Role of the cyclooxygenase 2-thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo

Toxicology and Applied Pharmacology

Volumn 234, Issue 1, 2009, Pages 33-40

  Teraoka, Hiroki ^a   Kubota, Akira ^a   Dong, Wu ^a,b   Kawai, Yusuke ^a   Yamazaki, Koji ^c   Mori, Chisato ^c   Harada, Yoshiteru ^d   Peterson, Richard E ^e   Hiraga, Takeo ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b INNER MONGOLIA UNIVERSITY FOR NATIONALITIES   (China)

^c CHIBA UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Blood flow; Cardiovascular toxicity; COX 1; COX 2; CYP5A; Danio rerio; Halogenated aromatic hydrocarbon; Prostaglandin; TCDD; Thromboxane; Zebrafish embryo

Indexed keywords

1 ACETYL 2 (8 CHLORO 10,11 DIHYDRODIBENZ[B,F][1,4]OXAZEPINE 10 CARBONYL)HYDRAZINE; 11 FLUORO 9,15 DIHYDROXY 15 (2 INDANYL) 16,17,18,19,20 PENTANORPROSTA 5,13 DIENOIC ACID; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 6 [2 (2 CHLOROPHENYL) 4 (2 HYDROXYPHENYL) 1,3 DIOXAN 5 YL] 4 HEXENOIC ACID; ANTISENSE OLIGONUCLEOTIDE; CAY 10441; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ELONGATION FACTOR 1ALPHA; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EDEMA; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; ENZYME INHIBITION; GENE EXPRESSION; MESENCEPHALON; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROSTAGLANDIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZEBRA FISH;

ANIMALS; CYCLOOXYGENASE 2; EMBRYO, NONMAMMALIAN; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; MESENCEPHALON; PROSTAGLANDINS; RECEPTORS, THROMBOXANE; REGIONAL BLOOD FLOW; TETRACHLORODIBENZODIOXIN; THROMBOXANE-A SYNTHASE; ZEBRAFISH;

DANIO RERIO;

EID: 57149107118     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.09.021     Document Type: Article

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