Platelet Function in the Newborn

Platelets

Volumn , Issue , 2013, Pages 503-516

  Israels, Sara J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882611892     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-387837-3.00025-0     Document Type: Chapter

References (150)

1. Andrew M., Paes B., Milner R., Johnston M., Mitchell L., Tollefsen D.M., et al. The development of the human coagulation system in the full term infant. Blood 1987, 70:165-172.
2. Andrew M., Paes B., Milner R., Johnston M., Mitchell L., Tollefsen D.M., et al. Development of the human coagulation system in the healthy premature infant. Blood 1988, 72:1651-1657.
3. Andrew M., Schmidt B., Mitchell L., Paes B., Ofosu F. Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb Haemost 1990, 63:27-30.
4. Andrew M., Brooker L., Leaker M., Paes B., Weitz J. Fibrin clot lysis by thrombolytic agents is impaired in newborns due to low plasminogen concentration. Thromb Haemost 1990, 68:325-330.
5. Blanchette V.S., Rand M.L. Platelet disorders in newborn infants: diagnosis and management. Semin Perinatol 1997, 21:53-62.
6. Kuhne T., Imbach P. Neonatal platelet physiology and pathology. Eur J Pediatr 1998, 57:87-94.
7. Israels S.J., Rand M.L., Michelson A.D. Neonatal platelet function. Sem Thromb Hemost 2003, 29:363-371.
8. Saxonhouse M.A., Sola M.C. Platelet function in term and preterm neonates. Clin Perinatol 2004, 31:15-28.
9. Wiedmeier S.E., Henry E., Sola-Visner M.C., Christensen R.D. Platelet reference ranges for neonates, defined using data from over 47000 patients in a multihospital healthcare system. J Perinatol 2009, 29:130-136.
10. Forestier F., Daffos F., Galacteros F., Bardakjian J., Rainaut M., Beuzard Y. Hematological values of 163 normal fetuses between 18 and 30 weeks of gestation. Pediatr Res 1986, 20:342-346.
11. Kipper S., Sieger L. Whole blood platelet volumes in newborn infants. J Pediatr 1982, 101:763-766.
12. Arad I.D., Alpan G., Sznajderman S.D., Eldor A. The mean platelet volume (MPV) in the neonatal period. Am J Perinatol 1986, 3:1-3.
13. Clapp D.W., Baley J.E., Gerson S.T. Gestational age-dependent changes in circulating hemopoietic stem cells in newborn infants. J Lab Clin Med 1989, 113:422-427.
14. Murray N.A., Roberts I.A.G. Circulating megakaryocytes and their progenitors (BFU-MK and CFU-MK) in term and pre-term neonates. Br J Haematol 1995, 89:41-46.
15. Murray N.A., Watts T.L., Roberts I.A.G. Endogenous thrombopoietin levels and effect of recombinant human thrombopoietin on megakaryocyte precursors in term and preterm babies. Pediatr Res 1998, 43:148-151.
16. Liu Z.-J., Italiano J, Ferrer-Marin F., Gutti R., Bailey M., Poterjoy B., et al. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood 2011, 117:4106-4117.
17. Sola-Visner M.C., Christensen R.D., Hutson A.D., Rimsza L.M. Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and nonthrombocytopenic neonates. Pediatr Res 2007, 61:479-484.
18. Jilma-Stohlawetz P., Homoncik M., Jilma B., Folman C.C., von dem Borne A.E., Bernaschek G., et al. High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis. Br J Haematol 2001, 112:466-468.
19. Peterec S.M., Brennan S.A., Rinder H.M., Wnek J.L., Beardsley D.S. Reticulated platelet values in normal and thrombocytopenic neonates. J Pediatr 1996, 129:269-274.
20. Joseph M.A., Adams D., Maragos J., Saving K.L. Flow cytometry of neonatal platelet RNA. J Pediatr Hematol/Oncol 1996, 18:277-281.
21. Saxonhouse M.A., Sola M.C., Pastos K.M., Ignatz M.E., Hutson A.D., Christensen R.D., et al. Reticulated platelet percentages in term and preterm neonates. J Pediatr Hematol/Oncol 2004, 26:797-802.
22. Kienast J., Schmitz G. Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic disorders. Blood 1990, 75:116-121.
23. Ault K.A., Rinder H., Mitchell J., Carmody M.B., Vary C.P.H., Hillman R.S. The significance of platelets with increased RNA content (reticulated platelets): a measure of the rate of thrombopoiesis. Am J Clin Pathol 1992, 98:637-646.
24. Ishiguro K., Nakahata T., Matsubara K., Hayashi Y., Kato T., Suzuki Y., et al. Age-related changes in thrombopoietin in children: reference interval for serum thrombopoietin level. Br J Haematol 1999, 106:884-888.
25. Watts T.L., Murray N.A., Roberts I.A.G. Thrombopoietin has a primary role in the regulation of platelet production in preterm babies. Pediatr Res 1999, 46:28-32.
26. Sola M.C., Calhoun D.A., Hutson A.D., Christensen R.D. Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit. Br J Haematol 1999, 104:90-92.
27. Albert T.S.E., Meng Y.G., Simms P., Cohen R.L., Phibbs R.H. Thrombopoietin in the thrombocytopenic term and preterm newborn. Pediatrics 2000, 105:1286-1291.
28. Paul D.A., Leef K.H., Taylor S., McKenzie S. Thrombopoietin in preterm infants: gestational age-dependent response. J Pediatr Hematol/Oncol 2002, 24:304-309.
29. Traycoff C.M., Abboud M.R., Laver J., Clapp D.W., Hoffman R, Law P, et al. Human umbilical cord blood hematopoietic progenitor cells: are they the same as their adult bone marrow counterparts?. Blood Cells 1994, 20:382-391.
30. Sola M.C., Du Y., Hutson A.D., Christensen R.D. Dose-response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and non-thrombocytopenic neonates to recombinant thrombopoietin. Br J Haematol 2000, 110:449-453.
31. Pastos K.M., Slayton W.B., Rimsza L.M., Young L., Sola-Visner M.C. Differential effects of recombinant thrombopoietin and bone marrow stromal conditioned media on neonatal versus adult megakaryocytes. Blood 2006, 108:3360-3362.
32. Sola M.C., Rimsza L.M. Mechanisms underlying thrombocytopenia in the neonatal intensive care unit. Acta Paediatr (Suppl) 2002, 438:66-73.
33. Brown R.E., Rimsza L.M., Pastos K., Young L, Saxonhouse MA, Bailey M, et al. Effects of sepsis on neonatal thrombopoiesis. Pediatr Res 2008, 64:399-404.
34. Ferrer-Marin F., Liu A.-J., Gutti R., Sola-Visner M. Neonatal thrombocytopenia and megakaryocytopoiesis. Sem Hematol 2010, 47:281-288.
35. Ts'ao C.H., Green D., Schultz K. Function and ultrastructure of platelets of neonates: enhanced ristocetin aggregation of neonatal platelets. Br J Haematol 1976, 32:225-233.
36. Suarez C.R., Gonzalez J., Menendez C., Fareed J., Fresco R., Walenga J. Neonatal and maternal platelets: activation at time of birth. Am J Hematol 1988, 29:18-21.
37. Saving K.L., Jennings D.E., Aldag J.C., Caughey R.C. Platelet ultrastructure of high-risk premature infants. Thromb Res 1994, 73:371-384.
38. Saving K.L., Aldag J., Jennings D., Caughey B., Regan M., Powers W. Electron microscopic characterization of neonatal platelet ultrastructure: effects of sampling techniques. Thromb Res 1991, 61:65-80.
39. Israels S.J., Daniels M., McMillan E.M. Deficient collagen-induced activation in the newborn platelet. Pediatr Res 1990, 27:337-343.
40. Gruel Y., Boizard B., Daffos F., Forestier F., Caen J., Wautier J.L. Determination of platelet antigens and glycoproteins in the human fetus. Blood 1986, 68:488-492.
41. Shenkman B., Linder N., Savion N., Tamarin I., Dardik R., Kennet G., et al. Increased neonatal platelet deposition on subendothelium under flow conditions: the role of plasma von Willebrand factor. Pediatr Res 1999, 45:270-275.
42. Kuhne T., Ryan G., Blanchette V., Semple J.W., Hornstein A., Mody M., et al. Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants. Pediatr Res 1996, 40:876-880.
43. Simak J., Holada K., Janota J., Stranak Z. Surface expression of major membrane glycoproteins on resting and TRAP-activated neonatal platelets. Pediatr Res 1999, 46:445-449.
44. Hezard N., Potron G., Schlegel N., Amory C., Leroux B, Nguyen P. Unexpected persistence of platelet hyporeactivity beyond the neonatal period: a flow cytometric study in neonates, infants and older children. Thromb Haemost 2003, 90:116-123.
45. Schmugge M., Rand M.L., Bang K.W.A., Mody M., Dunn M.S., Amankwah K.S., et al. The relationship of von Willebrand factor binding to activated platelet from healthy neonates and adults. Pediatr Res 2003, 54:474-479.
46. Schlagenhauf A., Schweintzger S., Birner-Gruenberger R., Leschnik B., Muntean W. Newborn platelets: lower levels of protease-activated receptors cause hypoaggregability to thrombin. Platelets 2010, 21:641-647.
47. Corby D.G., O'Barr T.P. Decreased alpha-adrenergic receptors in newborn platelets: cause of abnormal response to epinephrine. Dev Pharmacol Ther 1981, 2:215-225.
48. Ward S.L., Schuetz S., Wachsman L., Bean X.D., Bautista D., Buckley S., et al. Elevated plasma norepinephrine levels in infants of substance-abusing mothers. Am J Dis Child 1991, 145:44-48.
49. Israels S.J., Odaibo F.S., Robertson C., McMillan E.M., McNicol A. Deficient thromboxane synthesis and response in platelets from premature infants. Pediatr Res 1997, 41:218-223.
50. Bernhard H., Rosenkranz A., Petritsch M., Kofeler H., Rehak T., Novak M., et al. Phospholipid content, expression and support of thrombin generation of neonatal platelets. Acta Paediatr 2009, 98:251-255.
51. Corby D.G., Zuck T.F. Newborn platelet dysfunction: a storage pool and release defect. Thromb Haemost 1976, 36:200-207.
52. Whaun J.M. The platelet of the newborn infant: 5-hydroxytryptamine uptake and release. Thrombos Diathes Haemorrh 1973, 30:327-333.
53. Flachaire E., Beney C., Berthier A., Salandre J., Quincy C., Renaud B. Determination of reference values for serotonin concentration in platelet of healthy newborns, children, adults and elderly subjects by HPLC with electrochemical detection. Clin Chem 1990, 36:2117-2120.
54. Whaun J.M. Platelet function in the neonate: including qualitative platelet abnormalities associated with bleeding. Developmental and neonatal hematology 1988, 131-144. Raven Press, New York. J.A. Stockman, C. Pochedly (Eds.).
55. Mankin P., Maragos J., Akhand M., Saving K.L. Impaired platelet-dense granule release in neonates. J Pediatr Hematol/Oncol 2000, 22:143-147.
56. Anderson G.M., Czarkowski K., Ravski N., Epperson C.N. Platelet serotonin in newborns and infants: ontogeny, heritability, and effect of in utero exposure to selective serotonin reuptake inhibitors. Pediatr Res 2004, 56:418-422.
57. Anderson G.M., Stevenson J.M., Cohen D.J. Steady-state model for plasma free and platelet serotonin in man. Life Sci 1987, 41:1777-1785.
58. Israels S.J., Gowen B., Gerrard J.M. Contractile activity of neonatal platelets. Pediatr Res 1987, 21:293-295.
59. Israels S.J. Diagnostic evaluation of platelet function disorders in neonates and children: an update. Sem Thromb Hemost 2009, 35:181-188.
60. Andrew M., Castle V., Mitchell L., Paes B. Modified bleeding time in the infant. Am J Hematol 1989, 30:190-191.
61. Andrew M., Paes B., Bowker J., Vegh P. Evaluation of an automated bleeding time device in the newborn. Am J Hematol 1990, 35:275-277.
62. Katz J.A., Moake J.L., McPherson P.D., Weinstein M.J., Moise K.J., Carpenter R.J., et al. Relationship between human development and disappearance of unusually large von Willebrand factor multimers from plasma. Blood 1989, 73:1851-1858.
63. Weinstein M.J., Blanchard R., Moake J.L., Vosburgh E., Moise K. Fetal and neonatal von Willebrand factor (vWF) is unusually large and similar to the vWF in patients with thrombotic thrombocytopenic purpura. Br J Haematol 1989, 72:68-72.
64. 2 with the length of the bleeding time. Clin Invest Med 1989, 12:165-171.
65. Del Vecchio A., Latini G., Henry E., Christensen R.D. Template bleeding times of 240 neonates born at 24 to 41 weeks gestation. J Perinatol 2008, 28:427-431.
66. Sola M.C., del Vecchio A., Edwards T.J., Suttner D., Hutson A.D., Christensen R.D. The relationship between hematocrit and bleeding time in very low birth weight infants during the first week of life. J Perinatol 2001, 21:368-371.
67. Kundu S.K., Heilmann E.J., Sio R., Garcia C., Ostgaard R.A. Characterization of an in vitro platelet function analyzer, PFA-100®. Clin Appl Thromb/Hemost 1996, 2:241-249.
68. Favalaro E.J., Facey D., Henniker A. Use of a novel platelet function analyzer (PFA-100™) with a high sensitivity to disturbances in von Willebrand factor to screen for von Willebrand's disease and other disorders. Am J Hematol 1999, 62:165-174.
69. Fressinaud E., Veyradier A., Truchaud F., Martin I., Boyer-Nemann C., Trossaert M., et al. Screening for von Willebrand disease with a new analyzer using high shear stress: a study of 60 cases. Blood 1998, 91:1325-1331.
70. Israels S.J., Cheang T., McMillan-Ward E.M., Houston D. Comparison of the PFA-100® platelet function analyzer and the template bleeding time in evaluation of patients with a clinical bleeding history [abstract]. Blood 1999, 94(Suppl. 1):452a.
71. Carcao M.D., Blanchette V.S., Dean J.A., He L., Kern M.A., Stain A.M., et al. The platelet function analyzer (PFA-100®): a novel in vitro system for evaluation of primary haemostasis in children. Br J Haematol 1998, 101:70-73.
72. Israels S.J., Cheang T., McMillan-Ward E.M., Cheang M. Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer. J Pediatr 2001, 138:116-119.
73. Roschitz B., Sudi K., Kostenberger M., Muntean W. Shorter PFA-100 closure times in neonates than in adults: role of red cells, white cells, platelets and von Willebrand factor. Acta Paediatr 2001, 90:664-670.
74. Boudewijns M., Raes M., Peeters V., Mewis A., Cartuyvels R., Magerman K., et al. Evaluation of platelet function on cord blood in 80 healthy term neonates using the platelet function analyser (PFA-100): shorter in vitro bleeding times in neonates than adults. Eur J Pediatr 2003, 162:212-213.
75. Saxonhouse M.A., Garner R., Mammel L., Li Q., Muller K.E., Greywoode J., et al. Closure times measured by the platelet function analyzer PFA-100® are longer in neonatal blood compared to cord blood samples. Neonatology 2010, 97:242-249.
76. Varon D., Dardik R., Shenkman B., Kotev-Emeth S., Farzame N., Tamarin I., et al. A new method for quantitative analysis of whole blood platelet interaction with the extracellular matrix under flow conditions. Thromb Res 1997, 85:283-294.
77. Linder N., Shenkman B., Levin E., Sirota L., Vishne T.H., Tamarin I., et al. Deposition of whole blood platelets on extracellular matrix under flow conditions in preterm infants. Arch Dis Child 2002, 86:F127-F130.
78. Levy-Shraga Y., Maayan-Metzger A., Lubetsky A., Shenkman B., Kuint J., Martinowitz U., et al. Platelet function of newborns as tested by the cone and plate(let) analyzer correlates with gestational age. Acta Haematol 2006, 115:152-156.
79. Mulles M.M., Hathaway W.E. Altered platelet function in newborns. Pediatr Res 1970, 4:229-237.
80. Corby D.G., Schulman I. The effects of antenatal drug administration on aggregation of platelets of newborn infants. J Pediatr 1971, 79:307-313.
81. Corby D.G., O'Barr T.P. Neonatal platelet function: a membrane-related phenomenon?. Haemostasis 1981, 10:177-185.
82. 2 production in whole blood: the effect of maternal low dose aspirin. Br J Obstet Gynecol 1994, 101:203-208.
83. Israels S.J., Andrew M. Neonatal haemostasis. Haemostasis and thrombosis 1994, 1017-1055. Churchill Livingstone, Edinburgh. 3rd ed. A.L. Bloom, C.D. Forbes, D.P. Thomas, E.G.D. Tuddenham (Eds.).
84. Johnson S.S., Montgomery R.R., Hathaway W.E. Newborn factor VIII complex: elevated activities in term infants and alterations in electrophoretic mobility related to illness and activated coagulation. Br J Haemotol 1981, 47:597-606.
85. Ferrer-Marin F., Chavda C., Lampa M., Michelson A.D., Frelinger A.L., Sola-Visner M. Effects of in vitro adult platelet transfusions on neonatal hemostasis. J Thromb Haemost 2011, 9:1020-1028.
86. Michelson A.D. Platelet function in the newborn. Semin Thromb Hemost 1998, 24:507-512.
87. Gatti L., Guarneri D., Caccamo M.L., Gianotti G.A., Marini A. Platelet activation in newborns detected by flow-cytometry. Biol Neonate 1996, 70:322-327.
88. Rajasekhar D., Kestin A.S., Bednarek F.J., Ellis P.A., Barnard M.R., Michelson A.D. Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood. Thromb Haemost 1994, 72:957-963.
89. Rajasekhar D., Barnard M.R., Bednarek F.J., Michelson A.D. Platelet hyporeactivity in very low birth weight neonates. Thromb Haemost 1997, 77:1002-1007.
90. Bednarek F.J., Bean S., Barnard M.R., Frelinger A.L., Michelson A.D. The platelet hyporeactivity of extremely low birth weight neonates is age-dependent. Thromb Res 2009, 124:42-45.
91. Ichinose F., Uezono S., Muto R., Uchida H., Hatori F., Terui K., et al. Platelet hyporeactivity in young infants during cardiopulmonary bypass. Anesth Analg 1999, 88:258-262.
92. Traverso C.I., Caprini J.A., Arcelus J.I., Muto R., Uchida H., Hatori F., Terui K. The normal thromboelastogram and its interpretation. Sem Thromb Hemost 1995, 21(Suppl. 4):7-13.
93. Miller B.E., Bailey J.M., Mancuso T.J., Weinstein M.S., Holbrook G.W., Silvey E.M., et al. Functional maturity of the coagulation system in children: an evaluation using thrombelastography. Anesth Analg 1997, 84:745-748.
94. Kettner S.C., Pollak A., Zimpfer M., Seybold T., Pruser A.R., Herkner K., et al. Heparinase-modified thrombelastography in term and preterm neonates. Anesth Analg 2004, 98:1650-1652.
95. Edwards R.M., Naik-Mathuria B.J., Gay A.N., Olutoye O.O., Teruya J. Parameters of thromboelastography in healthy newborns. Am J Clin Pathol 2008, 130:99-102.
96. Cvirn G., Gallistl S., Kutschera J., Wagner T., Ferstl U., Jurgens G., et al. Clot strength: a comparison between cord and adult blood by means of thrombelastometry. J Pediatr Hematol Oncol 2008, 30:210-213.
97. Nicolini U., Guarneri D., Gianotti G.A., Campagnoli C., Crosignani P.G., Gatti L. Maternal and fetal platelet activation in normal pregnancy. Obstet Gynecol 1994, 83:65-69.
98. Grosshaupt B., Muntean W., Sedlmayr P. Hyporeactivity of neonatal platelets is not caused by preactivation during birth. Eur J Pediatr 1997, 156:944-948.
99. Irken G., Uysal K.M., Olgun N., Undar B., Akkoc N., Ozkan H., et al. Platelet activation during the early neonatal period. Biol Neonate 1998, 73:166-171.
100. Schweintzger S., Schlangenhauf A., Leschnik B., Rinner B., Bernhard H., Novak M., et al. Microparticles in newborn cord blood: slight elevation after normal delivery. Thromb Res 2011, 128:62-67.
101. Trudinger B., Song J.Z., Wu Z.H., Wang J. Placental insufficiency is characterized by platelet activation in the fetus. Obstet Gynecol 2003, 101:975-981.
102. Castle V., Coates G., Mitchell L.G., O'Brodovich H., Andrew M. The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbit. Thromb Haemost 1988, 59:45-48.
103. Cheung P.-Y., Stevens J.P., Haase E., Stang L., Bigam D.L., Etches W., et al. Platelet dysfunction in asphyxiated newborn piglets resuscitated with 21% and 100% oxygen. Pediatr Res 2006, 59:636-640.
104. Rehak T., Cvirn G., Gallistl S., Leschnik B., Kostenberger M., Katzer H., et al. Increased shear stress- and ristocetin-induced binding of von Willebrand factor to platelets in cord compared with adult plasma. Thromb Haemost 2004, 92:682-687.
105. Dong J.F., Moake J.L., Nolasco L., Bernardo A., Arceneaux W., Shrimpton C.N., et al. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood 2002, 100:4033-4039.
106. Tsai H.M. Shear stress and von Willebrand factor in health and disease. Sem Thromb Hemost 2003, 29:479-488.
107. Mannucci P.M., Canciani T., Forza I., Lussana F., Lattuada A., Rossi E. Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood 2001, 98:2730-2735.
108. Tsai H.M., Saroda R., Downes K.A. Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood. Thromb Res 2003, 108:121-125.
109. Schmugge M., Dunn M.S., Amankwah K.S., Blanchette V.S., Freedman J., Rand M.L. The activity of the von Willebrand factor cleaving protease ADAMTS-13 in newborn infants. J Thromb Haemost 2004, 2:228-233.
110. Fischer B.E., Thomas K.B., Dorner F. Von Willebrand Factor: measuring its antigen or function? Correlation between the level of antigen, activity, and multimer size using various detection systems. Thromb Res 1998, 91:39-43.
111. Finkelstein Y., Shenkman B., Sirota L., Vishne T.H., Dardik R., Varon D., et al. Whole blood platelet deposition on extracellular matrix under flow conditions in preterm neonatal sepsis. Eur J Pediatr 2002, 161:270-274.
112. Stuart M.J., Allen J.B. Arachidonic acid metabolism in the neonatal platelet. Pediatrics 1982, 69:714-718.
113. Stuart M.J., Dusse J., Clark D.A., Walenga R.W. Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine. Pediatr Res 1984, 18:823-826.
114. Stuart M.J., Oski F.A. Vitamin E and platelet function. Am J Pediatr Hematol/Oncol 1979, 1:77-82.
115. Brass L.F., Manning D.R., Cichowski K., Abrams C.S. Signaling through G proteins in platelets: to integrins and beyond. Thromb Haemost 1997, 78:581-589.
116. Israels S.J., Cheang T., Robertson C., McMillan-Ward E.M., McNicol A. Impaired signal transduction in neonatal platelets. Pediatr Res 1999, 45:687-691.
117. Gelman B., Setty B.N.Y., Chen D., Amin-Hanjani S.A., Stuart M.J. Impaired mobilization of intracellular calcium in neonatal platelets. Pediatr Res 1996, 39:692-696.
118. Schmugge M., Bang K.W.A., Blanchette V.S., Albisetti M., Connolly B.L., Freedman J., et al. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. Acta Haematol 2007, 117:145-148.
119. Saving K.L., Mankin P., Maragos J., Adams D., Caughy R. Association of whole blood aggregation response with immunogold-labeled glycoproteins in adult and neonatal platelets. Thromb Res 2001, 101:73-81.
120. Michelson A.D., Rajasekhar D., Bednarek F.J., Barnard M.R. Platelet and platelet-derived microparticle surface factor V/Va binding in whole blood: differences between neonates and adults. Thromb Haemost 2000, 84:689-694.
121. Israels S.J., McMillan-Ward E.M. Procoagulant activity of neonatal platelets. J Thromb Haemost 2003, (Suppl. 1):P1277.
122. Stuart M.J., Dusse J. In vitro comparison of the efficacy of cyclooxygenase inhibitors on the adult versus neonatal platelet. Biol Neonate 1985, 47:265-269.
123. Bleyer W.A., Brekenridge R.T. Studies on the detection of adverse drug reactions in the newborn II. The effects of prenatal aspirin on newborn hemostasis. J Am Med Assoc 1970, 213:2049-2053.
124. Stuart M.J., Gross S.J., Elrad H., Graeber J.E. Effects of acetylsalicylic-acid ingestion on maternal and neonatal hemostasis. N Engl J Med 1982, 307:909-912.
125. Norton M.E., Merrill J., Cooper B., Kullaer J., Clyman R.I. Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 1993, 329:1602-1607.
126. Benigni A., Gregorini G., Frusca T., Chiabrando C., Ballerini S., Valcamonico A., et al. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med 1989, 321:357-362.
127. Duley L., Henderson-Smart D., Knight M., King J. Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review. Br Med J 2001, 322:329-333.
128. Leonhardt A., Bernert S., Watzer B., Schmitz-Ziegler G., Seyberth H.W. Low-dose aspirin in pregnancy: maternal and neonatal aspirin concentration and neonatal prostanoid formation. Pediatrics 2003, 111:e77-e81.
129. Unsworth J., d'Assis-Fonseca A., Beswick D.T. Serum salicylate levels in a breastfed infant. Ann Rheum 1987, 46:638-639.
130. Corazza M.S., Davis R.F., Merritt T.A., Bejar R., Cvetnic W. Prolonged bleeding time in preterm infants receiving indomethacin for patent ductus arteriosus. J Pediatr 1984, 105:292-296.
131. Sekar K.C., Corff K.E. Treatment of patent ductus arteriosus: indomethacin or ibuprofen?. J Perinatol 2008, 28(Suppl 1):S60-S62.
132. Sheffield M.J., Schmutz N., Lambert D.K., Henry E., Christensen R.D. Ibuprofen lysine administration to neonates with a patent ductus arteriosus: effect on platelet plug formation assessed by in vivo and in vitro measurements. J Perinatol 2009, 29:39-43.
133. Ylikorkala O., Halmesmaki E., Viinikka L. Effect of ethanol on thromboxane and prostacyclin synthesis by fetal platelets and umbilical artery. Life Sciences 1987, 41:371-376.
134. Cheung P.Y., Salas E., Schulz R., Radomski M.W. Nitric oxide and platelet function: implications for neonatology. Semin Perinatol 1997, 21:409-417.
135. Varels A.F., Runge A., Ignano L.J., Chandhuri G. Nitric oxide and prostacyclin inhibit fetal platelet aggregation: a response similar to that observed in adults. Am J Obstet Gynecol 1992, 167:1599-1604.
136. George T.N., Johnson K.J., Bates J.N., Segar J.L. The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. J Pediatr 1998, 132:731-734.
137. Cheung P.Y., Salas E., Etches P.C., Phillipos E., Schulz R., Radomski M.W. Inhaled nitric oxide and inhibition of platelet aggregation in critically ill neonates. Lancet 1998, 351:1181-1182.
138. Keh D., Kurer I., Dudenhausen J.W., Woltmann W., Falke K.J., Gerlach H. Response of neonatal platelets to nitric oxide in vitro. Intensive Care Med 2001, 27:283-286.
139. Watała C., Chudzik A., Tchrzewski H., Gwoździński K. Impaired action of nitric oxide on blood platelets in premature newborns. Arch Med Sci 2008, 4:315-323.
140. Hoehn T., Krause M.F., Buhrer C. Inhaled nitric oxide in premature infants-a meta-analysis. J Perinat Med 2000, 28:7-13.
141. Koren G., Matsui D., Einarson A., Knoppert E., Steiner M. Is maternal use of selective serotonin reuptake inhibitors in the third trimester of pregnancy harmful to neonates?. Can Med Assoc J 2005, 172:1457-1459.
142. Maayan-Metzger A., Kuint J., Lubetsky A., Shenkman B., Mazkereth R., Kenet G. Maternal selective serotonin reuptake inhibitor intake does not seem to affect neonatal platelet function tests. Acta Haematol 2006, 115:157-161.
143. Epperson C.N., Jatlow P.I., Czarkowski K., Anderson G.M. Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairs. Pediatrics 2003, 112:e425-e429.
144. Stuart M.J., Elrad H., Graeber J.E., Hakanson D.O., Sunderji S.J., Barcvinchak M.K. Increased synthesis of prostaglandin endoperoxides and platelet hyperfunction in infants of mothers with diabetes mellitus. J Lab Clin Med 1979, 94:12-26.
145. 2 production in newborn infants of diabetic mothers. Prostaglandins Leukotrienes Med 1986, 21:299-304.
146. Oppenheimer E.H., Esterly J.R. Thrombosis in the newborn: comparison between infants of diabetic and nondiabetic mothers. J Pediatr 1965, 67:549-556.
147. Strauss T., Maayan-Metzger A., Simchen M.J., Morag I., Shenkman B., Kuint J., et al. Impaired platelet function in neonates born to mothers with diabetes or hypertension during pregnancy. Klin Padiatr 2010, 222:154-157.
148. Echtler K., Stark K., Lorenz M., Kerstan S., Walch A., Jennen L., et al. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nature Med 2010, 16:75-82.
149. Clyman R., Chemtob S. Vessel remodeling in the newborn: platelets fill the gap. Nature Med 2010, 16:33-35.
150. Sallmon H., Weber S.C., von Gise A., Koehne P., Hansmann G. Ductal closure in neonates: a developmental perspective on platelet-endothelial interactions. Blood Coagul Fibrinolysis 2011, 22:242-244.