Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs

Molecular and Biochemical Parasitology

Volumn 106, Issue 1, 2000, Pages 1-10

  Bakker, Barbara M ^a   Westerhoff, Hans V ^b,c   Opperdoes, Fred R ^d,e   Michels, Paul A M ^d,e  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c Univ A   (Netherlands)

^d DE DUVE INSTITUTE   (Belgium)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Drugs; Glycolysis; Inhibitors; Metabolic control analysis; Review; Trypanosoma brucei

Indexed keywords

FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE; GLUCOSE TRANSPORTER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; PHOSPHOGLYCERATE KINASE;

ANTIMICROBIAL ACTIVITY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME INHIBITION; GLUCOSE TRANSPORT; GLYCOLYSIS; METABOLIC INHIBITION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIPARASITIC AGENTS; DRUG DESIGN; ENZYME INHIBITORS; GLYCOLYSIS; PHLORETIN; SESQUITERPENES; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0033977087     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00197-8     Document Type: Short Survey

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