-
1
-
-
0014578352
-
Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion
-
Arnold JE, Healy JK Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion. Am. J. Med. 1969, 47:461-472.
-
(1969)
Am. J. Med.
, vol.47
, pp. 461-472
-
-
Arnold, J.E.1
Healy, J.K.2
-
2
-
-
0032811792
-
Evidence for linkage between essential hypertension and a putative locus on human chromosome 17
-
Baima J, Nicolaou M, Schwartz F, et al. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension 1999, 34:4-7.
-
(1999)
Hypertension
, vol.34
, pp. 4-7
-
-
Baima, J.1
Nicolaou, M.2
Schwartz, F.3
-
3
-
-
0018118115
-
Familial hyperkalemia, hypertension, and hyporeninemia with normal aldosterone levels. A tubular defect in potassium handling
-
Brautbar N, Levi J, Rosler A, Leitesdorf, et al. Familial hyperkalemia, hypertension, and hyporeninemia with normal aldosterone levels. A tubular defect in potassium handling. Arch. Intern. Med. 1978, 138:607-610.
-
(1978)
Arch. Intern. Med.
, vol.138
, pp. 607-610
-
-
Brautbar, N.1
Levi, J.2
Rosler, A.3
Leitesdorf4
-
4
-
-
26744443958
-
Chronic hyperkalemia in siblings associated with enhanced renal chloride absorption [abstract]
-
Bravo E, Textor S, Mujais S, Cotton D Chronic hyperkalemia in siblings associated with enhanced renal chloride absorption [abstract]. Clin. Res. 1980, 28:782A.
-
(1980)
Clin. Res.
, vol.28
-
-
Bravo, E.1
Textor, S.2
Mujais, S.3
Cotton, D.4
-
5
-
-
33745076253
-
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells
-
Cai H, Cebotaru V, Wang YH, et al. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int. 2006, 69:2162-2170.
-
(2006)
Kidney Int.
, vol.69
, pp. 2162-2170
-
-
Cai, H.1
Cebotaru, V.2
Wang, Y.H.3
-
6
-
-
13344295074
-
Mutations in subunits of the epithelial sodium channel cause wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1
-
Chang SS, Grunder S, Hanukoglu A, et al. Mutations in subunits of the epithelial sodium channel cause wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat. Genet. 1996, 12:248-253.
-
(1996)
Nat. Genet.
, vol.12
, pp. 248-253
-
-
Chang, S.S.1
Grunder, S.2
Hanukoglu, A.3
-
7
-
-
0037457954
-
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl-transporting epithelia
-
Choate KA, Kahle KT, Wilson FH, Nelson-Williams C, Lifton RP WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl-transporting epithelia. Proc. Natl Acad. Sci. USA 2003, 100:663-668.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 663-668
-
-
Choate, K.A.1
Kahle, K.T.2
Wilson, F.H.3
Nelson-Williams, C.4
Lifton, R.P.5
-
8
-
-
0035571328
-
Mutations in the Na-Cl cotransporter reduce blood pressure in humans
-
Cruz DN, Simon DB, Nelson-Williams C, et al. Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension 2001, 37:1458-1464.
-
(2001)
Hypertension
, vol.37
, pp. 1458-1464
-
-
Cruz, D.N.1
Simon, D.B.2
Nelson-Williams, C.3
-
9
-
-
32444437942
-
WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
-
de Los Heros P, Kahle KT, Rinehart J, et al. WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc. Natl Acad. Sci. USA 2006, 103:1976-1981.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 1976-1981
-
-
de Los Heros, P.1
Kahle, K.T.2
Rinehart, J.3
-
10
-
-
0344197746
-
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform
-
Delaloy C, Lu J, Houot AM, et al. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol. Cell. Biol. 2003, 23:9208-9221.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9208-9221
-
-
Delaloy, C.1
Lu, J.2
Houot, A.M.3
-
12
-
-
0033855576
-
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension
-
Disse-Nicodème S, Achard JM, Desitter I, et al. A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am. J. Hum. Genet. 2000, 67:302-310.
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 302-310
-
-
Disse-Nicodème, S.1
Achard, J.M.2
Desitter, I.3
-
13
-
-
0042847432
-
PASK (prolinealanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)
-
Dowd BF, Forbush B PASK (prolinealanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). J. Biol. Chem. 2003, 278:27347-27353.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27347-27353
-
-
Dowd, B.F.1
Forbush, B.2
-
14
-
-
84949312562
-
Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: possible hereditary cell membrane defect
-
Farfel Z, Iaina A, Rosenthal T, Waks U, Shibolet S, Gafni J Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: possible hereditary cell membrane defect. Arch. Intern. Med. 1978, 138:1828-1832.
-
(1978)
Arch. Intern. Med.
, vol.138
, pp. 1828-1832
-
-
Farfel, Z.1
Iaina, A.2
Rosenthal, T.3
Waks, U.4
Shibolet, S.5
Gafni, J.6
-
15
-
-
0018153427
-
Proximal renal tubular acidosis: association with familial normaldosteronemic hyperpotassemia and hypertension
-
Farfel Z, Iaina A, Levi J, Gafni J Proximal renal tubular acidosis: association with familial normaldosteronemic hyperpotassemia and hypertension. Arch. Intern. Med. 1978, 138:1837-1840.
-
(1978)
Arch. Intern. Med.
, vol.138
, pp. 1837-1840
-
-
Farfel, Z.1
Iaina, A.2
Levi, J.3
Gafni, J.4
-
16
-
-
20444431956
-
WNK4 regulates airway Na+ transport: study of familial hyperkalaemia and hypertension
-
Farfel Z, Mayan H, Yaacov Y, et al. WNK4 regulates airway Na+ transport: study of familial hyperkalaemia and hypertension. Eur. J. Clin. Invest. 2005, 35:410-415.
-
(2005)
Eur. J. Clin. Invest.
, vol.35
, pp. 410-415
-
-
Farfel, Z.1
Mayan, H.2
Yaacov, Y.3
-
17
-
-
30644458584
-
Volume sensitivity of cation-chloride cotransporters is modulated by the interaction of two kinases: SPAK and WNK4
-
Gagnon KB, England R, Delpire E Volume sensitivity of cation-chloride cotransporters is modulated by the interaction of two kinases: SPAK and WNK4. Am. J. Physiol. Cell Physiol. 2006, 290:C134-C142.
-
(2006)
Am. J. Physiol. Cell Physiol.
, vol.290
-
-
Gagnon, K.B.1
England, R.2
Delpire, E.3
-
18
-
-
30644472724
-
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter
-
Gagnon KB, England R, Delpire E Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Mol. Cell. Biol. 2006, 26:689-698.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 689-698
-
-
Gagnon, K.B.1
England, R.2
Delpire, E.3
-
19
-
-
0027405688
-
Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter
-
Gamba G, Saltzberg SN, Lombardi M, et al. Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter. Proc. Natl Acad. Sci. USA 1993, 90:2749-2753.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 2749-2753
-
-
Gamba, G.1
Saltzberg, S.N.2
Lombardi, M.3
-
20
-
-
0031861245
-
Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I
-
Geller DS, Rodriguez-Soriano J, Vallo Boado A, et al. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat. Genet. 1998, 19:279-281.
-
(1998)
Nat. Genet.
, vol.19
, pp. 279-281
-
-
Geller, D.S.1
Rodriguez-Soriano, J.2
Vallo Boado, A.3
-
21
-
-
23244460555
-
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene
-
Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension 2005, 46:295-300.
-
(2005)
Hypertension
, vol.46
, pp. 295-300
-
-
Golbang, A.P.1
Murthy, M.2
Hamad, A.3
-
22
-
-
33845361061
-
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved
-
Golbang AP, Cope G, Hamad A, et al. Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. Am. J. Physiol. Renal Physiol. 2006, 291:F1369-F1376.
-
(2006)
Am. J. Physiol. Renal Physiol.
, vol.291
-
-
Golbang, A.P.1
Cope, G.2
Hamad, A.3
-
23
-
-
0014870575
-
Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction
-
Gordon RD, Geddes RA, Pawsey CG, O'Halloran MW Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction. Australas. Ann. Med. 1970, 19:287-294.
-
(1970)
Australas. Ann. Med.
, vol.19
, pp. 287-294
-
-
Gordon, R.D.1
Geddes, R.A.2
Pawsey, C.G.3
O'Halloran, M.W.4
-
24
-
-
0002500726
-
Gordon's syndrome: a sodium-volume dependent form of hypertension with a genetic basis
-
Raven Press, New York, J.H. Laragh, B.M. Brenner (Eds.)
-
Gordon R, Klemm S, Tunny T, Stowasser M Gordon's syndrome: a sodium-volume dependent form of hypertension with a genetic basis. Hypertension: Pathophysiology, Diagnosis and Management 1995, 2111-2123. Raven Press, New York. 2nd edn. J.H. Laragh, B.M. Brenner (Eds.).
-
(1995)
Hypertension: Pathophysiology, Diagnosis and Management
, pp. 2111-2123
-
-
Gordon, R.1
Klemm, S.2
Tunny, T.3
Stowasser, M.4
-
25
-
-
33645379951
-
Familial hyperkalemic hypertension
-
Hadchouel J, Delaloy C, Faure S, Achard JM, Jeunemaitre X Familial hyperkalemic hypertension. J. Am. Soc. Nephrol. 2006, 17:208-217.
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 208-217
-
-
Hadchouel, J.1
Delaloy, C.2
Faure, S.3
Achard, J.M.4
Jeunemaitre, X.5
-
26
-
-
34147121186
-
Intersectin links WNK kinases to endocytosis of ROMK1
-
He G, Wang HR, Huang SK, Huang CL Intersectin links WNK kinases to endocytosis of ROMK1. J. Clin. Invest. 2007, 117:1078-1087.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1078-1087
-
-
He, G.1
Wang, H.R.2
Huang, S.K.3
Huang, C.L.4
-
27
-
-
9844221411
-
Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10
-
Julier C, Delépine M, Keavney B, et al. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum. Mol. Genet. 1997, 6:2077-2085.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 2077-2085
-
-
Julier, C.1
Delépine, M.2
Keavney, B.3
-
28
-
-
0345659215
-
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
-
Kahle KT, Wilson FH, Leng Q, et al. WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat. Genet. 2003, 35:372-376.
-
(2003)
Nat. Genet.
, vol.35
, pp. 372-376
-
-
Kahle, K.T.1
Wilson, F.H.2
Leng, Q.3
-
29
-
-
1242319290
-
WNK4 regulates apical and basolateral Cl2 flux in extrarenal epithelia
-
Kahle KT, Gimenez I, Hassan H, et al. WNK4 regulates apical and basolateral Cl2 flux in extrarenal epithelia. Proc. Natl Acad. Sci. USA 2004, 101:2064-2069.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 2064-2069
-
-
Kahle, K.T.1
Gimenez, I.2
Hassan, H.3
-
30
-
-
4344656182
-
WNK kinases: molecular regulators of integrated epithelial ion transport
-
Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP WNK kinases: molecular regulators of integrated epithelial ion transport. Curr. Opin. Nephrol. Hypertens. 2004, 13:557-562.
-
(2004)
Curr. Opin. Nephrol. Hypertens.
, vol.13
, pp. 557-562
-
-
Kahle, K.T.1
Wilson, F.H.2
Lalioti, M.3
Toka, H.4
Qin, H.5
Lifton, R.P.6
-
31
-
-
6944227814
-
Paracellular Cl2 permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension
-
Kahle KT, Macgregor GG, Wilson FH, et al. Paracellular Cl2 permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc. Natl Acad. Sci. USA 2004, 101:14877-14882.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 14877-14882
-
-
Kahle, K.T.1
Macgregor, G.G.2
Wilson, F.H.3
-
32
-
-
28044473649
-
2 in and out of cells: implications for control of cell volume and neuronal excitability
-
2 in and out of cells: implications for control of cell volume and neuronal excitability. Proc. Natl Acad. Sci. USA, 2005, 102:16783-16788.
-
(2005)
Proc. Natl Acad. Sci. USA,
, vol.102
, pp. 16783-16788
-
-
Kahle, K.T.1
Rinehart, J.2
de Los Heros, P.3
-
33
-
-
0026354824
-
The syndrome of hypertension and hyperkalemia with normal GFR (Gordon's syndrome): is there increased proximal sodium reabsorption?
-
Klemm SA, Gordon RD, Tunny TJ, Thompson RE The syndrome of hypertension and hyperkalemia with normal GFR (Gordon's syndrome): is there increased proximal sodium reabsorption?. Clin. Invest. Med. 1991, 14:551-558.
-
(1991)
Clin. Invest. Med.
, vol.14
, pp. 551-558
-
-
Klemm, S.A.1
Gordon, R.D.2
Tunny, T.J.3
Thompson, R.E.4
-
34
-
-
4744369165
-
Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
-
Kokubo Y, Kamide K, Inamoto N et al Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. J. Hum. Genet. 2004, 49:507-515.
-
(2004)
J. Hum. Genet.
, vol.49
, pp. 507-515
-
-
Kokubo, Y.1
Kamide, K.2
Inamoto N, E.A.3
-
35
-
-
33749118898
-
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
-
Lalioti MD, Zhang J, Volkman HM, et al. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat. Genet. 2006, 38:1124-1132.
-
(2006)
Nat. Genet.
, vol.38
, pp. 1124-1132
-
-
Lalioti, M.D.1
Zhang, J.2
Volkman, H.M.3
-
36
-
-
31944441600
-
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
-
Lazrak A, Liu Z, Huang CL Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc. Natl Acad. Sci. USA 2006, 103:1615-1620.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 1615-1620
-
-
Lazrak, A.1
Liu, Z.2
Huang, C.L.3
-
37
-
-
27744471780
-
Aldosterone and tight junctions: modulation of claudin-4 phosphorylation in renal collecting duct cells
-
Le Moellic C, Boulkroun S, González-Nunez D, et al. Aldosterone and tight junctions: modulation of claudin-4 phosphorylation in renal collecting duct cells. Am. J. Physiol. Cell Physiol. 2005, 289:C1513-C1521.
-
(2005)
Am. J. Physiol. Cell Physiol.
, vol.289
-
-
Le Moellic, C.1
Boulkroun, S.2
González-Nunez, D.3
-
38
-
-
22844441657
-
Properties of WNK1 and implications for other family members
-
Lenertz LY, Lee BH, Min X, et al. Properties of WNK1 and implications for other family members. J. Biol. Chem. 2005, 280:26653-26658.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26653-26658
-
-
Lenertz, L.Y.1
Lee, B.H.2
Min, X.3
-
39
-
-
0033770421
-
Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study
-
Levy D, DeStefano AL, Larson MG, et al. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension 2000, 36:477-483.
-
(2000)
Hypertension
, vol.36
, pp. 477-483
-
-
Levy, D.1
DeStefano, A.L.2
Larson, M.G.3
-
40
-
-
0022000291
-
Familiar hyperkalaemic acidosis
-
Licht JH, Amundson D, Hsueh WA, Lombardo JV Familiar hyperkalaemic acidosis. Q. J. Med. 1985, 54:161-176.
-
(1985)
Q. J. Med.
, vol.54
, pp. 161-176
-
-
Licht, J.H.1
Amundson, D.2
Hsueh, W.A.3
Lombardo, J.V.4
-
41
-
-
0035936780
-
Molecular mechanisms of human hypertension
-
Lifton RP, Gharavi AG, Geller DS Molecular mechanisms of human hypertension. Cell 2001, 104:545-556.
-
(2001)
Cell
, vol.104
, pp. 545-556
-
-
Lifton, R.P.1
Gharavi, A.G.2
Geller, D.S.3
-
42
-
-
0037312921
-
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
-
Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 2003, 33:177-182.
-
(2003)
Nat. Genet.
, vol.33
, pp. 177-182
-
-
Lohmueller, K.E.1
Pearce, C.L.2
Pike, M.3
Lander, E.S.4
Hirschhorn, J.N.5
-
43
-
-
19244386918
-
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21
-
Mansfield TA, Simon DB, Farfel Z, et al. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat. Genet. 1997, 16:202-205.
-
(1997)
Nat. Genet.
, vol.16
, pp. 202-205
-
-
Mansfield, T.A.1
Simon, D.B.2
Farfel, Z.3
-
44
-
-
0036328423
-
Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density
-
Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J. Clin. Endocrinol. Metab. 2002, 87:3248-3254.
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 3248-3254
-
-
Mayan, H.1
Vered, I.2
Mouallem, M.3
Tzadok-Witkon, M.4
Pauzner, R.5
Farfel, Z.6
-
45
-
-
3142600709
-
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
-
Min X, Lee BH, Cobb MH, Goldsmith EJ Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure 2004, 12:1303-1311.
-
(2004)
Structure
, vol.12
, pp. 1303-1311
-
-
Min, X.1
Lee, B.H.2
Cobb, M.H.3
Goldsmith, E.J.4
-
46
-
-
30044442784
-
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
-
Moriguchi T, Urushiyama S, Hisamoto N, et al. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J. Biol. Chem. 2005, 280:42685-42693.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 42685-42693
-
-
Moriguchi, T.1
Urushiyama, S.2
Hisamoto, N.3
-
47
-
-
0022993920
-
Pseudohypoaldosteronism type II: proximal renal tubular acidosis and dDAVP-sensitive renal hyperkalemia
-
Nahum H, Paillard M, Prigent A, et al. Pseudohypoaldosteronism type II: proximal renal tubular acidosis and dDAVP-sensitive renal hyperkalemia. Am. J. Nephrol. 1986, 6:253-262.
-
(1986)
Am. J. Nephrol.
, vol.6
, pp. 253-262
-
-
Nahum, H.1
Paillard, M.2
Prigent, A.3
-
48
-
-
26444443132
-
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study
-
Newhouse SJ, Wallace C, Dobson R, et al. Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum. Mol. Genet. 2005, 14:1805-1814.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 1805-1814
-
-
Newhouse, S.J.1
Wallace, C.2
Dobson, R.3
-
49
-
-
33748430618
-
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells
-
Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Biochem. Biophys. Res. Commun. 2006, 349:804-808.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.349
, pp. 804-808
-
-
Ohta, A.1
Yang, S.S.2
Rai, T.3
Chiga, M.4
Sasaki, S.5
Uchida, S.6
-
50
-
-
33748043980
-
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo
-
O'Reilly M, Marshall E, Macgillivray T, et al. Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J. Am. Soc. Nephrol. 2006, 17:2402-2413.
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 2402-2413
-
-
O'Reilly, M.1
Marshall, E.2
Macgillivray, T.3
-
51
-
-
75949143620
-
Hypertension and hyperpotassaemia without renal disease in a young male
-
Paver WK, Pauline GJ Hypertension and hyperpotassaemia without renal disease in a young male. Med. J. Aust. 1964, 2:305-306.
-
(1964)
Med. J. Aust.
, vol.2
, pp. 305-306
-
-
Paver, W.K.1
Pauline, G.J.2
-
52
-
-
0035486680
-
The role of SGK1 in hormone-regulated sodium transport
-
Pearce D The role of SGK1 in hormone-regulated sodium transport. Trends Endocrinol. Metab. 2001, 12:341-347.
-
(2001)
Trends Endocrinol. Metab.
, vol.12
, pp. 341-347
-
-
Pearce, D.1
-
53
-
-
0037184942
-
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)
-
Piechotta K, Lu J, Delpire E Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J. Biol. Chem. 2002, 277:50812-50819.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50812-50819
-
-
Piechotta, K.1
Lu, J.2
Delpire, E.3
-
54
-
-
0346101747
-
Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl2 cotransporter in the nervous system: evidence for a scaffolding role of the kinase
-
Piechotta K, Garbarini N, England R, Delpire E Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl2 cotransporter in the nervous system: evidence for a scaffolding role of the kinase. J. Biol. Chem. 2003, 278:52848-52856.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52848-52856
-
-
Piechotta, K.1
Garbarini, N.2
England, R.3
Delpire, E.4
-
55
-
-
0023901499
-
Familial pseudohypoaldosteronism
-
Popow C, Pollak A, Herkner K, Scheibenreiter S, Swoboda W Familial pseudohypoaldosteronism. Acta Paediatr. Scand. 1988, 77:136-141.
-
(1988)
Acta Paediatr. Scand.
, vol.77
, pp. 136-141
-
-
Popow, C.1
Pollak, A.2
Herkner, K.3
Scheibenreiter, S.4
Swoboda, W.5
-
56
-
-
0033963206
-
Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy
-
Reilly RF, Ellison DH Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Physiol. Rev. 2000, 80:277-313.
-
(2000)
Physiol. Rev.
, vol.80
, pp. 277-313
-
-
Reilly, R.F.1
Ellison, D.H.2
-
57
-
-
34247205230
-
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
-
Ring AM, Cheng SX, Leng Q, et al. WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc. Natl Acad. Sci. USA 2007, 104:4020-4024.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 4020-4024
-
-
Ring, A.M.1
Cheng, S.X.2
Leng, Q.3
-
58
-
-
34247236088
-
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
-
Ring AM, Cheng SX, Leng Q, et al. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proc. Natl Acad. Sci. USA 2007, 104:4025-4029.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 4025-4029
-
-
Ring, A.M.1
Cheng, S.X.2
Leng, Q.3
-
59
-
-
85047690446
-
Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance
-
Rubera I, Loffing J, Palmer LG, et al. Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J. Clin. Invest. 2003, 112:554-565.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 554-565
-
-
Rubera, I.1
Loffing, J.2
Palmer, L.G.3
-
60
-
-
0035804277
-
DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
-
Sacks FM, Svetkey LP, Vollmer WM, et al. DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N. Engl J. Med. 2001, 344:3-10.
-
(2001)
N. Engl J. Med.
, vol.344
, pp. 3-10
-
-
Sacks, F.M.1
Svetkey, L.P.2
Vollmer, W.M.3
-
61
-
-
0019480065
-
Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption
-
Schambelan M, Sebastian A, Rector FC Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int. 1981, 19:716-727.
-
(1981)
Kidney Int.
, vol.19
, pp. 716-727
-
-
Schambelan, M.1
Sebastian, A.2
Rector, F.C.3
-
62
-
-
9044235777
-
Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
-
Simon DB, Nelson-Williams C, Bia MJ, et al. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat. Genet. 1996, 12:24-30.
-
(1996)
Nat. Genet.
, vol.12
, pp. 24-30
-
-
Simon, D.B.1
Nelson-Williams, C.2
Bia, M.J.3
-
63
-
-
0015613483
-
Short stature, hyperkalemia and acidosis: A defect in renal transport of potassium
-
Spitzer A, Edelmann CM, Goldberg LD, Henneman PH Short stature, hyperkalemia and acidosis: A defect in renal transport of potassium. Kidney Int. 1973, 3:251-257.
-
(1973)
Kidney Int.
, vol.3
, pp. 251-257
-
-
Spitzer, A.1
Edelmann, C.M.2
Goldberg, L.D.3
Henneman, P.H.4
-
64
-
-
0014405891
-
Syndrome of idiopathic hyperkalaemia and hypertension with decreased plasma renin activity: effects on plasma renin and aldosterone of reducing the serum potassium level
-
Stokes GS, Gentle JL, Edwards KD, Stewart JH Syndrome of idiopathic hyperkalaemia and hypertension with decreased plasma renin activity: effects on plasma renin and aldosterone of reducing the serum potassium level. Med. J. Aust. 1968, 2:1050-1054.
-
(1968)
Med. J. Aust.
, vol.2
, pp. 1050-1054
-
-
Stokes, G.S.1
Gentle, J.L.2
Edwards, K.D.3
Stewart, J.H.4
-
65
-
-
0026023350
-
Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism
-
Take C, Ikeda K, Kurasawa T, Kurokawa K Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism. N. Engl. J. Med. 1991, 324:472-476.
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 472-476
-
-
Take, C.1
Ikeda, K.2
Kurasawa, T.3
Kurokawa, K.4
-
66
-
-
33644874530
-
Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population
-
Tobin MD, Raleigh SM, Newhouse S, et al. Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation 2005, 112:3423-3429.
-
(2005)
Circulation
, vol.112
, pp. 3423-3429
-
-
Tobin, M.D.1
Raleigh, S.M.2
Newhouse, S.3
-
67
-
-
0022904906
-
Mineralocorticoid-induced kaliuresis in type-II pseudohypoaldosteronism
-
Travis PS, Cushner HM Mineralocorticoid-induced kaliuresis in type-II pseudohypoaldosteronism. Am. J. Med. Sci. 1986, 292:235-240.
-
(1986)
Am. J. Med. Sci.
, vol.292
, pp. 235-240
-
-
Travis, P.S.1
Cushner, H.M.2
-
68
-
-
0000726724
-
Diuretics in the management of hypertension
-
Raven Press, New York, J.H. Laragh, B.M. Brenner (Eds.)
-
Unwin RJ, Ligueros M, Shakelton C, Wilcox CS Diuretics in the management of hypertension. Hypertension: Pathophysiology, Diagnosis and Management 1995, 2785-2799. Raven Press, New York. 2nd edn. J.H. Laragh, B.M. Brenner (Eds.).
-
(1995)
Hypertension: Pathophysiology, Diagnosis and Management
, pp. 2785-2799
-
-
Unwin, R.J.1
Ligueros, M.2
Shakelton, C.3
Wilcox, C.S.4
-
69
-
-
0035817725
-
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms
-
Verissimo F, Jordan P WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene 2001, 20:5562-5569.
-
(2001)
Oncogene
, vol.20
, pp. 5562-5569
-
-
Verissimo, F.1
Jordan, P.2
-
70
-
-
26844532768
-
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
-
Vitari AC, Deak M, Morrice NA, Alessi DR The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem. J. 2005, 391:17-24.
-
(2005)
Biochem. J.
, vol.391
, pp. 17-24
-
-
Vitari, A.C.1
Deak, M.2
Morrice, N.A.3
Alessi, D.R.4
-
72
-
-
0016282699
-
Hyperkalemia, acidosis, and short stature associated with a defect in renal potassium excretion
-
Weinstein SF, Allan DM, Mendoza SA Hyperkalemia, acidosis, and short stature associated with a defect in renal potassium excretion. J. Pediatr. 1974, 85:355-358.
-
(1974)
J. Pediatr.
, vol.85
, pp. 355-358
-
-
Weinstein, S.F.1
Allan, D.M.2
Mendoza, S.A.3
-
73
-
-
17944373014
-
Human hypertension caused by mutations in WNK kinases
-
Wilson FH, Disse-Nicodème S, Choate KA, et al. Human hypertension caused by mutations in WNK kinases. Science 2001, 293:1107-1112.
-
(2001)
Science
, vol.293
, pp. 1107-1112
-
-
Wilson, F.H.1
Disse-Nicodème, S.2
Choate, K.A.3
-
74
-
-
0037457965
-
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
-
Wilson FH, Kahle KT, Sabath E, et al. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc. Natl Acad. Sci. USA 2003, 100:680-684.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 680-684
-
-
Wilson, F.H.1
Kahle, K.T.2
Sabath, E.3
-
75
-
-
0034595634
-
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
-
Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J. Biol. Chem. 2000, 275:16795-167801.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16795-167801
-
-
Xu, B.1
English, J.M.2
Wilsbacher, J.L.3
Stippec, S.4
Goldsmith, E.J.5
Cobb, M.H.6
-
76
-
-
2242435334
-
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation
-
Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J. Biol. Chem. 2002, 277:48456-48462.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48456-48462
-
-
Xu, B.E.1
Min, X.2
Stippec, S.3
Lee, B.H.4
Goldsmith, E.J.5
Cobb, M.H.6
-
77
-
-
22544472397
-
WNK1 activates SGK1 to regulate the epithelial sodium channel
-
Xu BE, Stippec S, Chu PY, et al. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc. Natl Acad. Sci. USA 2005, 102:10315-10320.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 10315-10320
-
-
Xu, B.E.1
Stippec, S.2
Chu, P.Y.3
-
78
-
-
26644449443
-
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism
-
Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J. Biol. Chem. 2005, 280:34218-34223.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 34218-34223
-
-
Xu, B.E.1
Stippec, S.2
Lazrak, A.3
Huang, C.L.4
Cobb, M.H.5
-
79
-
-
0026573653
-
Disturbed calcium metabolism in offspring of hypertensive parents
-
Yamakawa H, Suzuki H, Nakamura M, Ohno Y, Saruta T Disturbed calcium metabolism in offspring of hypertensive parents. Hypertension 1992, 19:528-534.
-
(1992)
Hypertension
, vol.19
, pp. 528-534
-
-
Yamakawa, H.1
Suzuki, H.2
Nakamura, M.3
Ohno, Y.4
Saruta, T.5
-
80
-
-
11144354175
-
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
-
Yamauchi K, Rai T, Kobayashi K, et al. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc. Natl Acad. Sci. USA 2004, 101:4690-4694.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4690-4694
-
-
Yamauchi, K.1
Rai, T.2
Kobayashi, K.3
-
81
-
-
0037382807
-
WNK kinases regulate thiazide-sensitive Na-Cl cotransport
-
Yang CL, Angell J, Mitchell R, Ellison DH WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J. Clin. Invest. 2003, 111:1039-1045.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1039-1045
-
-
Yang, C.L.1
Angell, J.2
Mitchell, R.3
Ellison, D.H.4
-
82
-
-
18244373189
-
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport
-
Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J. Clin. Invest. 2005, 115:1379-1387.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1379-1387
-
-
Yang, C.L.1
Zhu, X.2
Wang, Z.3
Subramanya, A.R.4
Ellison, D.H.5
-
83
-
-
34247617951
-
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model
-
Yang SS, Morimoto T, Rai T, et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007, 5:331-344.
-
(2007)
Cell Metab.
, vol.5
, pp. 331-344
-
-
Yang, S.S.1
Morimoto, T.2
Rai, T.3
-
84
-
-
10744226663
-
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention
-
Zambrowicz BP, Abuin A, Ramirez-Solis R, et al. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc. Natl Acad. Sci. USA 2003, 100:14109-14114.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 14109-14114
-
-
Zambrowicz, B.P.1
Abuin, A.2
Ramirez-Solis, R.3
|