WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism

Journal of Biological Chemistry

Volumn 280, Issue 40, 2005, Pages 34218-34223

  Xu, Bing E ^a   Stippec, Steve ^a   Lazrak, Ahmed ^a   Huang, Chou Long ^a   Cobb, Melanie H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ALCOHOLS; ENZYME INHIBITION; GENETIC ENGINEERING; PATIENT TREATMENT; PROTEINS;

CATALYTIC SITE ORGANIZATION; HYPERTENSIVE PATIENTS; PROTEIN KINASE; WNK1 ACTIVATES;

BIOCATALYSTS;

GLUCOCORTICOID; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE WNK1; PROTEIN SERINE THREONINE KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM CHANNEL; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME MECHANISM; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PSEUDOHYPOALDOSTERONISM; SODIUM CURRENT; TWO HYBRID SYSTEM; WNK1 GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CATALYTIC DOMAIN; CELL LINE; DNA MUTATIONAL ANALYSIS; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; EPITHELIAL SODIUM CHANNEL; HYPERTENSION; IMMEDIATE-EARLY PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INTRONS; KIDNEY; MICE; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 26644449443     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505735200     Document Type: Article

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