Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A)

Biochemical Pharmacology

Volumn 75, Issue 9, 2008, Pages 1689-1696

  Terada, Tomohiro ^a   Inui, Ken ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

H+ organic cation antiporter; MATE1; MATE2 K; OCT; Organic cation transporter; Renal tubular secretion

Indexed keywords

CIMETIDINE; METFORMIN; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; OXALIPLATIN; PROCAINAMIDE; PROTEIN MATE; UNCLASSIFIED DRUG;

ARTICLE; BASOLATERAL MEMBRANE; BRUSH BORDER; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG STRUCTURE; DRUG TRANSPORT; HUMAN; KIDNEY FUNCTION; KIDNEY TUBULE EPITHELIUM; KIDNEY TUBULE EXCRETION; MEMBRANE POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 41949113401     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.12.008     Document Type: Note

References (55)

1. Inui K., Takano M., and Hori R. Organic cation transport in the renal brush-border and basolateral membranes. In: Hatano M. (Ed). Nephrology (1991), Springer-Verlag, Tokyo 1391-1398
2. Pritchard J.B., and Miller D.S. Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73 (1993) 765-796
3. Inui K., and Okuda M. Cellular and molecular mechanisms of renal tubular secretion of organic anions and cations. Clin Exp Nephrol 2 (1998) 100-108
4. Gründemann D., Gorboulev V., Gambaryan S., Veyhl M., and Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372 (1994) 549-552
5. Okuda M., Saito H., Urakami Y., Takano M., and Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 224 (1996) 500-507
6. Inui K., Masuda S., and Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int 58 (2000) 944-958
7. Burckhardt G., and Wolff N.A. Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 278 (2000) F853-F866
8. Jonker J.W., and Schinkel A.H. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J Pharmacol Exp Ther 308 (2004) 2-9
9. Wright S.H. Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics. Toxicol Appl Pharmacol 204 (2005) 309-319
10. Koepsell H., Lips K., and Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24 (2007) 1227-1251
11. 1 cells. J Biol Chem 272 (1997) 10408-10413
12. Tamai I., Yabuuchi H., Nezu J., Sai Y., Oku A., Shimane M., et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419 (1997) 107-111
13. Tamai I., Nakanishi T., Kobayashi D., China K., Kosugi Y., Nezu J., et al. Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Mol Pharm 1 (2004) 57-66
14. Ohashi R., Tamai I., Nezu J., Nikaido H., Hashimoto N., Oku A., et al. Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol 59 (2001) 358-366
15. Takano M., Inui K., Okano T., Saito H., and Hori R. Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles. Biochim Biophys Acta 773 (1984) 113-124
16. Motohashi H., Sakurai Y., Saito H., Masuda S., Urakami Y., Goto M., et al. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13 (2002) 866-874
17. Gründemann D., Harlfinger S., Golz S., Geerts A., Lazar A., Berkels R., et al. Discovery of the ergothioneine transporter. Proc Natl Acad Sci USA 102 (2005) 5256-5261
18. Grigat S., Harlfinger S., Pal S., Striebinger R., Golz S., Geerts A., et al. Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations. Biochem Pharmacol 74 (2007) 309-316
19. Morita Y., Kodama K., Shiota S., Mine T., Kataoka A., Mizushima T., et al. NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother 42 (1998) 1778-1782
20. Brown M.H., Paulsen I.T., and Skurray R.A. The multidrug efflux protein NorM is a prototype of a new family of transporters. Mol Microbiol 31 (1999) 394-395
21. Putman M., van Veen H.W., and Konings W.N. Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev 64 (2000) 672-693
22. Hvorup R.N., Winnen B., Chang A.B., Jiang Y., Zhou X.F., and Saier Jr. M.H. The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem 270 (2003) 799-813
23. Otsuka M., Matsumoto T., Morimoto R., Arioka S., Omote H., and Moriyama Y. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102 (2005) 17923-17928
24. +/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17 (2006) 2127-2135
25. +/organic cation antiporter MATE1. Pharm Res 23 (2006) 1696-1701
26. + antiporter in the kidney. Drug Metab Dispos 34 (2006) 1868-1874
27. Zhang X., Cherrington N.J., and Wright S.H. Molecular identification and functional characterization of rabbit MATE1 and MATE2-K. Am J Physiol Renal Physiol 293 (2007) F360-F370
28. +-organic cation antiporters. Biochem Pharmacol 74 (2007) 359-371
29. Omote H., Hiasa M., Matsumoto T., Otsuka M., and Moriyama Y. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. Trends Pharmacol Sci 27 (2006) 587-593
30. +/organic cation exporter. Am J Physiol Cell Physiol 293 (2007) C1437-C1444
31. Kobara A., Hiasa M., Matsumoto T., Otsuka M., Omote H., and Moriyama Y. A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail. Arch Biochem Biophys 469 (2008) 195-199
32. Hiasa M., Matsumoto T., Komatsu T., and Moriyama Y. Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. Am J Physiol Cell Physiol 291 (2006) C678-C686
33. Nishihara K., Masuda S., Ji L., Katsura T., and Inui K. Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats. Biochem Pharmacol 73 (2007) 1482-1490
34. +/organic cation antiporter MATE1. Am J Physiol Renal Physiol 292 (2007) F593-F598
35. -) exit. Pflügers Arch 402 (1984) 300-305
36. +/organic cation antiport system. J Pharmacol Exp Ther 233 (1985) 181-185
37. Yonezawa A., Masuda S., Yokoo S., Katsura T., and Inui K. Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther 319 (2006) 879-886
38. Yokoo S., Yonezawa A., Masuda S., Fukatsu A., Katsura T., and Inui K. Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. Biochem Pharmacol 74 (2007) 477-487
39. +/multidrug antiporter in Vibrio parahaemolyticus. J Bacteriol 187 (2005) 1552-1558
40. +/organic cation antiport system in rat renal brush-border membranes. J Biol Chem 264 (1989) 12232-12237
41. Hori R., Maegawa H., Okano T., Takano M., and Inui K. Effect of sulfhydryl reagents on tetraethylammonium transport in rat renal brush border membranes. J Pharmacol Exp Ther 241 (1987) 1010-1016
42. +/organic cation antiporter multidrug and toxin extrusion (MATE). Mol Pharmacol 71 (2007) 1487-1493
43. Pelis R.M., Zhang X., Dangprapai Y., and Wright S.H. Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2. J Biol Chem 281 (2006) 35272-35280
44. Pavlova A., Sakurai H., Leclercq B., Beier D.R., Yu A.S., and Nigam S.K. Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol 278 (2000) F635-F643
45. Urakami Y., Nakamura N., Takahashi K., Okuda M., Saito H., Hashimoto Y., et al. Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett 461 (1999) 339-342
46. Urakami Y., Okuda M., Saito H., and Inui K. Hormonal regulation of organic cation transporter OCT2 expression in rat kidney. FEBS Lett 473 (2000) 173-176
47. Ji L., Masuda S., Saito H., and Inui K. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int 62 (2002) 514-524
48. Thomas M.C., Tikellis C., Burns W.C., Thallas V., Forbes J.M., Cao Z., et al. Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Kidney Int 63 (2003) 2152-2161
49. Asaka J., Terada T., Okuda M., Katsura T., and Inui K. Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3. Pharm Res 23 (2006) 697-704
50. Asaka J., Terada T., Ogasawara K., Katsura T., and Inui K. Characterization of the basal promoter element of human organic cation transporter 2 gene. J Pharmacol Exp Ther 321 (2007) 684-689
51. +/organic cation antiporters (MATE1). Am J Physiol Renal Physiol 293 (2007) F1564-F1570
52. Shu Y., Sheardown S.A., Brown C., Owen R.P., Zhang S., Castro R.A., et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 117 (2007) 1422-1431
53. Shu Y., Brown C., Castro R.A., Shi R.J., Lin E.T., Owen R.P., et al. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther 83 (2008) 273-280
54. Yonezawa A., Masuda S., Nishihara K., Yano I., Katsura T., and Inui K. Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat. Biochem Pharmacol 70 (2005) 1823-1831
55. Terada T., and Inui K. Gene expression and regulation of drug transporters in the intestine and kidney. Biochem Pharmacol 73 (2007) 440-449