Neonatal Thrombocytopenia and Megakaryocytopoiesis

Seminars in Hematology

Volumn 47, Issue 3, 2010, Pages 281-288

  Ferrer Marin, Francisca ^a   Liu, Zhi Jian ^a   Gutti, Ravi ^a   Sola Visner, Martha ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELTROMBOPAG; ROMIPLOSTIM; THROMBOPOIETIN; THROMBOPOIETIN MIMETIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; DISEASE MODEL; DISEASE SEVERITY; DRUG MECHANISM; DRUG SAFETY; HOSPITAL ADMISSION; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IN VITRO STUDY; IN VIVO STUDY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MORBIDITY; NEONATAL THROMBOCYTOPENIA; NEWBORN INTENSIVE CARE; NEWBORN MORTALITY; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPOIESIS; TREATMENT RESPONSE;

BLOOD PLATELETS; HUMANS; INFANT, NEWBORN; MEGAKARYOCYTES; THROMBOCYTOPENIA; THROMBOPOIETIN;

EID: 77953903454     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2010.04.002     Document Type: Article

References (47)

1. Wiedmeier S.E., Henry E., Sola-Visner M.C., Christensen R.D. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol 2009, 29:130-136.
2. Dreyfus M., Kaplan C., Verdy E., Schlegel N., Durand-Zaleski I., Tchernia G. Frequency of immune thrombocytopenia in newborns: a prospective study. Immune thrombocytopenia working group. Blood 1997, 89:4402-4406.
3. Castle V., Andrew M., Kelton J., Giron D., Johnston M., Carter C. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr 1986, 108:749-755.
4. Mehta P., Vasa R., Neumann L., Karpatkin M. Thrombocytopenia in the high-risk infant. J Pediatr 1980, 97:791-794.
5. Christensen R.D., Henry E., Wiedmeier S.E., et al. Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system. J Perinatol 2006, 26:348-353.
6. Baer V.L., Lambert D.K., Henry E., Christensen R.D. Severe thrombocytopenia in the nicu. Pediatrics 2009, 124:e1095-e1100.
7. Stanworth S.J., Clarke P., Watts T., et al. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics 2009, 124:e826-e834.
8. Lupton B.A., Hill A., Whitfield M.F., Carter C.J., Wadsworth L.D., Roland E.H. Reduced platelet count as a risk factor for intraventricular hemorrhage. Am J Dis Child 1988, 142:1222-1224.
9. Bussel J.B., Sola-Visner M. Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia. Semin Perinatol 2009, 33:35-42.
10. Josephson C.D., Su L.L., Christensen R.D., et al. Platelet transfusion practices among neonatologists in the united states and canada: results of a survey. Pediatrics 2009, 123:278-285.
11. Del Vecchio A., Sola M.C., Theriaque D.W., et al. Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion 2001, 41:803-808.
12. Dohner M.L., Wiedmeier S.E., Stoddard R.A., et al. Very high users of platelet transfusions in the neonatal intensive care unit. Transfusion 2009, 49:869-872.
13. Kenton A.B., Hegemier S., Smith E.O., et al. Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity. J Perinatol 2005, 25:173-177.
14. Bonifacio L., Petrova A., Nanjundaswamy S., Mehta R. Thrombocytopenia related neonatal outcome in preterms. Indian J Pediatr 2007, 74:269-274.
15. Baer V.L., Lambert D.K., Henry E., Snow G.L., Sola-Visner M.C., Christensen R.D. Do platelet transfusions in the NICU adversely affect survival?. Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system. J Perinatol 2007, 27:790-796.
16. Sola M.C., Juul S.E., Meng Y.G., et al. Thrombopoietin (tpo) in the fetus and neonate: Tpo concentrations in preterm and term neonates, and organ distribution of tpo and its receptor (c-mpl) during human fetal development. Early Hum Dev 1999, 53:239-250.
17. Murray N.A., Watts T.L., Roberts I.A. Endogenous thrombopoietin levels and effect of recombinant human thrombopoietin on megakaryocyte precursors in term and preterm babies. Pediatr Res 1998, 43:148-151.
18. Walka M.M., Sonntag J., Dudenhausen J.W., Obladen M. Thrombopoietin concentration in umbilical cord blood of healthy term newborns is higher than in adult controls. Biol Neonate 1999, 75:54-58.
19. Nishihira H., Toyoda Y., Miyazaki H., Kigasawa H., Ohsaki E. Growth of macroscopic human megakaryocyte colonies from cord blood in culture with recombinant human thrombopoietin (c-mpl ligand) and the effects of gestational age on frequency of colonies. Br J Haematol 1996, 92:23-28.
20. Olson T.A., Levine R.F., Mazur E.M., Wright D.G., Salvado A.J. Megakaryocytes and megakaryocyte progenitors in human cord blood. Am J Pediatr Hematol Oncol 1992, 14:241-247.
21. Allen Graeve J.L., de Alarcon P.A. Megakaryocytopoiesis in the human fetus. Arch Dis Child 1989, 64:481-484.
22. de Alarcon P.A., Graeve J.L. Analysis of megakaryocyte ploidy in fetal bone marrow biopsies using a new adaptation of the feulgen technique to measure DNA content and estimate megakaryocyte ploidy from biopsy specimens. Pediatr Res 1996, 39:166-170.
23. + cells are correlated with different levels of platelet release. Blood 2002, 99:888-897.
24. Slayton W.B., Wainman D.A., Li X.M., et al. Developmental differences in megakaryocyte maturation are determined by the microenvironment. Stem Cells 2005, 23:1400-1408.
25. Ignatz M., Sola-Visner M., Rimsza L.M., et al. Umbilical cord blood produces small megakaryocytes after transplantation. Biol Blood Marrow Transplant 2007, 13:145-150.
26. Gutti R S.H., Bailey M., Liu Z.J., Sola-Visner M. Neonatal and adult megakaryocytes have different microRNA expression profiles, which might contribute to their biological differences. Society of Pediatric Research Meeting E-PAS 2009, 2730.4.
27. Watts T.L., Murray N.A., Roberts I.A. Thrombopoietin has a primary role in the regulation of platelet production in preterm babies. Pediatr Res 1999, 46:28-32.
28. Sola M.C., Calhoun D.A., Hutson A.D., Christensen R.D. Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit. Br J Haematol 1999, 104:90-92.
29. Brown R.E., Rimsza L.M., Pastos K., et al. Effects of sepsis on neonatal thrombopoiesis. Pediatr Res 2008, 64:399-404.
30. Colarizi P., Fiorucci P., Caradonna A., Ficuccilli F., Mancuso M., Papoff P. Circulating thrombopoietin levels in neonates with infection. Acta Paediatr 1999, 88:332-337.
31. Sola M.C., Slayton W.B., Rimsza L.M., et al. A neonate with severe thrombocytopenia and radio-ulnar synostosis. J Perinatol 2004, 24:528-530.
32. Harker L.A. Kinetics of thrombopoiesis. J Clin Invest 1968, 47:458-465.
33. Harker L.A., Finch C.A. Thrombokinetics in man. J Clin Invest 1969, 48:963-974.
34. Sola-Visner M.C., Christensen R.D., Hutson A.D., Rimsza L.M. Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and nonthrombocytopenic neonates. Pediatr Res 2007, 61:479-484.
35. Hu Z., Slayton W.B., Rimsza L.M., Bailey M., Sallmon H., Sola-Visner M.C. Differences between newborn and adult mice in their response to immune thrombocytopenia. Neonatology 2010, 98:100-108.
36. Sola M.C., Du Y., Hutson A.D., Christensen R.D. Dose-response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and non-thrombocytopenic neonates to recombinant thrombopoietin. Br J Haematol 2000, 110:449-453.
37. Pastos K.M., Slayton W.B., Rimsza L.M., Young L., Sola-Visner M.C. Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes. Blood 2006, 108:3360-3362.
38. Sola M.C., Christensen R.D., Hutson A.D., Tarantal A.F. Pharmacokinetics, pharmacodynamics, and safety of administering pegylated recombinant megakaryocyte growth and development factor to newborn rhesus monkeys. Pediatr Res 2000, 47:208-214.
39. Liu Z.J.B.M., Gutti R., Sallmon H., Sola-Visner M. Thrombopoietin stimulates the cytoplasmic maturation of low-ploidy neonatal megakaryocytes through the mTOR pathway. Society of Pediatric Research Meeting E-PAS 2009, 2730.1.
40. Murray N.A., Howarth L.J., McCloy M.P., Letsky E.A., Roberts I.A. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med 2002, 12:35-41.
41. Garcia M.G., Duenas E., Sola M.C., Hutson A.D., Theriaque D., Christensen R.D. Epidemiologic and outcome studies of patients who received platelet transfusions in the neonatal intensive care unit. J Perinatol 2001, 21:415-420.
42. Erhardt J.A., Erickson-Miller C.L., Aivado M., Abboud M., Pillarisetti K., Toomey J.R. Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function. Exp Hematol 2009, 37:1030-1037.
43. Aher S.M., Ohlsson A. Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database 2006, 3. CD004865.
44. Liu H., Jia D., Fu J., et al. Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells. Neuroscience 2009, 164:1521-1530.
45. Dame C., Wolber E.M., Freitag P., Hofmann D., Bartmann P., Fandrey J. Thrombopoietin gene expression in the developing human central nervous system. Brain Res Dev Brain Res 2003, 143:217-223.
46. Ehrenreich H., Hasselblatt M., Knerlich F., et al. A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain. Proc Natl Acad Sci U S A 2005, 102:862-867.
47. Samoylenko A., Byts N., Rajalingam K., et al. Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and erk signalling. Cell Signal 2008, 20:154-162.