메뉴 건너뛰기




Volumn 51, Issue 3, 2013, Pages 467-475

Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis

Author keywords

Betaine; Choline; Insulin sensitivity; Obesity; Phosphatidylcholine

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETAINE; BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CARBON; CHOLINE; DNA; ESTROGEN; FIBROBLAST GROWTH FACTOR 21; HISTONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLCHOLINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84882405007     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2012-0518     Document Type: Conference Paper
Times cited : (97)

References (92)
  • 1
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - A new worldwide definition
    • Alberti KG, Zimmet P, Shaw J. The metabolic syndrome - a new worldwide definition. Lancet 2005;366:1059-62.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 2
    • 84862075971 scopus 로고    scopus 로고
    • Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes
    • Sung KC, Jeong WS, Wild SH, Byrne CD. Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes. Diabetes Care 2012;35:717-22.
    • (2012) Diabetes Care , vol.35 , pp. 717-722
    • Sung, K.C.1    Jeong, W.S.2    Wild, S.H.3    Byrne, C.D.4
  • 3
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 5
    • 33646710996 scopus 로고    scopus 로고
    • Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study
    • Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA, et al. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006;83:905-11.
    • (2006) Am J Clin Nutr , vol.83 , pp. 905-911
    • Cho, E.1    Zeisel, S.H.2    Jacques, P.3    Selhub, J.4    Dougherty, L.5    Colditz, G.A.6
  • 6
    • 34547750947 scopus 로고    scopus 로고
    • Usual choline and betaine dietary intake and incident coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study
    • Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G. Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord 2007;7:20.
    • (2007) BMC Cardiovasc Disord , vol.7 , pp. 20
    • Bidulescu, A.1    Chambless, L.E.2    Siega-Riz, A.M.3    Zeisel, S.H.4    Heiss, G.5
  • 7
    • 62149099618 scopus 로고    scopus 로고
    • Repeatability and measurement error in the assessment of choline and betaine dietary intake: The Atherosclerosis Risk in Communities (ARIC) study
    • Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G. Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study. Nutr J 2009;8:14.
    • (2009) Nutr J , vol.8 , pp. 14
    • Bidulescu, A.1    Chambless, L.E.2    Siega-Riz, A.M.3    Zeisel, S.H.4    Heiss, G.5
  • 10
    • 77952649081 scopus 로고    scopus 로고
    • Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain
    • Craciunescu CN, Johnson AR, Zeisel SH. Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain. J Nutr 2010;140:1162-6.
    • (2010) J Nutr , vol.140 , pp. 1162-1166
    • Craciunescu, C.N.1    Johnson, A.R.2    Zeisel, S.H.3
  • 11
    • 77951458462 scopus 로고    scopus 로고
    • Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men
    • Shin W, Yan J, Abratte CM, Vermeylen F, Caudill MA. Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men. J Nutr 2010;140:975-80.
    • (2010) J Nutr , vol.140 , pp. 975-980
    • Shin, W.1    Yan, J.2    Abratte, C.M.3    Vermeylen, F.4    Caudill, M.A.5
  • 12
    • 51749099188 scopus 로고    scopus 로고
    • Adequate intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load
    • Veenema K, Solis C, Li R, Wang W, Maletz CV, Abratte CM, et al. Adequate intake levels of choline are sufficient for preventing elevations in serum markers of liver dysfunction in Mexican American men but are not optimal for minimizing plasma total homocysteine increases after a methionine load. Am J Clin Nutr 2008;88:685-92.
    • (2008) Am J Clin Nutr , vol.88 , pp. 685-692
    • Veenema, K.1    Solis, C.2    Li, R.3    Wang, W.4    Maletz, C.V.5    Abratte, C.M.6
  • 13
    • 38749098623 scopus 로고    scopus 로고
    • Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women
    • Abratte CM, Wang W, Li R, Moriarty DJ, Caudill MA. Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women. J Nutr Biochem 2008;19:158-65.
    • (2008) J Nutr Biochem , vol.19 , pp. 158-165
    • Abratte, C.M.1    Wang, W.2    Li, R.3    Moriarty, D.J.4    Caudill, M.A.5
  • 14
    • 0034870968 scopus 로고    scopus 로고
    • Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: Proof of a human choline requirement: A placebo-controlled trial
    • Buchman AL, Ament ME, Sohel M, Dubin M, Jenden DJ, Roch M, et al. Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. J Parenter Enteral Nutr 2001;25:260-8.
    • (2001) J Parenter Enteral Nutr , vol.25 , pp. 260-268
    • Buchman, A.L.1    Ament, M.E.2    Sohel, M.3    Dubin, M.4    Jenden, D.J.5    Roch, M.6
  • 16
    • 34248348719 scopus 로고    scopus 로고
    • Sex and menopausal status influence human dietary requirements for the nutrient choline
    • Fischer LM, Da Costa K, Kwock L, Stewart P, Lu T-S, Stabler S, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr 2007;85:1275-85.
    • (2007) Am J Clin Nutr , vol.85 , pp. 1275-1285
    • Fischer, L.M.1    Da Costa, K.2    Kwock, L.3    Stewart, P.4    Lu, T.-S.5    Stabler, S.6
  • 17
    • 27644581598 scopus 로고    scopus 로고
    • Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
    • Kohlmeier M, Da Costa KA, Fischer LM, Zeisel SH. Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci USA 2005;102:16025-30.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16025-16030
    • Kohlmeier, M.1    Da Costa, K.A.2    Fischer, L.M.3    Zeisel, S.H.4
  • 18
    • 3042696730 scopus 로고    scopus 로고
    • Elevated serum creatine phosphokinase in choline-deficient humans: Mechanistic studies in C2C12 mouse myoblasts
    • Da Costa KA, Badea M, Fischer LM, Zeisel SH. Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr 2004;80:163-70.
    • (2004) Am J Clin Nutr , vol.80 , pp. 163-170
    • Da Costa, K.A.1    Badea, M.2    Fischer, L.M.3    Zeisel, S.H.4
  • 21
    • 3242698799 scopus 로고    scopus 로고
    • Periconceptional dietary intake of choline and betaine and neural tube defects in offspring
    • Shaw GM, Carmichael SL, Yang W, Selvin S, Schaffer DM. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol 2004;160:102-9.
    • (2004) Am J Epidemiol , vol.160 , pp. 102-109
    • Shaw, G.M.1    Carmichael, S.L.2    Yang, W.3    Selvin, S.4    Schaffer, D.M.5
  • 22
    • 82355188293 scopus 로고    scopus 로고
    • The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort
    • Poly C, Massaro JM, Seshadri S, Wolf PA, Cho E, Krall E, et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr 2011;94:1584-91.
    • (2011) Am J Clin Nutr , vol.94 , pp. 1584-1591
    • Poly, C.1    Massaro, J.M.2    Seshadri, S.3    Wolf, P.A.4    Cho, E.5    Krall, E.6
  • 23
  • 25
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011;472:57-63.
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3    Koeth, R.4    Levison, B.S.5    Dugar, B.6
  • 27
    • 34547782307 scopus 로고    scopus 로고
    • Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes
    • Resseguie M, Song J, Niculescu MD, Da Costa KA, Randall TA, Zeisel SH. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J 2007;21:2622-32.
    • (2007) FASEB J , vol.21 , pp. 2622-2632
    • Resseguie, M.1    Song, J.2    Niculescu, M.D.3    Da Costa, K.A.4    Randall, T.A.5    Zeisel, S.H.6
  • 28
    • 78651393082 scopus 로고    scopus 로고
    • Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction
    • Resseguie ME, Da Costa KA, Galanko JA, Patel M, Davis IJ, Zeisel SH. Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem 2011;286:1649-58.
    • (2011) J Biol Chem , vol.286 , pp. 1649-1658
    • Resseguie, M.E.1    Da Costa, K.A.2    Galanko, J.A.3    Patel, M.4    Davis, I.J.5    Zeisel, S.H.6
  • 29
    • 62149129730 scopus 로고    scopus 로고
    • Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted
    • Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc 2009;109:313-8.
    • (2009) J Am Diet Assoc , vol.109 , pp. 313-318
    • Ivanov, A.1    Nash-Barboza, S.2    Hinkis, S.3    Caudill, M.A.4
  • 30
    • 77955807773 scopus 로고    scopus 로고
    • Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline
    • Sha W, Da Costa KA, Fischer LM, Milburn MV, Lawton KA, Berger A, et al. Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J 2010;24:2962-75.
    • (2010) FASEB J , vol.24 , pp. 2962-2975
    • Sha, W.1    Da Costa, K.A.2    Fischer, L.M.3    Milburn, M.V.4    Lawton, K.A.5    Berger, A.6
  • 31
    • 33845574569 scopus 로고    scopus 로고
    • Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    • Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, Ng RK, et al. Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. J Lipid Res 2006;47:2280-90.
    • (2006) J Lipid Res , vol.47 , pp. 2280-2290
    • Rizki, G.1    Arnaboldi, L.2    Gabrielli, B.3    Yan, J.4    Lee, G.S.5    Ng, R.K.6
  • 32
    • 33747079056 scopus 로고    scopus 로고
    • A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet
    • Raubenheimer PJ, Nyirenda MJ, Walker BR. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes 2006;55:2015-20.
    • (2006) Diabetes , vol.55 , pp. 2015-2020
    • Raubenheimer, P.J.1    Nyirenda, M.J.2    Walker, B.R.3
  • 33
    • 84860864339 scopus 로고    scopus 로고
    • Mouse betainehomocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue
    • Teng YW, Ellis JM, Coleman RA, Zeisel SH. Mouse betainehomocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. J Biol Chem 2012;287:16187-98.
    • (2012) J Biol Chem , vol.287 , pp. 16187-16198
    • Teng, Y.W.1    Ellis, J.M.2    Coleman, R.A.3    Zeisel, S.H.4
  • 34
    • 80054691714 scopus 로고    scopus 로고
    • Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    • Teng YW, Mehedint MG, Garrow TA, Zeisel SH. Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem 2011;286:36258-67.
    • (2011) J Biol Chem , vol.286 , pp. 36258-36267
    • Teng, Y.W.1    Mehedint, M.G.2    Garrow, T.A.3    Zeisel, S.H.4
  • 35
    • 84860864339 scopus 로고    scopus 로고
    • Mouse betainehomocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue
    • Teng YW, Ellis JM, Coleman RA, Zeisel SH. Mouse betainehomocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue. J Biol Chem 2012;287:16187-98.
    • (2012) J Biol Chem , vol.287 , pp. 16187-16198
    • Teng, Y.W.1    Ellis, J.M.2    Coleman, R.A.3    Zeisel, S.H.4
  • 36
    • 77954575279 scopus 로고    scopus 로고
    • Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
    • Jacobs RL, Zhao Y, Koonen DP, Sletten T, Su B, Lingrell S, et al. Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem 2010;285:22403-13.
    • (2010) J Biol Chem , vol.285 , pp. 22403-22413
    • Jacobs, R.L.1    Zhao, Y.2    Koonen, D.P.3    Sletten, T.4    Su, B.5    Lingrell, S.6
  • 38
    • 77951468032 scopus 로고    scopus 로고
    • Betaine improved adipose tissue function in mice fed a high-fat diet: A mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease
    • Wang Z, Yao T, Pini M, Zhou Z, Fantuzzi G, Song Z. Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol 2010;298:G634-42.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298
    • Wang, Z.1    Yao, T.2    Pini, M.3    Zhou, Z.4    Fantuzzi, G.5    Song, Z.6
  • 39
    • 20444500564 scopus 로고    scopus 로고
    • Potential nutritional and physiological functions of betaine in livestock
    • Eklund M, Bauer E, Wamatu J, Mosenthin R. Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev 2005;18:31-48.
    • (2005) Nutr Res Rev , vol.18 , pp. 31-48
    • Eklund, M.1    Bauer, E.2    Wamatu, J.3    Mosenthin, R.4
  • 40
    • 0035287467 scopus 로고    scopus 로고
    • Effects of betaine on growth, carcass characteristics, pork quality, and plasma metabolites of finishing pigs
    • Matthews JO, Southern LL, Higbie AD, Persica MA, Bidner TD. Effects of betaine on growth, carcass characteristics, pork quality, and plasma metabolites of finishing pigs. J Anim Sci 2001;79:722-8.
    • (2001) J Anim Sci , vol.79 , pp. 722-728
    • Matthews, J.O.1    Southern, L.L.2    Higbie, A.D.3    Persica, M.A.4    Bidner, T.D.5
  • 41
    • 0036484496 scopus 로고    scopus 로고
    • Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed-restricted pig
    • Fernandez-Figares I, Wray-Cahen D, Steele NC, Campbell RG, Hall DD, Virtanen E, et al. Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed-restricted pig. J Anim Sci 2002;80:421-8.
    • (2002) J Anim Sci , vol.80 , pp. 421-428
    • Fernandez-Figares, I.1    Wray-Cahen, D.2    Steele, N.C.3    Campbell, R.G.4    Hall, D.D.5    Virtanen, E.6
  • 42
    • 0034734744 scopus 로고    scopus 로고
    • The effect of dl-methionine and betaine on growth performance and carcass characteristics in broilers
    • Esteve-Garcia E, Mack S. The effect of dl-methionine and betaine on growth performance and carcass characteristics in broilers. Anim Feed Sci Technol 2000;87:85-93.
    • (2000) Anim Feed Sci Technol , vol.87 , pp. 85-93
    • Esteve-Garcia, E.1    Mack, S.2
  • 43
    • 0036829164 scopus 로고    scopus 로고
    • Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects
    • Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7.
    • (2002) Am J Clin Nutr , vol.76 , pp. 961-967
    • Schwab, U.1    Torronen, A.2    Toppinen, L.3    Alfthan, G.4    Saarinen, M.5    Aro, A.6
  • 44
    • 80052720773 scopus 로고    scopus 로고
    • Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise
    • Hoffman JR, Ratamess NA, Kang J, Gonzalez AM, Beller NA, Craig SA. Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise. J Strength Cond Res 2011;25:2235-41.
    • (2011) J Strength Cond Res , vol.25 , pp. 2235-2241
    • Hoffman, J.R.1    Ratamess, N.A.2    Kang, J.3    Gonzalez, A.M.4    Beller, N.A.5    Craig, S.A.6
  • 45
    • 84856140602 scopus 로고    scopus 로고
    • The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men
    • Trepanowski JF, Farney TM, McCarthy CG, Schilling BK, Craig SA, Bloomer RJ. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength Cond Res 2011;25:3461-71.
    • (2011) J Strength Cond Res , vol.25 , pp. 3461-3471
    • Trepanowski, J.F.1    Farney, T.M.2    McCarthy, C.G.3    Schilling, B.K.4    Craig, S.A.5    Bloomer, R.J.6
  • 47
    • 42449163324 scopus 로고    scopus 로고
    • Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women
    • Konstantinova SV, Tell GS, Vollset SE, Nygard O, Bleie O, Ueland PM. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr 2008;138:914-20.
    • (2008) J Nutr , vol.138 , pp. 914-920
    • Konstantinova, S.V.1    Tell, G.S.2    Vollset, S.E.3    Nygard, O.4    Bleie, O.5    Ueland, P.M.6
  • 48
    • 84857030977 scopus 로고    scopus 로고
    • Cysteine and obesity: Consistency of the evidence across epidemiologic, animal and cellular studies
    • Elshorbagy AK, Kozich V, Smith AD, Refsum H. Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies. Curr Opin Clin Nutr Metab Care 2012;15:49-57.
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 49-57
    • Elshorbagy, A.K.1    Kozich, V.2    Smith, A.D.3    Refsum, H.4
  • 49
    • 0037233236 scopus 로고    scopus 로고
    • Predictors of change in plasma total cysteine: Longitudinal findings from the Hordaland homocysteine study
    • El-Khairy L, Vollset SE, Refsum H, Ueland PM. Predictors of change in plasma total cysteine: longitudinal findings from the Hordaland homocysteine study. Clin Chem 2003;49:113-20.
    • (2003) Clin Chem , vol.49 , pp. 113-120
    • El-Khairy, L.1    Vollset, S.E.2    Refsum, H.3    Ueland, P.M.4
  • 50
    • 51749124918 scopus 로고    scopus 로고
    • Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: Does cysteine link amino acid and lipid metabolism?
    • Elshorbagy AK, Nurk E, Gjesdal CG, Tell GS, Ueland PM, Nygard O, et al. Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr 2008;88:738-46.
    • (2008) Am J Clin Nutr , vol.88 , pp. 738-746
    • Elshorbagy, A.K.1    Nurk, E.2    Gjesdal, C.G.3    Tell, G.S.4    Ueland, P.M.5    Nygard, O.6
  • 51
    • 0018353829 scopus 로고
    • Comparison of the effects of insulin and insulin-like agents on different aspects of adipocyte metabolism
    • Olefsky JM. Comparison of the effects of insulin and insulin-like agents on different aspects of adipocyte metabolism. Horm Metab Res 1979;11:209-13.
    • (1979) Horm Metab Res , vol.11 , pp. 209-213
    • Olefsky, J.M.1
  • 52
    • 0015959226 scopus 로고
    • 2+ - Dependent thiol activation of fat cell glucose utilization
    • 2+ - dependent thiol activation of fat cell glucose utilization. J Biol Chem 1974;249:1001-6.
    • (1974) J Biol Chem , vol.249 , pp. 1001-1006
    • Czech, M.P.1    Lawrence Jr., J.C.2    Lynn, W.S.3
  • 56
    • 68149098866 scopus 로고    scopus 로고
    • Identification of a physiologically relevant endogenous ligand for PPARalpha in liver
    • Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, et al. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 2009;138:476-88.
    • (2009) Cell , vol.138 , pp. 476-488
    • Chakravarthy, M.V.1    Lodhi, I.J.2    Yin, L.3    Malapaka, R.R.4    Xu, H.E.5    Turk, J.6
  • 57
    • 33646133412 scopus 로고    scopus 로고
    • PPAR-alpha and insulin sensitivity
    • Haluzik MM, Haluzik M. PPAR-alpha and insulin sensitivity. Physiol Res 2006;55:115-22.
    • (2006) Physiol Res , vol.55 , pp. 115-122
    • Haluzik, M.M.1    Haluzik, M.2
  • 58
    • 0034744590 scopus 로고    scopus 로고
    • PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice
    • Tordjman K, Bernal-Mizrachi C, Zemany L, Weng S, Feng C, Zhang F, et al. PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J Clin Invest 2001;107:1025-34.
    • (2001) J Clin Invest , vol.107 , pp. 1025-1034
    • Tordjman, K.1    Bernal-Mizrachi, C.2    Zemany, L.3    Weng, S.4    Feng, C.5    Zhang, F.6
  • 59
    • 2442701392 scopus 로고    scopus 로고
    • PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
    • Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med 2004;10:530-4.
    • (2004) Nat Med , vol.10 , pp. 530-534
    • Koo, S.H.1    Satoh, H.2    Herzig, S.3    Lee, C.H.4    Hedrick, S.5    Kulkarni, R.6
  • 60
    • 0033569752 scopus 로고    scopus 로고
    • Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway
    • De Long CJ, Shen YJ, Thomas MJ, Cui Z. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem 1999;274:29683-8.
    • (1999) J Biol Chem , vol.274 , pp. 29683-29688
    • De Long, C.J.1    Shen, Y.J.2    Thomas, M.J.3    Cui, Z.4
  • 61
    • 79955371821 scopus 로고    scopus 로고
    • Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans
    • Da Costa KA, Sanders LM, Fischer LM, Zeisel SH. Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. Am J Clin Nutr 2011;93:968-74.
    • (2011) Am J Clin Nutr , vol.93 , pp. 968-974
    • Da Costa, K.A.1    Sanders, L.M.2    Fischer, L.M.3    Zeisel, S.H.4
  • 62
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147-52.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 63
    • 81055140116 scopus 로고    scopus 로고
    • A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans
    • Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, et al. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 2011;147:840-52.
    • (2011) Cell , vol.147 , pp. 840-852
    • Walker, A.K.1    Jacobs, R.L.2    Watts, J.L.3    Rottiers, V.4    Jiang, K.5    Finnegan, D.M.6
  • 64
    • 80755168893 scopus 로고    scopus 로고
    • FoxO feedback control of basal IRS-2 expression in pancreatic beta-cells is distinct from that in hepatocytes
    • Tsunekawa S, Demozay D, Briaud I, McCuaig J, Accili D, Stein R, et al. FoxO feedback control of basal IRS-2 expression in pancreatic beta-cells is distinct from that in hepatocytes. Diabetes 2011;60:2883-91.
    • (2011) Diabetes , vol.60 , pp. 2883-2891
    • Tsunekawa, S.1    Demozay, D.2    Briaud, I.3    McCuaig, J.4    Accili, D.5    Stein, R.6
  • 66
    • 44349124501 scopus 로고    scopus 로고
    • Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver
    • Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, et al. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res 2008;32:1049-58.
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 1049-1058
    • Ji, C.1    Shinohara, M.2    Vance, D.3    Than, T.A.4    Ookhtens, M.5    Chan, C.6
  • 67
    • 0029787429 scopus 로고    scopus 로고
    • Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase
    • Garrow TA. Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J Biol Chem 1996;271:22831-8.
    • (1996) J Biol Chem , vol.271 , pp. 22831-22838
    • Garrow, T.A.1
  • 68
    • 14044268131 scopus 로고    scopus 로고
    • Effects of betaine intake on plasma homocysteine concentrations and consequences for health
    • Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab 2005;6:15-22.
    • (2005) Curr Drug Metab , vol.6 , pp. 15-22
    • Olthof, M.R.1    Verhoef, P.2
  • 69
    • 59649127761 scopus 로고    scopus 로고
    • Importance of methyl donors during reproduction
    • Zeisel SH. Importance of methyl donors during reproduction. Am J Clin Nutr 2009;89:673S - 7S.
    • (2009) Am J Clin Nutr , vol.89
    • Zeisel, S.H.1
  • 70
    • 77955635459 scopus 로고    scopus 로고
    • Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus
    • Mehedint MG, Craciunescu CN, Zeisel SH. Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci USA 2010;107:12834-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12834-12839
    • Mehedint, M.G.1    Craciunescu, C.N.2    Zeisel, S.H.3
  • 71
    • 30744479491 scopus 로고    scopus 로고
    • Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
    • Niculescu MD, Craciunescu CN, Zeisel SH. Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J 2006;20:43-9.
    • (2006) FASEB J , vol.20 , pp. 43-49
    • Niculescu, M.D.1    Craciunescu, C.N.2    Zeisel, S.H.3
  • 72
    • 0036322831 scopus 로고    scopus 로고
    • Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring
    • Cooney CA, Dave AA, Wolff GL. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 2002;132:2393S - 400S.
    • (2002) J Nutr , vol.132
    • Cooney, C.A.1    Dave, A.A.2    Wolff, G.L.3
  • 73
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
    • Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003;23:5293-300.
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 74
    • 84864652235 scopus 로고    scopus 로고
    • Epigenetics: The missing link to understanding beta-cell dysfunction in the pathogenesis of type 2 diabetes
    • Gilbert ER, Liu D. Epigenetics: the missing link to understanding beta-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics 2012;7:841-52.
    • (2012) Epigenetics , vol.7 , pp. 841-852
    • Gilbert, E.R.1    Liu, D.2
  • 75
    • 84870847241 scopus 로고    scopus 로고
    • Metabolic memory and chronic diabetes complications: Potential role for epigenetic mechanisms
    • Intine RV, Sarras MP Jr. Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms. Curr Diab Rep 2012;12:551-9.
    • (2012) Curr Diab Rep , vol.12 , pp. 551-559
    • Intine, R.V.1    Sarras Jr., M.P.2
  • 76
    • 84863334811 scopus 로고    scopus 로고
    • Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes
    • Yang BT, Dayeh TA, Volkov PA, Kirkpatrick CL, Malmgren S, Jing X, et al. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol 2012;26:1203-12.
    • (2012) Mol Endocrinol , vol.26 , pp. 1203-1212
    • Yang, B.T.1    Dayeh, T.A.2    Volkov, P.A.3    Kirkpatrick, C.L.4    Malmgren, S.5    Jing, X.6
  • 77
    • 41149172495 scopus 로고    scopus 로고
    • Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    • Ling C, Del Guerra S, Lupi R, Ronn T, Granhall C, Luthman H, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008;51:615-22.
    • (2008) Diabetologia , vol.51 , pp. 615-622
    • Ling, C.1    Del Guerra, S.2    Lupi, R.3    Ronn, T.4    Granhall, C.5    Luthman, H.6
  • 78
    • 84860476723 scopus 로고    scopus 로고
    • Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function
    • doi:36010.31371/journal. pone.0036047
    • Johnson A, Lao S, Wang T, Galanko J, Zeisel SH. Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS ONE 2012;7:e36047 doi:36010.31371/journal. pone.0036047.
    • (2012) PLoS ONE , vol.7
    • Johnson, A.1    Lao, S.2    Wang, T.3    Galanko, J.4    Zeisel, S.H.5
  • 79
    • 84860476723 scopus 로고    scopus 로고
    • Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function
    • Johnson AR, Lao S, Wang T, Galanko JA, Zeisel SH. Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS One 2012;7:e36047.
    • (2012) PLoS One , vol.7
    • Johnson, A.R.1    Lao, S.2    Wang, T.3    Galanko, J.A.4    Zeisel, S.H.5
  • 80
    • 79952295016 scopus 로고    scopus 로고
    • A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals
    • Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin T P, et al. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. J Clin Endocrinol Metab 2011;96:775-81.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 775-781
    • Boyle, K.E.1    Canham, J.P.2    Consitt, L.A.3    Zheng, D.4    Koves, T.R.5    Gavin, T.P.6
  • 81
    • 80054942844 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and insulin resistance from the outside in: Extracellular matrix, the cytoskeleton, and mitochondria
    • Coletta DK, Mandarino LJ. Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria. Am J Physiol Endocrinol Metab 2011;301:E749-55.
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Coletta, D.K.1    Mandarino, L.J.2
  • 83
    • 0035877633 scopus 로고    scopus 로고
    • Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade
    • Mahadev K, Zilbering A, Zhu L, Goldstein BJ. Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem 2001;276:21938-42.
    • (2001) J Biol Chem , vol.276 , pp. 21938-21942
    • Mahadev, K.1    Zilbering, A.2    Zhu, L.3    Goldstein, B.J.4
  • 84
    • 1342304048 scopus 로고    scopus 로고
    • The NAD (P) H oxidase homolog Nox4 modulates insulinstimulated generation of H2O2 and plays an integral role in insulin signal transduction
    • Mahadev K, Motoshima H, Wu X, Ruddy JM, Arnold RS, Cheng G, et al. The NAD (P) H oxidase homolog Nox4 modulates insulinstimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol 2004;24:1844-54.
    • (2004) Mol Cell Biol , vol.24 , pp. 1844-1854
    • Mahadev, K.1    Motoshima, H.2    Wu, X.3    Ruddy, J.M.4    Arnold, R.S.5    Cheng, G.6
  • 85
    • 77957229010 scopus 로고    scopus 로고
    • Insulin signaling meets mitochondria in metabolism
    • Cheng Z, Tseng Y, White MF. Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab 2010;21:589-98.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 589-598
    • Cheng, Z.1    Tseng, Y.2    White, M.F.3
  • 86
    • 84856415487 scopus 로고    scopus 로고
    • The role of mitochondria in insulin resistance and type 2 diabetes mellitus
    • Szendroedi J, Phielix E, Roden M. The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol 2012;8:92-103.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 92-103
    • Szendroedi, J.1    Phielix, E.2    Roden, M.3
  • 87
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 2000;1492:203-6.
    • (2000) Biochim Biophys Acta , vol.1492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 88
    • 0024999212 scopus 로고
    • A rat brain cytosolic N-methyltransferase (s) activity converting phosphorylethanolamine into phosphorylcholine
    • Andriamampandry C, Massarelli R, Freysz L, Kanfer JN. A rat brain cytosolic N-methyltransferase (s) activity converting phosphorylethanolamine into phosphorylcholine. Biochem Biophys Res Commun 1990;171:758-63.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 758-763
    • Andriamampandry, C.1    Massarelli, R.2    Freysz, L.3    Kanfer, J.N.4
  • 91
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009;58:250-9.
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3    Stanislaus, S.4    Chen, M.5    Sivits, G.6
  • 92
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007;5:415-25.
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3    Ding, X.4    Gautron, L.5    Parameswara, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.