A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1

Journal of Biological Chemistry

Volumn 287, Issue 37, 2012, Pages 31561-31573

  Egenberger, Brigitte ^a   Gorboulev, Valentin ^a   Keller, Thorsten ^a   Gorbunov, Dmitry ^a   Gottlieb, Neha ^a   Geiger, Dietmar ^b   Mueller, Thomas D ^b   Koepsell, Hermann ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CYSTEINE RESIDUES; DIFFUSION SYSTEMS; EXTRACELLULAR; EXTRACELLULAR SUBSTRATES; FLUORESCENCE DETECTION; GLYCINE RESIDUES; HELIX BENDING; HOMOLOGY MODELING; METHANETHIOSULFONATE; ORGANIC CATION TRANSPORTERS; POTENTIAL-DEPENDENT; STRUCTURAL CHANGE; SUBSTRATE BINDING; TRANSMEMBRANES; TRANSPORT ACTIVITY; VOLTAGE CLAMP; XENOPUS LAEVIS OOCYTES;

AMINO ACIDS; ENZYME ACTIVITY; FLUOROMETERS; POSITIVE IONS;

SUBSTRATES;

[2 (TRIMETHYLAMMONIUM)ETHYL]METHANETHIOSULFONATE; AMINO ACID; GLYCINE; MALEIMIDE; ORGANIC CATION TRANSPORTER 1; SULFONIC ACID DERIVATIVE; TETRAMETHYLRHODAMINE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FLUOROMETRY; LIGAND BINDING; MEMBRANE TRANSPORT; MUTANT; MUTATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; BINDING SITES; CATECHOLAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HEK293 CELLS; HUMANS; ION CHANNEL GATING; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; SUBSTRATE SPECIFICITY; XENOPUS LAEVIS;

RATTUS; XENOPUS LAEVIS;

EID: 84866133123     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.388793     Document Type: Article

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