.M., Love J.M., McAleer M.A., Prins J.B., et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 351:1991;542-547
57. Toubas P.L., Abla K.A., Cao W., Logan L.G., Seale T.W. Latency to enter a mirrored chamber: a novel behavioral assay for anxiolytic agents. Pharmacology, Biochemistry, and Behavior. 35:1990;121-126
58. Trullas R., Jackson B., Skolnick P. Genetic differences in a tail suspension test for evaluating antidepressant activity. Psychopharmacology. 99:1989;287-288
59. Turri M.G., Talbot C.J., Radcliffe R.A., Wehner J.M., Flint J. High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mammalian Genome. 10:1999;1098-1101
60. Visscher P.M., Hopper J.L. Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data. Annals of Human Genetics. 65:2001;583-601
61. Wehner J.M., Radcliffe R.A., Rosmann S.T., Christensen S.C., Rasmussen D.L., Fulker D.W., Wiles M. Quantitative trait locus analysis of contextual fear conditioning in mice. Nature Genetics. 17:1997;331-334
62. Zondervan K.T., Cardon L.R. The complex interplay among factors that influence allelic association. Nature Review. Genetics. 5:2004;89-100
63. Zuckerman M., Kuhlman D.M., Camac C. What lies beyond E and N? Factor analysis of scales believed to measure basic dimensions of personality. Journal of Personality and Social Psychology. 54:1988;96-107