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Volumn 11, Issue 7, 2013, Pages 855-866

Targeted silencing of BjMYB28 transcription factor gene directs development of low glucosinolate lines in oilseed Brassica juncea

Author keywords

Brassica juncea; Glucosinolates; MYB28; RNAi suppression; Secondary metabolites; Transgenic plants

Indexed keywords

BRASSICA; BRASSICA JUNCEA;

EID: 84882709816     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12078     Document Type: Article
Times cited : (64)

References (52)
  • 1
    • 84856146029 scopus 로고    scopus 로고
    • RNA interference in designing transgenic crops
    • Ali, N., Datta, S.K. and Datta, K. (2010) RNA interference in designing transgenic crops. GM Crops, 1, 207-213.
    • (2010) GM Crops , vol.1 , pp. 207-213
    • Ali, N.1    Datta, S.K.2    Datta, K.3
  • 2
    • 35848967577 scopus 로고    scopus 로고
    • A passage through in vitro culture leads to efficient production of true marker-free transgenic plants in Brassica juncea using the Cre-loxP system
    • Arumugam, N., Gupta, V., Jagannath, A., Mukhopadhyay, A., Pradhan, A.K., Burma, P.K. and Pental, D. (2007) A passage through in vitro culture leads to efficient production of true marker-free transgenic plants in Brassica juncea using the Cre-loxP system. Trans. Res. 16, 703-712.
    • (2007) Trans. Res. , vol.16 , pp. 703-712
    • Arumugam, N.1    Gupta, V.2    Jagannath, A.3    Mukhopadhyay, A.4    Pradhan, A.K.5    Burma, P.K.6    Pental, D.7
  • 3
    • 58549109807 scopus 로고    scopus 로고
    • Fine mapping of loci involved with glucosinolate biosynthesis in oilseed mustard (Brassica juncea) using genomic information from allied species
    • Bisht, N.C., Gupta, V., Ramchiary, N., Sodhi, Y.S., Mukhopadhyay, A., Arumugam, N., Pental, D. and Pradhan, A.K. (2009) Fine mapping of loci involved with glucosinolate biosynthesis in oilseed mustard (Brassica juncea) using genomic information from allied species. Theor. Appl. Genet. 118, 413-421.
    • (2009) Theor. Appl. Genet. , vol.118 , pp. 413-421
    • Bisht, N.C.1    Gupta, V.2    Ramchiary, N.3    Sodhi, Y.S.4    Mukhopadhyay, A.5    Arumugam, N.6    Pental, D.7    Pradhan, A.K.8
  • 4
    • 0030793027 scopus 로고    scopus 로고
    • Will low-glucosinolate lines of the mustards Brassica juncea and Sinapis alba be vulnerable to insect pests?
    • Bodnaryk, R.P. (1997) Will low-glucosinolate lines of the mustards Brassica juncea and Sinapis alba be vulnerable to insect pests? Can. J. Plant Sci. 77, 283-287.
    • (1997) Can. J. Plant Sci. , vol.77 , pp. 283-287
    • Bodnaryk, R.P.1
  • 5
    • 0037311116 scopus 로고    scopus 로고
    • Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana
    • Brown, P.D., Tokuhisa, J.G., Reichelt, M. and Gershenzon, J. (2003) Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana. Phytochemistry, 62, 471-481.
    • (2003) Phytochemistry , vol.62 , pp. 471-481
    • Brown, P.D.1    Tokuhisa, J.G.2    Reichelt, M.3    Gershenzon, J.4
  • 6
    • 84882580091 scopus 로고    scopus 로고
    • and Performance of Australian canola quality Indian mustard breeding lines. Proceedings 10th Int. Rapeseed Congress, Canberra, Australia, 26-29 September (CD-ROM).
    • Burton, W.A., Pymer, S.J., Salisbury, P.A., Kirk, J.T.O. and Oram, R.N. (1999) Performance of Australian canola quality Indian mustard breeding lines. Proceedings 10th Int. Rapeseed Congress, Canberra, Australia, 26-29 September (CD-ROM).
    • (1999)
    • Burton, W.A.1    Pymer, S.J.2    Salisbury, P.A.3    Kirk, J.T.O.4    Oram, R.N.5
  • 7
    • 0000177833 scopus 로고    scopus 로고
    • Molecular markers for low-glucosinolate alleles in oilseed rape (Brassica napus L.)
    • Campos de Quiros, H.C. and Mithen, R. (1996) Molecular markers for low-glucosinolate alleles in oilseed rape (Brassica napus L.). Mol. Breed. 2, 277-281.
    • (1996) Mol. Breed. , vol.2 , pp. 277-281
    • Campos de Quiros, H.C.1    Mithen, R.2
  • 8
    • 43049096784 scopus 로고    scopus 로고
    • Glucosinolates in Brassica foods: bioavailability in food and significance for human health
    • Cartea, M.E. and Velasco, P. (2008) Glucosinolates in Brassica foods: bioavailability in food and significance for human health. Phytochem. Rev. 7, 213-229.
    • (2008) Phytochem. Rev. , vol.7 , pp. 213-229
    • Cartea, M.E.1    Velasco, P.2
  • 9
    • 84861012383 scopus 로고    scopus 로고
    • Evaluation of candidate reference genes for gene expression normalization in Brassica juncea using real time quantitative RT-PCR
    • Chandna, R., Augustine, R. and Bisht, N.C. (2012) Evaluation of candidate reference genes for gene expression normalization in Brassica juncea using real time quantitative RT-PCR. PLoS ONE, 7, e36918.
    • (2012) PLoS ONE , vol.7
    • Chandna, R.1    Augustine, R.2    Bisht, N.C.3
  • 10
  • 11
    • 77954188270 scopus 로고    scopus 로고
    • Glucosinolates, structures and analysis in food
    • Clarke, D.B. (2010) Glucosinolates, structures and analysis in food. Anal. Methods, 2, 310-325.
    • (2010) Anal. Methods , vol.2 , pp. 310-325
    • Clarke, D.B.1
  • 12
    • 58149242371 scopus 로고    scopus 로고
    • Glucosinolate metabolites required for an Arabidopsis innate immune response
    • Clay, N.K., Adio, A.M., Carine, C., Jander, G. and Ausubel, F.M. (2009) Glucosinolate metabolites required for an Arabidopsis innate immune response. Science, 323, 95-101.
    • (2009) Science , vol.323 , pp. 95-101
    • Clay, N.K.1    Adio, A.M.2    Carine, C.3    Jander, G.4    Ausubel, F.M.5
  • 14
    • 0030931522 scopus 로고    scopus 로고
    • Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
    • Fahey, J.W., Zhang, Y. and Talalay, P. (1997) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl Acad. Sci. USA, 94, 10367-10372.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10367-10372
    • Fahey, J.W.1    Zhang, Y.2    Talalay, P.3
  • 15
    • 0035808553 scopus 로고    scopus 로고
    • The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    • Fahey, J.W., Zalcmann, A.T. and Talalay, P. (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry, 56, 5-51.
    • (2001) Phytochemistry , vol.56 , pp. 5-51
    • Fahey, J.W.1    Zalcmann, A.T.2    Talalay, P.3
  • 16
    • 82955237367 scopus 로고    scopus 로고
    • Characterization of metabolite quantitative trait loci and metabolic networks that control glucosinolate concentration in the seeds and leaves of Brassica napus
    • Feng, J., Long, Y., Shi, L., Shi, J., Barker, G. and Meng, J. (2012) Characterization of metabolite quantitative trait loci and metabolic networks that control glucosinolate concentration in the seeds and leaves of Brassica napus. New Phytol. 193, 96-108.
    • (2012) New Phytol. , vol.193 , pp. 96-108
    • Feng, J.1    Long, Y.2    Shi, L.3    Shi, J.4    Barker, G.5    Meng, J.6
  • 17
    • 0030948221 scopus 로고    scopus 로고
    • Glucosinolates and disease resistance in oilseed rape (Brassica napus spp oleifera)
    • Giamoustaris, A. and Mithen, R. (1997) Glucosinolates and disease resistance in oilseed rape (Brassica napus spp oleifera). Plant. Pathol. 46, 271-275.
    • (1997) Plant. Pathol. , vol.46 , pp. 271-275
    • Giamoustaris, A.1    Mithen, R.2
  • 18
    • 34447094126 scopus 로고    scopus 로고
    • The R2R3-MYB transcription factor HAG1/MYB28 is a regulator of methionine-derived glucosinolate biosynthesis in Arabidopsis thaliana
    • Gigolashvili, T., Yatusevich, R., Berger, B., Muller, C. and Flugge, U.I. (2007) The R2R3-MYB transcription factor HAG1/MYB28 is a regulator of methionine-derived glucosinolate biosynthesis in Arabidopsis thaliana. Plant J. 51, 247-261.
    • (2007) Plant J. , vol.51 , pp. 247-261
    • Gigolashvili, T.1    Yatusevich, R.2    Berger, B.3    Muller, C.4    Flugge, U.I.5
  • 19
    • 58149328651 scopus 로고    scopus 로고
    • Specific and coordinated control of indole and aliphatic glucosinolate biosynthesis by R2R3-MYB transcription factors in Arabidopsis thaliana
    • Gigolashvili, T., Berger, B. and Flugge, U.I. (2009) Specific and coordinated control of indole and aliphatic glucosinolate biosynthesis by R2R3-MYB transcription factors in Arabidopsis thaliana. Phytochem. Rev. 8, 3-13.
    • (2009) Phytochem. Rev. , vol.8 , pp. 3-13
    • Gigolashvili, T.1    Berger, B.2    Flugge, U.I.3
  • 20
    • 32544436982 scopus 로고    scopus 로고
    • Glucosinolate metabolism and its control
    • Grubb, C.D. and Abel, S. (2006) Glucosinolate metabolism and its control. Trends Plant Sci. 11, 89-100.
    • (2006) Trends Plant Sci. , vol.11 , pp. 89-100
    • Grubb, C.D.1    Abel, S.2
  • 21
    • 33745218882 scopus 로고    scopus 로고
    • Biology and biochemistry of glucosinolates
    • Halkier, B.A. and Gershenzon, J. (2006) Biology and biochemistry of glucosinolates. Annu. Rev. Plant Biol. 57, 303-333.
    • (2006) Annu. Rev. Plant Biol. , vol.57 , pp. 303-333
    • Halkier, B.A.1    Gershenzon, J.2
  • 23
    • 43149099706 scopus 로고    scopus 로고
    • The cancer chemopreventive action of phytochemicals derived from glucosinolates
    • Hayes, J.D., Kelleher, M.O. and Eggleston, I.M. (2008) The cancer chemopreventive action of phytochemicals derived from glucosinolates. Eur. J. Nutr. 47, 73-88.
    • (2008) Eur. J. Nutr. , vol.47 , pp. 73-88
    • Hayes, J.D.1    Kelleher, M.O.2    Eggleston, I.M.3
  • 24
    • 33746655320 scopus 로고    scopus 로고
    • Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels
    • Hill, J., Nelson, E., Tilman, D., Polasky, S. and Tiffany, D. (2006) Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels. Proc. Natl Acad. Sci. USA, 103, 11206-11210.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 11206-11210
    • Hill, J.1    Nelson, E.2    Tilman, D.3    Polasky, S.4    Tiffany, D.5
  • 26
    • 60549091080 scopus 로고    scopus 로고
    • Role of glucosinolates in insect plant relationships and multitrophic interactions
    • Hopkins, R.J., van Dam, N.M. and van Loon, J.J.A. (2009) Role of glucosinolates in insect plant relationships and multitrophic interactions. Annu. Rev. Entomol. 54, 57-83.
    • (2009) Annu. Rev. Entomol. , vol.54 , pp. 57-83
    • Hopkins, R.J.1    van Dam, N.M.2    van Loon, J.J.A.3
  • 28
    • 33847354310 scopus 로고    scopus 로고
    • Myzus persicae (green peach aphid) feeding on Arabidopsis induces the formation of a deterrent indole glucosinolate
    • Kim, J.H. and Jander, G. (2007) Myzus persicae (green peach aphid) feeding on Arabidopsis induces the formation of a deterrent indole glucosinolate. Plant J. 49, 1008-1019.
    • (2007) Plant J. , vol.49 , pp. 1008-1019
    • Kim, J.H.1    Jander, G.2
  • 30
    • 57649136468 scopus 로고    scopus 로고
    • Competition, herbivory and genetics interact to determine the accumulation and fitness consequences of a defense metabolite
    • Lankau, R.A. and Kliebenstein, D.J. (2009) Competition, herbivory and genetics interact to determine the accumulation and fitness consequences of a defense metabolite. J. Ecol. 97, 78-88.
    • (2009) J. Ecol. , vol.97 , pp. 78-88
    • Lankau, R.A.1    Kliebenstein, D.J.2
  • 31
    • 0141872958 scopus 로고    scopus 로고
    • Transgene-induced RNA interference: a strategy for overcoming gene redundancy in polyploids to generate loss-of-function mutations
    • Lawrence, R.J. and Pikaard, C.S. (2003) Transgene-induced RNA interference: a strategy for overcoming gene redundancy in polyploids to generate loss-of-function mutations. Plant J. 36, 114-121.
    • (2003) Plant J. , vol.36 , pp. 114-121
    • Lawrence, R.J.1    Pikaard, C.S.2
  • 32
    • 4544282106 scopus 로고    scopus 로고
    • Genetic analysis of agronomic and quality traits in mustard (Brassica juncea)
    • Lionneton, E., Aubert, G., Ochatt, S. and Merah, O. (2004) Genetic analysis of agronomic and quality traits in mustard (Brassica juncea). Theor. Appl. Genet. 109, 792-799.
    • (2004) Theor. Appl. Genet. , vol.109 , pp. 792-799
    • Lionneton, E.1    Aubert, G.2    Ochatt, S.3    Merah, O.4
  • 33
    • 79953029685 scopus 로고    scopus 로고
    • MAM gene silencing leads to the induction of C3 and reduction of C4 and C5 side-chain aliphatic glucosinolates in Brassica napus
    • Liu, Z., Hammerlindl, J., Keller, W., McVetty, P.B.E., Daayf, F., Quiros, C.F. and Li, G. (2011) MAM gene silencing leads to the induction of C3 and reduction of C4 and C5 side-chain aliphatic glucosinolates in Brassica napus. Mol. Breed. 27, 467-478.
    • (2011) Mol. Breed. , vol.27 , pp. 467-478
    • Liu, Z.1    Hammerlindl, J.2    Keller, W.3    McVetty, P.B.E.4    Daayf, F.5    Quiros, C.F.6    Li, G.7
  • 34
    • 84859949615 scopus 로고    scopus 로고
    • Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the glucosinolate-ALK gene family
    • Liu, Z., Hirani, A.H., McVetty, P.B.E., Daayf, F., Quiros, C.F. and Li, G. (2012) Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the glucosinolate-ALK gene family. Plant Mol. Biol. 79, 179-189.
    • (2012) Plant Mol. Biol. , vol.79 , pp. 179-189
    • Liu, Z.1    Hirani, A.H.2    McVetty, P.B.E.3    Daayf, F.4    Quiros, C.F.5    Li, G.6
  • 35
    • 0345358629 scopus 로고    scopus 로고
    • Molecular mapping of seed aliphatic glucosinolates in Brassica juncea
    • Mahmood, T., Ekuere, U., Yeh, F., Good, A.G. and Stringam, G.R. (2003) Molecular mapping of seed aliphatic glucosinolates in Brassica juncea. Genome, 46, 753-760.
    • (2003) Genome , vol.46 , pp. 753-760
    • Mahmood, T.1    Ekuere, U.2    Yeh, F.3    Good, A.G.4    Stringam, G.R.5
  • 37
    • 84984529490 scopus 로고
    • Rapeseed meal-glucosinolates and their antinutritional effects. Part II. Flavour and palatability
    • Mawson, R., Heaney, R.K., Zdunczyk, Z. and Kozlowska, H. (1993) Rapeseed meal-glucosinolates and their antinutritional effects. Part II. Flavour and palatability. Mol. Nutr. Food Res. 37, 336-344.
    • (1993) Mol. Nutr. Food Res. , vol.37 , pp. 336-344
    • Mawson, R.1    Heaney, R.K.2    Zdunczyk, Z.3    Kozlowska, H.4
  • 38
    • 0023108937 scopus 로고
    • Characterization and sequence determination of the replicatory region in the hairy-root-inducing plasmid pRiA4b
    • Nishiguchi, R., Takanami, M. and Oka, A. (1981) Characterization and sequence determination of the replicatory region in the hairy-root-inducing plasmid pRiA4b. Mol. Gen. Genet. 206, 1-8.
    • (1981) Mol. Gen. Genet. , vol.206 , pp. 1-8
    • Nishiguchi, R.1    Takanami, M.2    Oka, A.3
  • 40
    • 84882566814 scopus 로고    scopus 로고
    • and Canola quality Brassica juncea, a new oilseed crop for the Canadian prairies. Proceedings 10th Int. Rapeseed Congress, Canberra, Australia, 26-29 September (CD-ROM).
    • Potts, D., Rakow, G. and Males, D.R. (1999) Canola quality Brassica juncea, a new oilseed crop for the Canadian prairies. Proceedings 10th Int. Rapeseed Congress, Canberra, Australia, 26-29 September (CD-ROM).
    • (1999)
    • Potts, D.1    Rakow, G.2    Males, D.R.3
  • 41
    • 0027144938 scopus 로고
    • Heterosis breeding in Indian mustard (Brassica juncea L. Czern & Coss): analysis of com-ponent characters contributing to heterosis for yield
    • Pradhan, A.K., Sodhi, Y.S., Mukhopadhyay, A. and Pental, D. (1993) Heterosis breeding in Indian mustard (Brassica juncea L. Czern & Coss): analysis of com-ponent characters contributing to heterosis for yield. Euphytica, 69, 219-229.
    • (1993) Euphytica , vol.69 , pp. 219-229
    • Pradhan, A.K.1    Sodhi, Y.S.2    Mukhopadhyay, A.3    Pental, D.4
  • 42
    • 36348932230 scopus 로고    scopus 로고
    • QTL analysis reveals context-dependent loci for seed glucosinolate trait in the oilseed Brassica juncea: importance of recurrent selection backcross (RSB) scheme for the identification of 'true' QTL
    • Ramchiary, N., Bisht, N.C., Gupta, V., Mukhopadhyay, A., Arumugam, N., Sodhi, Y.S., Pental, D. and Pradhan, A.K. (2007) QTL analysis reveals context-dependent loci for seed glucosinolate trait in the oilseed Brassica juncea: importance of recurrent selection backcross (RSB) scheme for the identification of 'true' QTL. Theor. Appl. Genet. 116, 77-85.
    • (2007) Theor. Appl. Genet. , vol.116 , pp. 77-85
    • Ramchiary, N.1    Bisht, N.C.2    Gupta, V.3    Mukhopadhyay, A.4    Arumugam, N.5    Sodhi, Y.S.6    Pental, D.7    Pradhan, A.K.8
  • 43
    • 0036942580 scopus 로고    scopus 로고
    • Genetic analysis of total glucosinolate in crosses involving a high glucosinolate Indian variety and a low glucosinolate line of Brassica juncea
    • Sodhi, Y.S., Mukhopadhyay, A., Arumugam, N., Verma, J.K., Gupta, V., Pental, D. and Pradhan, A.K. (2002) Genetic analysis of total glucosinolate in crosses involving a high glucosinolate Indian variety and a low glucosinolate line of Brassica juncea. Plant Breed. 121, 508-511.
    • (2002) Plant Breed. , vol.121 , pp. 508-511
    • Sodhi, Y.S.1    Mukhopadhyay, A.2    Arumugam, N.3    Verma, J.K.4    Gupta, V.5    Pental, D.6    Pradhan, A.K.7
  • 44
    • 44449155741 scopus 로고    scopus 로고
    • A systems biology approach identifies a R2R3MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolate
    • Sønderby, I.E., Hansen, B.G., Bjarnholt, N., Ticconi, C., Halkier, B.A. and Kliebenstein, D.J. (2007) A systems biology approach identifies a R2R3MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolate. PLoS ONE, 2, e1322.
    • (2007) PLoS ONE , vol.2
    • Sønderby, I.E.1    Hansen, B.G.2    Bjarnholt, N.3    Ticconi, C.4    Halkier, B.A.5    Kliebenstein, D.J.6
  • 45
    • 77951986187 scopus 로고    scopus 로고
    • A Complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolate in Arabidopsis
    • Sønderby, I.E., Burow, M., Rowe, H.C., Kliebenstein, D.J. and Halkier, B.A. (2010a) A Complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolate in Arabidopsis. Plant Physiol. 153, 348-363.
    • (2010) Plant Physiol. , vol.153 , pp. 348-363
    • Sønderby, I.E.1    Burow, M.2    Rowe, H.C.3    Kliebenstein, D.J.4    Halkier, B.A.5
  • 46
    • 77953366823 scopus 로고    scopus 로고
    • Biosynthesis of glucosinolates-gene discovery and beyond
    • Sønderby, I.E., Geu-Flores, F. and Halkier, B.A. (2010b) Biosynthesis of glucosinolates-gene discovery and beyond. Trends Plant Sci. 15, 283-290.
    • (2010) Trends Plant Sci. , vol.15 , pp. 283-290
    • Sønderby, I.E.1    Geu-Flores, F.2    Halkier, B.A.3
  • 47
  • 48
    • 0029185573 scopus 로고
    • Biosynthesis and partitioning of individual glucosinolates between pod walls and seeds and evidence for the occurrence of PAPS: desulphoglucosinolate sulphotransferase in seeds of oilseed rape (Brassica napus L.)
    • Toroser, D., Griffiths, H., Wood, C. and Thomas, D.R. (1995) Biosynthesis and partitioning of individual glucosinolates between pod walls and seeds and evidence for the occurrence of PAPS: desulphoglucosinolate sulphotransferase in seeds of oilseed rape (Brassica napus L.). J. Exp. Bot. 46, 1753-1760.
    • (1995) J. Exp. Bot. , vol.46 , pp. 1753-1760
    • Toroser, D.1    Griffiths, H.2    Wood, C.3    Thomas, D.R.4
  • 49
    • 80052888450 scopus 로고    scopus 로고
    • Glucosinolate biosynthetic genes in Brassica rapa
    • Wang, H., Wu, J., Sun, S., Liu, B., Cheng, F., Sun, R. and Wang, X. (2011) Glucosinolate biosynthetic genes in Brassica rapa. Gene, 487, 135-142.
    • (2011) Gene , vol.487 , pp. 135-142
    • Wang, H.1    Wu, J.2    Sun, S.3    Liu, B.4    Cheng, F.5    Sun, R.6    Wang, X.7
  • 50
    • 0006896221 scopus 로고
    • Pest incidence on single low and double low oilseed rape lines
    • Williams, I.H. (1989) Pest incidence on single low and double low oilseed rape lines. Asp. Appl. Biol. 23, 277-286.
    • (1989) Asp. Appl. Biol. , vol.23 , pp. 277-286
    • Williams, I.H.1
  • 51
    • 0036615409 scopus 로고    scopus 로고
    • Glucosinolate research in the Arabidopsis era
    • Wittstock, U. and Halkier, B.A. (2002) Glucosinolate research in the Arabidopsis era. Trends Plant Sci. 6, 263-270.
    • (2002) Trends Plant Sci. , vol.6 , pp. 263-270
    • Wittstock, U.1    Halkier, B.A.2


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