Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2832-2836

  Nolan, K A ^a   Humphries, M P ^a   Bryce, R A ^a   Stratford, I J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Docking; Imidazoacridinones; NQO2; Structure activity relationships

Indexed keywords

IMIDAZOACRIDIN 6 ONE; OXIDOREDUCTASE; OXIDOREDUCTASE INHIBITOR; QUINONE OXIDOREDUCTASE 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG STRUCTURE; ENZYME ACTIVITY; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACRIDINES; ACRIDONES; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; DATABASES, FACTUAL; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINONE REDUCTASES; THERMODYNAMICS;

EID: 77950862471     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.051     Document Type: Article

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