DNA-Damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 346, Issue 3, 2013, Pages 393-405

  Polewska, Joanna ^a   Skwarska, Anna ^a   Augustin, Ewa ^a   Konopa, Jerzy ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; IMIDACRINE; PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATG5 GENE; AUTOPHAGY; BECLIN 1 GENE; CANCER CELL CULTURE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ACRIDINE ORANGE; AMINOACRIDINES; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; DOWN-REGULATION; FLUORESCENT DYES; G1 PHASE; G2 PHASE; GENE SILENCING; HUMANS; LUNG NEOPLASMS; MEMBRANE PROTEINS; ORGANELLES;

EID: 84882363104     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.203851     Document Type: Article

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