The homeodomain gene Pitx2 is expressed in primitive hematopoietic stem/progenitor cells but not in their differentiated progeny

Experimental Hematology

Volumn 29, Issue 7, 2001, Pages 894-902

  Degar, Barbara A ^a   Baskaran, Namadev ^a   Hulspas, Rudolph ^b   Quesenberry, Peter J ^b   Weissman, Sherman M ^a   Forget, Bernard G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA FRAGMENT; HOMEODOMAIN PROTEIN; TRANSCRIPTIIIN FACTOR PITX2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CELL CULTURE; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA LIBRARY; GENE EXPRESSION; HEMATOPOIETIC CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TECHNIQUE;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED BALB C; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS;

EID: 0034949611     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00661-0     Document Type: Conference Paper

References (63)

1. What defines a pluripotent hematopoietic stem cell (PHSC); will the real PHSC please stand up!
2. Purification and characterization of mouse hematopoietic stem cells
3. Purification and characterization of heterogeneous hematopoietic stem cell populations expressing high levels of c-kit receptor
4. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells
5. Cellular and developmental properties of fetal hematopoietic stem cells
6. In vivo and in vitro characterization of long term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection
7. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
8. The Ikaros gene is required for the development of all lymphoid lineages
9. Absence of blood formation in mice lacking the T cell leukemia oncoprotein tal-1/SCL
10. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
11. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
12. An early haematopoietic defect in mice lacking the transcription factor GATA-2
13. Inhibition of granulocytic differentiation by mNotch1.
14. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
15. Homeobox genes in normal hematopoiesis and leukemia
16. Homeobox genes in hematopoiesis and leukemogenesis
17. The transcriptional control of hematopoiesis
18. The genetic program of hematopoietic stem cells
19. Preparation of cDNA from single cells and subcellular regions
20. PCR amplification of up to 35kb DNA with high fidelity and high yield from λ bacteriophage templates
21. Uniform amplification of a mixture of deoxyribonucleic acids with varying GC content
22. Cloning the differences between two complex genomes
23. Comparative genomic analysis of tumors; detection of DNA losses and amplification
24. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
25. Identifying differences in mRNA expression by representational difference analysis of cDNA
26. Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis
27. Pitx2 determines left-right asymmetry of internal organs in vertebrates
28. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signalling pathway in determination of left-right asymmetry
29. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
30. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry
31. Pituitary homeobox 2, a novel member of the bicoid-related homeobox genes, is a potential regulator of anterior structure formation
32. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
33. Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain
34. Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1, and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation
35. Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene
36. Cell cycle analysis and synchronization of pluripotent hematopoietic progenitor stem cells
37. Potential and distribution of transplanted hematopoietic stem cells in a nonablated mouse model
38. - hematopoietic stem cell populations
39. A simple and very efficient method for generating cDNA libraries
40. A mouse genomic library in the bacteriophage P1 cloning system; organization and characterization
41. Ultrastructure of primitive hematopoietic stem cells isolated using probes of functional status
42. low/- hematopoietic stem cell
43. + bone marrow cells
44. Hox genes in vertebrate development
45. + subpopulations of human bone marrow cells
46. Hox homeobox genes as regulators of normal and leukemic hematopoiesis
47. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
48. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
49. Dysregulation of a homeobox gene Hox11 by the t(10;14) in T cell leukemias
50. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemias
51. Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut
52. Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis
53. BMP-4 responsive regulation of dorsal-ventral patterning of the homeobox protein Mix.1
54. Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice
55. Altered Hox expression and segmental identity in Mll-mutant mice
56. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice; a method to create fusion oncogenes
57. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development
58. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
59. Dosage requirement of Pitx2 for development of multiple organs
60. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism
61. The homeobox gene Pitx2; mediator of asymmetric left-right signaling in vertebrate heart and gut looping
62. Pitx2 isoforms; involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry
63. Two-step regulation of left-right asymmetric expression of Pitx2; initiation by nodal signaling and maintenance by Nkx2