메뉴 건너뛰기




Volumn 25, Issue 2, 2013, Pages 130-145

Vaccine adjuvant formulations: A pharmaceutical perspective

Author keywords

Adjuvant; Alum; Emulsion; Formulations; PLG; Vaccine

Indexed keywords

ADJUVANT; ALPHA TOCOPHEROL; ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; ALUMINUM POTASSIUM SULFATE; ALUMINUM SALT; CLEVIDIPINE; DIAZEPAM; ETOMIDATE; FLUOSOL DA; HYDROXYL GROUP; INFLUENZA VACCINE; INTRALIPID; ISCOM; LIPOPROSTAGLANDIN E1; LIPOSOME; LIPOSYN II; MIFAMURTIDE; PHOSPHOLIPID; POLYMER; PROPOFOL; SOYBEAN OIL EMULSION; SQUALENE; TOLL LIKE RECEPTOR AGONIST; VACCINE; WART VIRUS VACCINE;

EID: 84882246220     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2013.05.007     Document Type: Review
Times cited : (138)

References (123)
  • 1
    • 77954436606 scopus 로고    scopus 로고
    • Continuous glucose monitoring in youth with type 1 diabetes: 12-month follow-up of the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial
    • Chase H.P., Beck R.W., Xing D., Tamborlane W.V., Coffey J., Fox L.A., et al. Continuous glucose monitoring in youth with type 1 diabetes: 12-month follow-up of the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial. Diabetes Technology & Therapeutics 2010, 12:507-515.
    • (2010) Diabetes Technology & Therapeutics , vol.12 , pp. 507-515
    • Chase, H.P.1    Beck, R.W.2    Xing, D.3    Tamborlane, W.V.4    Coffey, J.5    Fox, L.A.6
  • 3
    • 78049288264 scopus 로고    scopus 로고
    • Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
    • Bachmann M.F., Jennings G.T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nature Reviews Immunology 2010, 10:787-796.
    • (2010) Nature Reviews Immunology , vol.10 , pp. 787-796
    • Bachmann, M.F.1    Jennings, G.T.2
  • 5
    • 79954606125 scopus 로고    scopus 로고
    • A synthetic TLR4 agonist formulated in an emulsion enhances humoral and Type 1 cellular immune responses against GMZ2 - a GLURP-MSP3 fusion protein malaria vaccine candidate
    • Lousada-Dietrich S., Jogdand P.S., Jepsen S., Pinto V.V., Ditlev S.B., Christiansen M., et al. A synthetic TLR4 agonist formulated in an emulsion enhances humoral and Type 1 cellular immune responses against GMZ2 - a GLURP-MSP3 fusion protein malaria vaccine candidate. Vaccine 2011, 29:3284-3292.
    • (2011) Vaccine , vol.29 , pp. 3284-3292
    • Lousada-Dietrich, S.1    Jogdand, P.S.2    Jepsen, S.3    Pinto, V.V.4    Ditlev, S.B.5    Christiansen, M.6
  • 6
    • 84875240669 scopus 로고    scopus 로고
    • Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania
    • Fox C.B., Huynh C., O'Hara M.K., Onu A. Technology transfer of oil-in-water emulsion adjuvant manufacturing for pandemic influenza vaccine production in Romania. Vaccine 2013, 31(12):1633-1640.
    • (2013) Vaccine , vol.31 , Issue.12 , pp. 1633-1640
    • Fox, C.B.1    Huynh, C.2    O'Hara, M.K.3    Onu, A.4
  • 7
    • 69949105213 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders
    • Fukata M., Vamadevan A.S., Abreu M.T. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders. Seminars in Immunology 2009, 21:242-253.
    • (2009) Seminars in Immunology , vol.21 , pp. 242-253
    • Fukata, M.1    Vamadevan, A.S.2    Abreu, M.T.3
  • 8
    • 84867239659 scopus 로고    scopus 로고
    • Effects on immunogenicity by formulations of emulsion-based adjuvants for malaria vaccines
    • Fox C.B., Baldwin S.L., Vedvick T.S., Angov E., Reed S.G. Effects on immunogenicity by formulations of emulsion-based adjuvants for malaria vaccines. Clinical and Vaccine Immunology 2012, 19:1633-1640.
    • (2012) Clinical and Vaccine Immunology , vol.19 , pp. 1633-1640
    • Fox, C.B.1    Baldwin, S.L.2    Vedvick, T.S.3    Angov, E.4    Reed, S.G.5
  • 9
    • 33745851536 scopus 로고    scopus 로고
    • Adjuvant activity of CpG oligodeoxynucleotides
    • Klinman D.M. Adjuvant activity of CpG oligodeoxynucleotides. International Reviews of Immunology 2006, 25:135-154.
    • (2006) International Reviews of Immunology , vol.25 , pp. 135-154
    • Klinman, D.M.1
  • 10
    • 77149123313 scopus 로고    scopus 로고
    • Initial use of portable monitoring versus polysomnography to confirm obstructive sleep apnea in symptomatic patients: an economic decision model
    • Ayas N.T., Fox J., Epstein L., Ryan C.F., Fleetham J.A. Initial use of portable monitoring versus polysomnography to confirm obstructive sleep apnea in symptomatic patients: an economic decision model. Sleep Medicine 2010, 11:320-324.
    • (2010) Sleep Medicine , vol.11 , pp. 320-324
    • Ayas, N.T.1    Fox, J.2    Epstein, L.3    Ryan, C.F.4    Fleetham, J.A.5
  • 12
    • 0024208507 scopus 로고
    • Local anesthesia for radial artery cannulation: a comparison of a lidocaine-prilocaine emulsion and lidocaine infiltration
    • Russell G.N., Desmond M.J., Fox M.A. Local anesthesia for radial artery cannulation: a comparison of a lidocaine-prilocaine emulsion and lidocaine infiltration. Journal of Cardiothoracic Anesthesia 1988, 2:309-312.
    • (1988) Journal of Cardiothoracic Anesthesia , vol.2 , pp. 309-312
    • Russell, G.N.1    Desmond, M.J.2    Fox, M.A.3
  • 14
    • 77249176352 scopus 로고    scopus 로고
    • AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity
    • Didierlaurent A.M., Morel S., Lockman L., Giannini S.L., Bisteau M., Carlsen H., et al. AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. Journal of Immunology 2009, 183:6186-6197.
    • (2009) Journal of Immunology , vol.183 , pp. 6186-6197
    • Didierlaurent, A.M.1    Morel, S.2    Lockman, L.3    Giannini, S.L.4    Bisteau, M.5    Carlsen, H.6
  • 16
    • 37849039132 scopus 로고    scopus 로고
    • Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice
    • Wack A., Baudner B.C., Hilbert A.K., Manini I., Nuti S., Tavarini S., et al. Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice. Vaccine 2008, 26:552-561.
    • (2008) Vaccine , vol.26 , pp. 552-561
    • Wack, A.1    Baudner, B.C.2    Hilbert, A.K.3    Manini, I.4    Nuti, S.5    Tavarini, S.6
  • 18
    • 0025030378 scopus 로고
    • Characteristics of silent and painful ischaemia during ambulatory monitoring in patients with coronary arterial disease
    • Mulcahy D., Keegan J., Fox K.M. Characteristics of silent and painful ischaemia during ambulatory monitoring in patients with coronary arterial disease. International Journal of Cardiology 1990, 28:377-379.
    • (1990) International Journal of Cardiology , vol.28 , pp. 377-379
    • Mulcahy, D.1    Keegan, J.2    Fox, K.M.3
  • 19
    • 84859825056 scopus 로고    scopus 로고
    • The impact of a telemedicine monitoring system on positive airway pressure adherence in patients with obstructive sleep apnea: a randomized controlled trial
    • Fox N., Hirsch-Allen A.J., Goodfellow E., Wenner J., Fleetham J., Ryan C.F., et al. The impact of a telemedicine monitoring system on positive airway pressure adherence in patients with obstructive sleep apnea: a randomized controlled trial. Sleep 2012, 35:477-481.
    • (2012) Sleep , vol.35 , pp. 477-481
    • Fox, N.1    Hirsch-Allen, A.J.2    Goodfellow, E.3    Wenner, J.4    Fleetham, J.5    Ryan, C.F.6
  • 22
    • 35348968868 scopus 로고    scopus 로고
    • Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation
    • Hem S.L., Hogenesch H. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Review of Vaccines 2007, 6:685-698.
    • (2007) Expert Review of Vaccines , vol.6 , pp. 685-698
    • Hem, S.L.1    Hogenesch, H.2
  • 23
    • 77954762107 scopus 로고    scopus 로고
    • Preformulation studies - the next advance in aluminum adjuvant-containing vaccines
    • Hem S.L., HogenEsch H., Middaugh C.R., Volkin D.B. Preformulation studies - the next advance in aluminum adjuvant-containing vaccines. Vaccine 2010, 28:4868-4870.
    • (2010) Vaccine , vol.28 , pp. 4868-4870
    • Hem, S.L.1    HogenEsch, H.2    Middaugh, C.R.3    Volkin, D.B.4
  • 24
    • 0037205207 scopus 로고    scopus 로고
    • Aluminum salts in vaccines - US perspective
    • Baylor N.W., Egan W., Richman P. Aluminum salts in vaccines - US perspective. Vaccine 2002, 20(Suppl. 3):S18-S23.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 3
    • Baylor, N.W.1    Egan, W.2    Richman, P.3
  • 25
    • 33845187202 scopus 로고    scopus 로고
    • Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants
    • Romero Mendez I.Z., Shi Y., HogenEsch H., Hem S.L. Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants. Vaccine 2007, 25:825-833.
    • (2007) Vaccine , vol.25 , pp. 825-833
    • Romero Mendez, I.Z.1    Shi, Y.2    HogenEsch, H.3    Hem, S.L.4
  • 27
    • 78650555727 scopus 로고    scopus 로고
    • Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability
    • Clapp T., Siebert P., Chen D., Jones Braun L. Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability. Journal of Pharmaceutical Sciences 2011, 100:388-401.
    • (2011) Journal of Pharmaceutical Sciences , vol.100 , pp. 388-401
    • Clapp, T.1    Siebert, P.2    Chen, D.3    Jones Braun, L.4
  • 28
    • 17144427675 scopus 로고    scopus 로고
    • Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens
    • Jones L.S., Peek L.J., Power J., Markham A., Yazzie B., Middaugh C.R. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. Journal of Biological Chemistry 2005, 280:13406-13414.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 13406-13414
    • Jones, L.S.1    Peek, L.J.2    Power, J.3    Markham, A.4    Yazzie, B.5    Middaugh, C.R.6
  • 31
    • 0037205219 scopus 로고    scopus 로고
    • Elimination of aluminum adjuvants
    • Hem S.L. Elimination of aluminum adjuvants. Vaccine 2002, 20(Suppl. 3):S40-S43.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 3
    • Hem, S.L.1
  • 32
    • 34547699645 scopus 로고    scopus 로고
    • Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response
    • Hansen B., Sokolovska A., HogenEsch H., Hem S.L. Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response. Vaccine 2007, 25:6618-6624.
    • (2007) Vaccine , vol.25 , pp. 6618-6624
    • Hansen, B.1    Sokolovska, A.2    HogenEsch, H.3    Hem, S.L.4
  • 33
    • 67349137094 scopus 로고    scopus 로고
    • Relationship between tightness of binding and immunogenicity in an aluminum-containing adjuvant-adsorbed hepatitis B vaccine
    • Egan P.M., Belfast M.T., Gimenez J.A., Sitrin R.D., Mancinelli R.J. Relationship between tightness of binding and immunogenicity in an aluminum-containing adjuvant-adsorbed hepatitis B vaccine. Vaccine 2009, 27:3175-3180.
    • (2009) Vaccine , vol.27 , pp. 3175-3180
    • Egan, P.M.1    Belfast, M.T.2    Gimenez, J.A.3    Sitrin, R.D.4    Mancinelli, R.J.5
  • 34
    • 58249106119 scopus 로고    scopus 로고
    • Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response
    • Hansen B., Belfast M., Soung G., Song L., Egan P.M., Capen R., et al. Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response. Vaccine 2009, 27:888-892.
    • (2009) Vaccine , vol.27 , pp. 888-892
    • Hansen, B.1    Belfast, M.2    Soung, G.3    Song, L.4    Egan, P.M.5    Capen, R.6
  • 35
    • 79958819334 scopus 로고    scopus 로고
    • Effect of the strength of adsorption of HIV 1 SF162dV2gp140 to aluminum-containing adjuvants on the immune response
    • Hansen B., Malyala P., Singh M., Sun Y., Srivastava I., Hogenesch H., et al. Effect of the strength of adsorption of HIV 1 SF162dV2gp140 to aluminum-containing adjuvants on the immune response. Journal of Pharmaceutical Sciences 2011, 100:3245-3250.
    • (2011) Journal of Pharmaceutical Sciences , vol.100 , pp. 3245-3250
    • Hansen, B.1    Malyala, P.2    Singh, M.3    Sun, Y.4    Srivastava, I.5    Hogenesch, H.6
  • 36
    • 81955167447 scopus 로고    scopus 로고
    • Updated aluminum pharmacokinetics following infant exposures through diet and vaccination
    • Mitkus R.J., King D.B., Hess M.A., Forshee R.A., Walderhaug M.O. Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. Vaccine 2011, 29:9538-9543.
    • (2011) Vaccine , vol.29 , pp. 9538-9543
    • Mitkus, R.J.1    King, D.B.2    Hess, M.A.3    Forshee, R.A.4    Walderhaug, M.O.5
  • 37
    • 0021276823 scopus 로고
    • Diagnosis of broad complex tachycardias with ambulatory monitoring of atrial electrography
    • Lipkin D.P., Perrins E.J., Shapiro L.M., Ludgate L., Fox K.M. Diagnosis of broad complex tachycardias with ambulatory monitoring of atrial electrography. British Medical Journal 1984, 288:1713-1714.
    • (1984) British Medical Journal , vol.288 , pp. 1713-1714
    • Lipkin, D.P.1    Perrins, E.J.2    Shapiro, L.M.3    Ludgate, L.4    Fox, K.M.5
  • 39
    • 84866356164 scopus 로고    scopus 로고
    • Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue
    • Hu L., Joshi S.B., Andra K.K., Thakkar S.V., Volkin D.B., Bann J.G., et al. Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue. Journal of Pharmaceutical Sciences 2012, 101(11):4118-4128. 10.1002/jps.23294.
    • (2012) Journal of Pharmaceutical Sciences , vol.101 , Issue.11 , pp. 4118-4128
    • Hu, L.1    Joshi, S.B.2    Andra, K.K.3    Thakkar, S.V.4    Volkin, D.B.5    Bann, J.G.6
  • 40
    • 84872502459 scopus 로고    scopus 로고
    • Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine
    • Hu L., Joshi S.B., Liyanage M.R., Pansalawatta M., Alderson M.R., Tate A., et al. Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. Journal of Pharmaceutical Sciences 2013, 102:387-400.
    • (2013) Journal of Pharmaceutical Sciences , vol.102 , pp. 387-400
    • Hu, L.1    Joshi, S.B.2    Liyanage, M.R.3    Pansalawatta, M.4    Alderson, M.R.5    Tate, A.6
  • 41
    • 27744440480 scopus 로고    scopus 로고
    • (How) do aluminium adjuvants work
    • Brewer J.M. (How) do aluminium adjuvants work. Immunology Letters 2006, 102:10-15.
    • (2006) Immunology Letters , vol.102 , pp. 10-15
    • Brewer, J.M.1
  • 42
    • 0037205174 scopus 로고    scopus 로고
    • Mechanisms of stimulation of the immune response by aluminum adjuvants
    • HogenEsch H. Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine 2002, 20(Suppl. 3):S34-S39.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 3
    • HogenEsch, H.1
  • 43
    • 13444292001 scopus 로고    scopus 로고
    • Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro
    • Morefield G.L., Sokolovska A., Jiang D., HogenEsch H., Robinson J.P., Hem S.L. Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine 2005, 23:1588-1595.
    • (2005) Vaccine , vol.23 , pp. 1588-1595
    • Morefield, G.L.1    Sokolovska, A.2    Jiang, D.3    HogenEsch, H.4    Robinson, J.P.5    Hem, S.L.6
  • 44
    • 0030921599 scopus 로고    scopus 로고
    • Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties
    • Goto N., Kato H., Maeyama J., Shibano M., Saito T., Yamaguchi J., et al. Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties. Vaccine 1997, 15:1364-1371.
    • (1997) Vaccine , vol.15 , pp. 1364-1371
    • Goto, N.1    Kato, H.2    Maeyama, J.3    Shibano, M.4    Saito, T.5    Yamaguchi, J.6
  • 45
    • 0035144140 scopus 로고    scopus 로고
    • The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism
    • Ulanova M., Tarkowski A., Hahn-Zoric M., Hanson L.A. The Common vaccine adjuvant aluminum hydroxide up-regulates accessory properties of human monocytes via an interleukin-4-dependent mechanism. Infection and Immunity 2001, 69:1151-1159.
    • (2001) Infection and Immunity , vol.69 , pp. 1151-1159
    • Ulanova, M.1    Tarkowski, A.2    Hahn-Zoric, M.3    Hanson, L.A.4
  • 46
    • 0037435833 scopus 로고    scopus 로고
    • Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro
    • Sun H., Pollock K.G., Brewer J.M. Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine 2003, 21:849-855.
    • (2003) Vaccine , vol.21 , pp. 849-855
    • Sun, H.1    Pollock, K.G.2    Brewer, J.M.3
  • 47
    • 3843097243 scopus 로고    scopus 로고
    • Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type
    • Rimaniol A.C., Gras G., Verdier F., Capel F., Grigoriev V.B., Porcheray F., et al. Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type. Vaccine 2004, 22:3127-3135.
    • (2004) Vaccine , vol.22 , pp. 3127-3135
    • Rimaniol, A.C.1    Gras, G.2    Verdier, F.3    Capel, F.4    Grigoriev, V.B.5    Porcheray, F.6
  • 48
    • 45949083618 scopus 로고    scopus 로고
    • The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells
    • Seubert A., Monaci E., Pizza M., O'Hagan D.T., Wack A. The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. Journal of Immunology 2008, 180:5402-5412.
    • (2008) Journal of Immunology , vol.180 , pp. 5402-5412
    • Seubert, A.1    Monaci, E.2    Pizza, M.3    O'Hagan, D.T.4    Wack, A.5
  • 49
    • 2942701975 scopus 로고    scopus 로고
    • Promotion of B cell immune responses via an alum-induced myeloid cell population
    • Jordan M.B., Mills D.M., Kappler J., Marrack P., Cambier J.C. Promotion of B cell immune responses via an alum-induced myeloid cell population. Science 2004, 304:1808-1810.
    • (2004) Science , vol.304 , pp. 1808-1810
    • Jordan, M.B.1    Mills, D.M.2    Kappler, J.3    Marrack, P.4    Cambier, J.C.5
  • 51
    • 0009910959 scopus 로고
    • Transfusion of milk in cholera
    • Hodder E. Transfusion of milk in cholera. Practitioner 1873, 10:14.
    • (1873) Practitioner , vol.10 , pp. 14
    • Hodder, E.1
  • 52
    • 78651470720 scopus 로고    scopus 로고
    • Injectable lipid emulsions-advancements, opportunities and challenges
    • Hippalgaonkar K., Majumdar S., Kansara V. Injectable lipid emulsions-advancements, opportunities and challenges. AAPS PharmSciTech 2010, 11:1526-1540.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 1526-1540
    • Hippalgaonkar, K.1    Majumdar, S.2    Kansara, V.3
  • 54
    • 84868206480 scopus 로고    scopus 로고
    • AF03, an alternative squalene emulsion-based vaccine adjuvant prepared by a phase inversion temperature method
    • Klucker M.F., Dalencon F., Probeck P., Haensler J. AF03, an alternative squalene emulsion-based vaccine adjuvant prepared by a phase inversion temperature method. Journal of Pharmaceutical Sciences 2012, 101:4490-4500.
    • (2012) Journal of Pharmaceutical Sciences , vol.101 , pp. 4490-4500
    • Klucker, M.F.1    Dalencon, F.2    Probeck, P.3    Haensler, J.4
  • 55
    • 35349019722 scopus 로고    scopus 로고
    • MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection
    • O'Hagan D.T. MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection. Expert Review of Vaccines 2007, 6:699-710.
    • (2007) Expert Review of Vaccines , vol.6 , pp. 699-710
    • O'Hagan, D.T.1
  • 56
    • 0038330442 scopus 로고    scopus 로고
    • MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile
    • Podda A., Del Giudice G. MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. Expert Review of Vaccines 2003, 2:197-203.
    • (2003) Expert Review of Vaccines , vol.2 , pp. 197-203
    • Podda, A.1    Del Giudice, G.2
  • 57
    • 77957701029 scopus 로고    scopus 로고
    • Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence
    • Vesikari T., Karvonen A., Tilman S., Borkowski A., Montomoli E., Banzhoff A., et al. Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence. Pediatrics 2010, 126:e762-e770.
    • (2010) Pediatrics , vol.126
    • Vesikari, T.1    Karvonen, A.2    Tilman, S.3    Borkowski, A.4    Montomoli, E.5    Banzhoff, A.6
  • 58
    • 84874605485 scopus 로고    scopus 로고
    • Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis
    • Miller E., Andrews N., Stellitano L., Stowe J., Winstone A.M., Shneerson J., et al. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ 2013, 346:f794.
    • (2013) BMJ , vol.346
    • Miller, E.1    Andrews, N.2    Stellitano, L.3    Stowe, J.4    Winstone, A.M.5    Shneerson, J.6
  • 59
    • 84859054098 scopus 로고    scopus 로고
    • AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland
    • Nohynek H., Jokinen J., Partinen M., Vaarala O., Kirjavainen T., Sundman J., et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS ONE 2012, 7:e33536.
    • (2012) PLoS ONE , vol.7
    • Nohynek, H.1    Jokinen, J.2    Partinen, M.3    Vaarala, O.4    Kirjavainen, T.5    Sundman, J.6
  • 60
    • 84859027226 scopus 로고    scopus 로고
    • Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
    • Partinen M., Saarenpaa-Heikkila O., Ilveskoski I., Hublin C., Linna M., Olsen P., et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS ONE 2012, 7:e33723.
    • (2012) PLoS ONE , vol.7
    • Partinen, M.1    Saarenpaa-Heikkila, O.2    Ilveskoski, I.3    Hublin, C.4    Linna, M.5    Olsen, P.6
  • 61
    • 79960827514 scopus 로고    scopus 로고
    • Explorations of clinical trials and pharmacovigilance databases of MF59(R)-adjuvanted influenza vaccines for associated cases of narcolepsy
    • Tsai T.F., Crucitti A., Nacci P., Nicolay U., Della Cioppa G., Ferguson J., et al. Explorations of clinical trials and pharmacovigilance databases of MF59(R)-adjuvanted influenza vaccines for associated cases of narcolepsy. Scandinavian Journal of Infectious Diseases 2011, 43:702-706.
    • (2011) Scandinavian Journal of Infectious Diseases , vol.43 , pp. 702-706
    • Tsai, T.F.1    Crucitti, A.2    Nacci, P.3    Nicolay, U.4    Della Cioppa, G.5    Ferguson, J.6
  • 64
    • 79952362612 scopus 로고    scopus 로고
    • Adjuvant System AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity
    • Morel S., Didierlaurent A., Bourguignon P., Delhaye S., Baras B., Jacob V., et al. Adjuvant System AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity. Vaccine 2011, 29:2461-2473.
    • (2011) Vaccine , vol.29 , pp. 2461-2473
    • Morel, S.1    Didierlaurent, A.2    Bourguignon, P.3    Delhaye, S.4    Baras, B.5    Jacob, V.6
  • 65
    • 84882268679 scopus 로고    scopus 로고
    • Freund's complete and incomplete adjuvants, preparation, and quality control standards for experimental laboratory animals use
    • Stewart-Tull D. Freund's complete and incomplete adjuvants, preparation, and quality control standards for experimental laboratory animals use. Methods in Molecular Biology 2010, 5:9-72.
    • (2010) Methods in Molecular Biology , vol.5 , pp. 9-72
    • Stewart-Tull, D.1
  • 67
    • 80051558540 scopus 로고    scopus 로고
    • An alternative renewable source of squalene for use in emulsion adjuvants
    • Brito L.A., Chan M., Baudner B., Gallorini S., Santos G., O'Hagan D.T., et al. An alternative renewable source of squalene for use in emulsion adjuvants. Vaccine 2011, 29:6262-6268.
    • (2011) Vaccine , vol.29 , pp. 6262-6268
    • Brito, L.A.1    Chan, M.2    Baudner, B.3    Gallorini, S.4    Santos, G.5    O'Hagan, D.T.6
  • 68
    • 44749087196 scopus 로고    scopus 로고
    • Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions
    • Fox C.B., Anderson R.C., Dutill T.S., Goto Y., Reed S.G., Vedvick T.S. Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions. Colloids and Surfaces B: Biointerfaces 2008, 65:98-105.
    • (2008) Colloids and Surfaces B: Biointerfaces , vol.65 , pp. 98-105
    • Fox, C.B.1    Anderson, R.C.2    Dutill, T.S.3    Goto, Y.4    Reed, S.G.5    Vedvick, T.S.6
  • 69
    • 81955160717 scopus 로고    scopus 로고
    • Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions
    • Fox C.B., Baldwin S.L., Duthie M.S., Reed S.G., Vedvick T.S. Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. Vaccine 2011, 29:9563-9572.
    • (2011) Vaccine , vol.29 , pp. 9563-9572
    • Fox, C.B.1    Baldwin, S.L.2    Duthie, M.S.3    Reed, S.G.4    Vedvick, T.S.5
  • 70
    • 84879880507 scopus 로고    scopus 로고
    • The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect
    • pii: S0264-410X(13)00563-X
    • Calabro S., Tritto E., Pezzotti A., Taccone M., Muzzi A., Bertholet S., et al. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. Vaccine 2013, pii: S0264-410X(13)00563-X.
    • (2013) Vaccine
    • Calabro, S.1    Tritto, E.2    Pezzotti, A.3    Taccone, M.4    Muzzi, A.5    Bertholet, S.6
  • 72
    • 77957005783 scopus 로고    scopus 로고
    • Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model
    • Hamouda T., Chepurnov A., Mank N., Knowlton J., Chepurnova T., Myc A., et al. Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model. Human Vaccines 2010, 6:585-594.
    • (2010) Human Vaccines , vol.6 , pp. 585-594
    • Hamouda, T.1    Chepurnov, A.2    Mank, N.3    Knowlton, J.4    Chepurnova, T.5    Myc, A.6
  • 73
    • 79960120763 scopus 로고    scopus 로고
    • Intranasal immunization of ferrets with commercial trivalent influenza vaccines formulated in a nanoemulsion-based adjuvant
    • Hamouda T., Sutcliffe J.A., Ciotti S., Baker J.R. Intranasal immunization of ferrets with commercial trivalent influenza vaccines formulated in a nanoemulsion-based adjuvant. Clinical and Vaccine Immunology 2011, 18:1167-1175.
    • (2011) Clinical and Vaccine Immunology , vol.18 , pp. 1167-1175
    • Hamouda, T.1    Sutcliffe, J.A.2    Ciotti, S.3    Baker, J.R.4
  • 74
    • 84355161937 scopus 로고    scopus 로고
    • Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens
    • Stanberry L.R., Simon J.K., Johnson C., Robinson P.L., Morry J., Flack M.R., et al. Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens. Vaccine 2012, 30:307-316.
    • (2012) Vaccine , vol.30 , pp. 307-316
    • Stanberry, L.R.1    Simon, J.K.2    Johnson, C.3    Robinson, P.L.4    Morry, J.5    Flack, M.R.6
  • 75
    • 0034666727 scopus 로고    scopus 로고
    • Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered intranasally to healthy adults
    • Boyce T.G., Hsu H.H., Sannella E.C., Coleman-Dockery S.D., Baylis E., Zhu Y., et al. Safety and immunogenicity of adjuvanted and unadjuvanted subunit influenza vaccines administered intranasally to healthy adults. Vaccine 2000, 19:217-226.
    • (2000) Vaccine , vol.19 , pp. 217-226
    • Boyce, T.G.1    Hsu, H.H.2    Sannella, E.C.3    Coleman-Dockery, S.D.4    Baylis, E.5    Zhu, Y.6
  • 76
    • 0033605094 scopus 로고    scopus 로고
    • The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice
    • Barchfeld G.L., Hessler A.L., Chen M., Pizza M., Rappuoli R., Van Nest G.A. The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice. Vaccine 1999, 17:695-704.
    • (1999) Vaccine , vol.17 , pp. 695-704
    • Barchfeld, G.L.1    Hessler, A.L.2    Chen, M.3    Pizza, M.4    Rappuoli, R.5    Van Nest, G.A.6
  • 80
    • 9244255773 scopus 로고    scopus 로고
    • Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59, NIAID AIDS Vaccine Evaluation Group
    • Keefer M.C., Graham B.S., McElrath M.J., Matthews T.J., Stablein D.M., Corey L., et al. Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59, NIAID AIDS Vaccine Evaluation Group. AIDS Research and Human Retroviruses 1996, 12:683-693.
    • (1996) AIDS Research and Human Retroviruses , vol.12 , pp. 683-693
    • Keefer, M.C.1    Graham, B.S.2    McElrath, M.J.3    Matthews, T.J.4    Stablein, D.M.5    Corey, L.6
  • 81
    • 58049090288 scopus 로고    scopus 로고
    • Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02
    • Roestenberg M., Remarque E., de Jonge E., Hermsen R., Blythman H., Leroy O., et al. Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02. PLoS ONE 2008, 3:e3960.
    • (2008) PLoS ONE , vol.3
    • Roestenberg, M.1    Remarque, E.2    de Jonge, E.3    Hermsen, R.4    Blythman, H.5    Leroy, O.6
  • 82
    • 84855890988 scopus 로고    scopus 로고
    • GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults
    • Behzad H., Huckriede A.L., Haynes L., Gentleman B., Coyle K., Wilschut J.C., et al. GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults. Journal of Infectious Diseases 2012, 205:466-473.
    • (2012) Journal of Infectious Diseases , vol.205 , pp. 466-473
    • Behzad, H.1    Huckriede, A.L.2    Haynes, L.3    Gentleman, B.4    Coyle, K.5    Wilschut, J.C.6
  • 87
    • 77949388360 scopus 로고    scopus 로고
    • Criterion for excipients screening in the development of nanoemulsion formulation of three anti-inflammatory drugs
    • Shakeel F. Criterion for excipients screening in the development of nanoemulsion formulation of three anti-inflammatory drugs. Pharmaceutical Development and Technology 2010, 15:131-138.
    • (2010) Pharmaceutical Development and Technology , vol.15 , pp. 131-138
    • Shakeel, F.1
  • 88
    • 0000631893 scopus 로고
    • Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope
    • Bangham A.D., Horne R.W. Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. Journal of Molecular Biology 1964, 8:660-668.
    • (1964) Journal of Molecular Biology , vol.8 , pp. 660-668
    • Bangham, A.D.1    Horne, R.W.2
  • 89
    • 0016328268 scopus 로고
    • Liposomes as immunological adjuvants
    • Allison A.G., Gregoriadis G. Liposomes as immunological adjuvants. Nature 1974, 252:252.
    • (1974) Nature , vol.252 , pp. 252
    • Allison, A.G.1    Gregoriadis, G.2
  • 90
    • 79951899834 scopus 로고    scopus 로고
    • Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
    • Moon J.J., Suh H., Bershteyn A., Stephan M.T., Liu H., Huang B., et al. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nature Materials 2011, 10:243-251.
    • (2011) Nature Materials , vol.10 , pp. 243-251
    • Moon, J.J.1    Suh, H.2    Bershteyn, A.3    Stephan, M.T.4    Liu, H.5    Huang, B.6
  • 92
    • 33645104916 scopus 로고    scopus 로고
    • Immunogenicity and safety of a virosomal hepatitis A vaccine (Epaxal) in the elderly
    • D'Acremont V., Herzog C., Genton B. Immunogenicity and safety of a virosomal hepatitis A vaccine (Epaxal) in the elderly. Journal of Travel Medicine 2006, 13:78-83.
    • (2006) Journal of Travel Medicine , vol.13 , pp. 78-83
    • D'Acremont, V.1    Herzog, C.2    Genton, B.3
  • 93
    • 0027080416 scopus 로고
    • Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
    • Gluck R., Mischler R., Brantschen S., Just M., Althaus B., Cryz S.J. Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A. Journal of Clinical Investigation 1992, 90:2491-2495.
    • (1992) Journal of Clinical Investigation , vol.90 , pp. 2491-2495
    • Gluck, R.1    Mischler, R.2    Brantschen, S.3    Just, M.4    Althaus, B.5    Cryz, S.J.6
  • 94
    • 0017096531 scopus 로고
    • A surface antigen influenza vaccine. 1. Purification of haemagglutinin and neuraminidase proteins
    • Brady M.I., Furminger I.G. A surface antigen influenza vaccine. 1. Purification of haemagglutinin and neuraminidase proteins. Journal of Hygiene 1976, 77:161-172.
    • (1976) Journal of Hygiene , vol.77 , pp. 161-172
    • Brady, M.I.1    Furminger, I.G.2
  • 95
    • 0028318445 scopus 로고
    • Morphological and biochemical characterization of influenza vaccines commercially available in the United Kingdom
    • Renfrey S., Watts A. Morphological and biochemical characterization of influenza vaccines commercially available in the United Kingdom. Vaccine 1994, 12:747-752.
    • (1994) Vaccine , vol.12 , pp. 747-752
    • Renfrey, S.1    Watts, A.2
  • 96
    • 84862529712 scopus 로고    scopus 로고
    • Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status
    • Korsholm K.S., Andersen P.L., Christensen D. Cationic liposomal vaccine adjuvants in animal challenge models: overview and current clinical status. Expert Review of Vaccines 2012, 11:561-577.
    • (2012) Expert Review of Vaccines , vol.11 , pp. 561-577
    • Korsholm, K.S.1    Andersen, P.L.2    Christensen, D.3
  • 98
    • 77956397833 scopus 로고    scopus 로고
    • Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine
    • Even-Or O., Samira S., Rochlin E., Balasingam S., Mann A.J., Lambkin-Williams R., et al. Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine. Vaccine 2010, 28:6527-6541.
    • (2010) Vaccine , vol.28 , pp. 6527-6541
    • Even-Or, O.1    Samira, S.2    Rochlin, E.3    Balasingam, S.4    Mann, A.J.5    Lambkin-Williams, R.6
  • 99
    • 28144437548 scopus 로고    scopus 로고
    • Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate) - a novel adjuvant inducing both strong CMI and antibody responses
    • Davidsen J., Rosenkrands I., Christensen D., Vangala A., Kirby D., Perrie Y., et al. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate) - a novel adjuvant inducing both strong CMI and antibody responses. Biochimica et Biophysica Acta 2005, 1718:22-31.
    • (2005) Biochimica et Biophysica Acta , vol.1718 , pp. 22-31
    • Davidsen, J.1    Rosenkrands, I.2    Christensen, D.3    Vangala, A.4    Kirby, D.5    Perrie, Y.6
  • 100
    • 80052209319 scopus 로고    scopus 로고
    • The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production
    • Henriksen-Lacey M., Devitt A., Perrie Y. The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production. Journal of Controlled Release: Official Journal of the Controlled Release Society 2011, 154:131-137.
    • (2011) Journal of Controlled Release: Official Journal of the Controlled Release Society , vol.154 , pp. 131-137
    • Henriksen-Lacey, M.1    Devitt, A.2    Perrie, Y.3
  • 101
    • 67349263384 scopus 로고    scopus 로고
    • Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone) increases antibody response, cellular immunity, and antigenically drifted protection
    • Lay M., Callejo B., Chang S., Hong D.K., Lewis D.B., Carroll T.D., et al. Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone) increases antibody response, cellular immunity, and antigenically drifted protection. Vaccine 2009, 27:3811-3820.
    • (2009) Vaccine , vol.27 , pp. 3811-3820
    • Lay, M.1    Callejo, B.2    Chang, S.3    Hong, D.K.4    Lewis, D.B.5    Carroll, T.D.6
  • 102
    • 84882274621 scopus 로고    scopus 로고
    • Vaccine compositions comprising a saponin adjuvant. In: ORGANIZATION EP, editor
    • Vandepapeliere P. Vaccine compositions comprising a saponin adjuvant. In: ORGANIZATION EP, editor; 2011.
    • (2011)
    • Vandepapeliere, P.1
  • 106
    • 0027409962 scopus 로고
    • The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique
    • Jeffery H., Davis S.S., O'Hagan D.T. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharmaceutical Research 1993, 10:362-368.
    • (1993) Pharmaceutical Research , vol.10 , pp. 362-368
    • Jeffery, H.1    Davis, S.S.2    O'Hagan, D.T.3
  • 109
    • 81355141475 scopus 로고    scopus 로고
    • The long-term potential of biodegradable poly(lactide-co-glycolide) microparticles as the next-generation vaccine adjuvant
    • Jain S., O'Hagan D.T., Singh M. The long-term potential of biodegradable poly(lactide-co-glycolide) microparticles as the next-generation vaccine adjuvant. Expert Review of Vaccines 2011, 10:1731-1742.
    • (2011) Expert Review of Vaccines , vol.10 , pp. 1731-1742
    • Jain, S.1    O'Hagan, D.T.2    Singh, M.3
  • 110
    • 0842289361 scopus 로고    scopus 로고
    • Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B
    • Singh M., Kazzaz J., Chesko J., Soenawan E., Ugozzoli M., Giuliani M., et al. Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B. Journal of Pharmaceutical Sciences 2004, 93:273-282.
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , pp. 273-282
    • Singh, M.1    Kazzaz, J.2    Chesko, J.3    Soenawan, E.4    Ugozzoli, M.5    Giuliani, M.6
  • 111
    • 17644426388 scopus 로고    scopus 로고
    • Adsorption of a novel recombinant glycoprotein from HIV (Env gp120dV2 SF162) to anionic PLG microparticles retains the structural integrity of the protein, whereas encapsulation in PLG microparticles does not
    • Singh M., Chesko J., Kazzaz J., Ugozzoli M., Kan E., Srivastava I., et al. Adsorption of a novel recombinant glycoprotein from HIV (Env gp120dV2 SF162) to anionic PLG microparticles retains the structural integrity of the protein, whereas encapsulation in PLG microparticles does not. Pharmaceutical Research 2004, 21:2148-2152.
    • (2004) Pharmaceutical Research , vol.21 , pp. 2148-2152
    • Singh, M.1    Chesko, J.2    Kazzaz, J.3    Ugozzoli, M.4    Kan, E.5    Srivastava, I.6
  • 112
    • 61849172399 scopus 로고    scopus 로고
    • Enhancing the therapeutic efficacy of CpG oligonucleotides using biodegradable microparticles
    • Malyala P., O'Hagan D.T., Singh M. Enhancing the therapeutic efficacy of CpG oligonucleotides using biodegradable microparticles. Advanced Drug Delivery Reviews 2009, 61:218-225.
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 218-225
    • Malyala, P.1    O'Hagan, D.T.2    Singh, M.3
  • 114
    • 84860734680 scopus 로고    scopus 로고
    • MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine
    • Singh M., Kazzaz J., Ugozzoli M., Baudner B., Pizza M., Giuliani M., et al. MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine. Human Vaccines & Immunotherapeutics 2012, 8:486-490.
    • (2012) Human Vaccines & Immunotherapeutics , vol.8 , pp. 486-490
    • Singh, M.1    Kazzaz, J.2    Ugozzoli, M.3    Baudner, B.4    Pizza, M.5    Giuliani, M.6
  • 115
    • 78650537632 scopus 로고    scopus 로고
    • A two-stage strategy for sterilization of poly(lactide-co-glycolide) particles by gamma-irradiation does not impair their potency for vaccine delivery
    • Jain S., Malyala P., Pallaoro M., Giuliani M., Petersen H., O'Hagan D.T., et al. A two-stage strategy for sterilization of poly(lactide-co-glycolide) particles by gamma-irradiation does not impair their potency for vaccine delivery. Journal of Pharmaceutical Sciences 2011, 100:646-654.
    • (2011) Journal of Pharmaceutical Sciences , vol.100 , pp. 646-654
    • Jain, S.1    Malyala, P.2    Pallaoro, M.3    Giuliani, M.4    Petersen, H.5    O'Hagan, D.T.6
  • 116
    • 0022271839 scopus 로고
    • Modifications in the alditol acetate method for analysis of muramic acid and other neutral and amino sugars by capillary gas chromatography-mass spectrometry with selected ion monitoring
    • Whiton R.S., Lau P., Morgan S.L., Gilbart J., Fox A. Modifications in the alditol acetate method for analysis of muramic acid and other neutral and amino sugars by capillary gas chromatography-mass spectrometry with selected ion monitoring. Journal of Chromatography 1985, 347:109-120.
    • (1985) Journal of Chromatography , vol.347 , pp. 109-120
    • Whiton, R.S.1    Lau, P.2    Morgan, S.L.3    Gilbart, J.4    Fox, A.5
  • 117
    • 77955983000 scopus 로고    scopus 로고
    • Monitoring initial response to angiotensin-converting enzyme inhibitor-based regimens: an individual patient data meta-analysis from randomized, placebo-controlled trials
    • Bell K.J., Hayen A., Macaskill P., Craig J.C., Neal B.C., Fox K.M., et al. Monitoring initial response to angiotensin-converting enzyme inhibitor-based regimens: an individual patient data meta-analysis from randomized, placebo-controlled trials. Hypertension 2010, 56:533-539.
    • (2010) Hypertension , vol.56 , pp. 533-539
    • Bell, K.J.1    Hayen, A.2    Macaskill, P.3    Craig, J.C.4    Neal, B.C.5    Fox, K.M.6
  • 118
    • 78650522411 scopus 로고    scopus 로고
    • Adjuvating the adjuvant: facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells
    • Aichinger M.C., Ginzler M., Weghuber J., Zimmermann L., Riedl K., Schutz G., et al. Adjuvating the adjuvant: facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells. Vaccine 2011, 29:426-436.
    • (2011) Vaccine , vol.29 , pp. 426-436
    • Aichinger, M.C.1    Ginzler, M.2    Weghuber, J.3    Zimmermann, L.4    Riedl, K.5    Schutz, G.6
  • 119
    • 35348988624 scopus 로고    scopus 로고
    • IC31 and IC30, novel types of vaccine adjuvant based on peptide delivery systems
    • Lingnau K., Riedl K., von Gabain A. IC31 and IC30, novel types of vaccine adjuvant based on peptide delivery systems. Expert Review of Vaccines 2007, 6:741-746.
    • (2007) Expert Review of Vaccines , vol.6 , pp. 741-746
    • Lingnau, K.1    Riedl, K.2    von Gabain, A.3
  • 120
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway C.A. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symposia on Quantitative Biology 1989, 54(Pt 1):1-13.
    • (1989) Cold Spring Harbor Symposia on Quantitative Biology , vol.54 , Issue.PART 1 , pp. 1-13
    • Janeway, C.A.1
  • 122
    • 84859020840 scopus 로고    scopus 로고
    • Development and evaluation of AS03, an Adjuvant System containing alpha-tocopherol and squalene in an oil-in-water emulsion
    • Garcon N., Vaughn D.W., Didierlaurent A.M. Development and evaluation of AS03, an Adjuvant System containing alpha-tocopherol and squalene in an oil-in-water emulsion. Expert Review of Vaccines 2012, 11:349-366.
    • (2012) Expert Review of Vaccines , vol.11 , pp. 349-366
    • Garcon, N.1    Vaughn, D.W.2    Didierlaurent, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.