Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure

Journal of Pharmaceutical Sciences

Volumn 102, Issue 3, 2013, Pages 1086-1094

  Komazawa, Hiroki ^a   Yamaguchi, Hiroaki ^a   Hidaka, Kazuhiro ^a   Ogura, Jiro ^a   Kobayashi, Masaki ^a   Iseki, Ken ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Adenine induced CRF; Distribution; Elimination; Kidney uptake clearance; Pharmacokinetics; Transport; Transporters

Indexed keywords

ADENINE; BREAST CANCER RESISTANCE PROTEIN; CREATININE; MESSENGER RNA; METFORMIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PENICILLIN G; PEPTIDE TRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE KIDNEY FUNCTION RELATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG UPTAKE; GLOMERULUS FILTRATION RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOUSEKEEPING GENE; IN VIVO STUDY; KIDNEY CLEARANCE; KIDNEY CORTEX SLICE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA CONCENTRATION-TIME CURVE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING;

EID: 84878136349     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23433     Document Type: Article

References (32)

1. National Kidney Foundation. 2002. K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 39:S1-S266.
2. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H. 2002. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13:848-857.
3. Bachmakov I, Glaeser H, Endress B, Mörl F, König J, Fromm MF. 2009. Interaction of beta-blockers with the renal uptake transporter OCT2. Diabetes Obes Metab 11:1080-1083.
4. Lash LH, Putt DA, Cai H. 2006. Membrane transport function in primary cultures of human proximal tubular cells. Toxicology 228:200-218.
5. International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. 2010. Membrane transporters in drug development. Nat Rev Drug Discov 9:215-236.
6. Mónica Torres A, Mac Laughlin M, Muller A, Brandoni A, Anzai N, Endou H. 2005. Altered renal elimination of organic anions in rats with chronic renal failure. Biochim Biophys Acta 1740:29-37.
7. Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y. 2004. Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int 65:162-174.
8. Terai K, Mizukami K, Okada M. 2008. Comparison of chronic renal failure rats and modification of the preparation protocol as a hyperphosphataemia model. Nephrology (Carlton) 13:139-146.
9. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond FA, Mitchell A, Jones C, Bonnardeaux A, Pichette V. 2007. Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther 320:978-985.
10. Leblond F, Guévin C, Demers C, Pellerin I, Gascon-Barré M, Pichette V. 2001. Downregulation of hepatic cytochrome P450 in chronic renal failure. J Am Soc Nephrol 12:326-332.
11. Guévin C, Michaud J, Naud J, Leblond FA, Pichette V. 2002. Down-regulation of hepatic cytochrome p450 in chronic renal failure: Role of uremic mediators. Br J Pharmacol 137:1039-1046.
12. Ji L, Masuda S, Saito H, Inui K. 2002. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int 62:514-524.
13. Naud J, Michaud J, Beauchemin S, Hébert MJ, Roger M, Lefrancois S, Leblond FA, Pichette V. 2011. Effects of chronic renal failure on kidney drug transporters and cytochrome P450 in rats. Drug Metab Dispos 39:1363-1369.
14. Naud J, Michaud J, Leblond FA, Lefrancois S, Bonnardeaux A, Pichette V. 2008. Effects of chronic renal failure on liver drug transporters. Drug Metab Dispos 36:124-128.
15. Laouari D, Yang R, Veau C, Blanke I, Friedlander G. 2001. Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure. Am J Physiol Renal Physiol 280:F636-F645.
16. Helvig CF, Cuerrier D, Hosfield CM, Ireland B, Kharebov AZ, Kim JW, Ramjit NJ, Ryder K, Tabash SP, Herzenberg AM, Epps TM, Petkovich M. 2010. Dysregulation of renal vitamin D metabolism in the uremic rat. Kidney Int 78:463-472.
17. Yokote S, Yokoo T, Matsumoto K, Ohkido I, Utsunomiya Y, Kawamura T, Hosoya T. 2012. Metanephros transplantation inhibits the progression of vascular calcification in rats with adenine-induced renal failure. Nephron Exp Nephrol 120:e32-e40.
18. Shobeiri N, Adams MA, Holden RM. 2010. Vascular calcification in animal models of CKD: A review. Am J Nephrol 31:471-481.
19. Yokozawa T, Zheng PD, Oura H, Koizumi F. 1986. Animal model of adenine-induced chronic renal failure in rats. Nephron 44:230-234.
20. Dische Z, Borenfreund E. 1951. A new spectrophotometric method for the detection and determination of keto sugars and trioses. J Biol Chem. 192:583-587.
21. Jin HE, Hong SS, Choi MK, Maeng HJ, Kim DD, Chung SJ, Shim CK. 2009. Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis. Pharm Res 26:549-559.
22. Hori R, Ishikawa Y, Takano M, Okano T, Kitazawa S, Inui K. 1982. The interaction of cephalosporin antibiotics with renal cortex of rats: accumulation to cortical slices and binding to purified plasma membranes. Biochem Pharmacol 31:2267-2272.
23. Arayne MS, Sultana N, Zuberi MH, Siddiqui FA. 2010. Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection. J Chromatogr Sci 48:721-725.
24. McWhinney BC, Wallis SC, Hillister T, Roberts JA, Lipman J, Ungerer JP. 2010. Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci 878:2039-2043.
25. Vaziri ND, Yuan J, Rahimi A, Ni Z, Said H, Subramanian VS. 2012. Disintegration of colonic epithelial tight junction in uremia: A likely cause of CKD-associated inflammation. Nephrol Dial Transplant 27:2686-2693.
26. Fujita T, Ishihara K, Yasuda S, Nakamura T, Maeda M, Kobayashi M, Sahashi K, Ikeda Y, Kumagai Y, Majima M. 2012. In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats. J Pharmacol Exp Ther 341:626-633.
27. Nguy L, Nilsson H, Lundgren J, Johansson ME, Teerlink T, Scheffer PG, Guron G. 2012. Vascular function in rats with adenine-induced chronic renal failure. Am J Physiol Regul Integr Comp Physiol 302:R1426-R1435.
28. Yen CH, Lin KC, Leu S, Sun CK, Chang LT, Chai HT, Chung SY, Chang HW, Ko SF, Chen YT, Yip HK. 2012. Chronic exposure to environmental contaminant nonylphenol exacerbates adenine-induced chronic renal insufficiency: Role of signaling pathways and therapeutic impact of rosuvastatin. Eur J Pharm Sci 46:455-467.
29. Nozaki Y, Kusuhara H, Kondo T, Hasegawa M, Shiroyanagi Y, Nakazawa H, Okano T, Sugiyama Y. 2007. Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices. J Pharmacol Exp Ther 321:362-369.
30. Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y. 2002. Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 300:746-753.
31. Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K. 2005. Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet 20:379-386.
32. Uwai Y, Honjo H, Iwamoto K. 2012. Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3. Pharmacol Res 65:254-260.