Pitx2 in Cardiac Left-Right Asymmetry and Human Disease

Heart Development and Regeneration

Volumn , Issue , 2010, Pages 307-322

  Martin, James F ^a   Amendt, Brad A ^a   Brown, Nigel A ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882485533     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-381332-9.00015-3     Document Type: Chapter

References (114)

1. Ai D., Liu W., Ma L., Dong F., Lu M.F., Wang D., Verzi M.P., Cai C., Gage P.J., Evans S., Black B.L., Brown N.A., Martin J.F. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev. Biol. 2006, 296:437-449.
2. Ai D., Wang J., Amen M., Lu M.F., Amendt B.A., Martin J.F. Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development. Mol. Cell Biol. 2007, 27:5765-5775.
3. Amen M., Liu X., Vadlamudi U., Elizondo G., Diamond E., Engelhardt J.F., Amendt B.A. PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Mol. Cell Biol. 2007, 27:7560-7573.
4. Amen M., Espinoza H.M., Cox C., Liang X., Wang J., Link T.M., Brennan R.G., Martin J.F., Amendt B.A. Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/-catenin signaling. Nucleic Acids Res. 2008, 36(2):462-476.
5. Amendt B.A. The molecular and biochemical basis of Axenfeld-Rieger Syndrome. The Molecular Mechanisms of Axenfeld-Rieger Syndrome 2005, R. G. Landes Co, Austin, TX, Chapter 4. B.A. Amendt (Ed.).
6. Amendt B.A., Semina E.V., Alward W.L. Rieger syndrome: a clinical, molecular and biochemical analysis. Cell Mol. Life Sci. (Review) 2000, 57:1652-1666.
7. Arnold J.S., Werling U., Braunstein E.M., Liao J., Nowotschin S., Edelmann W., Hebert J.M., Morrow B.E. Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development 2006, 133:977-987.
8. Bajolle F., Zaffran S., Kelly R.G., Hadchouel J., Bonnet D., Brown N.A., Buckingham M.E. Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries. Circ. Res. 2006, 98:421-428.
9. Bamford R.N., Roessler E., Burdine R.D., Saplakoglu U., dela Cruz J., Splitt M., Goodship J.A., Towbin J., Bowers P., Ferrero G.B., Marino B., Schier A.F., Shen M.M., Muenke M., Casey B. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. Nat. Genet. 2000, 26:365-369.
10. Bartoloni L., Blouin J.L., Pan Y., Gehrig C., Maiti A.K., Scamuffa N., Rossier C., Jorissen M., Armengot M., Meeks M., Mitchison H.M., Chung E.M., Delozier-Blanchet C.D., Craigen W.J., Antonarakis S.E. Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia. Proc Natl Acad Sci USA 2002, 99:10282-10286.
11. Bekir N.A., Gungor K. Atrial septal defect with interatrial aneurysm and Axenfeld-Rieger syndrome. Acta Ophthalmol. Scand. 2000, 78:101-103.
12. Bilodeau S., Vallette-Kasic S., Gauthier Y., Figarella-Branger D., Brue T., Berthelet F., Lacroix A., Batista D., Stratakis C., Hanson J., Meij B., Drouin J. Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Genes Dev. 2006, 20:2871-2886.
13. Blaschke R.J., Hahurij N.D., Kuijper S., Just S., Wisse L.J., Deissler K., Maxelon T., Anastassiadis K., Spitzer J., Hardt S.E., Schöler H., Feitsma H., Rottbauer W., Blum M., Meijlink F., Rappold G., Gittenberger-de Groot A.C. Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation 2007, 115:1830-1838.
14. Bostrom M.P., Hutchins G.M. Arrested rotation of the outflow tract may explain double-outlet right ventricle. Circulation 1988, 77:1258-1265.
15. Brown C.O., Chi X., Garcia-Gras E., Shirai M., Feng X.H., Schwartz R.J. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J. Biol. Chem. 2004, 279:10659-10669.
16. Brown N.A., Wolpert L. The development of handedness in left/right asymmetry. Development 1990, 109:1-9.
17. Brown N.A., Anderson R.H. Symmetry and laterality in the human heart: developmental implications. Heart Development 1999, 447-462. Academic Press, San Diego, CA. R.P. Harvey, N. Rosenthal (Eds.).
18. Buckingham M., Meilhac S., Zaffran S. Building the mammalian heart from two sources of myocardial cells. Nat. Rev. Genet. 2005, 6:826-835.
19. Cai C.L., Liang X., Shi Y., Chu P.H., Pfaff S.L., Chen J., Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 2003, 5:877-889.
20. Campione M., Steinbeisser H., Schweickert A., Deissler K., van Bebber F., Lowe L.A., Nowotschin S., Viebahn C., Haffter P., Kuehn M.R., Blum M. The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development 1999, 126:1225-1234.
21. Campione M., Ros M.A., Icardo J.M., Piedra E., Christoffels V.M., Schweickert A., Blum M., Franco D., Moorman A.F. Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice. Dev. Biol. 2001, 231:252-264.
22. Capdevila J., Vogan K.J., Tabin C.J., Izpisua Belmonte J.C. Mechanisms of left-right determination in vertebrates. Cell 2000, 101:9-21.
23. Charles M.A., Suh H., Hjalt T.A., Drouin J., Camper S.A., Gage P.J. PITX genes are required for cell survival and Lhx3 activation. Mol. Endocrinol. 2005, 19:1893-1903.
24. Cox C.J., Espinoza H.M., McWilliams B., Chappell K., Morton L., Hjalt T.A., Semina E.V., Amendt B.A. Differential regulation of gene expression by PITX2 isoforms. J. Biol. Chem. 2002, 277:25001-25010.
25. Cunningham E.T., Eliott D., Miller N.R., Maumenee I.H., Green W.R. Familial Axenfeld-Rieger anomaly, atrial septal defect, and sensorineural hearing loss: a possible new genetic syndrome. Arch. Ophthalmol. 1998, 116:78-82.
26. Davis, N.M., Kurpios, N.A., Sun, X., Gros, J., Martin, J.F., Tabin, C.J., 2008. Gut looping is initiated by left-right asymmetric changes in the architecture of the dorsal mesentery. Dev. Cell in press.
27. Degar B.A., Baskaran N., Hulspas R., Quesenberry P.J., Weissman S.M., Forget B.G. The homeodomain gene Pitx2 is expressed in primitive hematopoietic stem/progenitor cells but not in their differentiated progeny. Exp. Hematol. 2001, 29:894-902.
28. Diehl A.G., Zareparsi S., Qian M., Khanna R., Angeles R., Gage P.J. Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. Invest. Ophthalmol. Vis. Sci. 2006, 47:1785-1793.
29. Dodou E., Verzi M.P., Anderson J.P., Xu S.M., Black B.L. Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development 2004, 131:3931-3942.
30. Dong F., Sun X., Liu W., Ai D., Klysik E., Lu M.F., Hadley J., Antoni L., Chen L., Baldini A., Francis-West P., Martin J.F. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development 2006, 133:4891-4899.
31. Franco D., Campione M., Kelly R., Zammit P.S., Buckingham M., Lamers W.H., Moorman A.F. Multiple transcriptional domains, with distinct left and right components, in the atrial chambers of the developing heart. Circ. Res. 2000, 87:984-991.
32. Gage P.J., Suh H., Camper S.A. Dosage requirement of Pitx2 for development of multiple organs. Development 1999, 126:4643-4651.
33. Gage P.J., Suh H., Camper S.A. The bicoid-related Pitx gene family in development. Mamm. Genome 1999, 10:197-200.
34. Ganga M., Espinoza H.M., Cox C.J., Morton L., Hjalt T.A., Lee Y., Amendt B.A. PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5. J. Biol. Chem. 2003, 278:22437-22445.
35. Gong Y., Mo C., Fraser S.E. Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 2004, 430:689-693.
36. Gronostajski R.M. Roles of the NFI/CTF gene family in transcription and development. Gene 2000, 249:31-45.
37. Gudbjartsson D.F., Arnar D.O., Helgadottir A., Gretarsdottir S., Holm H., Sigurdsson A., Jonasdottir A., Baker A., Thorleifsson G., Kristjansson K., et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007, 448:353-357.
38. Guichard C., Harricane M.C., Lafitte J.J., Godard P., Zaegel M., Tack V., Lalau G., Bouvagnet P. Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). Am. J. Hum. Genet. 2001, 68:1030-1035.
39. Haissaguerre M., Jais P., Shah D.C., Takahashi A., Hocini M., Quiniou G., Garrigue S., Le Mouroux A., Le Metayer P., Clementy J. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N. Engl. J. Med. 1998, 339:659-666.
40. Hamada H., Meno C., Watanabe D., Saijoh Y. Establishment of vertebrate left-right asymmetry. Nat. Rev. Genet. 2002, 3:103-113.
41. Hamblet N.S., Lijam N., Ruiz-Lozano P., Wang J., Yang Y., Luo Z., Mei L., Chien K.R., Sussman D.J., Wynshaw-Boris A. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 2002, 129:5827-5838.
42. Harvey R.P. Links in the left/right axial pathway. Cell 1998, 94:273-276.
43. Harvey R.P. Patterning the vertebrate heart. Nat. Rev. Genet. 2002, 3:544-556.
44. Hoogaars W.M., Engel A., Brons J.F., Verkerk A.O., de Lange F.J., Wong L.Y., Bakker M.L., Clout D.E., Wakker V., Barnett P., Ravesloot J.H., Moorman A.F., Verheijck E.E., Christoffels V.M. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007, 21:1098-1112.
45. Icardo J.M., Sanchez de Vega M.J. Spectrum of heart malformations in mice with situs solitus, situs inversus, and associated visceral heterotaxy. Circulation 1991, 84:2547-2558.
46. Kelly R.G., Brown N.A., Buckingham M.E. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev. Cell 2001, 1:435-440.
47. Kelly R.G., Jerome-Majewska L.A., Papaioannou V.E. The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum. Mol. Genet. 2004, 13:2829-2840.
48. Kioussi C., Briata P., Baek S.H., Rose D.W., Hamblet N.S., Herman T., Ohgi K.A., Lin C., Gleiberman A., Wang J., Brault V., Ruiz-Lozano P., Nguyen H.D., Kemler R., Glass C.K., Wynshaw-Boris A., Rosenfeld M.G. Identification of a Wnt/Dvl/beta-Catenin Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 2002, 111:673-685.
49. Kitamura K., Miura H., Miyagawa-Tomita S., Yanazawa M., Katoh-Fukui Y., Suzuki R., Ohuchi H., Suehiro A., Motegi Y., Nakahara Y., Kondo S., Yokoyama M. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism. Development 1999, 126:5749-5758.
50. Kosaki K., Bassi M.T., Kosaki R., Lewin M., Belmont J., Schauer G., Casey B. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development. Am. J. Hum. Genet. 1999, 64:712-721.
51. Lamba P., Hjalt T.A., Bernard D.J. Novel forms of Paired-like homeodomain transcription factor 2 (PITX2): generation by alternative translation initiation and mRNA splicing. BMC Mol. Biol. 2008, 28:9-31.
52. Lamolet B., Pulichino A.M., Lamonerie T., Gauthier Y., Brue T., Enjalbert A., Drouin J. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 2001, 104:849-859.
53. Levin M., Mercola M. The compulsion of chirality: toward an understanding of left-right asymmetry. Genes Dev. 1998, 12:763-769.
54. Levin M., Palmer A.R. Left-right patterning from the inside out: widespread evidence for intracellular control. Bioessays 2007, 29:271-287.
55. Liberatore C.M., Searcy-Schrick R.D., Vincent E.B., Yutzey K.E. Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region. Dev. Biol. 2002, 244:243-256.
56. Lickert H., Takeuchi J.K., Von Both I., Walls J.R., McAuliffe F., Adamson S.L., Henkelman R.M., Wrana J.L., Rossant J., Bruneau B.G. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature 2004, 432:107-112.
57. Lien C.L., McAnally J., Richardson J.A., Olson E.N. Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 2002, 244:257-266.
58. Lin C.R., Kioussi C., O'Connell S., Briata P., Szeto D., Liu F., Izpisua-Belmonte J.C., Rosenfeld M.G. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 1999, 401:279-282.
59. Lin L., Cui L., Zhou W., Dufort D., Zhang X., Cai C.L., Bu L., Yang L., Martin J., Kemler R., Rosenfeld M.G., Chen J., Evans S.M. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc. Natl. Acad. Sci. USA 2007, 104:9313-9318.
60. Liu C., Liu W., Lu M.F., Brown N.A., Martin J.F. Regulation of left-right asymmetry by thresholds of Pitx2c activity. Development 2001, 128:2039-2048.
61. Liu C., Liu W., Palie J., Lu M.F., Brown N.A., Martin J.F. Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development 2002, 129:5081-5091.
62. Liu W., Selever J., Lu M.F., Martin J.F. Genetic dissection of pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis, and cell migration. Development 2003, 130:6375-6385.
63. Liu W., Selever J., Wang D., Lu M.F., Moses K.A., Schwartz R.J., Martin J.F. Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc. Natl. Acad. Sci. USA 2004, 101:4489-4494.
64. Logan M., Pagan-Westphal S.M., Smith D.M., Paganessi L., Tabin C.J. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 1998, 94:307-317.
65. Lomonico M.P., Moore G.W., Hutchins G.M. Rotation of the junction of the outflow tract and great arteries in the embryonic human heart. Anat. Rec. 1986, 216:544-549.
66. Lu J.R., Bassel-Duby R., Hawkins A., Chang P., Valdez R., Wu H., Gan L., Shelton J.M., Richardson J.A., Olson E.N. Control of facial muscle development by MyoR and capsulin. Science 2002, 298:2378-2381.
67. Lu M.F., Pressman C., Dyer R., Johnson R.L., Martin J.F. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature 1999, 401:276-278.
68. Mammi I., De Giorgio P., Clementi M., Tenconi R. Cardiovascular anomaly in Rieger Syndrome: heterogeneity or contiguity?. Acta. Ophthalmol. Scand. 1998, 76:509-512.
69. Meilhac S.M., Esner M., Kelly R.G., Nicolas J.F., Buckingham M.E. The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev. Cell 2004, 6:685-698.
70. Meilhac S.M., Esner M., Kerszberg M., Moss J.E., Buckingham M.E. Oriented clonal cell growth in the developing mouse myocardium underlies cardiac morphogenesis. J. Cell Biol. 2004, 164:97-109.
71. Meno C., Shimono A., Saijoh Y., Yashiro K., Mochida K., Ohishi S., Noji S., Kondoh H., Hamada H. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 1998, 94:287-297.
72. Meno C., Gritsman K., Ohishi S., Ohfuji Y., Heckscher E., Mochida K., Shimono A., Kondoh H., Talbot W.S., Robertson E.J., Schier A.F., Hamada H. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 1999, 4:287-298.
73. Mommersteeg M.T., Brown N.A., Prall O.W., de Gier-de Vries C., Harvey R.P., Moorman A.F., Christoffels V.M. Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ. Res. 2007, 101:902-909.
74. Mommersteeg M.T., Hoogaars W.M., Prall O.W., de Gier-de Vries C., Wiese C., Clout D.E., Papaioannou V.E., Brown N.A., Harvey R.P., Moorman A.F., Christoffels V.M. Molecular pathway for the localized formation of the sinoatrial node. Circ. Res. 2007, 100:354-362.
75. Nonaka S., Shiratori H., Saijoh Y., Hamada H. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 2002, 418:96-99.
76. Nowotschin S., Liao J., Gage P.J., Epstein J.A., Campione M., Morrow B.E. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development 2006, 133:1565-1573.
77. Nunes I., Tovmasian L.T., Silva R.M., Burke R.E., Goff S.P. Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc. Natl. Acad. Sci. USA 2003, 100:4245-4250.
78. Park M., Moon R.T. The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat. Cell Biol. 2002, 4:20-25.
79. Phillips H.M., Murdoch J.N., Chaudhry B., Copp A.J., Henderson D.J. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ. Res. 2005, 96:292-299.
80. Piotrowski T., Ahn D.G., Schilling T.F., Nair S., Ruvinsky I., Geisler R., Rauch G.J., Haffter P., Zon L.I., Zhou Y., Foott H., Dawid I.B., Ho R.K. The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development 2003, 130:5043-5052.
81. Prall O.W., Menon M.K., Solloway M.J., Watanabe Y., Zaffran S., Bajolle F., Biben C., McBride J.J., Robertson B.R., Chaulet H., et al. An nkx2-5/bmp2/smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 2007, 128:947-959.
82. Roberts C.W., Orkin S.H. The SWI/SNF complex - chromatin and cancer. Nat. Rev. Cancer 2004, 4:133-142.
83. Rulifson I.C., Karnik S.K., Heiser P.W., ten Berge D., Chen H., Gu X., Taketo M.M., Nusse R., Hebrok M., Kim S.K. Wnt signaling regulates pancreatic beta cell proliferation. Proc. Natl. Acad. Sci. USA 2007, 104:6247-6252.
84. Ryan A.K., Blumberg B., Rodriguez-Esteban C., Yonei-Tamura S., Tamura K., Tsukui T., de la Pena J., Sabbagh W., Greenwald J., Choe S., Norris D.P., Robertson E.J., Evans R.M., Rosenfeld M.G., Izpisúa Belmonte J.C. Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 1998, 394:545-551.
85. Shen M.M. Nodal signaling: developmental roles and regulation. Development 2007, 134:1023-1034.
86. Schneitz K., Spielmann P., Noll M. Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Genes Dev. 1993, 7:114-129.
87. Schweickert A., Steinbeisser H., Blum M. Differential gene expression of Xenopus Pitx1, Pitx2b and Pitx2c during cement gland, stomodeum and pituitary development. Mech. Dev. 2001, 107:191-194.
88. Semina E.V., Reiter R., Leysens N.J., Alward W.L., Small K.W., Datson N.A., Siegel- Bartelt J., Bierke-Nelson D., Bitoun P., Zabel B.U., Carey J.C., Murray J.C. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nat. Genet. 1996, 14:392-399.
89. Semina E.V., Ferrell R.E., Mintz-Hittner H.A., Bitoun P., Alward W.L., Reiter R.S., Funkhauser C., Daack-Hirsch S., Murray J.C. A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Nat. Genet. 1998, 19:167-170.
90. Shapiro M.D., Marks M.E., Peichel C.L., Blackman B.K., Nereng K.S., Jonsson B., Schluter D., Kingsley D.M. Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks. Nature 2004, 428:717-723.
91. Shih H.P., Gross M.K., Kioussi C. Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc. Natl. Acad. Sci. USA 2007, 104:5907-5912.
92. Shiratori H., Sakuma R., Watanabe M., Hashiguchi H., Mochida K., Sakai Y., Nishino J., Saijoh Y., Whitman M., Hamada H. Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. Mol. Cell 2001, 7:137-149.
93. Shiratori H., Yashiro K., Shen M.M., Hamada H. Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development 2006, 133:3015-3025.
94. Smidt M.P., Cox J.J., van Schaick H.S., Coolen M., Schepers J., van der Kleij A.M., Burbach J.P. Analysis of three Ptx2 splice variants on transcriptional activity and differential expression pattern in the brain. J. Neurochem. 2000, 75:1818-1825.
95. St Amand T.R., Zhang Y., Semina E.V., Zhao X., Hu Y., Nguyen L., Murray J.C., Chen Y. Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev. Biol. 2000, 217:323-332.
96. Sugishita Y., Watanabe M., Fisher S.A. The development of the embryonic outflow tract provides novel insights into cardiac differentiation and remodeling. Trends Cardiovasc. Med. 2004, 14:235-241.
97. Supp D.M., Witte D.P., Potter S.S., Brueckner M. Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature 1997, 389:963-966.
98. Supp D.M., Potter S.S., Brueckner M. Molecular motors: the driving force behind mammalian left-right development. Trends Cell Biol. 2000, 10:41-45.
99. Takeuchi J.K., Mileikovskaia M., Koshiba-Takeuchi K., Heidt A.B., Mori A.D., Arruda E.P., Gertsenstein M., Georges R., Davidson L., Mo R., Hui C.C., Henkelman R.M., Nemer M., Black B.L., Nagy A., Bruneau B.G. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 2005, 132:2463-2474.
100. Vadlamudi U., Espinoza H.M., Ganga M., Martin D.M., Liu X., Engelhardt J.F., Amendt B.A. PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter. J. Cell Sci. 2005, 118:1129-1137.
101. van den Munckhof P., Luk K.C., Ste-Marie L., Montgomery J., Blanchet P.J., Sadikot A.F., Drouin J. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development 2003, 130:2535-2542.
102. von Both I., Silvestri C., Erdemir T., Lickert H., Walls J.R., Henkelman R.M., Rossant J., Harvey R.P., Attisano L., Wrana J.L. Foxh1 is essential for development of the anterior heart field. Dev. Cell 2004, 7:331-345.
103. Waldo K.L., Hutson M.R., Ward C.C., Zdanowicz M., Stadt H.A., Kumiski D., Abu-Issa R., Kirby M.L. Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. Dev. Biol. 2005, 281:78-90.
104. Ward C., Stadt H., Hutson M., Kirby M.L. Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia. Dev. Biol. 2005, 284:72-83.
105. Webb S., Qayyum S.R., Anderson R.H., Lamers W.H., Richardson M.K. Septation and separation within the outflow tract of the developing heart. J. Anat. 2003, 202:327-342.
106. Wei Q., Adelstein R.S. Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling. Mol. Biol. Cell 2002, 13:683-697.
107. Xu H., Morishima M., Wylie J.N., Schwartz R.J., Bruneau B.G., Lindsay E.A., Baldini A. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development 2004, 131:3217-3227.
108. Xu H., Cerrato F., Baldini A. Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development 2005, 132:4387-4395.
109. Yamamoto M., Mine N., Mochida K., Sakai Y., Saijoh Y., Meno C., Hamada H. Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 2003, 130:1795-1804.
110. Yashiro K., Shiratori H., Hamada H. Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature 2007, 450:285-288.
111. Yu X., Amand T.R., Wang S., Li G., Zhang Y., Hu Y.P., Nguyen L., Qiu M.S., Chen Y.P. Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick. Development 2001, 128:1005-1013.
112. Yutzey K.E., Kirby M.L. Wherefore heart thou? Embryonic origins of cardiogenic mesoderm. Dev. Dyn. 2002, 223:307-320.
113. Zhao Y., Morales D.C., Hermesz E., Lee W.K., Pfaff S.L., Westphal H. Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development. Mech. Dev. 2006, 123(8):605-613.
114. Zhou W., Lin L., Majumdar A., Li X., Zhang X., Liu W., Etheridge L., Shi Y., Martin J., Van de Ven W., Kaartinen V., Wynshaw-Boris A., McMahon A.P., Rosenfeld M.G., Evans S.M. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat. Genet. 2007, 39:1225-1234.