Endogenous thrombopoietin levels and effect of recombinant human thrombopoietin on megakaryocyte precursors in term and preterm babies

Pediatric Research

Volumn 43, Issue 1, 1998, Pages 148-151

  Murray, Neil A ^a   Watts, Timothy L ^a   Roberts, Irene A G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT THROMBOPOIETIN; THROMBOPOIETIN;

ARTICLE; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; DOSE RESPONSE; FEMALE; FETUS GROWTH; HUMAN; INFANT; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; NEWBORN; PREMATURITY; PRIORITY JOURNAL; STEM CELL; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

EID: 0031890376     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199801000-00023     Document Type: Article

References (21)

1. Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C 1986 Frequency and mechanism of neonatal thrombocytopenia. J Pediatr 108:749-755
2. Metha P, Rohitkumar V, Neumann L, Karpatkin M 1980 Thrombocytopenia in the high risk infant. J Pediatr 97:791-794
3. Murray NA, Roberts IAG 1996 Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates. Pediatr Res 40:112-119
4. Tahara T, Usuki K, Sato H, Ohashi H, Monta H, Tsumura H, Matsumoto A, Miyazaki H, Urabe A, Kato T 1996 A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. Br J Haematol 93:783-788
5. Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR 1996 Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068-4071
6. Nishihira H, Toyoda Y, Miyazaki H, Kigasawa H, Ohsaki E 1996 Growth of macroscopic human megakaryocyte colonies from cord blood with recombinant human thrombopoietin (c-Mpl ligand) and the effects of gestational age on frequency of colonies. Br J Haematol 92:23-28
7. Murray NA, Roberts IAG 1995 Circulating megakaryocytes and their progenitors (BFU-MK and CFU-MK) in term and preterm neonates. Br J Haematol 89:41-46
8. + cells and the GP IIb/IIIa marker. Exp Hematol 21:1473-1479
9. Zucker-Franklin D, Yang JS, Grusky G 1992 Characterization of glycoprotein IIb/IIIa-positive cells in human cord blood: their potential usefulness as megakaryocyte progenitors. Blood 79:347-355
10. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg Jr LA, Goeddel DV, Eaton DL 1994 Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533-538
11. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC 1994 Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565-568
12. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC 1994 Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568-571
13. Wendung F, Maraskovsky E, Debill N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W 1994 c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571-574
14. Eaton DL, de Sauvage FJ 1997 Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis. Exp Hematol 25:1-7
15. Teramura M, Katahira J, Hoshino S, Motoji T, Oshimi K 1988 Clonal growth of human megakaryocyte progenitors in serum-free cultures: effect of recombinant human interleukin 3. Exp Hematol 16:843-848
16. Traycoff CM, Abboud MR, Laver J, Clapp DW, Hoffman R, Law P, Srour EF 1994 Human umbilical cord blood hematopoietic progenitor cells: are they the same as their adult bone marrow counterparts? Blood Cells 20:382-391
17. Christensen RD, Liechty KW, Koenig JM, Schibler KR, Ohls RK 1991 Administration of erythropoietin to newborn rats results in diminished neutrophil production. Blood 78:1241-1246
18. Koenig JM, Christensen RD 1990 Effect of erythropoietin on granulopoiesis: in vitro and in vivo studies in weanling rats. Pediatr Res 27:583-587
19. Christensen RD, Koenig JM, Viskochil DH, Rothstein G 1989 Down-modulation of neutrophil production by erythropoietin in human hematopoietic clones. Blood 74:817-822
20. Shannon KM 1990 Anaemia of prematurity: progress and prospects. Am J Pediatr Hematol Oncol 12:16-22
21. van den Ven C, Fernandez GW, Herbst T, Knoppel A, Cairo MS 1997 Sequential treatment with rmIL-3 or simultaneous treatment with rmIL-3 or rhIL-11 with thrombopoietin (TPO) fails to enhance in vivo neonatal rat thrombocytopoiesis. Exp Hematol 25:1005-1012