Effects of stabilizers on the destabilization of proteins upon adsorption to aluminum salt adjuvants

Journal of Pharmaceutical Sciences

Volumn 96, Issue 3, 2007, Pages 547-557

  Peek, Laura J ^a   Martin, Talia T ^a   Nation, Charity Elk ^a,b   Pegram, Shannel A ^a,c   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Haskell Indian Nations University   (United States)

^c NORFOLK STATE UNIVERSITY   (United States)

Author keywords

Adsorption; Calorimetry (DSC); Excipients; Fluorescence spectroscopy; Protein formulation; Protein structure; Stability; Stabilization; Vaccine adjuvants; Vaccines

Indexed keywords

ADJU PHOS; ADJUVANT; ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; ALUMINUM SALT; EXCIPIENT; PROTEIN DERIVATIVE; STABILIZING AGENT; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; FLUORESCENCE ANALYSIS; ISOTHERM; PROTEIN STABILITY; TEMPERATURE MEASUREMENT;

EID: 33947538420     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20762     Document Type: Article

References (17)

1. Jones LS, Peek LJ, Power J, Markham A, Yazzie B, Middaugh CR. 2005. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J Biol Chem 280:13406-13414.
2. Brandau DT, Jones LS, Wiethoff CM, Rexroad J, Middaugh CR. 2003. Thermal stability of vaccines. J Pharm Sci 92:218-231.
3. Rexroad J, Wiethoff CM, Jones LS, Middaugh CR. 2002. Lyophilization and the thermostability of vaccines. Cell Preservation Technol 1:91-104.
4. Setia S, Mainzer H, Washington ML, Coil G, Snyder R, Weniger BG. 2002. Frequency and causes of vaccine wastage. Vaccine 20:1148-1156.
5. Zaffran M. 1996. Vaccine transport and storage: Environmental challenges. Dev Biol Stand 87:9-17.
6. Gupta RK. 1998. Aluminum compounds as vaccine adjuvants. Adv Drug Deliv Rev 32:155-172.
7. Singh M, O'Hagan DT. 2002. Recent advances in vaccine adjuvants. Pharm Res 19:715.
8. Vogel FR, Powell MF, Alving CR. 1995. A compendium of vaccine adjuvants and excipients. In: Powell MF, Newman MJ, editors, Vaccine design: The subunit and adjuvant approach. New York: Plenum Press, pp 1-114.
9. Gupta RK, Rost BE, Relyveld E, Siber GR. 1995. Adjuvant properties of aluminum and calcium compounds. In: Powell MF, Newman MJ, editors, Vaccine design: The subunit and adjuvant approach. New York: Plenum Press. pp 229-248.
10. Al-Shakhshir RH, Regnier FE, White JL, Hem SL. 1995. Contribution of electrostatic and hydrophobic interactions to the adsorption of proteins by aluminium-containing adjuvants. Vaccine 13:41-44.
11. Iyer S, HogenEsch H, Hem SL. 2003. Effect of the degree of phosphate substitution in aluminum hydroxide adjuvant on the adsorption of phosphorylated proteins. Pharm Dev Technol 8:81-86.
12. Iyer S, Robinett RS, HogenEsch H, Hem SL. 2004. Mechanism of adsorption of hepatitis B surface antigen by aluminum hydroxide adjuvant. Vaccine 22:1475-1479.
13. Lindblad EB. 2004. Aluminium compounds for use in vaccines. Immunol Cell Biol 82:497-505.
14. Seeber SJ, White JL, Hem SL. 1991. Predicting the adsorption of proteins by aluminium-containing adjuvants. Vaccine 9:201-203.
15. Ametani A, Sakurai T, Katakura Y, Kuhara S, Hirakawa H, Hosoi T, Dosako S, Kaminogawa S. 2003. Amino acid residue substitution at T-cell determinant-flanking sites in beta-lactoglobulin modulates antigen presentation to T cells through subtle conformational change. Biosci Biotechnol Biochem 67:1507-1514.
16. So T, Ito HO, Koga T, Watanabe S, Ueda T, Imoto T. 1997. Depression of T-cell epitope generation by stabilizing hen lysozyme. J Biol Chem 272:32136-32140.
17. Thai R, Moine G, Desmadril M, Servent D, Tarride JL, Menez A, Leonetti M. 2004. Antigen stability controls antigen presentation. J Biol Chem 279:50257-50266.