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Volumn 15, Issue 2, 2013, Pages 581-588

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney

Author keywords

cation; kidney; MATE; OCT

Indexed keywords

CIMETIDINE; CISPLATIN; MEMBRANE PROTEIN; METFORMIN; MULTIDRUG AND TOXIN EXTRUSION PROTEIN; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 4; ORGANIC CATION TRANSPORTER 5; UNCLASSIFIED DRUG;

EID: 84877026119     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-013-9465-7     Document Type: Review
Times cited : (166)

References (54)
  • 1
    • 0002366243 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of renal tubular secretion of organic anions and cations
    • 10.1007/BF02479930 1:CAS:528:DyaK1cXlvFygtr4%3D
    • Inui K, Okuda M. Cellular and molecular mechanisms of renal tubular secretion of organic anions and cations. Clin Exp Nephrol. 1998;2:100-8.
    • (1998) Clin Exp Nephrol , vol.2 , pp. 100-108
    • Inui, K.1    Okuda, M.2
  • 2
    • 0033921479 scopus 로고    scopus 로고
    • Structure of renal organic anion and cation transporters
    • 10836973 1:CAS:528:DC%2BD3cXks1ymtLw%3D
    • Burckhardt G, Wolff NA. Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol. 2000;278:F853-66.
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Burckhardt, G.1    Wolff, N.A.2
  • 3
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • 10972658 10.1046/j.1523-1755.2000.00251.x 1:CAS:528:DC%2BD3cXmsleitr4%3D
    • Inui K, Masuda S, Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 2000;58:944-58.
    • (2000) Kidney Int , vol.58 , pp. 944-958
    • Inui, K.1    Masuda, S.2    Saito, H.3
  • 4
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • 7990927 10.1038/372549a0 1:STN:280:DyaK2M%2Fot12jtQ%3D%3D
    • Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 1994;372:549-52.
    • (1994) Nature , vol.372 , pp. 549-552
    • Grundemann, D.1    Gorboulev, V.2    Gambaryan, S.3    Veyhl, M.4    Koepsell, H.5
  • 5
    • 0034935038 scopus 로고    scopus 로고
    • Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (OCT1 [Slc22a1]) gene
    • 11463829 10.1128/MCB.21.16.5471-5477.2001 1:CAS:528:DC%2BD3MXlslOjtb4%3D
    • Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW, et al. Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (OCT1 [Slc22a1]) gene. Mol Cell Biol. 2001;21:5471-7.
    • (2001) Mol Cell Biol , vol.21 , pp. 5471-5477
    • Jonker, J.W.1    Wagenaar, E.2    Mol, C.A.3    Buitelaar, M.4    Koepsell, H.5    Smit, J.W.6
  • 6
    • 0036205460 scopus 로고    scopus 로고
    • Gene expression levels and immunolocalization of organic ion transporters in the human kidney
    • 11912245 1:CAS:528:DC%2BD38XjtFSnsb8%3D
    • Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, et al. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol. 2002;13:866-74.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 866-874
    • Motohashi, H.1    Sakurai, Y.2    Saito, H.3    Masuda, S.4    Urakami, Y.5    Goto, M.6
  • 7
    • 0030590117 scopus 로고    scopus 로고
    • CDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
    • 8702418 10.1006/bbrc.1996.1056 1:CAS:528:DyaK28Xktl2qurg%3D
    • Okuda M, Saito H, Urakami Y, Takano M, Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun. 1996;224:500-7.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 500-507
    • Okuda, M.1    Saito, H.2    Urakami, Y.3    Takano, M.4    Inui, K.5
  • 8
    • 0030763035 scopus 로고    scopus 로고
    • Cloning and characterization of two human polyspecific organic cation transporters
    • 9260930 10.1089/dna.1997.16.871 1:CAS:528:DyaK2sXltFGlsbk%3D
    • Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, et al. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997;16:871-81.
    • (1997) DNA Cell Biol , vol.16 , pp. 871-881
    • Gorboulev, V.1    Ulzheimer, J.C.2    Akhoundova, A.3    Ulzheimer-Teuber, I.4    Karbach, U.5    Quester, S.6
  • 9
    • 0142123151 scopus 로고    scopus 로고
    • Deficiency in the organic cation transporters 1 and 2 (OCT1/OCT2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations
    • 14560032 10.1128/MCB.23.21.7902-7908.2003 1:CAS:528:DC%2BD3sXosFOgtLg%3D
    • Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH. Deficiency in the organic cation transporters 1 and 2 (OCT1/OCT2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol. 2003;23:7902-8.
    • (2003) Mol Cell Biol , vol.23 , pp. 7902-7908
    • Jonker, J.W.1    Wagenaar, E.2    Van Eijl, S.3    Schinkel, A.H.4
  • 10
    • 0033770499 scopus 로고    scopus 로고
    • Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules
    • 11083459 1:CAS:528:DC%2BD3cXnsVyhsrw%3D
    • Sugawara-Yokoo M, Urakami Y, Koyama H, Fujikura K, Masuda S, Saito H, et al. Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules. Histochem Cell Biol. 2000;114:175-80.
    • (2000) Histochem Cell Biol , vol.114 , pp. 175-180
    • Sugawara-Yokoo, M.1    Urakami, Y.2    Koyama, H.3    Fujikura, K.4    Masuda, S.5    Saito, H.6
  • 11
    • 0034975789 scopus 로고    scopus 로고
    • Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice
    • 11390648 10.1128/MCB.21.13.4188-4196.2001 1:CAS:528:DC%2BD3MXksVOrtrY%3D
    • Zwart R, Verhaagh S, Buitelaar M, Popp-Snijders C, Barlow DP. Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice. Mol Cell Biol. 2001;21:4188-96.
    • (2001) Mol Cell Biol , vol.21 , pp. 4188-4196
    • Zwart, R.1    Verhaagh, S.2    Buitelaar, M.3    Popp-Snijders, C.4    Barlow, D.P.5
  • 12
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • 9426230 10.1016/S0014-5793(97)01441-5 1:CAS:528:DyaK2sXnvFGksrw%3D
    • Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett. 1997;419:107-11.
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3    Sai, Y.4    Oku, A.5    Shimane, M.6
  • 13
    • 0032577202 scopus 로고    scopus 로고
    • CDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • 9618255 10.1006/bbrc.1998.8669 1:CAS:528:DyaK1cXjsFyjtr8%3D
    • Wu X, Prasad PD, Leibach FH, Ganapathy V. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998;246:589-95.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4
  • 14
    • 84860873283 scopus 로고    scopus 로고
    • The ergothioneine transporter controls and indicates ergothioneine activity - A review
    • 22182480 10.1016/j.ypmed.2011.12.001
    • Grundemann D. The ergothioneine transporter controls and indicates ergothioneine activity - a review. Prev Med. 2012;54(Suppl):S71-4.
    • (2012) Prev Med , vol.54 , Issue.SUPPL.
    • Grundemann, D.1
  • 15
    • 0034749436 scopus 로고    scopus 로고
    • Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules
    • 11758759 10.1023/A:1013070128668 1:CAS:528:DC%2BD3MXos1aqu7s%3D
    • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K. Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001;18:1528-34.
    • (2001) Pharm Res , vol.18 , pp. 1528-1534
    • Urakami, Y.1    Okuda, M.2    Masuda, S.3    Akazawa, M.4    Saito, H.5    Inui, K.6
  • 16
    • 33645220096 scopus 로고    scopus 로고
    • Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants
    • 16307453 10.1002/jps.20536 1:CAS:528:DC%2BD28XlvVSiuw%3D%3D
    • Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J Pharm Sci. 2006;95:25-36.
    • (2006) J Pharm Sci , vol.95 , pp. 25-36
    • Fujita, T.1    Urban, T.J.2    Leabman, M.K.3    Fujita, K.4    Giacomini, K.M.5
  • 17
    • 15744362693 scopus 로고    scopus 로고
    • Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2
    • 15630081 10.1124/mol.104.004713 1:CAS:528:DC%2BD2MXjtFWmsrs%3D
    • Suhre WM, Ekins S, Chang C, Swaan PW, Wright SH. Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2. Mol Pharmacol. 2005;67:1067-77.
    • (2005) Mol Pharmacol , vol.67 , pp. 1067-1077
    • Suhre, W.M.1    Ekins, S.2    Chang, C.3    Swaan, P.W.4    Wright, S.H.5
  • 18
    • 62549101989 scopus 로고    scopus 로고
    • Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
    • 19426682 10.1016/j.bcp.2009.01.010 1:CAS:528:DC%2BD1MXjsFSgs78%3D
    • Kimura N, Masuda S, Katsura T, Inui K. Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2. Biochem Pharmacol. 2009;77:1429-36.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1429-1436
    • Kimura, N.1    Masuda, S.2    Katsura, T.3    Inui, K.4
  • 19
    • 79960155485 scopus 로고    scopus 로고
    • Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2
    • 21599003 10.1021/jm2001629 1:CAS:528:DC%2BC3MXnt1agsL0%3D
    • Kido Y, Matsson P, Giacomini KM. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem. 2011;54:4548-58.
    • (2011) J Med Chem , vol.54 , pp. 4548-4558
    • Kido, Y.1    Matsson, P.2    Giacomini, K.M.3
  • 20
    • 84871904912 scopus 로고    scopus 로고
    • Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2
    • 23034939 10.1152/ajprenal.00486.2012 1:CAS:528:DC%2BC3sXit1ygtbg%3D
    • Harper JN, Wright SH. Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2. Am J Physiol Renal Physiol. 2013;304:F56-67.
    • (2013) Am J Physiol Renal Physiol , vol.304
    • Harper, J.N.1    Wright, S.H.2
  • 21
    • 78651362677 scopus 로고    scopus 로고
    • Substrate recognition and translocation by polyspecific organic cation transporters
    • 21194363 10.1515/bc.2011.009 1:CAS:528:DC%2BC3MXkvFCrsbw%3D
    • Koepsell H. Substrate recognition and translocation by polyspecific organic cation transporters. Biol Chem. 2011;392:95-101.
    • (2011) Biol Chem , vol.392 , pp. 95-101
    • Koepsell, H.1
  • 22
    • 3042726691 scopus 로고    scopus 로고
    • Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney
    • 15212162 10.1023/B:PHAM.0000029286.45788.ad 1:CAS:528: DC%2BD2cXktlyktbY%3D
    • Urakami Y, Kimura N, Okuda M, Inui K. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res. 2004;21:976-81.
    • (2004) Pharm Res , vol.21 , pp. 976-981
    • Urakami, Y.1    Kimura, N.2    Okuda, M.3    Inui, K.4
  • 23
    • 34250205751 scopus 로고    scopus 로고
    • Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2
    • 17072098 10.2133/dmpk.21.432 1:CAS:528:DC%2BD28XhtlWnsr%2FO
    • Okuda M, Kimura N, Inui K. Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2. Drug Metab Pharmacokinet. 2006;21:432-6.
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 432-436
    • Okuda, M.1    Kimura, N.2    Inui, K.3
  • 24
    • 34250220670 scopus 로고    scopus 로고
    • Lack of effect of DX-619, a novel des-fluoro(6)-quinolone, on glomerular filtration rate measured by serum clearance of cold iohexol
    • 17371829 10.1128/AAC.01223-06 1:CAS:528:DC%2BD2sXmtlKku7k%3D
    • Sarapa N, Wickremasingha P, Ge N, Weitzman R, Fuellhart M, Yen C, et al. Lack of effect of DX-619, a novel des-fluoro(6)-quinolone, on glomerular filtration rate measured by serum clearance of cold iohexol. Antimicrob Agents Chemother. 2007;51:1912-7.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1912-1917
    • Sarapa, N.1    Wickremasingha, P.2    Ge, N.3    Weitzman, R.4    Fuellhart, M.5    Yen, C.6
  • 25
    • 78650514267 scopus 로고    scopus 로고
    • Prediction of fluoroquinolone-induced elevation in serum creatinine levels: A case of drug-endogenous substance interaction involving the inhibition of renal secretion
    • 21124314 10.1038/clpt.2010.232 1:STN:280:DC%2BC3M%2FltFKnsQ%3D%3D
    • Imamura Y, Murayama N, Okudaira N, Kurihara A, Okazaki O, Izumi T, et al. Prediction of fluoroquinolone-induced elevation in serum creatinine levels: A case of drug-endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther. 2011;89:81-8.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 81-88
    • Imamura, Y.1    Murayama, N.2    Okudaira, N.3    Kurihara, A.4    Okazaki, O.5    Izumi, T.6
  • 26
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
    • 17473959 10.1007/s11095-007-9254-z 1:CAS:528:DC%2BD2sXnt1Clu7Y%3D
    • Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications. Pharm Res. 2007;24:1227-51.
    • (2007) Pharm Res , vol.24 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 27
    • 29144523534 scopus 로고    scopus 로고
    • A human transporter protein that mediates the final excretion step for toxic organic cations
    • 16330770 10.1073/pnas.0506483102 1:CAS:528:DC%2BD2MXhtlersr7F
    • Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A. 2005;102:17923-8.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17923-17928
    • Otsuka, M.1    Matsumoto, T.2    Morimoto, R.3    Arioka, S.4    Omote, H.5    Moriyama, Y.6
  • 29
    • 81355124801 scopus 로고    scopus 로고
    • Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
    • 21457222 10.1111/j.1476-5381.2011.01394.x 1:CAS:528:DC%2BC3MXhsFyqsLzN
    • Yonezawa A, Inui K. Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics. Br J Pharmacol. 2011;164:1817-25.
    • (2011) Br J Pharmacol , vol.164 , pp. 1817-1825
    • Yonezawa, A.1    Inui, K.2
  • 31
    • 34548048791 scopus 로고    scopus 로고
    • Molecular identification and functional characterization of rabbit MATE1 and MATE2-K
    • 17442726 10.1152/ajprenal.00102.2007 1:CAS:528:DC%2BD2sXovFWms7o%3D
    • Zhang X, Cherrington NJ, Wright SH. Molecular identification and functional characterization of rabbit MATE1 and MATE2-K. Am J Physiol Renal Physiol. 2007;293:F360-70.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Zhang, X.1    Cherrington, N.J.2    Wright, S.H.3
  • 33
    • 84861540616 scopus 로고    scopus 로고
    • Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K
    • 22419765 10.1124/jpet.112.191577 1:CAS:528:DC%2BC38XotlWlt7k%3D
    • Astorga B, Ekins S, Morales M, Wright SH. Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K. J Pharmacol Exp Ther. 2012;341:743-55.
    • (2012) J Pharmacol Exp Ther , vol.341 , pp. 743-755
    • Astorga, B.1    Ekins, S.2    Morales, M.3    Wright, S.H.4
  • 35
    • 77954905149 scopus 로고    scopus 로고
    • Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice
    • 20484555 10.1124/jpet.110.169433 1:CAS:528:DC%2BC3cXht1Kisb%2FK
    • Watanabe S, Tsuda M, Terada T, Katsura T, Inui K. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010;334:651-6.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 651-656
    • Watanabe, S.1    Tsuda, M.2    Terada, T.3    Katsura, T.4    Inui, K.5
  • 36
    • 24344461838 scopus 로고    scopus 로고
    • Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1
    • 16098483 10.1016/j.bcp.2005.06.024 1:CAS:528:DC%2BD2MXpvFegsrc%3D
    • Ueo H, Motohashi H, Katsura T, Inui K. Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005;70:1104-13.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1104-1113
    • Ueo, H.1    Motohashi, H.2    Katsura, T.3    Inui, K.4
  • 37
    • 51249105551 scopus 로고    scopus 로고
    • Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1
    • 18674516 10.1016/j.bcp.2008.07.005 1:CAS:528:DC%2BD1cXhtFaitr3O
    • Sato T, Masuda S, Yonezawa A, Tanihara Y, Katsura T, Inui K. Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. Biochem Pharmacol. 2008;76:894-903.
    • (2008) Biochem Pharmacol , vol.76 , pp. 894-903
    • Sato, T.1    Masuda, S.2    Yonezawa, A.3    Tanihara, Y.4    Katsura, T.5    Inui, K.6
  • 38
    • 63849121023 scopus 로고    scopus 로고
    • Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells
    • 19164462 10.1124/jpet.108.147918 1:CAS:528:DC%2BD1MXksVKnurY%3D
    • Tsuda M, Terada T, Ueba M, Sato T, Masuda S, Katsura T, et al. Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells. J Pharmacol Exp Ther. 2009;329:185-91.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 185-191
    • Tsuda, M.1    Terada, T.2    Ueba, M.3    Sato, T.4    Masuda, S.5    Katsura, T.6
  • 39
    • 79956333806 scopus 로고    scopus 로고
    • Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects
    • 21544077 10.1038/clpt.2011.36 1:CAS:528:DC%2BC3MXmtlagtb8%3D
    • Kusuhara H, Ito S, Kumagai Y, Jiang M, Shiroshita T, Moriyama Y, et al. Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects. Clin Pharmacol Ther. 2011;89:837-44.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 837-844
    • Kusuhara, H.1    Ito, S.2    Kumagai, Y.3    Jiang, M.4    Shiroshita, T.5    Moriyama, Y.6
  • 40
    • 84855995429 scopus 로고    scopus 로고
    • Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
    • 22072731 10.1124/jpet.111.184986 1:CAS:528:DC%2BC38XjtVSltLc%3D
    • Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, et al. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. J Pharmacol Exp Ther. 2012;340:393-403.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 393-403
    • Ito, S.1    Kusuhara, H.2    Yokochi, M.3    Toyoshima, J.4    Inoue, K.5    Yuasa, H.6
  • 41
    • 33644664085 scopus 로고    scopus 로고
    • Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
    • 16272756 10.2133/dmpk.20.379 1:CAS:528:DC%2BD2MXhtleksbzM
    • Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, et al. Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005;20:379-86.
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 379-386
    • Kimura, N.1    Masuda, S.2    Tanihara, Y.3    Ueo, H.4    Okuda, M.5    Katsura, T.6
  • 42
    • 80054970528 scopus 로고    scopus 로고
    • A common 5′-UTR variant in MATE2-K is associated with poor response to metformin
    • 21956618 10.1038/clpt.2011.165 1:CAS:528:DC%2BC3MXhtlGlsLnE
    • Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, et al. A common 5′-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther. 2011;90:674-84.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 674-684
    • Choi, J.H.1    Yee, S.W.2    Ramirez, A.H.3    Morrissey, K.M.4    Jang, G.H.5    Joski, P.J.6
  • 43
    • 66849142125 scopus 로고    scopus 로고
    • Targeted disruption of the multidrug and toxin extrusion 1 (MATE1) gene in mice reduces renal secretion of metformin
    • 19332510 10.1124/mol.109.056242 1:CAS:528:DC%2BD1MXmvVWqsLo%3D
    • Tsuda M, Terada T, Mizuno T, Katsura T, Shimakura J, Inui K. Targeted disruption of the multidrug and toxin extrusion 1 (MATE1) gene in mice reduces renal secretion of metformin. Mol Pharmacol. 2009;75:1280-6.
    • (2009) Mol Pharmacol , vol.75 , pp. 1280-1286
    • Tsuda, M.1    Terada, T.2    Mizuno, T.3    Katsura, T.4    Shimakura, J.5    Inui, K.6
  • 44
    • 84860865479 scopus 로고    scopus 로고
    • Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis
    • 22242910 10.1111/j.1476-5381.2012.01853.x 1:CAS:528:DC%2BC38XotlWmtrg%3D
    • Toyama K, Yonezawa A, Masuda S, Osawa R, Hosokawa M, Fujimoto S, et al. Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. Br J Pharmacol. 2012;166:1183-91.
    • (2012) Br J Pharmacol , vol.166 , pp. 1183-1191
    • Toyama, K.1    Yonezawa, A.2    Masuda, S.3    Osawa, R.4    Hosokawa, M.5    Fujimoto, S.6
  • 45
    • 75649118895 scopus 로고    scopus 로고
    • Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients
    • 20016398 10.1097/FPC.0b013e328335639f 1:CAS:528:DC%2BC3cXnvFyqsg%3D%3D
    • Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, et al. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. Pharmacogenet Genomics. 2010;20:135-8.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 135-138
    • Toyama, K.1    Yonezawa, A.2    Tsuda, M.3    Masuda, S.4    Yano, I.5    Terada, T.6
  • 46
    • 69449098951 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
    • 19536068 10.1038/clpt.2009.92 1:CAS:528:DC%2BD1MXhtVGqu7nL
    • Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther. 2009;86:299-306.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 299-306
    • Tzvetkov, M.V.1    Vormfelde, S.V.2    Balen, D.3    Meineke, I.4    Schmidt, T.5    Sehrt, D.6
  • 47
    • 72049089059 scopus 로고    scopus 로고
    • Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications
    • 19837111 10.1016/j.pharmthera.2009.09.008 1:CAS:528:DC%2BD1MXhsFyiu7%2FI
    • Saito H. Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol Ther. 2010;125:79-91.
    • (2010) Pharmacol Ther , vol.125 , pp. 79-91
    • Saito, H.1
  • 48
    • 79551489546 scopus 로고    scopus 로고
    • +/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents
    • 21144842 10.1016/j.bcp.2010.11.016 1:CAS:528:DC%2BC3MXhtlKmu7k%3D
    • +/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents. Biochem Pharmacol. 2011;81:563-8.
    • (2011) Biochem Pharmacol , vol.81 , pp. 563-568
    • Yonezawa, A.1    Inui, K.2
  • 49
    • 77957929019 scopus 로고    scopus 로고
    • Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity
    • 20813096 10.1016/j.bcp.2010.08.019 1:CAS:528:DC%2BC3cXhtlSmsbfP
    • Nakamura T, Yonezawa A, Hashimoto S, Katsura T, Inui K. Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity. Biochem Pharmacol. 2010;80:1762-7.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1762-1767
    • Nakamura, T.1    Yonezawa, A.2    Hashimoto, S.3    Katsura, T.4    Inui, K.5
  • 50
    • 84876296735 scopus 로고    scopus 로고
    • Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events
    • 22569819 10.1007/s10157-012-0638-y 1:CAS:528:DC%2BC38XhvVCks7bP
    • Iwata K, Aizawa K, Kamitsu S, Jingami S, Fukunaga E, Yoshida M, et al. Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events. Clin Exp Nephrol. 2012;16:843-51.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 843-851
    • Iwata, K.1    Aizawa, K.2    Kamitsu, S.3    Jingami, S.4    Fukunaga, E.5    Yoshida, M.6
  • 51
    • 54249106729 scopus 로고    scopus 로고
    • Genetic variants of the organic cation transporter 2 influence the disposition of metformin
    • 18401339 10.1038/clpt.2008.61 1:CAS:528:DC%2BD1cXht1OisLvP
    • Song IS, Shin HJ, Shim EJ, Jung IS, Kim WY, Shon JH, et al. Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther. 2008;84:559-62.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 559-562
    • Song, I.S.1    Shin, H.J.2    Shim, E.J.3    Jung, I.S.4    Kim, W.Y.5    Shon, J.H.6
  • 52
    • 70249087629 scopus 로고    scopus 로고
    • Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2
    • 19540211 10.1016/j.bcp.2009.06.014 1:CAS:528:DC%2BD1MXhtFGqsLrO
    • Tanihara Y, Masuda S, Katsura T, Inui K. Protective effect of concomitant administration of imatinib on cisplatin-induced nephrotoxicity focusing on renal organic cation transporter OCT2. Biochem Pharmacol. 2009;78:1263-71.
    • (2009) Biochem Pharmacol , vol.78 , pp. 1263-1271
    • Tanihara, Y.1    Masuda, S.2    Katsura, T.3    Inui, K.4
  • 53
    • 15344346237 scopus 로고    scopus 로고
    • Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney
    • 15640376 10.1124/dmd.104.002519 1:CAS:528:DC%2BD2MXjtFequ7c%3D
    • Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I. Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005;33:495-9.
    • (2005) Drug Metab Dispos , vol.33 , pp. 495-499
    • Ishiguro, N.1    Saito, A.2    Yokoyama, K.3    Morikawa, M.4    Igarashi, T.5    Tamai, I.6
  • 54
    • 82455168816 scopus 로고    scopus 로고
    • Design and optimization of dosage regimens: Pharmacokinetic data
    • L.L. Brunton B.A. Chabner B.C. Knollmann (eds) 12 McGraw-Hill New York
    • Thummel KE, Shen DD, Isoherranen N. Design and optimization of dosage regimens: pharmacokinetic data. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman and Gilman's the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill; 2011. p. 1891-990.
    • (2011) Goodman and Gilman's the Pharmacological Basis of Therapeutics , pp. 1891-1990
    • Thummel, K.E.1    Shen, D.D.2    Isoherranen, N.3


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