Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel™, Montanide ISA 720 or AS02

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Roestenberg, Meta ^a   Remarque, Ed ^b   de Jonge, Erik ^a   Hermsen, Rob ^a   Blythman, Hildur ^c   Leroy, Odile ^c   Imoukhuede, Egeruan ^c   Jepsen, Soren ^c   Ofori Anyinam, Opokua ^d   Faber, Bart ^b   Kocken, Clemens H M ^b   Arnold, Miranda ^b   Walraven, Vanessa ^b   Teelen, Karina ^a   Roeffen, Will ^a   de Mast, Quirijn ^a   Ballou, W Ripley ^d,f   Cohen, Joe ^d   Dubois, Marie Claude ^d   Ascarateil, Stéphane ^e   van der Ven, Andre ^a   Thomas, Alan ^b   Sauerwein, Robert ^a   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^c European Malaria Vaccine Initiative   (Denmark)

^d GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^e SEPPIC   (France)

^f BILL AND MELINDA GATES FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; ALUMINUM HYDROXIDE; APICAL MEMBRANE ANTIGEN 1; AS02; MALARIA VACCINE; MONTANIDE ISA 720; UNCLASSIFIED DRUG; DRUG DERIVATIVE; IMMUNOLOGICAL ADJUVANT; MANNITOL; MANNITYL OLEATE; OLEIC ACID; RECOMBINANT VACCINE;

ABDOMINAL PAIN; ADULT; ANTIPROTOZOAL ACTIVITY; ARTHRALGIA; ARTICLE; CELLULAR IMMUNITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FEVER; DRUG FORMULATION; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; GROWTH INHIBITION; HUMAN; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; INJECTION SITE ABSCESS; INJECTION SITE ERYTHEMA; INJECTION SITE INDURATION; INJECTION SITE PAIN; INJECTION SITE REACTION; INJECTION SITE SWELLING; MALAISE; MALARIA FALCIPARUM; MALE; MEROZOITE; NAUSEA; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPOROZOITE; TREATMENT RESPONSE; ADOLESCENT; ALGORITHM; ANIMAL; DOSE RESPONSE; IMMUNOLOGY; MIDDLE AGED; TREATMENT OUTCOME;

PICHIA PASTORIS; PLASMODIUM FALCIPARUM;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; ALGORITHMS; ALUMINUM HYDROXIDE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALARIA VACCINES; MALARIA, FALCIPARUM; MALE; MANNITOL; MIDDLE AGED; OLEIC ACIDS; PLASMODIUM FALCIPARUM; TREATMENT OUTCOME; VACCINES, SYNTHETIC; YOUNG ADULT;

EID: 58049090288     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003960     Document Type: Article

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