A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin.

Drug metabolism letters

Volumn 4, Issue 4, 2010, Pages 185-194

  Zhang, J G ^a   Ho, Thuy ^b   Callendrello, Alanna L ^b   Crespi, Charles L ^b   Stresser, David M ^b  

^a BD Biosciences Discovery Labware   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA NAPHTHOFLAVONE; CYP1A2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 1A2; CYTOCHROME P450 3A; MESSENGER RNA; N DEMETHYLASE; PHENOBARBITAL; RIFAMPICIN; S MEPHENYTOIN N DEMETHYLASE; S-MEPHENYTOIN N-DEMETHYLASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BIOASSAY; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; ENZYME INDUCTION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; LIVER CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STANDARD; TIME; WESTERN BLOTTING;

ARYL HYDROCARBON HYDROXYLASES; BETA-NAPHTHOFLAVONE; BIOLOGICAL ASSAY; BLOTTING, WESTERN; CELLS, CULTURED; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDPOINT DETERMINATION; ENZYME INDUCTION; HEPATOCYTES; HUMANS; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFAMPIN; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 78650336624     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231210792928224     Document Type: Article

References (0)