Meta-analysis of genome-wide association studies for personality

Molecular Psychiatry

Volumn 17, Issue 3, 2012, Pages 337-349

  De Moor, M H M ^a   Costa, P T ^b   Terracciano, A ^b   Krueger, R F ^c   De Geus, E J C ^a   Toshiko, T ^b   Penninx, B W J H ^d,e,f   Esko, T ^g,h   Madden, P A F ⁱ   Derringer, J ^c   Amin, N ^j   Willemsen, G ^a   Hottenga, J J ^a   Distel, M A ^a   Uda, M ^k   Sanna, S ^k   Spinhoven, P ^e   Hartman, C A ^d   Sullivan, P ^l   Realo, A ^g   Allik, J ^g   Heath, A C ⁱ   Pergadia, M L ⁱ   Agrawal, A ⁱ   Lin, P ⁱ   Grucza, R ⁱ   Nutile, T ^m   Ciullo, M ^m   Rujescu, D ⁿ   Giegling, I ⁿ   Konte, B ⁿ   Widen, E ^o   Cousminer, D L ^o   Eriksson, J G ^o,p,q,r,s   Palotie, A ^o,t,u   Peltonen, L ^o,t,u   Luciano, M ^v   Tenesa, A ^w   Davies, G ^v   Lopez, L M ^v   Hansell, N K ^x   Medland, S E ^x   Ferrucci, L ^b   Schlessinger, D ^b   Montgomery, G W ^x   Wright, M J ^x   Aulchenko, Y S ^j   Janssens, A C J W ^j   Oostra, B A ^j   Metspalu, A ^g,h   Abecasis, G R ^y   Deary, I J ^v   Raikkonen K ^o   Bierut, L J ⁱ   Martin, N G ^x   Van Duijn, C M ^j   Boomsma, D I ^a   more..

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g UNIVERSITY OF TARTU   (Estonia)

^h UNIVERSITY OF TARTU   (Estonia)

ⁱ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j ERASMUS MEDICAL CENTER   (Netherlands)

^k CNR   (Italy)

^l UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^m INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

ⁿ LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^o UNIVERSITY OF HELSINKI   (Finland)

^p NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^q VAASA CENTRAL HOSPITAL   (Finland)

^r HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^s FOLKHÄLSAN RESEARCH CENTER   (Finland)

^t WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^u BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^v UNIVERSITY OF EDINBURGH   (United Kingdom)

^w WESTERN GENERAL HOSPITAL   (United Kingdom)

^x QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^y UNIVERSITY OF MICHIGAN   (United States)

more..

Author keywords

Five Factor Model; genetic variants; genome wide association; meta analysis; personality

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHROMOSOME 18Q; COMPUTER MODEL; CONTROLLED STUDY; EUROPEAN UNION; EXTRAVERSION; FEMALE; GENE EXPRESSION; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE MAP; HUMAN; MALE; META ANALYSIS; NEUROSIS; ONCOGENE RAS; PERSONALITY; PERSONALITY TEST; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENOSINE TRIPHOSPHATASES; ADULT; AGED; AUSTRALIA; CHROMOSOMES, HUMAN; COMPUTER SIMULATION; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXPLORATORY BEHAVIOR; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MODELS, PSYCHOLOGICAL; PERSONALITY; PERSONALITY INVENTORY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SAMPLING STUDIES; UNITED STATES;

EID: 84857356586     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2010.128     Document Type: Article

References (72)

1. Costa PT, McCrae RR. Professional Manual: Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor-Inventory (NEO-FFI). Psychological Assessment Resources: Odessa, FL, 1992.
2. Samuel DB, Widiger TA. A meta-analytic review of the relationships between the five-factor model and DSM-IV-TR personality disorders: a facet level analysis. Clin Psychol Rev 2008; 28: 1326-1342.
3. Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS. A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 2006; 163: 857-864. (Pubitemid 44464534)
4. Terracciano A, Lockenhoff CE, Zonderman AB, Ferrucci L, Costa PT. Personality predictors of longevity: activity, emotional stability, and conscientiousness. Psychosom Med 2008; 70: 621-627.
5. Dick DM, Aliev F, Wang JC, Grucza RA, Schuckit M, Kuperman S et al. Using dimensional models of externalizing psychopathology to aid in gene identification. Arch Gen Psychiatry 2008; 65: 310-318. (Pubitemid 351342447)
6. Kendler KS, Gatz M, Gardner CO, Pedersen NL. Personality and major depression-a Swedish longitudinal, population-based twin study. Arch Gen Psychiatry 2006; 63: 1113-1120. (Pubitemid 44498390)
7. Lahey BB. Public health significance of neuroticism. Am Psychol 2009; 64: 241-256.
8. Bienvenu OJ, Samuels JF, Costa PT, Reti IM, Eaton WW, Nestadt G. Anxiety and depressive disorders and the five-factor model of personality: a higher-and lower-order personality trait investigation in a community sample. Depress Anxiety 2004; 20: 92-97. (Pubitemid 39441757)
9. Fanous A, Gardner CO, Prescott CA, Cancro R, Kendler KS. Neuroticism, major depression and gender: a Population-Based Twin Study. Psychol Med 2002; 32: 719-728. (Pubitemid 34495689)
10. Kendler KS, Myers J. The genetic and environmental relationship between major depression and the five-factor model of personality. Psychol Med 2009; 40: 1-6.
11. Weiss A, Sutin AR, Duberstein PR, Friedman B, Bagby RM, Costa PT. The personality domains and styles of the five-factor model are related to incident depression in Medicare recipients aged 65 to 100. Am J Geriatr Psychiatry 2009; 17: 591-601.
12. Terracciano A, Costa PT. Smoking and the Five-Factor Model of personality. Addiction 2004; 99: 472-481. (Pubitemid 38496663)
13. Terracciano A, Lockenhoff CE, Crum RM, Bienvenu OJ, Costa PT. Five-factor model personality profiles of drug users. BMC Psychiatry 2008; 8: 22.
14. Saulsman LM, Page AC. The five-factor model and personality disorder empirical literature: a meta-analytic review. Clin Psychol Rev 2004; 23: 1055-1085. (Pubitemid 38077220)
15. Thoresen CJ, Bradley JC, Bliese PD, Thoresen JD. The big five personality traits and individual job performance growth trajectories in maintenance and transitional job stages. J Appl Psychol 2004; 89: 835-853. (Pubitemid 39443371)
16. De Moor MHM, Beem AL, Stubbe JH, Boomsma DI, de Geus EJC. Regular exercise, anxiety, depression and personality: a population-based study. Prev Med 2006; 42: 273-279.
17. Rhodes RE, Smith NEI. Personality correlates of physical activity: a review and meta-analysis. Br J Sports Med 2006; 40: 958-965. (Pubitemid 44902278)
18. Bouchard TJ, Loehlin JC. Genes, evolution, and personality. Behav Genet 2001; 31: 243-273. (Pubitemid 33026085)
19. Vernon PA, Martin RA, Schermer JA, Mackie A. A behavioral genetic investigation of humor styles and their correlations with the Big-5 personality dimensions. Pers Ind Diff 2008; 44: 1116-1125.
20. Distel MA, Trull TJ, Willemsen G, Vink JM, Derom CA, Lynskey MT et al. The Five Factor Model of personality and borderline personality disorder: a genetic analysis of comorbidity. Biol Psychiatry 2009; 66: 1131-1138.
21. Pilia G, Chen WM, Scuteri A, Orru M, Albai G, Dei M et al. Heritability of cardiovascular and personality traits in 6,148 sardinians. Plos Genet 2006; 2: 1207-1223. (Pubitemid 44298495)
22. Jang KL, Livesley WJ, Angleitner A, Riemann R, Vernon PA. Genetic and environmental influences on the covariance of facets defining the domains of the five-factor model of personality. Pers Ind Diff 2002; 33: 83-101.
23. Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG et al. Awhole genome association study of neuroticism using DNA pooling. Mol Psychiatry 2008; 13: 302-312. (Pubitemid 351272652)
24. van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Moller HJ, Hettema JM et al. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Arch Gen Psychiatry 2008; 65: 1062-1071.
25. Kuo PH, Neale MC, Riley BP, Patterson DG, Walsh D, Prescott CA et al. A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence. Am J Med Genet B 2007; 144B: 463-468. (Pubitemid 46983156)
26. Neale BM, Sullivan PF, Kendler KS. A genome scan of neuroticism in nicotine dependent smokers. Am J Med Genet B 2005; 132B: 65-69. (Pubitemid 40066198)
27. Gillespie NA, Zhu G, Evans DM, Medland SE, Wright MJ, Martin NG. A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lie. J Pers 2008; 76: 1415-1446.
28. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S et al. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 2003; 72: 879-890. (Pubitemid 36403307)
29. Nash MW, Huezo-Diaz P, Sterne A, Purcell S, Hoda F, Cherny SS et al. Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. Hum Mol Genet 2004; 13: 2173-2182. (Pubitemid 39359918)
30. Hettema JM, Van den Oord EJCG, An SS, Kendler KS, Chen XN. Follow-up association study of novel neuroticism gene MAMDC1. Psychiatric Genet 2009; 19: 213-214.
31. Terracciano A, Sanna S, Uda M, Deiana B, Usala G, Busonero F et al. Genome-wide association scan for five major dimensions of personality. Mol Psychiatry 2010; 15: 647-656.
32. Boomsma DI, de Geus EJC, Vink JM, Stubbe JH, Distel MA, Hottenga JJ et al. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet 2006; 9: 849-857. (Pubitemid 46093769)
33. Penninx BWJH, Beekman ATF, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al. The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int J Methods Psychiatric Res 2008; 17: 121-140.
34. Manolio TA, Rodriguez LL, Brooks L, Abecasis G, Ballinger D, Daly M et al. New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet 2007; 39: 1045-1051. (Pubitemid 47340660)
35. Boomsma DI, Willemsen G, Sullivan PF, Heutink P, Meijer P, Sondervan D et al. Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. Eur J Hum Genet 2008; 16: 335-342. (Pubitemid 351292233)
36. Sullivan PF, de Geus EJC, Willemsen G, James MR, Smit JH, Zandbelt T et al. Genomewide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009; 14: 359-375.
37. Distel MA, Ligthart L,Willemsen G, Nyholt DR, Trull TJ, Boomsma DI. Personality, health and lifestyle in a questionnaire family study: a comparison between highly cooperative and less cooperative families. Twin Res Hum Genet 2007; 10: 348-353. (Pubitemid 46658531)
38. Pardo LM, MacKay I, Oostra B, van Duijn CM, Aulchenko YS. The effect of genetic drift in a young genetically isolated population. Ann Hum Genet 2005; 69: 288-295. (Pubitemid 40613730)
39. Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E et al. A genome-wide association study of alcohol dependence. Proc Natl Acad Sci USA 2010; 107: 5082-5087.
40. Barker DJP, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353: 1802-1809. (Pubitemid 41549892)
41. Eriksson JG, Osmond C, Kajantie E, Forsen TJ, Barker DJP. Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia 2006; 49: 2853-2858. (Pubitemid 44730287)
42. Raikkonen K, Pesonen AK, Heinonen K, Lahti J, Kajantie E, Forsen T et al. Infant growth and hostility in adult life. Psychosom Med 2008; 70: 306-313. (Pubitemid 351543492)
43. Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF. Genetic linkage findings for DSM-IV nicotine with-drawal in two populations. Am J Med Genet B 2009; 150B: 950-959.
44. Saccone SF, Pergadia ML, Loukola A, Broms U, Montgomery GW, Wang JC et al. Genetic linkage to chromosome 22q12 for a heavysmoking quantitative trait in two independent samples. Am J Hum Genet 2007; 80: 856-866. (Pubitemid 46668454)
45. Aitken JF, Green A, Eldridge A, Green L, Pfitzner J, Battistutta D et al. Comparability of nevus counts between and within examiners, and comparison with computer image-analysis. Br J Cancer 1994; 69: 487-491. (Pubitemid 24076466)
46. Wright MJ, Martin NG. Brisbane adolescent twin study: outline of study methods and research projects. Aus J Psychol 2004; 56: 65-78. (Pubitemid 39216642)
47. Distel MA, Trull TJ, Derom CA, Thiery EW, Grimmer MA, Martin NG et al. Heritability of borderline personality disorder features is similar across three countries. Psychol Med 2008; 38: 1219-1229.
48. Deary IJ, Gow AJ, Taylor MD, Corley J, Brett C, Wilson V et al. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr 2007; 7: 28.
49. Deary IJ, Whiteman MC, Starr JM, Whalley LJ, Fox HC. The impact of childhood intelligence on later life: following up the Scottish Mental Surveys of 1932 and 1947. J Pers Soc Psychol 2004; 86: 130-147. (Pubitemid 38134907)
50. Terracciano A, McCrae RR, Brant LJ, Costa PT. Hierarchical linear modeling analyses of the NEO-PI-R scales in the Baltimore longitudinal study of aging. Psychol Aging 2005; 20: 493-506. (Pubitemid 41572553)
51. Terracciano A, Costa PT, McCrae RR. Personality plasticity after age 30. Pers Soc Psychol Bull 2006; 32: 999-1009. (Pubitemid 44060249)
52. Metspalu A. The Estonian Genome Project. Drug Develop Res 2004; 62: 97-101. (Pubitemid 39578602)
53. Nelis M, Esko T, Magi R, Zimprich F, Zimprich A, Toncheva D et al. Genetic structure of Europeans: a view from the North-East. PLoS ONE 2009; 4: e5472.
54. McCrae RR, Costa PT, Martin TA. The NEO-PI-3: a more readable revised NEO Personality Inventory. J Pers Assess 2005; 84: 261-270. (Pubitemid 40726990)
55. Willemsen G, de Geus EJC, Bartels M, van Beijsterveldt CEM, Brooks AI, Estourgie-van Burk GF et al. The Netherlands Twin Register Biobank: a resource for genetic epidemiological studies. Twin Res Hum Genet 2010; 13: 231-245.
56. Rice JP, Reich T, Bucholz KK, Neuman RJ, Fishman R, Rochberg N et al. Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res 1995; 19: 1018-1023.
57. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition. Biometrics Research Department, New York State Psychiatric Institute: NY, 1995.
58. Folstein MF, Folstein SE, McHugh PR. Mini-Mental-Status-Test, German Edition. Beltz: Weinheim, 1993.
59. Allik J, Laidra K, Realo A, Pullmann H. Personality development from 12 to 18 years of age: changes in mean levels and structure of traits. Eur J Pers 2004; 18: 445-462. (Pubitemid 39621037)
60. Kallasmaa T, Allik J, Realo A, McCrae RR. The Estonian version of the NEO-PI-R: an examination of universal and culture-specific aspects of the five-factor model. Eur J Pers 2000; 14: 265-278.
61. Marchini J, Howie B, Myers S, McVean G, Donnelly P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 2007; 39: 906-913. (Pubitemid 47014502)
62. Chen WM, Abecasis GR. Family-based association tests for genomewide association scans. Am J Hum Genet 2007; 81: 913-926. (Pubitemid 47580246)
63. Abecasis G. METAL. 2009 URL: http://www.sph.umich.edu/csg/abecasis/Metal/ .
64. Dudbridge F, Gusnanto A. Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 2008; 32: 227-234. (Pubitemid 351550369)
65. Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, Brown KM et al. A versatile gene-based test for genome-wide association studies. Am J Hum Genet 2010; 87: 139-145.
66. Liu X, Yu XP, Zack DJ, Zhu H, Qian J. TiGER: a database for tissue-specific gene expression and regulation. BMC Bioinform 2008; 9: 271.
67. Karabay A, Yu WQ, Solowska JM, Baird DH, Baas PW. Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules. J Neurosci 2004; 24: 5778-5788. (Pubitemid 38857232)
68. Lee HH, Jan LY, Jan YN. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci USA 2009; 106: 6363-6368.
69. Toyo-Oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima YY et al. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet 2005; 14: 3113-3128. (Pubitemid 41631287)
70. Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010; 467: 832-838.
71. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR et al. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 2010; 42: 565-569.
72. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ et al. Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.