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Volumn 22, Issue 5, 2013, Pages 533-538

Polyspecific organic cation transporters and their biomedical relevance in kidney

Author keywords

nephrotoxicity; organic cation transporters; proton cation antiporters; renal cation transport; renal drug drug interaction

Indexed keywords

ANTIINFECTIVE AGENT; CARNITINE; CREATININE; DEBRISOQUINE; DESIPRAMINE; FLUOXETINE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; IMATINIB; INDINAVIR; LAMOTRIGINE; LEVOMEPROMAZINE; MAPROTILINE; METFORMIN; MITOXANTRONE; NISOXETINE; ONDANSETRON; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PAROXETINE; RHODAMINE 123; RITONAVIR; SPIPERONE; TRIMIPRAMINE; TROPISETRON;

EID: 84882450786     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328363ffaf     Document Type: Review
Times cited : (25)

References (53)
  • 1
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
    • Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 2007; 24:1227-1251.
    • (2007) Pharm Res , vol.24 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 2
    • 84875181483 scopus 로고    scopus 로고
    • The SLC22 family with transporters of organic cations, anions and zwitterions
    • Koepsell H. The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 2013; 34:413-435.
    • (2013) Mol Aspects Med , vol.34 , pp. 413-435
    • Koepsell, H.1
  • 3
    • 84877026119 scopus 로고    scopus 로고
    • Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney
    • Motohashi H, Inui KI. Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney. AAPS J 2013; 15:581-588.
    • (2013) AAPS J , vol.15 , pp. 581-588
    • Motohashi, H.1    Inui, K.I.2
  • 4
    • 79955919557 scopus 로고    scopus 로고
    • Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter
    • Komatsu T, Hiasa M, Miyaji T, et al. Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter. Int J Biochem Cell Biol 2011; 43:913-918.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 913-918
    • Komatsu, T.1    Hiasa, M.2    Miyaji, T.3
  • 5
    • 78651362677 scopus 로고    scopus 로고
    • Substrate recognition and translocation by polyspecific organic cation transporters
    • Koepsell H. Substrate recognition and translocation by polyspecific organic cation transporters. Biol Chem 2011; 392:95-101.
    • (2011) Biol Chem , vol.392 , pp. 95-101
    • Koepsell, H.1
  • 6
    • 78649646556 scopus 로고    scopus 로고
    • Organic cation transporters (OCTs,MATEs), in vitro and in vivo evidence for the importance in drug therapy
    • Nies AT, Koepsell H, Damme K, Schwab M. Organic cation transporters (OCTs,MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol 2010; 201:105-167.
    • (2010) Handb Exp Pharmacol , vol.201 , pp. 105-167
    • Nies, A.T.1    Koepsell, H.2    Damme, K.3    Schwab, M.4
  • 7
    • 33751168746 scopus 로고    scopus 로고
    • Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)
    • Yonezawa A, Masuda S, Yokoo S, et al. Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther 2006; 319:879-886.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 879-886
    • Yonezawa, A.1    Masuda, S.2    Yokoo, S.3
  • 8
    • 77950823207 scopus 로고    scopus 로고
    • Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue
    • More SS, Li S, Yee SW, et al. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther 2010; 9:1058-1069.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1058-1069
    • More, S.S.1    Li, S.2    Yee, S.W.3
  • 9
    • 84872688669 scopus 로고    scopus 로고
    • Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)
    • Tamai I. Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21). Biopharm Drug Dispos 2013; 34:29-44.
    • (2013) Biopharm Drug Dispos , vol.34 , pp. 29-44
    • Tamai, I.1
  • 10
    • 41949113401 scopus 로고    scopus 로고
    • Physiological and pharmacokinetic roles of H\+/organic cation antiporters (MATE/SLC47A)
    • Terada T, Inui K-I. Physiological and pharmacokinetic roles of H\+/organic cation antiporters (MATE/SLC47A). Biochem Pharmacol 2008; 75:1689-1696.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1689-1696
    • Terada, T.1    Inui, K.-I.2
  • 11
    • 84873928187 scopus 로고    scopus 로고
    • Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
    • Wittwer MB, Zur AA, Khuri N, et al. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 2013; 56:781-795.
    • (2013) J Med Chem , vol.56 , pp. 781-795
    • Wittwer, M.B.1    Zur, A.A.2    Khuri, N.3
  • 12
    • 80054801694 scopus 로고    scopus 로고
    • The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization
    • Keller T, Egenberger B, Gorboulev V, et al. The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. J Biol Chem 2011; 286:37874-37886.
    • (2011) J Biol Chem , vol.286 , pp. 37874-37886
    • Keller, T.1    Egenberger, B.2    Gorboulev, V.3
  • 13
    • 84857737656 scopus 로고    scopus 로고
    • The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization
    • Brast S, Grabner A, Sucic S, et al. The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization. FASEB J 2012; 26:976-986.
    • (2012) FASEB J , vol.26 , pp. 976-986
    • Brast, S.1    Grabner, A.2    Sucic, S.3
  • 14
    • 65949110578 scopus 로고    scopus 로고
    • Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine
    • Schmitt BM, Gorbunov D, Schlachtbauer P, et al. Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine. Am J Physiol Renal Physiol 2009; 296:F709-F722.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Schmitt, B.M.1    Gorbunov, D.2    Schlachtbauer, P.3
  • 15
    • 84871904912 scopus 로고    scopus 로고
    • Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2
    • Harper JN, Wright SH. Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2. Am J Physiol Renal Physiol 2013; 304:F56-F67.
    • (2013) Am J Physiol Renal Physiol , vol.304
    • Harper, J.N.1    Wright, S.H.2
  • 16
    • 84859719229 scopus 로고    scopus 로고
    • Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake
    • Choi MK, Song IS. Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Biopharm Drug Dispos 2012; 33:170-178.
    • (2012) Biopharm Drug Dispos , vol.33 , pp. 170-178
    • Choi, M.K.1    Song, I.S.2
  • 17
    • 84856233573 scopus 로고    scopus 로고
    • Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron
    • Tzvetkov MV, Saadatmand AR, Bokelmann K, et al. Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron. Pharmacogenomics J 2012; 12:22-29.
    • (2012) Pharmacogenomics J , vol.12 , pp. 22-29
    • Tzvetkov, M.V.1    Saadatmand, A.R.2    Bokelmann, K.3
  • 18
    • 84866133123 scopus 로고    scopus 로고
    • A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1
    • Egenberger B, Gorboulev V, Keller T, et al. A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1. J Biol Chem 2012; 287:31561-31573.
    • (2012) J Biol Chem , vol.287 , pp. 31561-31573
    • Egenberger, B.1    Gorboulev, V.2    Keller, T.3
  • 19
    • 80053286811 scopus 로고    scopus 로고
    • Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli
    • Pochini L, Scalise M, Galluccio M, et al. Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli. Biochem J 2011; 439:227-233.
    • (2011) Biochem J , vol.439 , pp. 227-233
    • Pochini, L.1    Scalise, M.2    Galluccio, M.3
  • 20
    • 84872804350 scopus 로고    scopus 로고
    • Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the nonneuronal cholinergic system
    • Pochini L, Scalise M, Galluccio M, Indiveri C. Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the nonneuronal cholinergic system. Life Sci 2012; 91:1013-1016.
    • (2012) Life Sci , vol.91 , pp. 1013-1016
    • Pochini, L.1    Scalise, M.2    Galluccio, M.3    Indiveri, C.4
  • 21
    • 68049094117 scopus 로고    scopus 로고
    • MATE1 has an external COOH terminus, consistent with a 13-helix topology
    • Zhang X, Wright SH. MATE1 has an external COOH terminus, consistent with a 13-helix topology. Am J Physiol Renal Physiol 2009; 297:F263-F271.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Zhang, X.1    Wright, S.H.2
  • 22
    • 84864987301 scopus 로고    scopus 로고
    • Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein
    • Zhang X, He X, Baker J, Tama F, et al. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. J Biol Chem 2012; 287:27971-27982.
    • (2012) J Biol Chem , vol.287 , pp. 27971-27982
    • Zhang, X.1    He, X.2    Baker, J.3    Tama, F.4
  • 23
    • 77958596325 scopus 로고    scopus 로고
    • Structure of a cation-bound multidrug and toxic compound extrusion transporter
    • He X, Szewczyk P, Karyakin A, et al. Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature 2010; 467:991-994.
    • (2010) Nature , vol.467 , pp. 991-994
    • He, X.1    Szewczyk, P.2    Karyakin, A.3
  • 24
    • 79960155485 scopus 로고    scopus 로고
    • Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter
    • Kido Y, Matsson P, Giacomini KM. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter. J Med Chem 2011; 54:4548-4558.
    • (2011) J Med Chem , vol.54 , pp. 4548-4558
    • Kido, Y.1    Matsson, P.2    Giacomini, K.M.3
  • 25
    • 84892542785 scopus 로고    scopus 로고
    • The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2
    • doi: 10.111/j.1472-8206.2012.01071. [Accessed January 2013]
    • Jouan E, Le VM, Denizot C, et al. The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2. Fundam Clin Pharmacol 2012; www.ncbi.nih.gov/pubmed/22913740, doi: 10.111/j.1472-8206.2012.01071. [Accessed January 2013]
    • (2012) Fundam Clin Pharmacol
    • Jouan, E.1    Le, V.M.2    Denizot, C.3
  • 26
    • 84867869728 scopus 로고    scopus 로고
    • N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K)
    • Ito S, Kusuhara H, Kumagai Y, et al. N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MATE1 and MATE2-K). Clin Pharmacol Ther 2012; 92:635-641.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 635-641
    • Ito, S.1    Kusuhara, H.2    Kumagai, Y.3
  • 27
    • 84857062912 scopus 로고    scopus 로고
    • Lamotrigine is a substrate for OCT1 in brain endothelial cells
    • Dickens D, Owen A, Alfirevic A, et al. Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochem Pharmacol 2012; 83:805-814.
    • (2012) Biochem Pharmacol , vol.83 , pp. 805-814
    • Dickens, D.1    Owen, A.2    Alfirevic, A.3
  • 28
    • 84859107661 scopus 로고    scopus 로고
    • The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1
    • Saadatmand AR, Tadjerpisheh S, Brockmö ller J, Tzvetkov MV. The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1. Biochem Pharmacol 2012; 83:1427-1434.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1427-1434
    • Saadatmand, A.R.1    Tadjerpisheh, S.2    Brockmö Ller, J.3    Tzvetkov, M.V.4
  • 29
    • 84860652339 scopus 로고    scopus 로고
    • Pharmacogenetics meets metabolomics: Discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition
    • Song IS, Lee DY, Shin MH, et al. Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. PLoS ONE 2012; 7:e36637.
    • (2012) PLoS ONE , vol.7
    • Song, I.S.1    Lee, D.Y.2    Shin, M.H.3
  • 30
    • 84871551884 scopus 로고    scopus 로고
    • Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods
    • Ishiguro N, Shimizu H, Kishimoto W, et al. Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug Metab Dispos 2013; 41:149-158.
    • (2013) Drug Metab Dispos , vol.41 , pp. 149-158
    • Ishiguro, N.1    Shimizu, H.2    Kishimoto, W.3
  • 31
    • 84866733724 scopus 로고    scopus 로고
    • Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3
    • Haenisch B, Drescher E, Thiemer L, et al. Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3. Naunyn Schmiedebergs Arch Pharmacol 2012; 385:1017-1023.
    • (2012) Naunyn Schmiedebergs Arch Pharmacol , vol.385 , pp. 1017-1023
    • Haenisch, B.1    Drescher, E.2    Thiemer, L.3
  • 32
    • 84866319957 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activation increases imatinib uptake and killing of chronic myeloid leukemia cells
    • Wang L, Giannoudis A, Austin G, Clark RE. Peroxisome proliferator- activated receptor activation increases imatinib uptake and killing of chronic myeloid leukemia cells. Exp Hematol 2012; 40:811-819.
    • (2012) Exp Hematol , vol.40 , pp. 811-819
    • Wang, L.1    Giannoudis, A.2    Austin, G.3    Clark, R.E.4
  • 33
    • 80054970528 scopus 로고    scopus 로고
    • A common 5'-UTR variant in MATE2-K is associated with poor response to metformin
    • Choi JH, Yee SW, Ramirez AH, et al. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther 2011; 90:674-684.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 674-684
    • Choi, J.H.1    Yee, S.W.2    Ramirez, A.H.3
  • 34
    • 84863750420 scopus 로고    scopus 로고
    • Organic anion and cation SLC22 'drug' transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule
    • Gallegos TF, Martovetsky G, Kouznetsova V, et al. Organic anion and cation SLC22 'drug' transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS ONE 2012; 7:e40796.
    • (2012) PLoS ONE , vol.7
    • Gallegos, T.F.1    Martovetsky, G.2    Kouznetsova, V.3
  • 35
    • 84155173299 scopus 로고    scopus 로고
    • DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
    • Schaeffeler E, Hellerbrand C, Nies AT, et al. DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med 2011; 3:82.
    • (2011) Genome Med , vol.3 , pp. 82
    • Schaeffeler, E.1    Hellerbrand, C.2    Nies, A.T.3
  • 36
    • 84858713948 scopus 로고    scopus 로고
    • Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
    • Heise M, Lautem A, Knapstein J, et al. Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance. BMC Cancer 2012; 12:109.
    • (2012) BMC Cancer , vol.12 , pp. 109
    • Heise, M.1    Lautem, A.2    Knapstein, J.3
  • 37
    • 84876691298 scopus 로고    scopus 로고
    • Long-term cisplatin exposure promotes methylation of the OCT1 gene in human esophageal cancer cells
    • Lin R, Li X, Li J, et al. Long-term cisplatin exposure promotes methylation of the OCT1 gene in human esophageal cancer cells. Dig Dis Sci 2013; 58:694-698.
    • (2013) Dig Dis Sci , vol.58 , pp. 694-698
    • Lin, R.1    Li, X.2    Li, J.3
  • 38
    • 79960120536 scopus 로고    scopus 로고
    • Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: Relationship to epigenetic variations in the 5'-upstream regulatory region
    • Saito J, Hirota T, Kikunaga N, et al. Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: relationship to epigenetic variations in the 5'-upstream regulatory region. J Pharm Sci 2011; 100:3875-3883.
    • (2011) J Pharm Sci , vol.100 , pp. 3875-3883
    • Saito, J.1    Hirota, T.2    Kikunaga, N.3
  • 39
    • 84869106659 scopus 로고    scopus 로고
    • Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARalpha-independent pathways
    • Asavapanumas N, Kittayaruksakul S, Meetam P, et al. Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARalpha-independent pathways. Drug Metab Pharmacokinet 2012; 27: 513-519.
    • (2012) Drug Metab Pharmacokinet , vol.27 , pp. 513-519
    • Asavapanumas, N.1    Kittayaruksakul, S.2    Meetam, P.3
  • 40
    • 84863453508 scopus 로고    scopus 로고
    • Effect of inflammation on molecular targets and drug transporters
    • Hanafy S, El-Kadi AO, Jamali F. Effect of inflammation on molecular targets and drug transporters. J Pharm Pharm Sci 2012; 15:361-375.
    • (2012) J Pharm Pharm Sci , vol.15 , pp. 361-375
    • Hanafy, S.1    El-Kadi, A.O.2    Jamali, F.3
  • 41
    • 79960615869 scopus 로고    scopus 로고
    • Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats
    • Naud J, Michaud J, Beauchemin S, et al. Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats. Drug Metab Dispos 2011; 39:1363-1369.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1363-1369
    • Naud, J.1    Michaud, J.2    Beauchemin, S.3
  • 42
    • 84878136349 scopus 로고    scopus 로고
    • Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure
    • Komazawa H, Yamaguchi H, Hidaka K, et al. Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure. J Pharm Sci 2013; 102:1086-1094.
    • (2013) J Pharm Sci , vol.102 , pp. 1086-1094
    • Komazawa, H.1    Yamaguchi, H.2    Hidaka, K.3
  • 43
    • 3042726691 scopus 로고    scopus 로고
    • Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney
    • Urakami Y, Kimura N, Okuda M, Inui KI. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res 2004; 21:976-981.
    • (2004) Pharm Res , vol.21 , pp. 976-981
    • Urakami, Y.1    Kimura, N.2    Okuda, M.3    Inui, K.I.4
  • 44
    • 34250005960 scopus 로고    scopus 로고
    • Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H\+-organic cation antiporters
    • Tanihara Y, Masuda S, Sato T, et al. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H\+-organic cation antiporters. Biochem Pharmacol 2007; 74:359-371.
    • (2007) Biochem Pharmacol , vol.74 , pp. 359-371
    • Tanihara, Y.1    Masuda, S.2    Sato, T.3
  • 45
    • 78650514267 scopus 로고    scopus 로고
    • Prediction of fluoroquinoloneinduced elevation in serum creatinine levels: A case of drug-endogenous substance interaction involving the inhibition of renal secretion
    • Imamura Y, Murayama N, Okudaira N, et al. Prediction of fluoroquinoloneinduced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther 2011; 89:81-88.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 81-88
    • Imamura, Y.1    Murayama, N.2    Okudaira, N.3
  • 46
    • 84863177864 scopus 로고    scopus 로고
    • Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients
    • Ciarimboli G, Lancaster CS, Schlatter E, et al. Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients. Clin Cancer Res 2012; 18:1101-1108.
    • (2012) Clin Cancer Res , vol.18 , pp. 1101-1108
    • Ciarimboli, G.1    Lancaster, C.S.2    Schlatter, E.3
  • 47
    • 84878624990 scopus 로고    scopus 로고
    • SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation
    • Reznichenko A, Sinkeler SJ, Snieder H, et al. SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation. Physiol Genomics 2013; 18:201-209.
    • (2013) Physiol Genomics , vol.18 , pp. 201-209
    • Reznichenko, A.1    Sinkeler, S.J.2    Snieder, H.3
  • 48
    • 84872679649 scopus 로고    scopus 로고
    • The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin
    • Stocker SL, Morrissey KM, Yee SW, et al. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther 2013; 93:186-194.
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 186-194
    • Stocker, S.L.1    Morrissey, K.M.2    Yee, S.W.3
  • 49
    • 69449098951 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
    • Tzvetkov MV, Vormfelde SV, Balen D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther 2009; 86:299-306.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 299-306
    • Tzvetkov, M.V.1    Vormfelde, S.V.2    Balen, D.3
  • 50
    • 79956333806 scopus 로고    scopus 로고
    • Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects
    • Kusuhara H, Ito S, Kumagai Y, et al. Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clin Pharmacol Ther 2011; 89:837-844.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 837-844
    • Kusuhara, H.1    Ito, S.2    Kumagai, Y.3
  • 51
    • 79551489546 scopus 로고    scopus 로고
    • Organic cation transporter OCT/SLC22A and H\+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents
    • Yonezawa A, Inui KI. Organic cation transporter OCT/SLC22A and H\+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents. Biochem Pharmacol 2011; 81:563-568.
    • (2011) Biochem Pharmacol , vol.81 , pp. 563-568
    • Yonezawa, A.1    Inui, K.I.2
  • 52
    • 84876296735 scopus 로고    scopus 로고
    • Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events
    • Iwata K, Aizawa K, Kamitsu S, et al. Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events. Clin Exp Nephrol 2012; 16:843-851.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 843-851
    • Iwata, K.1    Aizawa, K.2    Kamitsu, S.3
  • 53
    • 34250764918 scopus 로고    scopus 로고
    • Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity
    • Yokoo S, Yonezawa A, Masuda S, et al. Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol 2007; 74:477-487.
    • (2007) Biochem Pharmacol , vol.74 , pp. 477-487
    • Yokoo, S.1    Yonezawa, A.2    Masuda, S.3


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