Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

Nature Medicine

Volumn 19, Issue 8, 2013, Pages 1030-1038

  Marco, Sonia ^a   Giralt, Albert ^b,c   Petrovic, Milos M ^a,d   Pouladi, Mahmoud A ^e,f   Martínez Turrillas, Rebeca ^a   Martínez Hernández, José ^g   Kaltenbach, Linda S ^h   Torres Peraza, Jesús ^b   Graham, Rona K ^e   Watanabe, Masahiko ⁱ   Luján, Rafael ^g   Nakanishi, Nobuki ^j   Lipton, Stuart A ^j   Lo, Donald C ^h   Hayden, Michael R ^e,f,k   Alberch, Jordi ^b   Wesseling, John F ^a   Pérez Otaño, Isabel ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF BELGRADE   (Serbia)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f University of Castilla La Mancha   (Spain)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h HOKKAIDO UNIVERSITY   (Japan)

ⁱ BURNHAM INSTITUTE   (United States)

^j TEVA PHARMACEUTICALS   (Israel)

^k UNIVERSITÉ DE SHERBROOKE   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLUN3A PROTEIN; HUNTINGTIN; MUTANT PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS STRIATUM; GENE DELETION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SUBUNIT; SYNAPTIC MEMBRANE; WILD TYPE;

ANIMALS; BEHAVIOR, ANIMAL; CARRIER PROTEINS; CELL DEATH; DISEASE MODELS, ANIMAL; GENE DELETION; HEK293 CELLS; HUMANS; HUNTINGTON DISEASE; IMMUNOPRECIPITATION; MICE; MOTOR ACTIVITY; MUTANT PROTEINS; NEOSTRIATUM; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, N-METHYL-D-ASPARTATE; ROTAROD PERFORMANCE TEST; SYNAPSES;

EID: 84882275870     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3246     Document Type: Article

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