Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells

Cellular Signalling

Volumn 25, Issue 11, 2013, Pages 2281-2289

  Montero, Juan Carlos ^a   Seoane, Samuel ^a   Pandiella, Atanasio ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Breast cancer; IGF 1; P Rex; Tyrosine kinases

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; P REX1 PROTEIN; PROTEIN TYROSINE KINASE; RAC PROTEIN; SERINE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION;

BREAST CANCER; FGF; FGFR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GAP; GEF; GTPASE ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTOR; IGF-1; IGF-1R; INSULIN-LIKE GROWTH FACTOR-1; INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MTOR; NEUREGULIN; NRG; P-REX; PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE; PHOSPHOINOSITIDE 3-KINASE; PI3K; PIP(3); RECEPTOR TYROSINE KINASES; RTKS; TYROSINE KINASES;

BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; PHOSPHORYLATION; PRIMARY CELL CULTURE; RAC GTP-BINDING PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, IGF TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; SERINE; SIGNAL TRANSDUCTION;

EID: 84882773574     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.07.018     Document Type: Article

References (30)

1. Lemmon M.A., Schlessinger J. Cell 2010, 141(7):1117-1134.
2. Ocana A., Amir E., Seruga B., Martin M., Pandiella A. Cancer Treatment Reviews 2013, 39:68-76.
3. Bustelo X.R. Bioessays 2012, 34(9):748-759.
4. Montero J.C., Seoane S., Ocana A., Pandiella A. Oncogene 2011, 30(9):1059-1071.
5. Sosa M.S., Lopez-Haber C., Yang C., Wang H., Lemmon M.A., Busillo J.M., Luo J., Benovic J.L., Klein-Szanto A., Yagi H., Gutkind J.S., Parsons R.E., Kazanietz M.G. Molecular Cell 2010, 40(6):877-892.
6. Welch H.C., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., Stephens L.R. Cell 2002, 108(6):809-821.
7. Barber M.A., Donald S., Thelen S., Anderson K.E., Thelen M., Welch H.C. The Journal of Biological Chemistry 2007, 282(41):29967-29976.
8. Donald S., Hill K., Lecureuil C., Barnouin R., Krugmann S., John Coadwell W., Andrews S.R., Walker S.A., Hawkins P.T., Stephens L.R., Welch H.C. FEBS Letters 2004, 572(1-3):172-176.
9. Rosenfeldt H., Vazquez-Prado J., Gutkind J.S. FEBS Letters 2004, 572(1-3):167-171.
10. Fine B., Hodakoski C., Koujak S., Su T., Saal L.H., Maurer M., Hopkins B., Keniry M., Sulis M.L., Mense S., Hibshoosh H., Parsons R. Science 2009, 325(5945):1261-1265.
11. Qin J., Xie Y., Wang B., Hoshino M., Wolff D.W., Zhao J., Scofield M.A., Dowd F.J., Lin M.F., Tu Y. Oncogene 2009, 28(16):1853-1863.
12. Berger M.F., Hodis E., Heffernan T.P., Deribe Y.L., Lawrence M.S., Protopopov A., Ivanova E., Watson I.R., Nickerson E., Ghosh P., Zhang H., Zeid R., Ren X., Cibulskis K., Sivachenko A.Y., Wagle N., Sucker A., Sougnez C., Onofrio R., Ambrogio L., Auclair D., Fennell T., Carter S.L., Drier Y., Stojanov P., Singer M.A., Voet D., Jing R., Saksena G., Barretina J., Ramos A.H., Pugh T.J., Stransky N., Parkin M., Winckler W., Mahan S., Ardlie K., Baldwin J., Wargo J., Schadendorf D., Meyerson M., Gabriel S.B., Golub T.R., Wagner S.N., Lander E.S., Getz G., Chin L., Garraway L.A. Nature 2012, 485(7399):502-506.
13. Lindsay C.R., Lawn S., Campbell A.D., Faller W.J., Rambow F., Mort R.L., Timpson P., Li A., Cammareri P., Ridgway R.A., Morton J.P., Doyle B., Hegarty S., Rafferty M., Murphy I.G., McDermott E.W., Sheahan K., Pedone K., Finn A.J., Groben P.A., Thomas N.E., Hao H., Carson C., Norman J.C., Machesky L.M., Gallagher W.M., Jackson I.J., Van Kempen L., Beermann F., Der C., Larue L., Welch H.C., Ozanne B.W., Sansom O.J. Nature Communications 2011, 2:555.
14. Yuste L., Montero J.C., Esparis-Ogando A., Pandiella A. Cancer Research 2005, 65(15):6801-6810.
15. Seoane S., Montero J.C., Ocana A., Pandiella A. Journal of the National Cancer Institute 2010, 102(18):1432-1446.
16. Kumar S.R., Singh J., Xia G., Krasnoperov V., Hassanieh L., Ley E.J., Scehnet J., Kumar N.G., Hawes D., Press M.F., Weaver F.A., Gill P.S. The American Journal of Pathology 2006, 169(1):279-293.
17. Esparis-Ogando A., Ocana A., Rodriguez-Barrueco R., Ferreira L., Borges J., Pandiella A. Annals of Oncology 2008, 19(11):1860-1869.
18. Jain V.K., Turner N.C. Breast Cancer Research 2012, 14(3):208. 208.
19. Garcia-Echeverria C., Pearson M.A., Marti A., Meyer T., Mestan J., Zimmermann J., Gao J., Brueggen J., Capraro H.G., Cozens R., Evans D.B., Fabbro D., Furet P., Porta D.G., Liebetanz J., Martiny-Baron G., Ruetz S., Hofmann F. Cancer Cell 2004, 5(3):231-239.
20. Hernandez-Negrete I., Carretero-Ortega J., Rosenfeldt H., Hernandez-Garcia R., Calderon-Salinas J.V., Reyes-Cruz G., Gutkind J.S., Vazquez-Prado J. The Journal of Biological Chemistry 2007, 282(32):23708-23715.
21. Garcia-Martinez J.M., Moran J., Clarke R.G., Gray A., Cosulich S.C., Chresta C.M., Alessi D.R. The Biochemical Journal 2009, 421(1):29-42.
22. Montero J.C., Chen X., Ocana A., Pandiella A. Molecular Cancer Therapeutics 2012, 11(6):1342-1352.
23. Maira S.M., Stauffer F., Brueggen J., Furet P., Schnell C., Fritsch C., Brachmann S., Chene P., De Pover A., Schoemaker K., Fabbro D., Gabriel D., Simonen M., Murphy L., Finan P., Sellers W., Garcia-Echeverria C. Molecular Cancer Therapeutics 2008, 7(7):1851-1863.
24. Peterson T.R., Laplante M., Thoreen C.C., Sancak Y., Kang S.A., Kuehl W.M., Gray N.S., Sabatini D.M. Cell 2009, 137(5):873-886.
25. Thoreen C.C., Chantranupong L., Keys H.R., Wang T., Gray N.S., Sabatini D.M. Nature 2012, 485(7396):109-113.
26. Karamouzis M.V., Papavassiliou A.G. Critical Reviews in Oncology/Hematology 2012, 84(1):8-17.
27. Kim E.K., Yun S.J., Ha J.M., Kim Y.W., Jin I.H., Yun J., Shin H.K., Song S.H., Kim J.H., Lee J.S., Kim C.D., Bae S.S. Oncogene 2011, 30(26):2954-2963.
28. Pandiella A., Montero J.C. Clinical Cancer Research 2013, (PMDI: 23753921, in press). 10.1158/1078-0432.CCR-12-1662.
29. Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Science 2005, 307(5712):1098-1101.
30. Balamatsias D., Kong A.M., Waters J.E., Sriratana A., Gurung R., Bailey C.G., Rasko J.E., Tiganis T., Macaulay S.L., Mitchell C.A. The Journal of Biological Chemistry 2011, 286(50):43229-43240.